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Search Results: 1 - 10 of 1424 matches for " Veronica Baldo "
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Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance
Veronica Baldo,Jason Liang,Guoliang Wang,Huilin Zhou
Biomolecules , 2012, DOI: 10.3390/biom2040505
Abstract: In order to preserve genome integrity, extrinsic or intrinsic DNA damages must be repaired before they accumulate in cells and trigger other mutations and genome rearrangements. Eukaryotic cells are able to respond to different genotoxic stresses as well as to single DNA double strand breaks (DSBs), suggesting highly sensitive and robust mechanisms to detect lesions that trigger a signal transduction cascade which, in turn, controls the DNA damage response (DDR). Furthermore, cells must be able to distinguish natural chromosomal ends from DNA DSBs in order to prevent inappropriate checkpoint activation, DDR and chromosomal rearrangements. Since the original discovery of RAD9, the first DNA damage checkpoint gene identified in Saccharomyces cerevisiae, many genes that have a role in this pathway have been identified, including MRC1, MEC3, RAD24, RAD53, DUN1, MEC1 and TEL1. Extensive studies have established most of the genetic basis of the DNA damage checkpoint and uncovered its different functions in cell cycle regulation, DNA replication and repair, and telomere maintenance. However, major questions concerning the regulation and functions of the DNA damage checkpoint remain to be answered. First, how is the checkpoint activity coupled to DNA replication and repair? Second, how do cells distinguish natural chromosome ends from deleterious DNA DSBs? In this review we will examine primarily studies performed using Saccharomyces cerevisiae as a model system.
As categorias conhecimento e processos de Perfetti na leitura em língua materna: um experimento
Baldo, Alessandra;
Linguagem em (Dis)curso , 2008, DOI: 10.1590/S1518-76322008000200005
Abstract: perfetti et al. (1996) classify the components of reading comprehension into two main categories: process and knowledge categories. while lexical processes, working memory capacity, inference making and comprehension monitoring are situated in the first one, word knowledge and domain knowledge are placed in the second one. this paper aims at showing the relevance of the types of knowledge that make up the second category to the overall reading comprehension process, as well as the interdependence between both categories. in order to do so, a comparison was made between the strategies used by eight adult readers while answering specific questions related to vocabulary inference as part of an l1 reading test carried out through the verbal protocol technique. participants were divided into two groups of reading proficiency, according to their scores on the test. data analysis ratified the intrinsic relationship between word meanings and domain knowledge on reading comprehension processes, more specifically on lexical inferencing.
Recursos de inferência lexical em L2
Baldo, Alessandra
Letras de Hoje , 2009,
Abstract: Este artigo apresenta os resultados de um estudo sobre os recursos empregados para a realiza o de inferências lexicais por dezesseis sujeitos proficientes em leitura em L2, com base em Nassaji (2003). As principais quest es sob investiga o eram: (a) quais s o as estratégias e as fontes de conhecimento utilizadas pelos leitores?; (b) há uma rela o entre tipo de recurso utilizado e desempenho inferencial? A análise dos dados revelou que releitura e análise foram as estratégias preferenciais dos sujeitos, o mesmo valendo para as fontes de conhecimento discursivo e morfológico. Além disso, apesar de esses recursos terem sido empregados com eficácia na maioria dos casos, n o foi possível estabelecer correla o entre tipos de estratégias e de fontes de conhecimento mais utilizados e desempenho inferencial dos sujeitos.
As categorias conhecimento e processos de Perfetti na leitura em língua materna: um experimento
Alessandra Baldo
Linguagem em (Dis)curso , 2008,
Abstract: Perfetti et al. (1996) dividem em duas grandes categorias os componentes presentes na compreens o leitora: a de processos e a de conhecimento. Na primeira, est o os processos lexicais, a capacidade da memória de trabalho, a realiza o de inferências e o monitoramento da compreens o; na segunda, o significado das palavras e o conhecimento de domínio. O presente artigo tem como objetivos mostrar a importancia dos tipos de conhecimento implicados na segunda categoria para o processo global de compreens o leitora, como também a interdependência entre as duas categorias. Para tanto, foi realizada uma compara o entre as estratégias utilizadas por oito leitores adultos ao responderem a quest es específicas de inferência de vocabulário, a partir da aplica o de um teste de compreens o leitora em língua materna pela técnica dos protocolos verbais. Com base nos escores obtidos, os participantes foram divididos em dois grupos distintos de proficiência em leitura. A análise veio a corroborar a intrínseca rela o entre significado de palavras e conhecimento de domínio nos processos de compreens o leitora, em especial de inferência lexical.
Verbal Protocols Shortcomings on L2 Lexical Inferencing Research
Alessandra Baldo
Via Litterae , 2011,
Abstract: This article presents a reflection about the most significant problem of using verbal protocols in a study on lexical inferencing in a foreign language (Baldo et al, 2010), i.e., their subjective nature. First, a brief literature review about verbal protocols is presented, in order to help to understand the design of the study in which they were used. After that, samples of incongruent classifications by two independent researchers are analyzed. In the last part, the steps taken to deal with the methodological problems are discussed, in an attempt to contribute to future studies in which this research method is used.
Acerca de la localidad tipo y la distribución geográfica de Melanophryniscus klappenbachi Prigione & Langone, 2000 (Anura: Bufonidae)
Baldo, Diego
Cuadernos de Herpetología , 2001,
Abstract: Dada la distribución geográfica de esta especie en Argentina, Prigioni y Langone (op. cit.) sugieren que las citas de M. stelzneri fulvoguttatus para las provincias de Santa Fe (Baldo y Arzamendia, 1997) y Santiago del Estero (Basso y Williams, 1996) y para la localidad formose a de Bartolomé de las Casas (Gallardo, 1961; 1966) debían ser reexaminadas. Del examen del material en el que se basaron dichas citas, concluyo que pertenecen a M. klappenbachi.
Direct photon measurement in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV with ALICE
Baldo Sahlmueller
Physics , 2015,
Abstract: The ALICE experiment has measured the direct photon spectra in Pb-Pb collisions at $\sqrt{s_{NN}} = 2.76$ TeV for three different centrality selections. The measurement was performed emplying a method utilizing conversion of photons into $e^+e^-$ pairs in the detector material, and a method using the PHOS calorimeter. The two measurements were combined in order to measure direct photons over a broad transverse momentum range of $0.9 < p_{\rm T} < 14$ GeV/$c$. A direct photon signal was observed in the thermal region $0.9 < p_{\rm T} < 2.1$ GeV/$c$, with a significance of $2.6\sigma$ in the 20\% most central collisions. The corresponding direct photon spectrum can be described by an exponential with an inverse slope parameter of $(304 \pm 11^{\rm stat} \pm 40^{\rm syst})$ MeV, without subtracting the hard scattering component, which is somewhat larger than the inverse slope parameter of the direct photon spectrum at RHIC energies. Within uncertainties, the data can be described by different models for photon production in heavy-ion collisions. These proceedings provide a summary of the results published in [1] and [2].
Direct Photons and Photon-Hadron Correlations at PHENIX
Baldo Sahlmueller
Physics , 2011,
Abstract: Direct photons are a powerful tool to study the hot and dense matter created in heavy-ion collisions at RHIC, since they are created in the different stages of the collision. Since they do not interact via the strong force, they can travel through the hot and dense matter mostly unaffected. The PHENIX experiment has measured direct photons using different methods, over a broad range of transverse momentum (\pt), in different collision systems, and at different energies. These measurements help interpreting the measurement of hadrons as well as understanding the temperature of the created quark-gluon plasma (QGP). The azimuthal anisotropy of direct photons may shed light on the thermalization time of the medium. Using direct photons to tag jets is a crucial tool to understand the energy loss of scattered partons in the medium.
Extremely Early Diagnostic Test for Prostate Cancer  [PDF]
Veronica Jean James
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.23051
Abstract: Purpose: This article reports the results of a blinded fibre diffraction study of skin samples taken from TRAMP mice and age-matched controls to determine whether changes noted in fibre diffraction studies of human skin were present in these TRAMP mice studies. These mice are bred to progress to Gleeson Type 3 to Type 5 prostate cancer. Methods: Small strips, 1 mm × 5 mm, cut from the mouse skin samples were loaded into cells in the same way as human samples and slightly stretched to remove the crimp. They remained fully hydrated throughout exposure to the synchrotron beam. Results: The added change that was reported for prostate cancer in 2009 was obtained for all TRAMP mice samples, indicating that this change can be read as High Grade Cancer in human diagnostic tests. Discussion: These changes were evident for all 3 and 7 week old TRAMP mice samples but not for any of the control samples. This indicates that the changes in the fibre diffraction patterns appear much earlier than in any other available prostate cancer diagnostic test, as none of these can verify the presence of prostate cancer in the TRAMP mice before 10 weeks of age. The fibre diffraction test is therefore the most accurate and earliest test for high grade prostate cancer.
Exploiting Protein-Protein Interaction Networks for Genome-Wide Disease-Gene Prioritization
Emre Guney, Baldo Oliva
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043557
Abstract: Complex genetic disorders often involve products of multiple genes acting cooperatively. Hence, the pathophenotype is the outcome of the perturbations in the underlying pathways, where gene products cooperate through various mechanisms such as protein-protein interactions. Pinpointing the decisive elements of such disease pathways is still challenging. Over the last years, computational approaches exploiting interaction network topology have been successfully applied to prioritize individual genes involved in diseases. Although linkage intervals provide a list of disease-gene candidates, recent genome-wide studies demonstrate that genes not associated with any known linkage interval may also contribute to the disease phenotype. Network based prioritization methods help highlighting such associations. Still, there is a need for robust methods that capture the interplay among disease-associated genes mediated by the topology of the network. Here, we propose a genome-wide network-based prioritization framework named GUILD. This framework implements four network-based disease-gene prioritization algorithms. We analyze the performance of these algorithms in dozens of disease phenotypes. The algorithms in GUILD are compared to state-of-the-art network topology based algorithms for prioritization of genes. As a proof of principle, we investigate top-ranking genes in Alzheimer's disease (AD), diabetes and AIDS using disease-gene associations from various sources. We show that GUILD is able to significantly highlight disease-gene associations that are not used a priori. Our findings suggest that GUILD helps to identify genes implicated in the pathology of human disorders independent of the loci associated with the disorders.
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