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Search Results: 1 - 10 of 120191 matches for " Verónica Tangarife-Casta?o "
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Anti-Candida albicans activity, cytotoxicity and interaction with antifungal drugs of essential oils and extracts from aromatic and medicinal plants Actividad contra Candida albicans, citotoxicidad e interacción con antifúngicos de aceites esenciales y extractos de plantas medicinales y aromáticas
Verónica Tangarife-Castao,Julieth Correa-Royero,Bibiana Zapata-Londo?o,Camilo Durán
Infectio , 2011,
Abstract: Objective: To determine anti-Candida albicans activity, cytotoxicity and drug interaction of essential oils and extracts from plants collected in Colombia. Materials and methods: The antifungal activity was evaluated following the AFST-EUCAST protocol. With most active samples, the inhibition of the formation of germ tubes and budding, the in vitro pharmacodynamics, using time-kill assays, and the interaction with itraconazole and amphotericin B following the chequerboard technique were evaluated. The cytotoxicity assay for all samples was done using MTT. Results: Strong activity in 17.57% of the samples was found. The lowest MIC values were obtained with Piper bredemeyeri Jacq and Lippia origanoides Kunth (B) oils and Morinda royoc L extract. The three samples inhibited the formation of germ tubes and budding. P. bredemeyeri Jacq oil and M. royoc L extract samples showed fungicidal activity at 2xMIC. A synergistic effect was obtained with the combination of P. bredemeyeri Jacq oil and itraconazole, but not for the combination with amphotericin B. Active samples against C. albicans were not cytotoxic on Vero cells ATCC CCL-81, excluding P. bredemeyeri Jacq oil. Conclusions: The results of this study suggest that Colombian medicinal and aromatic plants represent an untapped source of compounds with anti-C. albicans activity that could be a resource in the development of new therapeutic natural products. Objetivo. Determinar la actividad anti-Candida albicans, la citotoxicidad y la interacción con antifúngicos de aceites y extractos de plantas recolectadas en Colombia. Materiales y métodos. La actividad antifúngica fue evaluada siguiendo el protocolo Antifungal Susceptibility Testing Subcommittee of the European Committee on Antimicrobial Susceptibility Testing (AFST-EUCAST). Con las muestras más activas se evaluó la inhibición de la formación de tubo germinal y la gemación, la farmacodinamia mediante curvas de tiempo muerte y la interacción con itraconazol y anfotericina B. Se determinó la citotoxicidad mediante la técnica MTT. Resultados. Se encontró actividad en 17,57 % de las muestras. La mayor actividad se obtuvo con los aceites de Piper bredemeyeri Jacq y Lippia origanoides Kunth (B) y el extracto de Morinda royoc L. Las tres muestras inhibieron la formación de tubo germinal y la gemación. El aceite de P. bredemeyeri Jacq y el extracto de M. royoc L mostraron actividad fungicida con dos veces la concentración inhibitoria mínima. Se encontró un efecto sinérgico por la combinación del aceite de P. bredemeyeri Jacq e itraconazol, pero no con anfoterici
Actividad antimicótica y citotóxica de híbridos de la combretastatina A4
Verónica Tangarife-Castao,Bibiana Zapata,Liliana A. Betancur-Galvis,Miguel A. González
Actualidades Biológicas , 2012,
Abstract:
Evaluación in vitro de la actividad antimicótica y antiviral de derivados de terpenil-1,4-nafto- y 1,4-antracenodiona
Vicky C. Roa-Linares,Verónica Tangarife-Castao,Bibiana Zapata,Ana C. Mesa- Arango
Actualidades Biológicas , 2012,
Abstract:
Anti-Candida albicans activity, cytotoxicity and interaction with antifungal drugs of essential oils and extracts from aromatic and medicinal plants
Tangarife-Castao,Verónica; Correa-Royero,Julieth; Zapata-Londo?o,Bibiana; Durán,Camilo; Stanshenko,Elena; Mesa-Arango,Ana Cecilia;
Infectio , 2011,
Abstract: objective: to determine anti-candida albicans activity, cytotoxicity and drug interaction of essential oils and extracts from plants collected in colombia. materials and methods: the antifungal activity was evaluated following the afst-eucast protocol. with most active samples, the inhibition of the formation of germ tubes and budding, the in vitro pharmacodynamics, using time-kill assays, and the interaction with itraconazole and amphotericin b following the chequerboard technique were evaluated. the cytotoxicity assay for all samples was done using mtt. results: strong activity in 17.57% of the samples was found. the lowest mic values were obtained with piper bredemeyeri jacq and lippia origanoides kunth (b) oils and morinda royoc l extract. the three samples inhibited the formation of germ tubes and budding. p. bredemeyeri jacq oil and m. royoc l extract samples showed fungicidal activity at 2xmic. a synergistic effect was obtained with the combination of p. bredemeyeri jacq oil and itraconazole, but not for the combination with amphotericin b. active samples against c. albicans were not cytotoxic on vero cells atcc ccl-81, excluding p. bredemeyeri jacq oil. conclusions: the results of this study suggest that colombian medicinal and aromatic plants represent an untapped source of compounds with anti-c. albicans activity that could be a resource in the development of new therapeutic natural products.
Los agaricales del estado de Aguascalientes
Lidia Marisela Pardavé Díaz,Lizbeth Flores Pardavé,Verónica Franco Ruiz Esparza,Rocío del Carmen Casta?eda Romo
Investigación y Ciencia de la Universidad Autónoma de Aguascalientes , 2012,
Abstract: Se presenta un estudio basado en el análisis de 306 especies de Agaricales, en el estado de Aguascalientes. Boletus edulis, Russula emetica, Agaricus brunnescens, Chlorophyllum molybdites, Stropharia semiglobata, Amanita caesarea, Laccaria amethystina, Amanita flavoconia y Clitocybe gibba fueron las especies más ampliamente distribuidas en el estado mientras que las familias con mayor representatividad fueron Tricholomataceae con 75 especies, Boletaceae con 50, Russulaceae con 31, Strophariaceae con 26 y Amanitaceae con 29 especies. La mayor riqueza de especies se concentra en los bosques de encino. Amanita muscaria, Boletus edulis y Psathyrella spadicea se incluyen como especies amenazadas mientras que Psilocybe caerulipes está sujeta a protección especial según la norma oficial mexicana (NOM-059-ECOL-2010).
La auditoría ética: herramienta para fortalecer la integridad del carácter organizacional
Rodríguez Córdoba,María del Pilar; Castao Vélez,Carlos Felipe; Osorio Gómez,Valentina; Zuluaga Arcila,Héctor Felipe; Duque Uribe,Verónica;
Innovar , 2006,
Abstract: this article springs from theoretical discussion about ethics and company ethics sustaining the authors’ position regarding how ethical stocktaking may become a tool for strengthening organisational integrity and lead to companies achieving their economic, social and environmental objectives. a qualitative methodology is proposed, seeking to evaluate the damage and benefits arising from an organisation’s activities in an attempt to improve its ethical performance and fulfil its social responsibility. the case of the universidad nacional de colombia’s manizales site is then presented, as an integral ethical development programme is being implemented there whose second stage consists of engaging in ethical audit.
Epidemiological Clinical Features and Evolution of Gastroduodenal Ulcer Bleeding in a Tertiary Care Hospital in Spain, during the Last Seven Years
Eugenia Lauret,Jesús Herrero,Lorena Blanco,Olegario Castao,Maria Rodriguez,Isabel Pérez,Verónica Alvarez,Adolfo Suárez,Luis Rodrigo
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/584540
Abstract: Background. Gastroduodenal ulcer bleeding is a common medical emergency. The aim of this study was to analyze the characteristics of bleeding episodes and to identify changes in the clinical trends over seven years. Methods. Retrospective observational clinical study on a cohort of 272 consecutive adult patients with peptic ulcer bleeding, during the 2006–2012 period. Results. Mean annual admission rate was 12.8 per 100.000 inhabitants. Men were predominant (71%), with a mean age of 66.6 years. Comorbidities were present in 131 cases (48.2%) and 156 patients (57.4%) had received ulcerogenic drugs. Duodenal ulcer was the commonest location (61%). Endoscopic therapy was necessary in 183 cases (67.3%) and rebleeding occurred in 30 patients (11%). Overall mortality rate was 5.5%, with a significant association with the presence of comorbidities ( ). There were no differences in trends of annual hospitalization, clinical features at presentation, and outcomes during this 7-years period. Conclusions. Annual hospitalization rates and prognosis of peptic ulcer bleeding have remained unchanged in the study period. This may be due to the fact that the effect of improved approach on this condition is probably counteracted by risk factors such as older age, severe comorbidities, and ulcerogenic drugs consumption, which have also remained stable over recent years. 1. Introduction Peptic ulcer bleeding remains a major clinical problem in the emergency setting, in Western countries. During the last decades, mortality rates from this gastrointestinal disorder have been reported to be stable, ranging between 5% and 15% worldwide [1, 2]. Despite increased knowledge about this condition, the use of improved diagnostics tools, the great advances in endoscopic therapy, and the routine use of ulcer treatment with proton pump inhibitors (PPIs) as well as eradication therapies against Helicobacter pylori, the published data on the changes in incidence and mortality for ulcer hemorrhage have been divergent [3–6]. In the nationwide population-based time-trend studies, a decline in general hospitalization rates was described over time, except among the elderly [4, 5]. By contrast, in regional population-based studies, the incidence of peptic ulcer bleeding was found unchanged [6]. The growing elderly population with presence of comorbidities and the gradual increase in prescription number of low-dose aspirin (ASA), nonsteroidal anti-inflammatory drugs (NSAID), and other antiplatelet or anticoagulant drugs have been recognized as some of the reasons for the expected changes on
In vitro antifungal activity and cytotoxic effect of essential oils and extracts of medicinal and aromatic plants against Candida krusei and Aspergillus fumigatus
Correa-Royero, Julieth;Tangarife, Verónica;Durán, Camilo;Stashenko, Elena;Mesa-Arango, Ana;
Revista Brasileira de Farmacognosia , 2010, DOI: 10.1590/S0102-695X2010005000021
Abstract: the plants are usually used in traditional medicine as antimicrobial agents and their essential oils and extracts have been known to possess antifungal activity. the aim of this study was to evaluate in vitro the activity of 32 essential oils and 29 extracts against c. krusei and a. fumigatus as well as the cytotoxic effect on vero cells. time-kill curve and interaction between antifungals and the most active sample against c. krusei, was also evaluated. the oils from c. ambrosioides and the extract of m. cucullata showed antifungal activity against c. krusei (gm-mic 7.82 and 31.25 μg/ml, respectively). l. citriodora was actives against c. krusei and a. fumigates (gm-mic = 99.21 μg/ml and 62.5 μg/ml respectively). time-kill assays done with c. ambrosioides oil showed fungicidal activity at 4x mic. the interaction of c. ambrosioides oil with itraconazole and amphotericin b was tested following the chequerboard technique. no interaction was detected for the combination of c. ambrosioides oil with amphotericin b and itraconazole (fici range = 1.03-1.06 and 1.03-1.00, respectively). cytotoxicity assays for all samples were carried out with mtt. only the oil from hedyosmun sp. and l. dulcis were cytotoxic.
In vitro antifungal activity and cytotoxic effect of essential oils and extracts of medicinal and aromatic plants against Candida krusei and Aspergillus fumigatus Atividade antifúngica in vitro e os efeitos citotóxicos de óleos essenciais e extratos de plantas medicinais e aromáticas contra Candida krusei e Aspergillus fumigatus
Julieth Correa-Royero,Verónica Tangarife,Camilo Durán,Elena Stashenko
Revista Brasileira de Farmacognosia , 2010,
Abstract: The plants are usually used in traditional medicine as antimicrobial agents and their essential oils and extracts have been known to possess antifungal activity. The aim of this study was to evaluate in vitro the activity of 32 essential oils and 29 extracts against C. krusei and A. fumigatus as well as the cytotoxic effect on Vero cells. Time-kill curve and interaction between antifungals and the most active sample against C. krusei, was also evaluated. The oils from C. ambrosioides and the extract of M. cucullata showed antifungal activity against C. krusei (GM-MIC 7.82 and 31.25 μg/mL, respectively). L. citriodora was actives against C. krusei and A. fumigates (GM-MIC = 99.21 μg/mL and 62.5 μg/mL respectively). Time-kill assays done with C. ambrosioides oil showed fungicidal activity at 4x MIC. The interaction of C. ambrosioides oil with itraconazole and amphotericin B was tested following the chequerboard technique. No interaction was detected for the combination of C. ambrosioides oil with amphotericin B and itraconazole (FICI range = 1.03-1.06 and 1.03-1.00, respectively). Cytotoxicity assays for all samples were carried out with MTT. Only the oil from Hedyosmun sp. and L. dulcis were cytotoxic. As plantas s o geralmente utilizadas na medicina tradicional como agentes antimicrobianos e seus óleos essenciais e extratos foram conhecidos por possuir atividade antifúngica. O objetivo deste estudo foi avaliar in vitro a atividade de 32 óleos essenciais e 29 extratos contra Candida krusei e Aspergillus fumigatus, bem como o efeito citotóxico em células Vero. A curva do tempo-morte e a intera o entre antifúngicos e Chenopodium ambrosioidese do extrato de Myrcia cucullata mostraram atividade antifúngica contra C. krusei (geometric means of the minimal inhibitory concentration [GM-MIC] 7,82 e 31,25 μg/mL, respectivamente). Lippia citriodora foi ativa contra C. krusei e A. fumigatus (GM-CIM = 99,21 μg/mL e 62,5 μg/mL, respectivamente). Os testes de tempo-morte feitos com óleo de C. ambrosioides mostraram atividade fungicida em 4x MIC. A intera o do óleo C. ambrosioides com itraconazol e anfotericina B foi testada pela técnica de xadrez. Nenhuma intera o foi detectada pela combina o do óleo C. ambrosioides com anfotericina B e itraconazol (intervalo fractional inhibitory index [FICI] = 1,03-1,06 e 1,03-1,00, respectivamente). Os ensaios de citotoxicidade para todas as amostras foram realizadas com MTT. Apenas os óleos Hedyosmun sp. e L. dulcis foram citotóxicos.
Prácticas y comportamientos sexuales de estudiantes de la Universidad de Manizales (Colombia) 2010
Ca?ón,Sandra Constanza; Castao Castrillón,José Jaime; Díaz,Sahira Alejandra; Hernández,Jhony Alexander; Hoyos Martínez,Yovanny; López Marín,Felipe; Manchego Arango,Katherina; Narváez,Carlos Wilson; Noguera,Verónica; Ortega,Andrea Marisol;
Psicología desde el Caribe , 2011,
Abstract: this study aims at investigating the practices and sexual behaviors in a university population since positive behaviors may develop best abilities for the prevention of high-risk behaviors, major sexual satisfaction and a more meaningful life. this was a cross-sectional study, which involved students from all programs of the universidad de manizales (caldas, colombia), who were between first and ninth semester. the sample of this study was 267 students of a population of 3600 regular students, which was obtained by probability sampling stratified by gender and program. the average age was 21.69, with a higher ratio of women (58.8%), 1.5% were homosexual and 5% bisexual; the most used contraception method was barrier methods (41.3%); 15.2% had had some kind of sexual transmission infection (sti). regarding sexual practices 22.8% performed the different practices (masturbation, oral sex, anal sex, vaginal sex), and the average age of first sexual intercourse was 16.09; 53.1% agrees with abortion and 84% agreed with its total decriminalization; 73.2% have an acceptance and tolerance of homosexuality. the study allowed seeing the influence of several variables such as gender, family, religion and educational background on behavior and responsible sexual practice.
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