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Search Results: 1 - 10 of 26941 matches for " Vesta; Lino-González "
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Niveles de plomo en sangre y factores de exposición en ni?os del estado de Morelos, México
Meneses-González,Fernando; Richardson,Vesta; Lino-González,Montserrat; Vidal,María Teresa;
Salud Pública de México , 2003, DOI: 10.1590/S0036-36342003000800006
Abstract: objective: to assess blood lead levels and lead exposure factors in children living in morelos state, mexico. material and methods: a cross-sectional study was conducted between june and october 1996, in 232 children aged 1-12 years, at hospital del ni?o morelense de cuernavaca, morelos, mexico. blood lead levels were measured by anodic voltameter, and exposure factors were collected by questionnaire. the lead concentration value was log transformed for statistical analysis. odds ratios were obtained for some risk factors. the statistical significative risk factors were later analyzed with anova. results: a total of 232 children were recruited (50% female); 73% resided in cuernavaca city. the geometric mean blood lead level was 6.7 μg/dl; 29.7% of the children had levels over 10 μg/dl; 66% reported use of lead glazed pottery for cooking, 36% for storing food, and 19% for drinking. conclusions: blood lead levels were similar to those reported in other mexican children studies, after the reduction of lead in gasoline. the main risk factors were use of lead glazed pottery and vehicle traffic intensity near the household. these results will be useful for future prevention and control interventions.
Niveles de plomo en sangre y factores de exposición en ni os del estado de Morelos, México
Meneses-González Fernando,Richardson Vesta,Lino-González Montserrat,Vidal María Teresa
Salud Pública de México , 2003,
Abstract: OBJETIVO: Evaluar los niveles de plomo en sangre de ni os morelenses y sus factores de exposición. MATERIAL Y MéTODOS: Estudio transversal para analizar, por voltametría anódica, los niveles de plomo en sangre de 232 ni os de 1 a 12 a os de edad, que acudieron de junio a octubre de 1996 al Hospital del Ni o Morelense de Cuernavaca, Morelos, México. Los factores de exposición se indagaron por cuestionario. El valor de concentración de plomo se transformó al logaritmo natural; se estimó la razón de momios para algunos factores de exposición que se incorporaron a un modelo de ANOVA. RESULTADOS: Se reclutaron 232 ni os (50% mujeres); 73% residentes en Cuernavaca. La media geométrica de plomo en sangre fue 6.7 μg/dl; 29.7% rebasaron los 10 μg/dl; 66% tenían antecedente de cocinar alimentos en barro vidriado; 36% de almacenar alimentos, y 19%, consumo de líquidos en ese material. CONCLUSIONES: Los niveles encontrados son similares a los reportados en otras poblaciones pediátricas mexicanas en los últimos a os. Entre los principales factores de exposición destacan el uso de barro vidriado para consumo de alimentos o líquidos y la intensidad del tráfico donde viven. Este es el primer estudio que documenta los niveles de plomo en sangre en población infantil de Morelos, México, y sus resultados son punto de partida para acciones futuras de control y prevención.
Comparative Molecular Mechanics and Quantum Mechanics Study of Monohydration of Nucleic Acid Bases  [PDF]
Job Lino-Pérez, Eduardo González-Jiménez, Alexandra Deriabina, Martha Velasco, Valery I. Poltev
Journal of Biophysical Chemistry (JBPC) , 2016, DOI: 10.4236/jbpc.2016.72005
Abstract: DNA is the most important biological molecule and its hydration contributes essentially to the structure and functions of the double helix. We analyze the monohydration of the individual bases of nucleic acids and their methyl derivatives using methods of Molecular Mechanics (MM) with the Poltev-Malenkov (PM), AMBER and OPLS force fields, as well as ab initio Quantum Mechanics (QM) calculations at MP2/6-31G(d,p) level of theory. A comparison is made between the calculated interaction energies and the experimental enthalpies of microhydration of bases, obtained from mass spectrometry at low temperatures. Each local water-base interaction energy minimum obtained with MM corresponds to the minimum obtained with QM. General qualitative agreement was observed in the geometrical characteristics of the local minima obtained via the two groups of methods. MM minima correspond to slightly more coplanar structures than those obtained via QM methods, and the absolute MM energy values overestimate corresponding values obtained with QM. For Adenine and Thymine the QM local minima energy values are closer to those obtained by the PM potential (average of 0.72 kcal/mol) than by the AMBER force field (1.86 kcal/mol). The differences in energy between MM and QM results are more pronounced for Guanine and Cytosine, especially for minima with the water molecule forming H-bonds with two proton-acceptor centers of the base. Such minima are the deepest ones obtained via MM methods while QM calculations result in the global minima corresponding to water molecule H-bonded to one acceptor and one donor site of the base. Calculations for trimethylated bases with a water molecule corroborate the MM results. The energy profiles were obtained with some degrees of freedom of the water molecule being frozen. This data will contribute to the improvement of the molecular mechanics force fields.
MODELO DE PRODUCCIóN DE DOS TONELADAS DE CARNE POR HECTáREA A O EN EL VALLE DEL SINú
Lino Torregroza, ,,,,Miguel Palomino,Marco González,Roger Salgado
Revista MVZ Córdoba , 2004,
Abstract: En una finca localizada en el municipio de Cereté, departamento de Córdoba, se evaluó técnica y económicamenteun modelo de producción proyectado para producir dos toneladas de carne por hectárea a o. Para el efecto,en una pradera sembrada con pasto estrella (Cynodon nlemfuensis) de dos hectáreas se estableció un sistemarotacional de 4 potreros, manejados con 15 días de descanso y 5 de ocupación con una carga de 7 animales/hectárea, con peso inicial de 131 kilos, suplementados durante la época de lluvias con 0.5 kilos/animal/día desemilla de algodón y en el período seco con ensilaje de maíz o de sorgo sudax, balanceado con 0.3% de ureamás 1.0 ó 1.5 kilos de semilla de algodón con salvado de arroz. La evaluación tuvo una duración de 365 días(31-05-02 al 31-05-03). Durante la época de lluvias (224 días) los animales obtuvieron una ganancia diariapromedia de 0.912 kilos/animal/día, mientras que en la época seca (141 días) alcanzaron un promedio de0.567 kilos/animal/día, para un promedio diario durante los 365 días de 0.777 kilos/animal/día. La gananciapromedia diaria por hectárea fue de 5.45 kilos lo que resultó en una ganancia de 1.988 kilos por hectárea a o,muy próximo al objetivo planteado. El análisis económico, incluyendo en el rubro de gastos el alquiler de latierra y los intereses al capital, arrojó una utilidad líquida por hectárea / a o de $1.541.176. Se concluyó quees posible la producción de dos toneladas de carne por hectárea a o bajo las condiciones del valle del Sinú yque además, el modelo propuesto es susceptible de ser mejorado en las estrategias alimenticias durante laépoca seca y la disponibilidad de pasto en el período de lluvias a fin de incrementar la rentabilidad.
Mortalidad por enfermedad diarreica en menores, antes y después de la introducción de la vacuna contra el rotavirus
Esparza-Aguilar,Marcelino; Bautista-Márquez,Aurora; González-Andrade,María del Carmen; Richardson-López-Collada,Vesta Louise;
Salud Pública de México , 2009, DOI: 10.1590/S0036-36342009000400004
Abstract: objective: to analyze the mortality due to acute diarrhea in children younger than five years old, before and after the introduction of rotavirus vaccine in mexico. material and methods: number of deaths and mortality rates due to acute diarrhea were compared by children's age and states' vaccine status using annual percentage differences before (2000-2005) and after (2006-2007) the introduction of the hrv. results: from 2000-2007, deaths due to acute diarrhea in children under five years of age dropped 42%. in those states that received the hrv early in 2006, diarrhea mortality decreased between 2006-2007 15.8% in children younger than one year old and 22.7% in children 1-4 years old. discussion: the observed reduction in mortality due to acute diarrhea in children under five years of age after 2005 can be, in part, attributed to the hrv.
Métodos para la detección de la infección por Helicobacter pylori
Bermúdez Díaz,Ludisleydis; Ernesto Torres Domínguez,Lino; Rodríguez González,Boris Luis;
Revista Cubana de Medicina , 2009,
Abstract: helicobacter pylori is a bacterium affecting gastric mucosa in more than 50% of world population, and has been recognized as the most important etiologic factor in the development of many gastric pathologies including gastritis, ulcer, gastric cancer, and the gastric mucosa-associated lymphoid tissue lymphoma (malt lymphoma). due to pathogenic potential of this bacterium, it is necessary to have effective methods for its detection. techniques used for helicobacter pylori infection detection are divided into two groups: invasive techniques, requiring a gastric endoscopy for biopsy obtention, and non-invasive techniques which are less aggressive for patient. this review is an updating of main techniques used in diagnosis of helicobacter pylori infection, which are in a continuous improvement.
Mielolipoma adrenal bilateral ligado a hipotiroidismo primario Bilateral adrenal myelolipoma linked to primary hypothyroidism
Levi González Rivero,Silvia Elena Turcios Tristá,Lino León Chiong,Esther Jequín Savariego
Revista Cubana de Endocrinología , 2010,
Abstract: Los mielolipomas adrenales son tumores benignos, no funcionantes e infrecuentes, generalmente de diagnóstico incidental, que eventualmente provocan síntomas locales. Tras una revisión de la literatura previa publicada, se realizó la descripción de un caso clínico de mielolipoma adrenal bilateral, que coexiste con hipotiroidismo primario, relación no reportada hasta el presente. Dichas masas tumorales se diagnosticaron en una mujer de 66 a os, aquejada de dolor abdominal recurrente, que además padecía hipotiroidismo e hipercolesterolemia, a la que se le practicó con éxito la exéresis de la lesión de mayor tama o. Se propuso un tratamiento diagnóstico-terapéutico para este tipo de tumores. The adrenal myelolipomas are benign tumors, non-functioning and infrequent, generally of incidental diagnosis which by chance provoke local symptoms. After a review of published previous literature it was possible to describe of a clinical case of bilateral adrenal myelolipoma coexisting with a primary hypothyroidism with a relation not reported until now. Such tumoral masses were diagnosed in a woman aged 66 with recurrent abdominal pain and hypothyroidism and hypercholesterolemia who undergoes successfully a exeresis of the bigger lesion. A diagnostic-therapeutic treatment was proposed for this type of tumors.
Métodos para la detección de la infección por Helicobacter pylori Techniques used for the Helicobacter pylori infection detection
Ludisleydis Bermúdez Díaz,Lino Ernesto Torres Domínguez,Boris Luis Rodríguez González
Revista Cubana de Medicina , 2009,
Abstract: Helicobacter pylori es una bacteria que infecta la mucosa gástrica de más del 50 % de la población mundial y ha sido reconocida como el factor etiológico más importante en el desarrollo de diversas afecciones gástricas como gastritis, úlcera, cáncer gástrico y el linfoma del tejido linfoide asociado a la mucosa gástrica (linfoma MALT). Por el potencial patogénico de esta bacteria, resulta necesario contar con métodos eficaces para su detección. Las técnicas empleadas para el diagnóstico de la infección por Helicobacter pylori se dividen en 2 grupos: técnicas invasivas, que requieren una endoscopia gástrica para la toma de biopsias y técnicas no invasivas que son menos agresivas para el paciente. Esta revisión constituye una actualización de las principales técnicas empleadas en el diagnóstico de la infección por Helicobacter pylori, las cuales continúan en constante perfeccionamiento. Helicobacter pylori is a bacterium affecting gastric mucosa in more than 50% of world population, and has been recognized as the most important etiologic factor in the development of many gastric pathologies including gastritis, ulcer, gastric cancer, and the gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). Due to pathogenic potential of this bacterium, it is necessary to have effective methods for its detection. Techniques used for Helicobacter pylori infection detection are divided into two groups: invasive techniques, requiring a gastric endoscopy for biopsy obtention, and non-invasive techniques which are less aggressive for patient. This review is an updating of main techniques used in diagnosis of Helicobacter pylori infection, which are in a continuous improvement.
EPIYA motif patterns among Cuban Helicobacter pylori CagA positive strains Patrón de los motivos EPIYA de cepas cubanas de Helicobacter pylori positivas para CagA
Lino E. Torres,Lidice González,Karelia Melián,Jordis Alonso
Biomédica , 2011,
Abstract: Introduction. It is known that polymorphisms in C-terminal region of CagA influence gastric disease development on Helicobacter pylori infection. Additionally, the geographic distribution of these polymorphisms has been associated with the appearance of more severe gastroduodenal pathologies. Objective. To determine the CagA phosphorylation motifs pattern (EPIYA pattern) in Cuban H. pylori isolates, and to study its association with patient’s pathologies. Materials and methods. DNAs from 95 H. pylori cagA-positive strains were used to amplify the 3’ variable region of cagA gene by PCR using two different strategies. Additionally, new primers were designed to identify either Western or Eastern CagA EPIYA motif type by PCR. To confirm the PCR results, PCR products from 14 representative isolates were purified and sequenced Results. The distribution of the EPIYA motif found was: 2 AB (2.1 %), 1 AC (1.1 %), 1 BC (1.1 %), 70 ABC (73.6 %), 19 ABCC (20 %), and 2 ABCCC (2.1 %). Sequencing analysis confirmed the PCR classification in the 14 studied strains and showed three strains with unusual nucleotide sequences, not reported before. Distribution of the EPIYA-ABC pattern was equivalent in all pathologies (78.9 % in gastric ulcer, 72.5 % in duodenal ulcer and 72.2 % in non-ulcer dyspepsia). Conclusion. The PCR results using the new primers confirmed that all studied strains carried the Western CagA type. No specific EPIYA motif was associated with peptic ulcer. This is the first report that shows EPIYA motif distribution in H. pylori isolates from the Caribbean region. Introducción. Se sabe que el polimorfismo en la región C-terminal de la citotoxina asociada al gen A (CagA) influye en el desarrollo de la enfermedad gástrica durante la infección por Helicobacter pylori. Objetivo. Determinar el número y el tipo de patrones de fosforilación de CagA (patrón EPIYA) en aislamientos cubanos de H. pylori, y estudiar su asociación con las enfermedades gástricas. Materiales y métodos. Se empleó el ADN de 95 cepas de H. pylori positivas para CagA, para amplificar la región 3’ variable del gen cagA por PCR, mediante el empleo de diferentes estrategias. Además, se dise aron nuevos cebadores para clasificar por PCR los aislamientos según el tipo de CagA, occidental o del este asiático. Los productos de PCR obtenidos de 14 aislamientos representativos se purificaron y secuenciaron para confirmar los resultados de la PCR. Resultados. La distribución de los patrones EPIYA encontrada, fue: 2 AB (2,1 %), 1 AC (1,1 %), 1 BC (1,1 %), 70 ABC (73,6 %), 19 ABCC (20 %), y 2 ABCCC (2,1
Comparative Molecular Mechanics and Quantum Mechanics Study of Microhydration of Nucleic Acid Bases
J. Lino,E. González,A. Deriabina,M. Velasco,V. Poltev
Quantitative Biology , 2013,
Abstract: DNA is the most important biological molecule, and its hydration contributes essentially to the structure and functions of the double helix. We analyze the microhydration of the individual bases of nucleic acids and their methyl derivatives using methods of molecular mechanics (MM) with the Poltev-Malenkov (PM), AMBER and OPLS force fields, as well as ab initio Quantum Mechanics (QM) calculations at MP2/6-31G(d,p) level of theory. A comparison is made between the calculated interaction energies and the experimental enthalpies of microhydration of bases, obtained from mass spectrometry at low temperatures. Each local water-base interaction energy minimum obtained with MM corresponds to the minimum obtained with QM. General qualitative agreement was observed in the geometrical characteristics of the local minima obtained via the two groups of methods. MM minima correspond to slightly more coplanar structures than those obtained via QM methods, and the absolute MM energy values overestimate corresponding values obtained with QM. For Adenine and Thymine the QM local minima energy values are closer to those obtained by the PM potential (average of 0.72 kcal/mol) than by the AMBER force field (1.86 kcal/mol). The differences in energy between MM and QM results are more pronounced for Guanine and Cytosine, especially for minima with the water molecule forming H-bonds with two proton-acceptor centers of the base. Such minima are the deepest ones obtained via MM methods while QM calculations result in the global minima corresponding to water molecule H-bonded to one acceptor and one donor site of the base. Calculations for trimethylated bases with a water molecule corroborate the MM results. The energy profiles were obtained with some degrees of freedom of the water molecule being frozen. This data will contribute to the improvement of the molecular mechanics force fields.
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