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Search Results: 1 - 10 of 4280 matches for " Vicki Price Clark "
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The Bridge Web Site: Growing and Sustaining Partnerships Between Ocean Science and Education
Vicki Price Clark,Lisa Ayers Lawrence,Christopher Petrone,Lee Larkin
Oceanography , 2009,
Abstract: When physicist Tim Berners-Lee and a team of fellow scientists at the European Center for High Energy Physics (CERN) launched the first-ever Web site in 1989, their goal was to make it easier for scientists to access research documents and scientific data (CERN, 2008). In 1998, Virginia Sea Grant educators at the Virginia Institute of Marine Science (VIMS) had a similar goal: to make ocean science educational resources and current research data more accessible to classroom teachers. The Virginia Sea Grant education team took the first step toward accomplishing this goal by launching a Web site of its own, called "Bridge." The name was inspired by the idea of a ship's bridge with a teacher at the helm, navigating "an ocean of marine education data." It also represents a bridge spanning the divide between the education and the ocean research communities, which is the essence of the Bridge project's mission.
Image-Based Treatment Planning of the Post-Lumpectomy Breast Utilizing CT and 3TMRI
Geraldine Jacobson,Gideon Zamba,Vicki Betts,M. Muruganandham,Joni Buechler-Price
International Journal of Breast Cancer , 2011, DOI: 10.4061/2011/246265
Abstract: Accurate lumpectomy cavity definition is critical in breast treatment planning. We compared contouring lumpectomy cavity volume and cavity visualization score (CVS) with CT versus 3T MRI. 29 patients were imaged with CT and 3T MRI. Seven additional boost planning sets were obtained for 36 image sets total. Three observers contoured the lumpectomy cavity on all images, assigning a cavity visualization score (CVS ) of 1 to 5. Measures of consistency and agreement for CT volumes were 98.84% and 98.62%, for T1 MRI were 95.65% and 95.55%, and for T2 MRI were 97.63% and 97.71%. The mean CT, T1 MRI, and T2 MRI CVS scores were 3.28, 3.38, and 4.32, respectively. There was a highly significant difference between CT and T2 scores ( ) and between T1 and T2 scores ( ). Interobserver consistency and agreement regarding volumes were high for all three modalities with T2 MRI CVS the highest. MRI may contribute to target definition in selected patients. 1. Introduction Definition of the lumpectomy cavity is a critical step in treatment planning for irradiation of the intact breast, breast boost, and for partial breast irradiation. Multiple studies have shown the limitations of single modality imaging with interobserver differences in lumpectomy cavity definition [1–4]. CT-based imaging is commonly used for breast treatment planning; but the limited soft tissue contrast of CT can result in poor visualization of the lumpectomy site in patients with dense breast parenchyma, small lumpectomy cavities, or a prolonged delay between surgery and treatment planning [2, 3]. MR imaging provides superior soft tissue contrast and may provide clearer visualization of the lumpectomy cavity. Although the diagnostic role of MRI in breast cancer management is expanding, MRI is rarely used as an imaging modality in post-lumpectomy radiation therapy planning. We compared contouring of the lumpectomy cavity volume and cavity visualization score (CVS) based on CT imaging compared to 3 Tesla magnetic resonance imaging, (3T MRI). 2. Methods and Materials This is an IRB-approved retrospective review of treatment planning imaging obtained for breast cancer patients following breast conserving surgery. From September 2008 to July 2009, 29 patients referred for intact breast irradiation had breast imaging performed using both CT and noncontrast 3T MRI. Of these, seven patients had repeat CT and MRI performed at the time of boost planning, providing 36 image sets. Sixteen patients did not receive chemotherapy. The average interval between surgery and image acquisition for this group was 28 days
Validation of multi-stage telephone-based identification of cognitive impairment and dementia
Valerie C Crooks, Linda Clark, Diana B Petitti, Helena Chui, Vicki Chiu
BMC Neurology , 2005, DOI: 10.1186/1471-2377-5-8
Abstract: The gold standard assessment of cognitive status was conducted at the University of Southern California Alzheimer Disease Research Center (USC ADRC). It involved an examination of patients with a memory complaint by a neurologist or psychiatrist specializing in cognitive disorders and administration of a battery of neuropsychologic tests. The method being evaluated was a multi-staged assessment using the Telephone Interview of Cognitive Status-modified (TICSm) with patients and the Telephone Dementia Questionnaire (TDQ) with a proxy. Elderly male and female patients who had received the gold standard in-person assessment were asked to also undergo the telephone assessment. The unweighted kappa statistic was calculated to compare the gold standard and the multistage telephone assessment methods. Sensitivity for classification with dementia and specificity for classification as normal were also calculated.Of 50 patients who underwent the gold standard assessment and were referred for telephone assessment, 38 (76%) completed the TICS. The mean age was 78.1 years and 26 (68%) were female. When comparing the gold standard assessment and the telephone method for classifying subjects as having dementia or no dementia, the sensitivity of the telephone method was 0.83 (95% confidence interval 0.36, 1.00), the specificity was 1.00 (95% confidence interval 0.89,1.00). Kappa was 0.89 (95% confidence interval 0.69, 1.000). Considering a gold-standard assessment of age-associated memory impairment as cognitive impairment, the sensitivity of the telephone approach is 0.38 (95% confidence interval 0.09, 0.76) specificity 0.96 (CI 0.45, 0.89) and kappa 0.61 (CI 0.37, 0.85).Use of a telephone interview to identify people with dementia or cognitive impairment is a promising and relatively inexpensive strategy for identifying potential participants in intervention and clinical research studies and for classifying subjects in epidemiologic studies.Epidemiologic studies of dementia gener
Clinical Trial Phases  [PDF]
Vicki L. Mahan
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.521175
Abstract:
Developers of drugs, biologicals, and medical devices must ensure product safety, demonstrate medical benefit in people, and mass produce the product. Preclinical development starts before clinical trials and the main goals are to determine safety and effectiveness of the intervention. If preclinical studies show that the therapy is safe and effective, clinical trials are started. Clinical trial phases are steps in the research to determine if an intervention would be beneficial or detrimental to humans and include Phases 0, I, II, III, IV, and V clinical studies. Understanding the basis of clinical trial phases will help researchers plan and implement clinical study protocols and, by doing so, improve the number of therapies coming to market for patients.
Optimizing performance per watt on GPUs in High Performance Computing: temperature, frequency and voltage effects
D. C. Price,M. A. Clark,B. R. Barsdell,R. Babich,L. J. Greenhill
Physics , 2014, DOI: 10.1007/s00450-015-0300-5
Abstract: The magnitude of the real-time digital signal processing challenge attached to large radio astronomical antenna arrays motivates use of high performance computing (HPC) systems. The need for high power efficiency (performance per watt) at remote observatory sites parallels that in HPC broadly, where efficiency is an emerging critical metric. We investigate how the performance per watt of graphics processing units (GPUs) is affected by temperature, core clock frequency and voltage. Our results highlight how the underlying physical processes that govern transistor operation affect power efficiency. In particular, we show experimentally that GPU power consumption grows non-linearly with both temperature and supply voltage, as predicted by physical transistor models. We show lowering GPU supply voltage and increasing clock frequency while maintaining a low die temperature increases the power efficiency of an NVIDIA K20 GPU by up to 37-48% over default settings when running xGPU, a compute-bound code used in radio astronomy. We discuss how temperature-aware power models could be used to reduce power consumption for future HPC installations. Automatic temperature-aware and application-dependent voltage and frequency scaling (T-DVFS and A-DVFS) may provide a mechanism to achieve better power efficiency for a wider range of codes running on GPUs
Radiation resistance genes discovered
Vicki Glaser
Genome Biology , 2001, DOI: 10.1186/gb-spotlight-20011129-01
Abstract: A screen of mutant yeast cells identified 107 new genes that affect sensitivity to ionizing radiation. This discovery more than triples the number of genetic loci believed to play a role in DNA repair and the related functions that are induced by radiation damage. More than half of these new yeast genes appear to have a homolog in the human gene pool, and 17 of those have been linked to various cancers.These genes may determine how well cells are able to survive exposure to radiation, and may even help predict sensitivity to other DNA-damaging agents, such as anti-cancer drugs. It is the ability to target these genes during the drug discovery process that could lead to the development of more effective chemotherapeutics.An important and unexpected finding of this study is that many of the newly identified radiation-resistance genes fall into functional groups not previously linked to genetic repair mechanisms. Many of them affect cell replication, recombination, and cell-cycle checkpoint functions - traditional pathways linked to the repair of nicks and breaks in the DNA. But others appear to be involved in a variety of cellular activities including chromatin remodeling, chromosome segregation, nuclear pore formation, transcription, Golgi/vacuolar activities, ubiquitin-mediated protein degradation, cytokinesis, mitochondrial activity and cell-wall maintenance."I only expected to find a few more [genes] and expected them to be related to a DNA metabolic effect," said Michael Resnick, from the Laboratory of Genetics at the National Institute of Environmental Health Sciences, a senior author of the study. "The discovery that genes involved in transcription and protein synthesis play a role in radiation sensitivity was quite a surprise", continued Resnick.Also surprising was the observation that mutations in genes that make nuclear pore proteins were essential for survival in radiation-damaged yeast. These proteins define the structure of nuclear pores, which control th
PREHISTORIC ETHNICITY AND STATUS BASED ON TEXTILE EVIDENCE FROM ARICA, CHILE
Cassman,Vicki;
Chungará (Arica) , 2000, DOI: 10.4067/S0717-73562000000200016
Abstract: several scholars have hypothesized the existence of chiefdoms and multiethnic stratified social systems in the prehistoric coastal oases of northern chile. the present research, using textiles associated with 436 mummies from three sites (az-140, az-71 and plm-9) in arica, chile, has allowed for a reevaluation of the social organization and the development of a new chronology. textiles associated with the mummies were analyzed for yarn characteristics, weave, dyes, surface embellishments, form, repair and overall style. also, a quality score was calculated for each textile. contrary to expectations, the textiles, especially shirts, indicated the individuals studied were not ethnically diverse, since an assortment of shirt styles was found at all three sites, and many individuals had a variety of these styles. status was evaluated using textile quality scores and qualities of nontextile grave goods. status differences were evident but were not extreme, and it is suggested that achieved status existed but not ascribed rank. finally, based on thirty-two new radiocarbon dates it appears the cultures once known, respectively as cabuza, maitas, san miguel, loreto viejo and regional development were not successive temporally, but represent overlapping styles of the same group of people living in arica from ad 900 to 1400
Desafiando os limites da cidadania da Uni?o Europeia: as disputas dos grupos roma acerca da (i)mobilidade
Squire, Vicki;
Contexto Internacional , 2011, DOI: 10.1590/S0102-85292011000100005
Abstract: this article examines recent struggles over the mobility of roma across europe in terms of the insights that these provide into the limits of european union (eu) citizenship. showing how the struggle to deport and contain roma citizens across member states of the union reflect a broader series of limits regarding eu citizenship, the analysis questions any simplistic assumptions regarding the progressiveness of european citizenship over national citizenship. rather, it points to the constitutive tensions between citizenship as derivative of the nationstate and citizenship as formed through free movement provisions, and reads these tensions as important in understanding the conditions under which contestations of the limitations of eu citizenship emerge. focusing specifically on the struggles of roma and sinti activists in italy, the article goes on to suggest that questions of mobility are critical to the transformation of european citizenship through 'acts of citizenship' that contest the limits of an eu citizenship regime. this is not understood in the sense that free movement automatically or inevitably rights the wrongs of territorial or nationally-inscribed regimes by including those who are excluded. rather, the article argues that mobilisations of roma around mobility are important both in contesting the internal differentiations of eu citizenship, as well as in reconfiguring the limits through which such a regime is inscribed as such. this occurs through acts whereby exclusionary processes such as criminalisation are transformed into claims to social justice. such claims might be said to take on new significance when developed at the european scale, since claims to social justice in this regard become 'transnational' in the scope of their enactment. however, the transnational cannot be understood in a fixed or spatially-contained sense when viewed through the lens of mobility, but is perhaps better understood as a means of questioning received ways of thinkin
Response by Vicki Thorson on "The Nursing Shortage: Is This Cycle Different?"
Vicki Thorson
Online Journal of Issues in Nursing , 2004,
Abstract:
Opening the Dialogue for Indigenous Knowledges Developments in Australia
Vicki Grieves
Cultural Studies Review , 2011,
Abstract: A review of Martin Nakata, Disciplining the Savages, Savaging the Disciplines (Aboriginal Studies Press, Canberra, 2007).
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