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Search Results: 1 - 8 of 8 matches for " Veeranjaneyulu Sadhanala "
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Asynchronous Parallel Block-Coordinate Frank-Wolfe
Yu-Xiang Wang,Veeranjaneyulu Sadhanala,Wei Dai,Willie Neiswanger,Suvrit Sra,Eric P. Xing
Mathematics , 2014,
Abstract: We develop mini-batched parallel Frank-Wolfe (conditional gradient) methods for smooth convex optimization subject to block-separable constraints. Our work includes the basic (batch) Frank-Wolfe algorithm as well as the recently proposed Block-Coordinate Frank-Wolfe (BCFW) method\citep{lacoste2012block} as special cases. Our algorithm permits asynchronous updates within the minibatch, and is robust to stragglers and faulty worker threads. Our analysis reveals how the potential speedups over BCFW depend on the minibatch size and how one can provably obtain large problem dependent speedups. We present several experiments to indicate empirical behavior of our methods, obtaining significant speedups over competing state-of-the-art (and synchronous) methods on structural SVMs.
Fault Tolerance in Grid Computing Using WADE
Gangineni Veeranjaneyulu
Journal of Global Research in Computer Science , 2012,
Abstract: Grid computing is a coordinated resource sharing and solving the problems in organizations which are dynamic and virtual in nature. Apart from the dynamic nature of grids which means that resources may enter and leave the grid at any time, in many cases outside of the applications, control grid resources are also heterogeneous in nature. Many grid applications will be running in environments where interaction faults are more commonly occur between diverse grid nodes. As resources may also be used outside of organizational boundaries, it becomes iteratively difficult to guarantee that a resource being used is not malicious one. Because of the diverse faults and failure conditions developing, deploying, and executing long running applications over the grid remains a challenge. Hence fault tolerance is an primary factor for grid computing. The prototype system is designed using agents to provide service replication, reactivation and avoids the single point of failure. The agents and the workflows are provided by a common software platform called WADE.
Improved Grid-Scan Localization Algorithm for Wireless Sensor Networks
Raghava Srinivasa Nallanthighal,Veeranjaneyulu Chinta
Journal of Engineering , 2014, DOI: 10.1155/2014/628161
Abstract: Localization is a fundamental and crucial service for various applications in wireless sensor networks (WSNs). In this paper an improved grid-scan localization algorithm has been proposed. In the proposed algorithm, information about 1-hop, 2-hop, and farther neighboring anchors has been collected that estimates the region using 1-hop anchors. Then, this estimated region is divided into a grid array, finding valid grids using 1-hop and 2-hop anchors information. In addition to that the farther anchor information further reduces the valid grids. The proposed algorithm achieves better location estimation accuracy than the existing grid-scan algorithm. 1. Introduction A wireless sensor network (WSN) consists of a number of randomly arranged sensor nodes. Each sensor node is capable of sensing and communicating with another sensor node in the designed communication range. In WSNs some sensor nodes have prior knowledge about their location which can be obtained from hardware connected to such nodes. These nodes are known as anchor nodes. The hardware may also be a GPS system. The sensor nodes which do not have knowledge about their location are called normal nodes. Some of the applications of such WSNs are vehicle tracking, target tracking, wildlife habitat monitoring, and disaster management. These applications without the knowledge of the location are absurd. One of the methods to obtain the location of a normal node is to connect the hardware to it. The WSNs consist of several hundreds of sensor nodes. Hence, the overall cost of WSNs increases. In some places GPS system cannot be operated such as mines and indoor environment as there is a problem in communication. To overcome the above problems several localization algorithms were proposed. Localization algorithms are classified into two categories: range-based algorithms and range-free algorithms. The range-based algorithms estimate the coordinates of nodes from pairwise distances using special hardware. This hardware is used to measure angle of arrival (AOA) [1], time of arrival (TOA) [2], time of difference arrival (TDOA) [3], received signal strength indicator (RSSI) [4], and so forth. The calculation of distance or angle can be affected by multipath propagation and noise. Moreover, these algorithms need additional devices to measure the angle or distance between sensor nodes. In range-free algorithms, the localization between normal nodes is obtained through connectivity with the neighboring sensors which do not require any additional hardware. This significantly reduces the overall cost and energy
International Journal of Engineering Science and Technology , 2010,
Abstract: During the last decade electric power industry has undergone considerable changes. System operators will need to be well-aware of the network capability to transfer. Various mathematical models have been developed to find Available Transfer Capacity (ATC) of transmission system. Most transfer studies Developed are based onlinear methods. One of the limitations of linear ATC is the error produced by neglecting the effect of reactive power flows in line loading. This paper describes a fast algorithm to incorporate this effect. The estimation of the line post -transfer complex flow is based on circle equations and a Megavar-corrected Megawatt limit. The algorithm is illustrated with a small example.
Acharya Ravi D.,Addeppali Veeranjaneyulu,Bhatt Lokesh,Kakkar Saloni
International Research Journal of Pharmacy , 2011,
Abstract: Diabetes mellitus (DM) is associated with an increased incidence of cardiovascular events and microvascular complications. These complications contribute to the morbidity and mortality associated with the disease. There is increasing evidence supporting a role for Matrix MetalloProteinases (MMPs) and their inhibitors (tissue inhibitors of matrix metalloproteinases—TIMPs) in the atherosclerotic process. The main cause of vascular complications is increase in collagen-4, Gelatinase A and B content of extracellular matrix of cells which lead to cell wall thickening in DM. The collagen content is regulated by MMP (Matrix MetalloProteinases) enzymes. The up-regulated levels of MMP-2 and MMP-9 enzymes are responsible for the increased collagen content in extracellular matrix, which further carries micro & macrovascular complications. The involvement of MMP-2 and MMP-9 enzymes in Diabetic Complications was determined by several scientists well before. The inhibitory effect of Theaflavins on Matrix Metalloproteinases was studied by some scientist on cancerous tumours. It has been reported in the literature that Teaflavins (Theaflavin) in Black Tea are inhibitors of MMP-2 & 9. So, here it was hypothesized that Black Tea which contains Theaflavin can be used for the treatment of DM Complications by inhibition of MMP 2 & 9. The efficacy was measured on Diabetic Cardiac Complications which are the development of a coronary microangiopathy and decrease of diastolic and systolic functions of the left ventricle were measured.
Effect of Sapindus trifoliatus on hyperalgesic in vivo migraine models
Arulmozhi, D.K.;Veeranjaneyulu, A.;Bodhankar, S.L.;Arora, S.K.;
Brazilian Journal of Medical and Biological Research , 2005, DOI: 10.1590/S0100-879X2005000300019
Abstract: phytotherapies have offered alternative sources of therapy for migraine and gained much importance in prophylactic treatment. sapindus trifoliatus is a medium-sized deciduous tree growing wild in south india that belongs to the family sapindaceae. the pericarp is reported for various medicinal properties. a thick aqueous solution of the pericarp is used for the treatment of hemicrania, hysteria or epilepsy in folklore medicine. we have investigated the antihyperalgesic effects of the lyophilized aqueous extract of s. trifoliatus in animal models predictive of experimental migraine models using morphine withdrawal-induced hyperalgesia on the hot-plate test and on 0.3% acetic acid-induced abdominal constrictions in adult male swiss albino mice. the extract significantly (n = 10, p < 0.05) increased the licking latency in the hot-plate test when administered ip at 10 mg/kg (6.70 ± 0.39 s in saline control vs 18.76 ± 0.96 s in s. trifoliatus-treated animals) and significantly (n = 10, p < 0.001) reduced the abdominal constrictions when administered ip at 2 and 10 mg/kg (40.20 ± 1.36 in saline control vs 30.20 ± 1.33 and 23.00 ± 0.98 for 2 and 10 mg/kg, ip, respectively, in s. trifoliatus-treated animals). furthermore, when administered ip at 20 and 100 mg/kg, the extract significantly (n = 10, p < 0.05) inhibited the apomorphine-induced climbing behavior in mice (climbing duration 15.75 ± 5.0 min for saline control vs 11.4 ± 1.28 and 3.9 ± 1.71 min for 20 and 100 mg/kg, respectively, in s. trifoliatus-treated animals). in receptor radioligand-binding studies, the extract exhibited affinity towards d2 receptors. the findings suggest that dopamine d2 antagonism could be the mechanism involved in the antihyperalgesic activity of the aqueous extract of s. trifoliatus.
Cardioprotective and β-adrenoceptor antagonistic activity of a newly synthesized aryloxypropanolamine derivative PP-36
Lokesh K Bhatt, Jyotika Bansal, Poonam Piplani, SL Bodhankar, A Veeranjaneyulu
Journal of Experimental Pharmacology , 2010, DOI: http://dx.doi.org/10.2147/JEP.S8960
Abstract: rdioprotective and β-adrenoceptor antagonistic activity of a newly synthesized aryloxypropanolamine derivative PP-36 Original Research (4205) Total Article Views Authors: Lokesh K Bhatt, Jyotika Bansal, Poonam Piplani, SL Bodhankar, A Veeranjaneyulu Published Date February 2010 Volume 2010:2 Pages 37 - 45 DOI: http://dx.doi.org/10.2147/JEP.S8960 Lokesh K Bhatt,1 Jyotika Bansal,2 Poonam Piplani,2 SL Bodhankar,3 A Veeranjaneyulu1 1Department of Pharmacology, School of Pharmacy and Technology Management, NMIMS University, Mumbai, India; 2University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India; 3Department of Pharmacology, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandawane, Pune, India Abstract: The present study was performed to evaluate the cardioprotective effects and pharmacological characterization of newly synthesized β-adrenoreceptor antagonists 3-(3-tertbutylamino- 2-hydroxypropoxy)-4-methoxybenzaldehyde (PP-36) in the rat model of coronary artery occlusion and reperfusion. Pre-ischemic administration (20 minutes before coronary occlusion) of PP-36 showed cardioprotective effects against ischemia/reperfusion injury in rats. PP-36 (6 mg kg-1) significantly reduced arrhythmia score (6.33 ± 0.55, P < 0.05), infarct size/left ventricle size (38.9 ± 3.2, P < 0.05) and no mortality compared to vehicle-treated control group (14.17 ± 1.83, 44.9 ± 4.6 and 17% respectively). In-vitro studies in rat isolated right atria, guinea-pig trachea and rat distal colon preparations, were carried out to investigate the potency of PP-36 towards different β-adrenoceptor subtypes. pA2/pKB values of PP-36 for β1- β2- and β3-adrenoceptors were 6.904 ± 0.190, 6.44 ± 0.129 and 5.773 ± 0.129, respectively. In conclusion, PP-36 is a β-adrenoceptor antagonist possessing potent anti-arrhythmic and cardioprotective effects against ischemia/reperfusion injury in rats.
Pulmonary Hypertension in Wild Type Mice and Animals with Genetic Deficit in KCa2.3 and KCa3.1 Channels
Christine Wandall-Frostholm, Lykke Moran Skaarup, Veeranjaneyulu Sadda, Gorm Nielsen, Elise R?ge Hedegaard, Susie Mogensen, Ralf K?hler, Ulf Simonsen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097687
Abstract: Objective In vascular biology, endothelial KCa2.3 and KCa3.1 channels contribute to arterial blood pressure regulation by producing membrane hyperpolarization and smooth muscle relaxation. The role of KCa2.3 and KCa3.1 channels in the pulmonary circulation is not fully established. Using mice with genetically encoded deficit of KCa2.3 and KCa3.1 channels, this study investigated the effect of loss of the channels in hypoxia-induced pulmonary hypertension. Approach and Result Male wild type and KCa3.1?/?/KCa2.3T/T(+DOX) mice were exposed to chronic hypoxia for four weeks to induce pulmonary hypertension. The degree of pulmonary hypertension was evaluated by right ventricular pressure and assessment of right ventricular hypertrophy. Segments of pulmonary arteries were mounted in a wire myograph for functional studies and morphometric studies were performed on lung sections. Chronic hypoxia induced pulmonary hypertension, right ventricular hypertrophy, increased lung weight, and increased hematocrit levels in either genotype. The KCa3.1?/?/KCa2.3T/T(+DOX) mice developed structural alterations in the heart with increased right ventricular wall thickness as well as in pulmonary vessels with increased lumen size in partially- and fully-muscularized vessels and decreased wall area, not seen in wild type mice. Exposure to chronic hypoxia up-regulated the gene expression of the KCa2.3 channel by twofold in wild type mice and increased by 2.5-fold the relaxation evoked by the KCa2.3 and KCa3.1 channel activator NS309, whereas the acetylcholine-induced relaxation - sensitive to the combination of KCa2.3 and KCa3.1 channel blockers, apamin and charybdotoxin - was reduced by 2.5-fold in chronic hypoxic mice of either genotype. Conclusion Despite the deficits of the KCa2.3 and KCa3.1 channels failed to change hypoxia-induced pulmonary hypertension, the up-regulation of KCa2.3-gene expression and increased NS309-induced relaxation in wild-type mice point to a novel mechanism to counteract pulmonary hypertension and to a potential therapeutic utility of KCa2.3/KCa3.1 activators for the treatment of pulmonary hypertension.
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