oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2018 ( 4 )

2016 ( 2 )

2015 ( 35 )

2014 ( 59 )

Custom range...

Search Results: 1 - 10 of 715 matches for " Vicki Hogan "
All listed articles are free for downloading (OA Articles)
Page 1 /715
Display every page Item
Clinical Trial Phases  [PDF]
Vicki L. Mahan
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.521175
Abstract:
Developers of drugs, biologicals, and medical devices must ensure product safety, demonstrate medical benefit in people, and mass produce the product. Preclinical development starts before clinical trials and the main goals are to determine safety and effectiveness of the intervention. If preclinical studies show that the therapy is safe and effective, clinical trials are started. Clinical trial phases are steps in the research to determine if an intervention would be beneficial or detrimental to humans and include Phases 0, I, II, III, IV, and V clinical studies. Understanding the basis of clinical trial phases will help researchers plan and implement clinical study protocols and, by doing so, improve the number of therapies coming to market for patients.
Automated electronic medical record sepsis detection in the emergency department
Su Q. Nguyen,Edwin Mwakalindile,James S. Booth,Vicki Hogan,Jordan Morgan,Charles T. Prickett,John P. Donnelly,Henry E. Wang
PeerJ , 2015, DOI: 10.7717/peerj.343
Abstract: Background. While often first treated in the emergency department (ED), identification of sepsis is difficult. Electronic medical record (EMR) clinical decision tools offer a novel strategy for identifying patients with sepsis. The objective of this study was to test the accuracy of an EMR-based, automated sepsis identification system.
Radiation resistance genes discovered
Vicki Glaser
Genome Biology , 2001, DOI: 10.1186/gb-spotlight-20011129-01
Abstract: A screen of mutant yeast cells identified 107 new genes that affect sensitivity to ionizing radiation. This discovery more than triples the number of genetic loci believed to play a role in DNA repair and the related functions that are induced by radiation damage. More than half of these new yeast genes appear to have a homolog in the human gene pool, and 17 of those have been linked to various cancers.These genes may determine how well cells are able to survive exposure to radiation, and may even help predict sensitivity to other DNA-damaging agents, such as anti-cancer drugs. It is the ability to target these genes during the drug discovery process that could lead to the development of more effective chemotherapeutics.An important and unexpected finding of this study is that many of the newly identified radiation-resistance genes fall into functional groups not previously linked to genetic repair mechanisms. Many of them affect cell replication, recombination, and cell-cycle checkpoint functions - traditional pathways linked to the repair of nicks and breaks in the DNA. But others appear to be involved in a variety of cellular activities including chromatin remodeling, chromosome segregation, nuclear pore formation, transcription, Golgi/vacuolar activities, ubiquitin-mediated protein degradation, cytokinesis, mitochondrial activity and cell-wall maintenance."I only expected to find a few more [genes] and expected them to be related to a DNA metabolic effect," said Michael Resnick, from the Laboratory of Genetics at the National Institute of Environmental Health Sciences, a senior author of the study. "The discovery that genes involved in transcription and protein synthesis play a role in radiation sensitivity was quite a surprise", continued Resnick.Also surprising was the observation that mutations in genes that make nuclear pore proteins were essential for survival in radiation-damaged yeast. These proteins define the structure of nuclear pores, which control th
PREHISTORIC ETHNICITY AND STATUS BASED ON TEXTILE EVIDENCE FROM ARICA, CHILE
Cassman,Vicki;
Chungará (Arica) , 2000, DOI: 10.4067/S0717-73562000000200016
Abstract: several scholars have hypothesized the existence of chiefdoms and multiethnic stratified social systems in the prehistoric coastal oases of northern chile. the present research, using textiles associated with 436 mummies from three sites (az-140, az-71 and plm-9) in arica, chile, has allowed for a reevaluation of the social organization and the development of a new chronology. textiles associated with the mummies were analyzed for yarn characteristics, weave, dyes, surface embellishments, form, repair and overall style. also, a quality score was calculated for each textile. contrary to expectations, the textiles, especially shirts, indicated the individuals studied were not ethnically diverse, since an assortment of shirt styles was found at all three sites, and many individuals had a variety of these styles. status was evaluated using textile quality scores and qualities of nontextile grave goods. status differences were evident but were not extreme, and it is suggested that achieved status existed but not ascribed rank. finally, based on thirty-two new radiocarbon dates it appears the cultures once known, respectively as cabuza, maitas, san miguel, loreto viejo and regional development were not successive temporally, but represent overlapping styles of the same group of people living in arica from ad 900 to 1400
Desafiando os limites da cidadania da Uni?o Europeia: as disputas dos grupos roma acerca da (i)mobilidade
Squire, Vicki;
Contexto Internacional , 2011, DOI: 10.1590/S0102-85292011000100005
Abstract: this article examines recent struggles over the mobility of roma across europe in terms of the insights that these provide into the limits of european union (eu) citizenship. showing how the struggle to deport and contain roma citizens across member states of the union reflect a broader series of limits regarding eu citizenship, the analysis questions any simplistic assumptions regarding the progressiveness of european citizenship over national citizenship. rather, it points to the constitutive tensions between citizenship as derivative of the nationstate and citizenship as formed through free movement provisions, and reads these tensions as important in understanding the conditions under which contestations of the limitations of eu citizenship emerge. focusing specifically on the struggles of roma and sinti activists in italy, the article goes on to suggest that questions of mobility are critical to the transformation of european citizenship through 'acts of citizenship' that contest the limits of an eu citizenship regime. this is not understood in the sense that free movement automatically or inevitably rights the wrongs of territorial or nationally-inscribed regimes by including those who are excluded. rather, the article argues that mobilisations of roma around mobility are important both in contesting the internal differentiations of eu citizenship, as well as in reconfiguring the limits through which such a regime is inscribed as such. this occurs through acts whereby exclusionary processes such as criminalisation are transformed into claims to social justice. such claims might be said to take on new significance when developed at the european scale, since claims to social justice in this regard become 'transnational' in the scope of their enactment. however, the transnational cannot be understood in a fixed or spatially-contained sense when viewed through the lens of mobility, but is perhaps better understood as a means of questioning received ways of thinkin
Response by Vicki Thorson on "The Nursing Shortage: Is This Cycle Different?"
Vicki Thorson
Online Journal of Issues in Nursing , 2004,
Abstract:
Opening the Dialogue for Indigenous Knowledges Developments in Australia
Vicki Grieves
Cultural Studies Review , 2011,
Abstract: A review of Martin Nakata, Disciplining the Savages, Savaging the Disciplines (Aboriginal Studies Press, Canberra, 2007).
PREHISTORIC ETHNICITY AND STATUS BASED ON TEXTILE EVIDENCE FROM ARICA, CHILE
Vicki Cassman
Chungará (Arica) - Revista de Antropología Chilena , 2000,
Abstract: Several scholars have hypothesized the existence of chiefdoms and multiethnic stratified social systems in the prehistoric coastal oases of Northern Chile. The present research, using textiles associated with 436 mummies from three sites (AZ-140, AZ-71 and PLM-9) in Arica, Chile, has allowed for a reevaluation of the social organization and the development of a new chronology. Textiles associated with the mummies were analyzed for yarn characteristics, weave, dyes, surface embellishments, form, repair and overall style. Also, a quality score was calculated for each textile. Contrary to expectations, the textiles, especially shirts, indicated the individuals studied were not ethnically diverse, since an assortment of shirt styles was found at all three sites, and many individuals had a variety of these styles. Status was evaluated using textile quality scores and qualities of nontextile grave goods. Status differences were evident but were not extreme, and it is suggested that achieved status existed but not ascribed rank. Finally, based on thirty-two new radiocarbon dates it appears the cultures once known, respectively as Cabuza, Maitas, San Miguel, Loreto Viejo and Regional Development were not successive temporally, but represent overlapping styles of the same group of people living in Arica from AD 900 to 1400 Diversos investigadores han postulado la existencia en la prehistoria de sistemas sociales estratificados y multietnico en las áreas costeras del norte de Chile. El presente estudio, utilizando los textiles de 436 momias de tres sitios (Az-140, Az-71 y Plm-9) en Arica, Chile, ha permitido una reevaluación de la organización social y el desarrollo de una cronología nueva. Los textiles asociados con las momias fueron analizados en cuanto a las características de la lana, el tejido, las tintas, los embellecimientos de las superficies, la forma, la reparación y el estilo. También se calculó un puntaje de calidad para cada textil. Al contrario de las expectativas, los textiles, especialmente las camisas, indicaron que los individuos estudiados no eran étnicamente diversos, debido a que se encontró un surtido de estilos de camisas en los tres sitios y muchos individuos tenían una variedad de estilos. El estatus fue evaluado usando la calidad de textiles y las cantidades de bienes funerarios no textiles. Las diferencias de estatus fueron evidentes, pero no extremas, sugiriendo que existía el estatus adquirido, pero no el rango adscrito. Finalmente, a base de 32 fechas radiocarbónicas, parece que las culturas conocidas como Cabuza, Maitas, San Miguel,
Spectroscopic and Variability Surveys for AGN in the Groth Survey Strip
Vicki Sarajedini
Physics , 2001,
Abstract: Preliminary results are presented for a spectroscopic survey of the Groth Survey Strip (GSS), a 40 by 3.5 arcminute region of the sky imaged with HST, for which several hundred galaxy spectra have been obtained as part of the DEEP project (http://deep.ucolick.org). At least 6 broad-line AGNs (primarily Seyfert 1s) have been detected as well as several narrow-line Seyfert 2 candidates. The Seyfert galaxies detected in our survey have integrated absolute magnitudes extending to M(B)~-17.5, probing fainter magnitudes and higher redshifts than existing optical spectroscopic surveys. We also discuss a variability study of the GSS using the original HST images from 1994 and new images obtained in 2001. The high resolution obtained with HST allows us to isolate and measure variable galactic nuclei too faint to be detected from the ground, reaching nuclear magnitudes of M(B)~-16 in galaxies to z=0.8. The combination of these techniques provides a powerful probe of the population of low-luminosity AGNs at moderate redshifts.
Agency, political economy, and the transnational democratic ideal
Brendan Hogan
Ethics & Global Politics , 2010, DOI: 10.3402/egp.v3i1.4852
Abstract:
Page 1 /715
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.