oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 522 )

2018 ( 714 )

2017 ( 725 )

2016 ( 991 )

Custom range...

Search Results: 1 - 10 of 404131 matches for " Victoria M Basham "
All listed articles are free for downloading (OA Articles)
Page 1 /404131
Display every page Item
BRCA1 and BRCA2 mutations in a population-based study of male breast cancer
Victoria M Basham, Julian M Lipscombe, Joanna M Ward, Simon A Gayther, Bruce AJ Ponder, Douglas F Easton, Paul DP Pharoah
Breast Cancer Research , 2001, DOI: 10.1186/bcr419
Abstract: We have carried out a population-based study of 94 MBC cases collected in the UK. We screened genomic DNA for mutations in BRCA1 and BRCA2 and used family history data from these cases to calculate the risk of breast cancer to female relatives of MBC cases. We also estimated the contribution of BRCA1 and BRCA2 to this risk.Nineteen cases (20%) reported a first-degree relative with breast cancer, of whom seven also had an affected second-degree relative. The breast cancer risk in female first-degree relatives was 2.4 times (95% confidence interval [CI] = 1.4–4.0) the risk in the general population. No BRCA1 mutation carriers were identified and five cases were found to carry a mutation in BRCA2. Allowing for a mutation detection sensitivity frequency of 70%, the carrier frequency for BRCA2 mutations was 8% (95% CI = 3–19). All the mutation carriers had a family history of breast, ovarian, prostate or pancreatic cancer. However, BRCA2 accounted for only 15% of the excess familial risk of breast cancer in female first-degree relatives.These data suggest that other genes that confer an increased risk for both female and male breast cancer have yet to be found.Male breast cancer (MBC) is a rare disease and little is known about its aetiology. However, female first-degree relatives of MBC cases are at increased risk of breast cancer [1,2,3,4,5,6], which suggests that there is an inherited component to the disease. Several genes that are associated with a high lifetime risk of breast cancer in women have been identified during the past decade. One of these, BRCA2, has also been shown to confer a significant risk of breast cancer in men, and a recent study found the risk of breast cancer in male BRCA2 mutation carriers from multiple case breast/ovarian cancer families to be 80-fold higher than in the general population [7]. This equates to a 7% risk of breast cancer by age 80. The prevalence of BRCA2 mutations in MBC cases unselected for family history has been estimated in
Design Optimization of Transistors Used for Neural Recording
Eric Basham,David Parent
Active and Passive Electronic Components , 2012, DOI: 10.1155/2012/472306
Abstract: Neurons cultured directly over open-gate field-effect transistors result in a hybrid device, the neuron-FET. Neuron-FET amplifier circuits reported in the literature employ the neuron-FET transducer as a current-mode device in conjunction with a transimpedance amplifier. In this configuration, the transducer does not provide any signal gain, and characterization of the transducer out of the amplification circuit is required. Furthermore, the circuit requires a complex biasing scheme that must be retuned to compensate for drift. Here we present an alternative strategy based on the design approach to optimize a single-stage common-source amplifier design. The design approach facilitates in circuit characterization of the neuron-FET and provides insight into approaches to improving the transistor process design for application as a neuron-FET transducer. Simulation data for a test case demonstrates optimization of the transistor design and significant increase in gain over a current mode implementation. 1. Introduction A transistor represents a unique type of transducer because it can both convert one type of energy to an electrical signal and amplify the resulting signal simultaneously. To amplify the signal, the correct amplification circuit topology must be chosen. A clever designer will optimize both the amplifier circuit and the transistor as part of an iterative design process. To our knowledge, a systematic methodology has not been presented to optimize the transistor structure and the amplification circuitry of neuron-FETs. The approach presented here relies on a circuit design strategy using the level of inversion methodology, also referred to as the approach [1–3]. This technique has recently gained widespread attention in the integrated circuit design community because it offers techniques for reducing power consumption and maximizing bandwidth in circuits designed to perform analog signal processing. The process of design may vary considerably as a function of the parameters under the designer's control. Printed circuit board-level engineering is done with discrete components. These system-level engineers select components from a range of available devices and then bias them appropriately. This is done by choosing the appropriate DC (static) operating points. Design with discrete components does not allow the designer control of intrinsic device parameters (i.e., width, length, oxide thickness, mobility, etc.). In contrast, integrated circuit engineers choose a process technology and then select dimensions (width and length) of individual
The Global Seismic Hazard Assessment Program (GSHAP)
D. Giardini,P. Basham
Annals of Geophysics , 1993, DOI: 10.4401/ag-4256
Abstract:
Technical guidelines for global seismic hazard assessment
P. Basham,D. Giardini
Annals of Geophysics , 1993, DOI: 10.4401/ag-4257
Abstract:
Los derechos humanos en la teoría de la justicia internacional de Rawls
Costa,M. Victoria;
Revista latinoamericana de filosof?-a , 2007,
Abstract: this paper examines john rawls' account of human rights, its basis, and the role that it plays in the wider context of his theory of international justice. it argues that the principle "peoples are to honor human rights" is qualitatively different from the rest of the principles of the law of peoples and requires a different justification. after discussing rawls' arguments in favor of the selection of this principle and pointing out their limitations, it presents the guidelines for an alternative strategy to defend human rights that takes into account their role in the international public political culture.
IMAGINARIOS DEL MIEDO EN EL CONTEXTO URBANO DE MANIZALES: IMPLICACIONES MEDIOAMBIENTALES
Valencia M. Victoria Eugenia
Gestión y Ambiente , 2008,
Abstract: El artículo es el resultado de un estudio adelantado en la Universidad Nacional de Colombia, Sede Manizales, en la Maestría en Medio Ambiente y Desarrollo (área de Estudios Urbanos). Buscó presentar de una manera compleja, rizomática y en red, las relaciones que en el contexto urbano, se establecen entre habitante y ciudad desde la emoción del miedo, y las posibles conexiones que desde lo simbólico, puedan darse frente a situaciones ambientales concretas. Los principales objetivos del estudio se orientaron a identificar los imaginarios del miedo provenientes de la vivencia urbana de algunos habitantes de la ciudad de Manizales, categorizar las principales temáticas y personajes generadores de miedo en el contexto urbano y conocer desde los relatos, las subjetividades y los niveles de conciencia frente al contexto medioambiental en el que se está inmerso. Gracias a elementos aportados desde la teoría psicoanalítica, se logró el dise o de una metodología cualitativa novedosa, basada en relatos que se apoyaron en fotografías de la ciudad. Algunas de las conclusiones del estudio, apuntaron a se alar una gran sensibilidad de los participantes hacia la problemática ambiental. Los temas de los relatos plantearon situaciones en las que las personas se sintieron vulnerables y en riesgo. Así mismo, en los contenidos de los relatos, los sistemas social y natural aparecieron como instancias complejas de mutua afectación. Al tiempo, se detectó en los contenidos de las historias, una necesidad personal de compromiso para el cambio de las realidades ambientales que se están viviendo.
Sociedad, Individuo y Organización
M. Victoria Sanagustín
Política y Sociedad , 2000, DOI: -
Abstract: Sin resumen
ANáLISIS DE LOS NIVELES DE METALES PESADOS (PB, CU, CR, ZN, NI Y CD) Y ASPECTOS REPRODUCTIVOS DEL DELFíN FRANCISCANA (PONTOPORIA BLAINVILLEI)
M. Victoria Panebianco
Mastozoolog?-a neotropical , 2012,
Abstract:
Data Load Manifestation In Process Chains In SAP Business Ware House
M. Victoria Hebseeba
Advanced Computing : an International Journal , 2012,
Abstract: This paper describes a unique technique to display the run times of the process chains, number of records transferred to each target, frequency and other details. We do not have any ready option provided by SAP to display all these details for multiple process chains in one place as displayed here. This customised report developed using business content info cubes helps us to analyse the run times for the loads in process chains and derive conclusions on the performance, data, frequency and other details. Report allows us to choose the result as per our requirement by providing the selection criteria in the selection screen.
Los derechos humanos en la teoría de la justicia internacional de Rawls
M. Victoria Costa
Revista Latinoamericana de Filosofía , 2007,
Abstract: Este artículo examina la concepción de los derechos humanos de John Rawls, sus fundamentos y el papel que ésta desempe a dentro del contexto más amplio de su teoría de la justicia internacional. Argumenta que el principio que dice que "los pueblos han de honrar los derechos humanos" es cualitativamente distinto al resto de los principios de la ley de los pueblos y requiere una justificación diferente. Luego de analizar los argumentos de Rawls en favor de la selección de este principio y se alar sus limitaciones, se presentan los lineamientos de una estrategia alternativa para defender los derechos humanos, a partir del examen de su papel en la cultura política pública internacional. This paper examines John Rawls' account of human rights, its basis, and the role that it plays in the wider context of his theory of international justice. It argues that the principle "Peoples are to honor human rights" is qualitatively different from the rest of the principles of the Law of Peoples and requires a different justification. After discussing Rawls' arguments in favor of the selection of this principle and pointing out their limitations, it presents the guidelines for an alternative strategy to defend human rights that takes into account their role in the international public political culture.
Page 1 /404131
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.