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Search Results: 1 - 10 of 215 matches for " Vasilis Tataridas "
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Prevalence of osteoporosis-osteopenia at lumbar spine and femur in an urban female population. An epidemiological study in the Athens Metropolitan area, Greece
Ioannis Legakis,Vasilis Papadopoulos,Vasilis Tataridas,Kyriakos Strigaris
Endocrinology Studies , 2012, DOI: 10.4081/es.2012.e1
Abstract: The aim of this study is to determine the prevalence of osteoporosis and osteopenia in a female urban population. Dual energy X-ray absorptiometry measurements were done at the lumbar spine (6920 females) and at the femur (3222 females) Bone mineral density (BMD) and corresponding T-scores were analysed using multivariate regression models. In females, the prevalence rate of osteoporosis was 15.3% at the lumbar spine and of osteopenia 36.5%. In females osteoporosis rate at the femur was 17.7% for the neck, 30.65% for the ward’s triangle and 1.86% for the tronchater, whereas the osteopenic rates were 53.3%, 44.7% and 32.09% respectively. A polynominal cubic model performed for age showed the steepest decline at the age of 55 years for the spine BMD (-0.973% change, 95% CI -1.031/-0.915) and at the age of 64 years for the femur BMD (-0.726% change, 95% CI - 0.793/-0.658). Actually sensitive interventions for prevention of osteoporosis in urban population need serious concern.
Exploring Secondary School Pupils’ ICT Engagement: A Validation Study  [PDF]
Kleopatra Nikolopoulou, Vasilis Gialamas
Creative Education (CE) , 2016, DOI: 10.4236/ce.2016.74059
Abstract: This paper regards a validation study aiming to explore secondary school pupils’ ICT engagement. A 36-item questionnaire was administered to 246 adolescents (12 - 15 years old) of an experimental school, in Greece. Four factors were extracted: “ICT self-concept”, “social exposure to ICT”, “interest in computers” and “interest in mobile devices”. The factorial structure of the “ICT engagement” questionnaire was revealed. The majority of the pupils expressed strong interest towards both computers and mobile devices. Over 90% of the adolescents believe that the internet is very useful to find practical information, that they can handle mobile phones confidently, and that they know how to download new applications for a mobile phone. Gender was statistically significant correlated to “ICT self-concept” and “social exposure to ICT”, where the boys had higher mean values in comparison to girls. The frequency of computer use had positive correlations with the factors “ICT self-concept”, “social exposure to ICT” and “interest in computers”. It is suggested to describe adolescents’ ICT engagement with respect to discrete dimensions. In particular, the dimensions-factors “interest in computers” and “interest in mobile devices” should be distinct when defining concepts related to ICT engagement. The questionnaire is suggested to be used with other adolescent populations of different countries, in order to reveal possible similarities and differences.
A/D Restrictions (Errors) in Ultra-Wideband Impulse Radios  [PDF]
Giorgos Tatsis, Constantinos Votis, Vasilis Raptis, Vasilis Christofilakis, Panos Kostarakis
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2010, DOI: 10.4236/ijcns.2010.35055
Abstract: Ultra-Wideband Impulse Radio (UWB-IR) technologies, although are relatively easy in transmission but they present difficulties in reception, in fact the reception of such waveform is a quite complicated matter. The main reason is that in fully digital receiver the received waveform must be sampled at a rate of several GHz. This paper focuses on the impact of the Analog to Digital (A/D) conversion stage that is used to sample the received waveform. More specifically we focus on the impact of the two main parameters that affect the performance of the Software Defined Radio (SDR) system. These parameters are the bit resolution and the time jittering. The influence of these parameters is deeply examined.
Inverse Supersymmetry Breaking in S1 × R3
Vasilis Oikonomou
Symmetry , 2010, DOI: 10.3390/sym2010366
Abstract: In this paper, we study the influence of hard supersymmetry breaking terms in a N = 1, d = 4 supersymmetric model, in S1 × R3 spacetime topology. It is shown that when the radius of the compact dimension is large supersymmetry is unbroken, and dynamically breaks as the radius decreases. We point out that this resembles the inverse symmetry breaking of continuous symmetries at finite temperature (however, in the case of supersymmetry, the role of the temperature is played by the compact dimension’s radius). Furthermore, we also find a universality in the dependence of the critical length Lc as a function of a coupling g3, after comparing all cases.
Vasilis Vasiliou
Human Genomics , 2011, DOI: 10.1186/1479-7364-5-3-137
Abstract: Our submission rate has increased and our publication rate is constant to the point that our Impact Factor will be provided by ISI by the summer of 2011.We have a new addition to our Editorial Board. I therefore welcome and introduce to you, Samir Zakhari, who is Director of the Division of Metabolism and Health Effects of the National Institute on Alcohol Abuse and Alcoholism at the National Institutes of Health, USA.In this issue, we start with the Research Highlights. Webb, Smith and Cotton then describe the difficulties associated with finding SNPs and related phenotypic data in world wide web resources using simple, uncomplicated search terms and they also provide a suggested solution. This is followed by the Filocamo and Morrone Review of the molecular basis and laboratory testing of lysosomal storage disorders, a group of more than 50 different inherited metabolic diseases. In the Update on Gene Completions and Annotations section, Smathers and Petersen review the human fatty acid-binding protein (FABP) family, a member to the superfamily of intracellular lipid-binding proteins. In this paper, the evolutionary divergences and functions of the FABPs are discussed. In Issue 5.2, Wright and Bruford provided an excellent Review on the nomenclature of non-coding RNAs (pp. 90-98). In the Software Review section of the current issue, Agirre and Eyras discuss databases and resources available for non-coding RNAs (sRNAs). They look at the main issues related to the integration and annotation of sRNA datasets. In the Genome Databases section, Valerio discusses toxicology models and databases as Critical Path toolkits for predicting toxicities early in drug development. Finally, Cassiman reviews the second edition of a book entitled 'Molecular Diagnostics' published by Elsevier (Academic Press) in 2010 and edited by George Patrinos and Wilhelm Ansorge.
Vasilis Vasiliou
Human Genomics , 2011, DOI: 10.1186/1479-7364-5-4-215
Abstract: Ikediobi and colleagues have characterised the population frequencies of clinically relevant phar-macogenetic traits in two distinct South African population groups residing in the Western Cape (the Xhosa and Cape Mixed Ancestry). Their data indicate diverse allele frequencies of key pharmaco-genetic genes within the African population. In the Update on Gene Completions and Annotations section, Jackson et al. provide an update on aldehyde dehydrogenase (ALDH) genes in several vertebrates and clarify the annotation found in the National Center for Biotechnology Information (NCBI) gene database. They also discuss gene-duplication and gene-loss events that may have occurred in the ALDH gene superfamily. In the Software Review section of the current issue, Lamy and colleagues discuss software for the genotyping of microarray single nucleotide polymorphisms, in particular software for Affymetrix and Illumina arrays. In Genome Databases, Jassal reviews the new version of the Reactome database and uses it to analyse the solute carrier (SLC) class of transporters. His study and the Reactome provide a basis for a number of analyses, which includes interactions, expression data, over-representation analysis and species comparison. Such analyses may provide the basis for further investigations using systems biology.Finally, Dan Nebert reviews the book, Designer Genes: A New Era in the Evolution of Man by Stephen Potter (Random House; 2010).
Vasilis Vasiliou
Human Genomics , 2009, DOI: 10.1186/1479-7364-3-2-101
Abstract: Mutations in another aldehyde dehydrogenase gene (ALDH5A1) are the molecular basis for succinate semialdehyde dehydrogenase (SSADH) deficiency, which is a neurological disorder associated with developmental delay, prominent language deficits, hypotonia, ataxia, hyporeflexia and seizures. Malaspina and colleagues report on the comparative genomics of ALDH5A1 and the accumulation of gamma-hydroxybutyrate associated with its deficiency. In another paper in this issue, Gherman et al. report on how the spatial configuration of neighbouring genes affects their regulation and function. Their systematic survey of the distribution and orientation of genes and the properties of intergenic intervals reveals previously unknown properties of the genome which will be the basis for further studies.Shukla et al. have used the whole-genome approach with molecular experiments to identify factors involved in conferring cellular resistance to carboplatin, a chemotherapeutic agent used in the management of many cancers, but with treatment limited by resistance and toxicity. They have identified and validated the CD44 gene as a major factor contributing to carboplatin resistance in tumour cell lines.Garenc et al. report on the effects of the LIPE C-60G polymorphism on body fat, plasma lipid and lipoprotein concentrations, and its interaction with physical activity. Their results suggest that the associations between physical activity and body fat and plasma lipoprotein/lipid concentrations in men are dependent on the LIPE C-60G polymorphism. The study highlights the importance of taking into account the role of gene-physical activity interactions in candidate gene studies of obesity and obesity-related traits.Matimba et al. describe novel SNPs of CYP2C9, CYP2C19, CYP2D6 and NAT2 genes in African populations. While confirming African-specific variants, they found only modest variation between different African ethnicities, indicating similar metabolic profiles for most drugs, yet stressin
Human Genomics begins ePub ahead of print and a discussion forum Aiming to Bridge Academia with the Pharmaceutical Industry
Vasilis Vasiliou
Human Genomics , 2011, DOI: 10.1186/1479-7364-5-5-419
Abstract: The open access, in combination with the ePub ahead of print, discussed below, will permit immediate public access to both the preliminary accepted version and the copyedited, typeset version published in the online journal. This option is in addition to the open access already provided through the National Institutes of Health's PubMed Central repository; all primary research published in Human Genomics is freely available through PubMed Central six months after publication.Starting in Volume 6, Human Genomics will have available the e-Pub ahead of print option for all publications. These are citations that publishers submit to PubMed for articles that appear on the publisher's website in advance of the journal release. The reason for the ePub ahead of print approach is to publish accepted, checked and proofread articles online prior to their appearance in the print version of a journal. Such an article is assigned a digital object identifier (DOI; a character string that serves as a unique identifier for an article and stays with the article even after it has been assigned volume, issue and page numbers), and is indexed by PubMed and other indexing services. As with many other journals, we believe that this is very important, simply because it allows an accepted paper (ePub article) to be cited immediately by its DOI and then associated with its traditional citation after it is published in print. The online access to 'ahead of print' articles will be limited to individual subscribers and to libraries with paid subscriptions.One of the unique features of Human Genomics is its role as the interface between the pharmaceutical industry and academic research. Our aim is to publish original research papers and review articles relevant to both. To support this feature further, we are introducing a forum, Aiming to Bridge Academia with the Pharmaceutical Industry.
Changes in Human Genomics
Vasilis Vasiliou
Human Genomics , 2011, DOI: 10.1186/1479-7364-5-2-75
Abstract: First and foremost, I am delighted to confirm that the Journal is now accepting submissions for open-access papers. We recognise the importance of open access to experts in the field - and the necessary speed with which work needs to be published - but also that the cost to authors is of course significant. In recognition of this we are offering all authors the opportunity to publish papers on an open-access basis, with full indexing in PubMed, Medline and Chemical Abstracts, at a fee of only US$750/£500 to cover production costs. We would be delighted if you would like to submit an open-access paper and would welcome any queries you might have. This opportunity is open to individuals as well as genetics associations, research institutions and universities wishing to publish collections of research papers, review articles and proceedings of meetings in a special issue of the Journal. For further details of the Journal and how to submit open-access papers, please contact me directly at: http://Vasilis.Vasiliou@ucdenver.edu webcite. You can also find further details at: http://www.henrystewart.com/hg.aspx webcite.It is with great pleasure that we welcome Mirella Filocamo, (G. Gaslini Institute, Italy), Tadashi Imanishi (Biomedicinal Information Research Center, Japan), Hidetoshi Inoko (Tokai University School of Medicine, Japan), Poh-San Lai (National University of Singapore, Singapore), George P. Patrinos (University of Patras, Greece) and Sumio Sugano (University of Tokyo, Japan) to our Editorial Board. We also welcome Thomas Schlitt, (King's College London, UK) who is replacing Mike Weale, (King's College London, UK) as the Software Review Editor. Mike remains on the Editorial Board of the Journal and we thank him for all the support he has given to this regular feature.Finally, this issue sees the first installment of the new regular feature for Human Genomics entitled 'Research Highlights', which collates and reviews some of the most cutting-edge research papers
Vasilis Vasiliou
Human Genomics , 2009, DOI: 10.1186/1479-7364-3-3-211
Abstract: In this issue of Human Genomics, a number of topics are covered, including the existence of ALDH2*2 in the Indian population, novel prediction methods for transcription factor binding sites, molecular technologies and bioinformatic tools, as well as Hox gene expression.Published in this issue is a very interesting study by Vaswani et al., exploring genes involved in alcohol metabolism that may be linked with alcoholism in the Indian population. Ethanol is metabolised to acetaldehyde mainly by alcohol dehydrogenase enzymes, and acetaldehyde is then metabolised to acetic acid by aldehyde dehydrogen-ases (ALDH). The ALDH2 gene product is a mito-chondrial protein responsible for acetaldehyde clearance. The ALDH2*2 allele (E487K) protects against alcoholism and is a determinant of alcohol avoidance in some East Asian populations. This is the first report of the existence of ALDH2*2 in the Indian population, and of a high frequency of ALDH2*2/*2 in Indian alcoholics.Wang et al. have developed a novel prediction method that employs genomic features related to the presence of regulatory elements to enable more accurate and efficient prediction of transcription factor binding sites (TFBSs). In their study, they used the transcription factor upstream stimulatory factor 1 (USF1) to evaluate the performance of this novel TFBS prediction method because of its known genetic association with coronary artery disease and the recent availability of USF1 chromatin immunoprecipitation microarray (ChIP-chip) results. This method can be also used for other transcription factors involved in human disease studies to help further our understanding of the biology of complex disease.An increased number of (TG/CA) repeats, especially in the first intron, have been suggestively associated with the regulation of the transcription of several cancer- and disease-related genes, including the genes encoding the epidermal growth factor receptor (EGFR), hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B
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