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Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model
Ebru Eren Akar,Veysiner,Cem Kü?ükerd?nmez,Yonca Ayd?n Akova
International Journal of Ophthalmology , 2013, DOI: 10.3980/j.issn.2222-3959.2013.02.05
Abstract: AIM:To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model.METHODS:Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups:bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15th day.RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P<0.05). In addition, bevacizumab group had significantly less neovascularized corneal areas and fewer blood vessels than ranibizumab and pegaptanib groups (both P<0.05). However, there was no significant difference between the ranibizumab and pegaptanib groups regarding percentage of neovascularized corneal areas and number of blood vessels (both P>0.05). CONCLUSION:Subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium were effective with no corneal epitheliopathy for inhibiting corneal neovascularization after corneal burn in rats. Bevacizumab was more effective than ranibizumab and pegaptanib sodium
Effect of Pterygium Surgery on Tear Osmolarity
Kemal Türky?lmaz,Veysiner,Mehmet ?ahin Sevim,Ali Kurt,Berrak ?ekeryapan,Mustafa Durmu?
Journal of Ophthalmology , 2013, DOI: 10.1155/2013/863498
Abstract: Purpose. To investigate changes of dry eye test results in patients who underwent pterygium surgery. Methods. Seventy-four patients who underwent primary pterygium surgery were enrolled in this study. At the baseline, 3-, 12-, and 18-month visits, measurements of tear osmolarity, BUT, and Schirmer test were performed. The patients were divided into 2 groups: Group 1, which consisted of patients in whom pterygium did not recur, and Group 2, which consisted of patients in whom pterygium recurred after surgery. Results. The patients in Group 1 had lower tear osmolarity levels after surgery than those at baseline (all ). In Group 2 the tear osmolarity levels did not differ from baseline after 18 months ( ). The prevalence rates of dry eye syndrome (DES) were lower than that at baseline and 18 months after surgery in Group 1 ( ). In Group 2, the incidence of DES was lower after 3 months than at baseline ( ) but was similar to the baseline rate after 12 and 18 months (both ). Conclusions. Anormal tear film function associated with pterygium. Pterygium excision improved tear osmolarity and tear film function. However, tear osmolarity deteriorated again with the recurrence of pterygium. 1. Introduction Pterygium is a common disease of the ocular surface characterized by the invasion of fibrovascular tissue from the bulbar conjunctiva onto the cornea. It can cause chronic ocular irritation, induced astigmatism, tear film disturbances, and decreased vision secondary to growth over the visual axis [1]. Although the exact etiology of pterygium is unknown, exposure to ultraviolet (UV) radiation is thought to be the major environmental risk factor [2]. Age, hereditary factors, sunlight, chronic inflammation, microtrauma, and dry eye are other possible contributing factors [3–6]. The most commonly accepted treatment for pterygium is surgical excision. However, the rate of recurrence after surgery is high [7]. Several studies have used tear function tests, such as the Schirmer test or tear breakup time (BUT), to investigate the relationship between pterygium and dry eye syndrome (DES), with conflicting results [5, 8, 9]. In addition, a very few studies have evaluated the effects of the excision of pterygium on tear function [10, 11]. Various methods (i.e., the BUT, Schirmer, and mucus fern tests) are available for the investigation of DES. However, these tests are not always reliable, and none of them alone is sufficient for diagnosis [12]. Elevated tear osmolarity has recently been shown to be a reliable indicator of DES, and it has been proposed as a potential gold
The Effect of Extremely Low Frequency Magnetic Field and Manganese on Bone Mineral Content and Density
Veysi Akpolat
Dicle Medical Journal , 2008,
Abstract: The aim of this study was to investigate the effect of extremely low frequency magnetic field (ELF MF) on bone that exposed us in our daily life. In our study, sixty four male Wistar-Albino rats were used. The rats were exposed to ELF MF (50Hz, 1.5mT) during 4 hours/day for 45 days. The experimental rats were divided into eight groups (n=8 per group). The groups were as follows; only ELF MF was exposed to 1.group, the ELF MF was exposed to the 2., 3. and 4.groups with the doses manganese (Mn) of 3.75 mg/kg, 15mg/kg and 60mg/kg respectively, the 5., 6. and 7.groups received Mn with the doses of 3.75 mg/kg, 15mg/kg and 60mg/kg respectively and lastly the 8.group was used as a control group (cage control). Total bone mineral content (TBMC) and total bone mineral density (TBMD) of rats were determined by dual-energy X-ray absorptiometry (DXA). Measurements were recorded for all groups and the levels were compared with the control group. The levels of TBMC increased significantly in 3., 4. and 7. groups compare to control group (p<0.05). However, significant differences was not found in relation to the levels of TBMD between groups. The following results could be derived for this study; i) an additive effect of EMF was observed in increasing of bone mineral content for the groups with manganese ii) EMF stimulates the increasing of TBMD iii) manganese has a positive effect on bone tissue.
Determination of osteoporosis risk using by neural networks method
Veysi Akpolat
Dicle Medical Journal , 2009,
Abstract: Artificial neural networks (ANNs) have become modeling tools that have found extensive acceptance and they have frequently used in applications in many disciplines for solving complex problems. Different ANN structures are valuable models, which are used in the medical field for the development of decision support systems. In this paper, the learning and classification processes are used for determining the level of bone-density (safe / risk of osteoporosis) in woman. In this study, three different structured neural networks were used for classifying of osteoporosis and the most efficient structure was determined. The training network structures were Multilayer perceptron neural network (MLP), Linear Vector Quantization (LVQ) and Self Organizing Map (SOM). Performance indicators and statistical measures were used for evaluating the structures and the results demonstrated that the MLP was the most efficient structure for classifying of osteoporosis.
Effect of Pterygium Surgery on Tear Osmolarity
Kemal Türkyılmaz,Veysi Öner,Mehmet Şahin Sevim,Ali Kurt
Journal of Ophthalmology , 2013, DOI: 10.1155/2013/863498
Mechanisms of preventative and therapeutic role of probiotics in different allergic and autoimmune disorders  [PDF]
ner ?zdemir
Open Journal of Immunology (OJI) , 2013, DOI: 10.4236/oji.2013.33015

The prevalence of allergic and autoimmune diseases has been increasing from the last decades of 20th century. Intestinal microflora contributes to antigen exposure in early life and is one of the most abundant sources of early immune stimulation as well as adaptation. Because allergic and autoimmune responses manifest early in life, there has been obvious interest in the potential benefits of modifying the gastrointestinal flora by using probiotic supplementation. So far, there have been several studies to address the role of probiotics in primary prevention and therapy, with a reported suspicious reduction in the incidence of atopic and autoimmune diseases. Here, our aim is to evaluate the available knowledge of mechanisms of preventative and therapeutic role of probiotics in different allergic and autoimmune disorders. Promising mechanisms of probiotic effects may be categorized as local and systemic effects. Local influences of probiotics potentially include reduction of gut permeability and systemic penetration of antigens, increased local immunoglobulin A production, and alteration of local inflammation or tolerance induction. Some possible systemic effects consist of anti-inflammatory effects mediated by Th17 cells and Toll-like receptors, Th1 skewing of responses to allergens, activation of tolerogenic dendritic cells, in addition to T-regulatory cell production.

EBG Frequency Response Tuning Using an Adjustable Air-Gap
Mehdi Veysi;Meisam Shafaee
PIER Letters , 2010, DOI: 10.2528/PIERL10101002
Abstract: A new adjustable Electromagnetic Band-Gap (EBG) structure whose frequency response is controllable by adjusting spacer height is proposed. The finite difference time domain method is adopted for the simulations. Results show that the desired frequency response can be selected by adjusting the spacer height. The effects of the air-gap on the polarization dependent and conventional EBG structures have been investigated both theoretically and numerically. The agreement between the theoretical calculations and numerical results is reasonably good.
The Relationship Between Parturient Paresis and Fat Cow Syndrome in Dairy Cows
Sevinc Mutlu,Aslan Veysi
Acta Veterinaria Scandinavica , 2003, DOI: 10.1186/1751-0147-44-s1-p135
The Changes of Metabolic Profile and Its Association with Fat Cow Syndrome in High Yielding Cows During Dry Period and After
Sevinc Mutlu,Aslan Veysi
Acta Veterinaria Scandinavica , 2003, DOI: 10.1186/1751-0147-44-s1-p29
Higgsless electroweak symmetry breaking at the LHC
Veysi Erkcan Ozcan
Physics , 2007, DOI: 10.1088/1742-6596/110/7/072030
Abstract: While the Higgs model is the best studied scenario of electroweak symmetry breaking, a number strongly-coupled models exist, predicting new signatures. Recent studies of WW and WZ final states at the ATLAS and CMS experiments are summarized and expected sensitivities are presented within the frameworks of the technicolor straw-man model and the electroweak chiral Lagrangian.
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