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Search Results: 1 - 10 of 3761 matches for " Victoria; Gibert "
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Use of functioning-disability and dependency for case-mix and subtyping of schizophrenia
Ochoa,Susana; Salvador-Carulla,Luis; Villalta-Gil,Victoria; Gibert,Karina; Haro,Josep Maria; ,;
The European Journal of Psychiatry , 2012, DOI: 10.4321/S0213-61632012000100001
Abstract: background and objectives: to evaluate the utility of the constructs functioning and disability (f & d) and dependency for case-mix and subtyping of patients with schizophrenia by psychosocial, clinical, use of services and attention received from informal carers. methods: a randomly selected total of 205 people with schizophrenia, and their careers were evaluated through panss, das-sv, objective and subjective burden scale (ecfos-ii) and use of services. results: two groups and four profiles were identified according to levels of dependency: the non-dependent group was made of two profiles: independent (i), and persons with disability in the community (dic). the dependent group included persons with dependency in the community (dec) and persons with dependency in hospital care (deh). there are clinical and psychosocial differences between these profiles being the dependent the most severe. regarding use of services, dec use the most resources, with the exception deh (more hospitalization resources). the dec profile generate greater family burden in the following areas; taking medication, being accompanied to appointments, and management than the dic, despite both groups showing a high need for support. conclusions: dependency is a relevant construct for case-mix and subtyping in schizophrenia, and it is related to severity both at the social and clinical level. dec generate more family burden than the other profiles, followed by dic (patients with schizophrenia with disability but non-dependent).
Use of functioning-disability and dependency for case-mix and subtyping of schizophrenia
Susana Ochoa,Luis Salvador-Carulla,Victoria Villalta-Gil,Karina Gibert
The European Journal of Psychiatry , 2012,
Abstract: Background and Objectives: To evaluate the utility of the constructs functioning and disability (F & D) and dependency for case-mix and subtyping of patients with schizophrenia by psychosocial, clinical, use of services and attention received from informal carers. Methods: A randomly selected total of 205 people with schizophrenia, and their careers were evaluated through PANSS, DAS-sv, Objective and Subjective Burden Scale (ECFOS-II) and use of services. Results: Two groups and Four profiles were identified according to levels of Dependency: The non-dependent group was made of two profiles: independent (I), and persons with disability in the community (DiC). The dependent group included persons with dependency in the community (DeC) and persons with dependency in hospital care (DeH). There are clinical and psychosocial differences between these profiles being the dependent the most severe. Regarding use of services, DeC use the most resources, with the exception DeH (more hospitalization resources). The DeC profile generate greater family burden in the following areas; taking medication, being accompanied to appointments, and management than the DiC, despite both groups showing a high need for support. Conclusions: Dependency is a relevant construct for case-mix and subtyping in schizophrenia, and it is related to severity both at the social and clinical level. DeC generate more family burden than the other profiles, followed by DiC (patients with schizophrenia with disability but non-dependent).
Knowledge discovery from data as a framework to decision support in medical domains
Karina Gibert
International Journal of Integrated Care , 2009,
Abstract:
Moderniser la ville, réaménager la rue à Ho Chi Minh Ville
Marie Gibert
EchoGéo , 2010,
Abstract: Cet article se propose de faire de la rue un objet géographique permettant de lire les recompositions socio-spatiales de Ho Chi Minh Ville, à l’heure de la politique volontariste de renouvellement urbain des autorités. C’est à partir d’un double héritage étranger que la trame urbaine de Ho Chi Minh Ville s’est ensuite auto-développée pendant trois décennies donnant naissance à des rues étroites, support d’un bati dense et bas, lieu de pratiques urbaines multiformes. La redéfinition contemporaine de l’échelle de ces rues, devant permettre la verticalisation du bati riverain, invite alors à interroger les différentes modalités de renouvellement de la rue ainsi que la réappropriation de cette dernière par les citadins. This article considers the streets of Ho Chi Minh City as an original geographicalobject of researchthatallows to read the socio-spatial restructuration of the city in the currentcontext of urbanrenewal official policies. The urbanfabric network of Ho Chi Minh City is first and foremost a double foreigninheritagefromboth the Chinese and the French periods. It thendevelopped by itselfduringthreedecades. This urbanhistoryled to the development of a very dense network of narrowalleys, withmultiformurbanfunctions. The current official redefinition of the streetsscaleaims to allow for the verticalisation of the buildings environment. Then, theseprojects of streetrenewalenables us to examine the variousmodalities of streetrenewal and its new appropriation by the urbancitizens.
BMP Signaling Modulates Hepcidin Expression in Zebrafish Embryos Independent of Hemojuvelin
Yann Gibert,Victoria J. Lattanzi,Aileen W. Zhen,Lea Vedder,Frédéric Brunet,Sarah A. Faasse,Jodie L. Babitt,Herbert Y. Lin,Matthias Hammerschmidt,Paula G. Fraenkel
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0014553
Abstract: Hemojuvelin (Hjv), a member of the repulsive-guidance molecule (RGM) family, upregulates transcription of the iron regulatory hormone hepcidin by activating the bone morphogenetic protein (BMP) signaling pathway in mammalian cells. Mammalian models have identified furin, neogenin, and matriptase-2 as modifiers of Hjv's function. Using the zebrafish model, we evaluated the effects of hjv and its interacting proteins on hepcidin expression during embryonic development. We found that hjv is strongly expressed in the notochord and somites of the zebrafish embryo and that morpholino knockdown of hjv impaired the development of these structures. Knockdown of hjv or other hjv-related genes, including zebrafish orthologs of furin or neogenin, however, failed to decrease hepcidin expression relative to liver size. In contrast, overexpression of bmp2b or knockdown of matriptase-2 enhanced the intensity and extent of hepcidin expression in zebrafish embryos, but this occurred in an hjv-independent manner. Furthermore, we demonstrated that zebrafish hjv can activate the human hepcidin promoter and enhance BMP responsive gene expression in vitro, but is expressed at low levels in the zebrafish embryonic liver. Taken together, these data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hjv.
Tissue Specific Roles for the Ribosome Biogenesis Factor Wdr43 in Zebrafish Development
Chengtian Zhao ,Viktoria Andreeva,Yann Gibert,Melissa LaBonty,Victoria Lattanzi,Shubhangi Prabhudesai,Yi Zhou,Leonard Zon,Kathleen L. McCann,Susan Baserga,Pamela C. Yelick
PLOS Genetics , 2014, DOI: doi/10.1371/journal.pgen.1004074
Abstract: During vertebrate craniofacial development, neural crest cells (NCCs) contribute to most of the craniofacial pharyngeal skeleton. Defects in NCC specification, migration and differentiation resulting in malformations in the craniofacial complex are associated with human craniofacial disorders including Treacher-Collins Syndrome, caused by mutations in TCOF1. It has been hypothesized that perturbed ribosome biogenesis and resulting p53 mediated neuroepithelial apoptosis results in NCC hypoplasia in mouse Tcof1 mutants. However, the underlying mechanisms linking ribosome biogenesis and NCC development remain poorly understood. Here we report a new zebrafish mutant, fantome (fan), which harbors a point mutation and predicted premature stop codon in zebrafish wdr43, the ortholog to yeast UTP5. Although wdr43 mRNA is widely expressed during early zebrafish development, and its deficiency triggers early neural, eye, heart and pharyngeal arch defects, later defects appear fairly restricted to NCC derived craniofacial cartilages. Here we show that the C-terminus of Wdr43, which is absent in fan mutant protein, is both necessary and sufficient to mediate its nucleolar localization and protein interactions in metazoans. We demonstrate that Wdr43 functions in ribosome biogenesis, and that defects observed in fan mutants are mediated by a p53 dependent pathway. Finally, we show that proper localization of a variety of nucleolar proteins, including TCOF1, is dependent on that of WDR43. Together, our findings provide new insight into roles for Wdr43 in development, ribosome biogenesis, and also ribosomopathy-induced craniofacial phenotypes including Treacher-Collins Syndrome.
Obliteration study of lambdatic and obelionic region sutures in ruminant, carnivores and hominids
Gibert, J.,Ribot, F.,Gibert, P.,Gibert, L.
Estudios Geologicos , 2006, DOI: 10.3989/egeol.0662112
Abstract: The morphology of Orce cranial fragment VM-0 is contrasted with the fronto-parietal region in artiodactyls, and the obelionic region in carnivores and primates including hominids. Sutural development at obelion is compared in those taxa throughout the growth period up to the onset of sutural obliteration, and ontogenetic differences between non-primates and primates lead us to conclude that the configuration in VM-0 more resembles that found in hominids than in artiodactyls or carnivores. Moreover, cranial capacity for VM-0 is estimated at >470cm3, comparable to Plio Pleistocene hominids, but greater than in young equids. La morfología del fragmento cranial de Orce (VM-0) se contrasta con la región fronto-parietal de los artiodáctilos y con la región obélica de los carnívoros y primates incluyendo los homínidos. Se compara en estos taxones, el desarrollo de las suturas en esta región a lo largo del periodo de crecimiento hasta que ocurre la obliteración de las mismas. Las diferencias ontogenéticas entre no primates y primates nos permiten concluir que la anatomía de VM-0 es más próxima a los hominidos que a la de los artiodáctilos y carnívoros. Se estima que la capacidad craneana de VM-0 tiene que ser > 470 cm3, comparable a la de los homínidos del Plio-Pleistoceno y mayor que la de los équidos juveniles.
Trabajando con alumnos no alfabetizados
Isabel Gibert Escofet
Foro de Profesores de E/LE , 2010,
Abstract: Cuándo aprendimos a leer y a escribir?, qué recuerdos guardamos de entonces? Desde luego, yo recuerdo alguno de mis primeros libros de lengua y guardo un borroso pero grato recuerdo de cómo mi maestra me ense ó las letras por sonidos, y recuerdo cuando a la be le llamaba bbbb y a la eme, mmm. También recuerdo el primer libro que leí; pero no os podría decir el momento exacto en que pasé de conocer el sonido y la grafía de las letras a juntarlas y a comprender lo que leía. El proceso de alfabetización es un proceso sumamente complicado por el nivel de abstracción que comporta; y me cuesta entender cómo ni os de tan corta edad pueden llegar a aprender a leer. Misterios del cerebro humano!
Jean Bruller, dessinateur et illustrateur de la littérature coloniale pour la jeunesse de l’entre-deux-guerres : de Loulou chez les nègres (1929) à Baba Diène et Morceau-de-Sucre (1937)
Nathalie Gibert-Joly
Strenae : Recherches sur les Livres et Objets Culturels de l'Enfance , 2012, DOI: 10.4000/strenae.493
Abstract: Cet article vise à mettre en exergue l’évolution des prises de position contre le colonialisme du dessinateur Jean Bruller, futur écrivain Vercors (1902-1991), dans l’entre-deux-guerres. L’Appel des 121 que Vercors signa sans hésiter en 1960 pour clamer publiquement le droit à l'insoumission dans la guerre d'Algérie, son combat dès 1955 en faveur de l’indépendance de ce pays pourraient nous conduire à une interprétation rétrospective erronée, celle d’un homme et d’un mythe de la résistance anticolonialiste dès le début de l’entrée dans l’age adulte et dans son parcours artistique vecteur de cette pensée. Les illustrations qu’il fournit pour la littérature de jeunesse de l’entre-deux-guerres, mais aussi l’une de ses créations personnelles prouvent au contraire que le dessinateur bascula d’une acceptation inconsciente à une interrogation critique du colonialisme du début des années vingt à la fin des années trente. De l’empan de Loulou chez les nègres à Baba Diène et Morceau-de-Sucre, nous distinguerons trois moments marqués par la publication d’ouvrages-clés pour comprendre la prise de conscience graduelle de Jean Bruller, visible dans ses choix collaboratifs comme dans les rapports entre le texte et ses dessins. Il est nécessaire de le situer dans un temps autant personnel qu’historique : celui d’un jeune homme dans un milieu éducatif et social donné, mais suffisamment attentif au monde pour avoir les moyens de s’en émanciper ; celui de l’artiste dans ses réalités symboliques et économiques, influencé par des réseaux de sociabilité correspondant à certains de ses idéaux ; celui d’artistes et d’écrivains qui s’interrogent, d’intellectuels qui prennent des positions de plus en plus tranchées au cours de ces années-là.
Los conceptos "mundo de la vida" y "mundo cotidiano- en la obra de Schutz
Galassi Jorge Gibert
Revista Colombiana de Sociología , 1999,
Abstract: El sociólogo Alfred Schutz posiblemente es el primero de los investigadores sociales que aplica la fenomenología a la comprensión de la realidad social. Gracias a una temprana difusión de sus ensayos y de una de sus obras importantes su pensamiento fue co
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