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Search Results: 1 - 10 of 399 matches for " Vida Jakovljevi? "
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Effect of chromium enriched fermentation product of barley and brewer’s yeast and its combination with rosiglitazone on experimentally induced hyperglycaemia in mice
Ceki? Vlada,Vasovi? Velibor,JakovljeviVida,Lalo?evi? Du?an
Srpski Arhiv za Celokupno Lekarstvo , 2011, DOI: 10.2298/sarh1110610c
Abstract: Introduction. In the recent years, herbal preparations have been more used to treat diabetes. Dietetic supplement based on barley and beer yeast enriched with chromium (BBCr) is registered in Serbia as a supplement in the treatment of type 2 diabetes. Objective. To investigate the effect of the preparation based on barley and brewer’s yeast with chromium (BBCr), rosiglitazone (R) and their combination (BBCr+R) on fasting glycaemia and glycaemia in mice after glucose, adrenalin and alloxan application. Methods. The animals were divided into three groups: glucose 500 mg/kg (I); adrenalin 0.2 mg/kg (II); and alloxan 100 mg/kg (III) and into subgroups according to the substance they received (BBCr: 750 mg/kg, R: 0.75 mg/kg and BBCr+R). Each animal was its own control in respect of glycaemia before and after the treatment with test substances, except for group III which contained a placebo subgroup. Results. BBCr caused a significant decrease of fasting glycaemia and significant reduction of glycaemia after glucose load compared to the values before treatment (7.4±0.6 mmol/l vs 9.2±0.6 mmol/l; p=0.01). R and BBCr+R significantly decreased glycaemia after adrenalin load (R: 8.6±1.8 mmol/l vs 15.4±3.2 mmol/l; p=0.004; BBCr+R: 9.6±2.4 mmol/l vs 15.0±4.4 mmol/l; p=0.04). After alloxan application the glycaemia was significantly lower in the subgroups treated with BBCr, R and BBCr+R compared to placebo subgroup (10.1±8.0 mmol/l vs 6.8±2.7 mmol/l vs 13.5±9.7 mmol/l vs 24.5±4.7 mmol/l; p=0.001). Conclusion. Pretreatment with BBCr caused a significant reduction of fasting glycaemia and glycaemia after glucose load. Rosiglitazone and BBCr+R caused a significant reduction of glycaemia after adrenalin load. Pretreatment with BBCr, R and BBCr+R prevented the onset of experimental diabetes caused by alloxan, which was confirmed by histological analysis of pancreas tissue.
Anti-Oxidative Activity of An Aqueous Suspension of Commercial Preparation of The Mushroom Coprinus comatus
Mira Popovi?,Sa?a Vukmirovi?,Neboj?a Stilinovi?,Ivan ?apo,Vida Jakovljevi
Molecules , 2010, DOI: 10.3390/molecules15074564
Abstract: In this study the effects of an aqueous suspension of a commercial preparation of the mushroom Coprinus comatus on oxidative stress induced in rats by alloxane and carbon tetrachloride was examined. The effects were estimated from changes in the biochemical parameters (xanthine oxidase, glutathione peroxidase and catalase activity, reduced glutathione content, and extent of lipid peroxidation) of liver homogenate as well as histological changes in the liver of the rats treated with alloxane and carbon tetrachloride. Two screening doses of alloxane sufficient to induce diabetes in rats did not have any significant effect on the examined biochemical parameters of liver homogenate or on the cytoarchitectonics of liver cross-sections. Treatment with carbon tetrachloride resulted in a significant increase in the intensity of lipid peroxidation and peroxydasis activity, as well as with decrease in catalase activity. Certain changes in liver cross sections were detected, such is lymphocyte infiltration of dilated sinusoid capillaries. Administration of Coprinus comatus suspension thus showed antioxidative potential, evidenced by an increase of antioxidative status of liver homogenate and prevention of histological changes in liver cross sections.
Kumulativisti ko nasle e i njegove aktuelne forme - prilog razumevanju kumulativisti kog na ina vi enja nau nih razvoja
Jakovljevi? Dragan
Theoria, Beograd , 2010, DOI: 10.2298/theo1002063j
Abstract: (nema ki) Obwohl er wohl den ltesten Standpunkt hinsichtlich der Interpretation wissenschaftlicher Entwicklungen darstellt, wird der Kumulativismus merkwürdigerweise bis in die gegenw rtige Diskussion hinein meistens unzureichend klar bestimmt. In dieser Folge wird seine Behandlung im Rahmen moderner Wissenschaftsheorie von einigen Miβverst ndnissen und groben Vereinfachungen begleitet. Die vorliegende Abhandlung bezweckt eine Er rterung konzeptioneller Eigentümlichkeiten sowie Kapazit ten der kummulativistischen Auslegung wissenschaftlicher Entwicklungen. Der Verfasser geht hierbei insbesondere auf Kritiken von K.R. Popper ein, die inzwischen die Schule gemacht haben. Diesen entgegen, wird nachgewiesen, dass die kummulativistische Deutung wissenschaftlicher Entwicklungen an keine induktivistische Methodologie der Theorienbildung gekoppelt zu werden braucht. Es erweist sich, dass in der wissenschaftstheoretischen Interpretation wissenschaftlicher Entwicklungen von zwei Gestalten des Kumulativismus die Rede sein kann: vom Whewellschen rigiden umfassenden Kumulativismus einerseits, der nur sehr eingeschr nkt auf die tats chliche Wissenschaftsgeschichte anwendbar ist, von einem partiellen und flexiblen Kumulativismus, der praktisch mit dem Popperschen evolutionistischen Modell koinzidiert und der breiter und vollst ndiger anwendbar ist. Die von Popper eingeleitete evolutionistische Interpretation der Wissenschaftsgeschichte zeigt sich als die am besten haltbare Form, in der die Idee einer Akumulation wissenschaftlichen Wissens im Rahmen wissenschaftlicher Entwicklungen heute vertretbar ist.
Die ansichten von toleranz und intoleranz
Jakovljevi? Dragan
Theoria, Beograd , 2008, DOI: 10.2298/theo0803085j
Abstract: (nema ki) Dieser Aufsatz bring zun chst eine Betrachtung über die Bedingungen, unter denen von einer Duldsamkeit sinnvollerweise gesprochen werden kann. Dem folgend wird ein Versuch entsprechender Begriffsbestimmung unternommen, wobei die Zweigbegriffe einer passiven (negativen) und einer t tigen (positiven) Toleranz ausgegrenzt werden. Der Verfasser weist zurück die kognitivistische Auslegung wie diese von J. Habermas vertreten wird als einseitig und empirisch unangem βen, und versucht anders als er die Frage nach der Natur des uns zum Tolerieren bewegenden R sonieren zu kl ren, sowie weshalb es eigentlich als gerechtfertigt anzusehen ist. Die Frage, ob die Toleranz als Ergebnis der freien Handlungswahl zu gelten hat, wird relativiert darauf, ob sie als ein moralisches Ph nomen eingestuft wird. Neben der Pr senz der freien Handlungswahl wird in dem Falle auch noch die Hanlungsbestimmung durch eine werthafte überzeugung in die Richtigkeit von der Differenzenachtung und dem duldsamen Umgehen mit ihnen als der eigentliche Handlungsgrund mitgemeint. Der Verfasser verweist aber zugleich auf weietere m gliche und in gesellschaftlichen Wirklichkeit real t tige Weisen zur Generierung von Toleranz und / oder Intoleranz. Abschliessend wird auf die Nuancenunterschiede hingewiesen bei der Fragestellung nach dem Tolerieren innerhalb von bestimmten Gesellschaften einerseits, und der derselben Fragestellung auf der zwischenstaatlichen bzw. interkulturellen Ebene andererseits.
Dead public spaces - live private corners: (Re)contextualization of musically public and private
Jakovljevi? Rastko
Muzikologija , 2009, DOI: 10.2298/muz0909051j
Abstract: The expressions of private and public musical life and experience are mostly discussed separately. This article joins these two concepts into one scope and surveys the identity of both. In ideal (utopian?) traditional context between private and public music experience (life), the context shows ideal vitality and consistence, while in an 'irregular' context these two concepts begin to distance themselves, opening space for marginality or so called 'errors'. This article studies bagpipe tradition in Serbia, at different stages of its development and in different periods, specifically focusing on rural and urban contexts in diverse sociopolitical conditions. Although bagpipe tradition still exists in Serbia it is far removed from what it once was, and the idea is to represent the contexts of that process, private and public, sociopolitical, and marginal aspects, from the 19th century (or hypothetically before then) until today.
Serbian and Canadian water quality index of Danube river in Serbia in 2010
Jakovljevi? Dejana
Journal of the Geographical Institute Jovan Cvijic, SASA , 2012, DOI: 10.2298/ijgi1203001j
Abstract: This paper aims to assess water quality of Danube River in Serbia for 2010. Two methodologies were applied for this purpose: Serbian Water Quality Index (SWQI) and Canadian Water Quality Index (CWQI). WQI value is dimensionless, single number ranging from 0 to 100 (best quality) derived from numerous physical, chemical, biological and microbiological parameters. SWQI was mainly good and very good. This methodology includes parameters for assessment of organic loading, but does not involve parameters of heavy metals concentration. For that purpose CWQI was used. Besides overall, CWQI was calculated for following uses: aquatic habitat, drinking, recreation, irrigation and livestock. Overall CWQI was marginal and fair, which was equivalent with poor and good SWQI. CWQI methodology showed increased concentration of copper in all cases which affected overall water quality and aquatic habitat while increased turbidity in many cases had negative influence on drinking water. Differences between SWQI and CWQI resulted from different methodology: different methods of calculation and parameters. In order to get more comparable results it is necessary to develop unique WQI methodology. [Projekat Ministarstva nauke Republike Srbije, br. 47007]
Frequency of alcohol use among elementary school pupils at Belgrade territory
Pavlovi? Zorana,Jakovljevi? Branko
Srpski Arhiv za Celokupno Lekarstvo , 2008, DOI: 10.2298/sarh0804141p
Abstract: Introduction Alcoholism is one of the most frequent modern diseases. These kinds of epidemiological studies have not been carried out in this country at a global level. Objective The aim of the study was to establish the spread of alcohol abuse among the young regarding the sex, and find the connection between the alcohol abuse and the consumption of drugs and cigarettes. Methods The study was carried out among the elementary school pupils of the seventh and eighth grade in the area of Belgrade from October 2003 to January 2004. Total of 457 pupils were involved; 229 (50.1%) were boys and 228 (49.9%) girls, aged 12-15 years, the average age being 13.4 years. The method used was the modified questionnaire European School Survey Project on Alcohol and Other Drugs, which the pupils filled in individually, voluntarily and anonymously. χ2-test, Student's t-test, Mann-Whitney Logistic Regression Test were used in statistical processing of the data. Results Almost 70% of the examinees have tried alcohol. Most of the examinees had the first contact with alcohol at the age of 11. Half of our examinees got drunk at least once in their life and about one fifth more than 20 times. The binge form of consumption (five or more drinks in a row) was evident in a quarter of our examinees. Our examinees use alcohol together with other psychoactive substances, mostly marijuana. It was observed that certain types of behavior, such as frequent going out in the evening, were directly related to the abuse of alcohol. Conclusion Two thirds of the examinees have tried alcohol. The first contact with alcohol is shifted to an earlier age (11 years). New trends of alcohol abuse have been noticed, such as binge form of consumption and the connection of use with other psychoactive substances. .
PHARMACOLOGICAL IN VITRO MODELS IN PRE-CLINICAL DRUG TESTING - EXAMPLE OF hSERT TRANSFECTED HUMAN EMBRYONIC KIDNEY CELLS
Mihajlo Jakovljevi,Olivera Milovanovi?
Acta Medica Medianae , 2012,
Abstract: Preclinical drug testing should be considered an important stage during examinations of its efficiency and safety in any likely indication observed. Purpose of the process is acquisition of substantial amount of particular drug-related data before approaching clinical trials in humans. Historical preclinical testing relied on available testing in microbe cultures and animal models. During recent decades laboratory techniques of human cell lines cultivation have been developed and improved. These provide unique possibility of drug acting mechanism testing in a simplified environment lacking basic homeostatic mechanisms. Some examples of these are measuring drug impact to biochemical transport, signaling or anabolic processes. Humane cell lines of embrional kidney 293 are an example of easy-to-grow and disseminate and quite endurable cell line. This methodological article notices some of the details of HEK293 cells cultivation and breading. We took transfection as an example of in vitro model creation for drug testing. Transfection refers to gene introduction into HEK293 cellular genome in order to achieve membrane expression of coded protein. In our case it would be human serotonin transporter. Article contains description of one particular methodological approach in measuring human serotonin transporter expression. The role and importance of serotonin pump in affective disorders genesis was already widely recognized. Aim of the paper was to emphasize feasibility of cell cultivation and its advantages in comparison with alternative traditional methods.
AVAILABLE TREATMENT APPROACHES OF ACUTE INFLUENZA H1N1 INFECTION AND ITS CLINICAL COMPLICATIONS
Mihajlo Jakovljevi,Stepanovi? Marija
Acta Medica Medianae , 2010,
Abstract: Human H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. It seems that the current wave of infections slowly moves towards the southern hemisphere; however, the WHO reports on certain foci in Southeast Asia, Western Africa and tropic islands of the Middle America do not exclude another reccurrence in the northern hemisphere. This drew the attention of epidemiologists due to the fact that the virus owns a very unique capsid which expresses proteins coded by genes originating from the human, swine and avian influenza virus and was not covered by the available seasonal vaccines. Although most of the cases exibit classical clinical presentation of influenza infection, there are special features like significant gastrointestinal symptomatology and vulnerability of the young population. With respectively small but significant portion of patients there have been noticed fulminant course of infection with poor prognosis including sudden development of respiratory failure and consciousness disturbances which require intensive care unit admission. Cytokine storm should be mentioned as one of the key pathogenic events contributing to the overall mortality in substantial portion of patients. If active immunization is assumed to be preventive measure of proven efficacy, clinicians are still in doubt how to treat a complicated course of infection. We should be aware that the first choice essential drugs, for which viral sensitivity has been certainly proved, are neuraminidasis inhibitors. Here we have to distinct between more available oseltamivir and less available zanamivir and peramivir which until now have shown absolute effectiveness in inhibiting viral strains replication in vivo. Success of direct antiviral protocols has also been noticed with inhaled synthetic nucleoside ribavirine applied locally. Bacterial pneumonia superimposed by the overall patient status should be treated in accordance with the available evidence-based guidelines. We should be aware that septic lung infection caused by multiresistant organisms irrespective of intensive treatment remains the main cause of lethal outcomes in serious clinical presentations of H1N1 infection.
The concept and importance of medical law
Jakovljevi? Branislava,Segedi Dimitrije
Medicinski Pregled , 2006, DOI: 10.2298/mpns0604135j
Abstract: Introduction. Medical law is a scientific discipline which has not been affirmed in our country, but at law schools in many developed countries it has gained the status of a separate scientific discipline and today it is studied with multidisciplinary cooperation of Schools of Medicine, Schools of Dentistry and Schools of Pharmacy. Generally speaking, medical law concerns the rights and duties of the medical profession. Ethics and legal questions of medical law. The progress of scientific research and of new technology used in diagnostics and treatment, opens new fields in terms of responsibility. Most European countries have legal institutions in the field of health care. These include laws and legal acts, as well as codification of professional norms. Law concerning physicians. Apart from the national law, there is also an international law concerning physisians. The World Health Organization and the World Association of Medical Doctors brought the following declarations: Declaration on Promotion of Patients' Rights, the Revised Lisbon Declaration on Patients' Rights, the Revised Helsinki Declaration on Biomedical Research Involving Human Subjects and the Council of Europe's Convention on Human Rights and Biomedicine. Conclusion. There is no national order of physicians in Serbia and Montenegro, because chambers of physisians with legal authority and mandatory membership have not been formed. The foundation of Chambers of Physicians of Vojvodina and Montenegro is the first step to goal achieving. .
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