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Search Results: 1 - 10 of 88403 matches for " Varja?i? Mirjana "
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Legal and medical aspects of the ethics committee’s work relating to abortion
Ponjavi? Zoran,VarjaiMirjana
Stanovni?tvo , 2011, DOI: 10.2298/stnv1101015p
Abstract: This paper analyses the legal and medical aspects of the work of ethics committees on abortion. According to the legislation of the Republic of Serbia, these committees are competent to determine justifiable terms for abortion after the twentieth week of the fetus. It is well known that abortion is not only a medical but a legal, ethic, social and demographic problem as well. A liberal solution in view of abortion in the first trimester has been accepted in most European countries, as by the legislature of the Republic of Serbia. Since prenatal diagnosis cannot always determine the fetus state with certainty but at times may do so at a later stage, abortion is then required when the child is already capable of extrauterine life. The necessity for performing abortion in the third trimester is thus a result of good knowledge of techno-medicine but also from the limited information it provides. In such situations, the physician needs confirmation and justification of his standpoint with respect to abortion through a legal formulation which should contain "minimum moral". Society has found a way to protect and help him through moral and ethic forms of prevention without anybody’s emotions being affected. Ethics committees should thus help the physician in view of determining the terms for performing late abortion, since the rules of doctor’s ethics are not sufficient in this case. The article especially analyses the work of the Ethics Committee of the Clinical Center in Kragujevac in the period 2000-2010. It is stated that the largest number of cases referred to determined diseases or fetus anomalies while only a negligible number (11.29%) to the illness of the mother. There were no requests for abortions due to legal reasons (pregnancies from criminal offences). A significant number (40.28%) of requests submitted to the Ethics Committee related to pregnancies under the 24th week of pregnancy. Since a pregnancy of 24 weeks represents a boundary line between a miscarriage and preterm birth, the paper proposes a shift in the boundary line of pregnancies which must be terminated according to the Ethics committee, from 20 weeks of gestation to 24 weeks of gestation. At the same time, the requirement for narrowing legal conditions for abortion in later phases of pregnancies is pointed out as well as abolition of legal indications.
Changes in parameters of glycoregulation in gestational diabetes mellitus patients with different approach to insulin therapy introduction
Mladenovi? Violeta,?uki? Aleksandar,VarjaiMirjana,Macut ?uro
Srpski Arhiv za Celokupno Lekarstvo , 2012, DOI: 10.2298/sarh1210583m
Abstract: Introduction. Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. The diagnosis of GDM is made by performing the oral glucose tolerance test (OGTT) in women with risk factors, usually during 24th to 28th week of gestation. The most common used insulin therapy regime is a conventional intensive insulin therapy with four daily doses. Objective. The aim of our study was to determine the changes in parameters of glycoregulation in GDM patients with different approach to the introduction of insulin therapy. Methods. Study group consisted of 50 pregnant women divided into two groups depending on the parameters of glycoregulation (glycemic profile and HbA1). Group 1 consisted of pregnant women initially treated with diet only and then, according to glycemic profile and HbA1 profile, in the next few weeks with insulin therapy. Group 2 were pregnant women who were treated with insulin therapy immediately after GDM diagnosis. Results. There was a statistically significant difference in mean glycemia values in the 60th and 120th minute between the two groups (p=0.001). There was a difference in mean value of fasting blood and postprandial glucose between the two groups; it was higher in Group 2. There was a statistically significant difference between the two groups in HbA1c value at the beginning (5.1±0.4% vs. 5.42±0.43%, p=0.005) and at the end of therapy (4.87±0.29% vs. 5.1±0.39 %, p=0.018). Conclusion. Satisfactory glycoregulation was achieved in both studied groups.
DIAGNOSIS OF GASTROSCHISIS IN THE FIRST TRIMESTER OF PREGNANCY - CASE REPORT
Dragan Lon?ar,Mirjana Varjai,Stefan Lon?ar
Acta Medica Medianae , 2011,
Abstract: Gastroschisis (gastroshisis) represents evisceration of the abdominal organs, most commonly small bowels, stomach and gonads through the front abdominal wall defect, almost always to the right of the umbilicus (90%) from which it is separated by thin skin bridge. The incidence of this anomaly is 0.5 to 4 per 10.000 liveborn babies. We presented a patient, aged 27 years, who had gastroschisis of the fetus in the 13th week of gestation diagnosed by ultrasound. Ultrasound examination is the method of choice for prenatal detection of fetal anomalies. By differential diagnosis, the possible existence of omphalocele should be eliminated using (2D, 3D) and power Doppler technology which significantly makes the assessment of gynecologist easier during establishment of the final diagnosis.
A study of alloreactivity in couples with habitual abortions of unknown etiology
Protrka Zoran,Jovanovi? Bo?idar,Protrka Olivera,VarjaiMirjana
Medicinski Pregled , 2005, DOI: 10.2298/mpns0510444p
Abstract: During 2003, we investigated 22 couples with three or more consecutive spontaneous abortions without liveborn children. The study group consisted of 9 couples with three or more successive spontaneous abortions without liveborn children and without known endogenous or exogenous causes of habitual abortions. The first control group comprised 9 couples with liveborn children, while the second one included 9 randomly selected couples without children. The Immunologic status was evaluated in regard to functional capacity of lymphocytes, response of T-lymphocytes to disabled histocompatible antigens of partner's lymphocytes, and T-lymphocytes to partner's alloantigens. In women from study and control groups there were no statistically significant differences in general Immunologic status (functional capacity of lymphocytes). In women from the study group, T-lymphocytes response to stimulation by disabled partner's lymphocytes was significantly lower compared to both control groups (P 0.05). However, the immunologic reaction of women from the study group to alloantigens of men from control groups did not show any significant difference compared to contra/ groups results (P > 0,05). According to our study, it can he concluded that imnntnologic factors have an important role in a great proportion of habitual abortions with unknown etiology.
Significance of pregnancy-associated plasma protein a (PAPP-a) concentration determination in the assessment of final outcome of pregnancy
Lon?ar Dragan,VarjaiMirjana,Arsenijevi? Slobodan
Vojnosanitetski Pregled , 2013, DOI: 10.2298/vsp110530023l
Abstract: Background/Aim. Pregnancy-associated plasma protein A (PAPP-A) is high molecular matrix metalloproteinase originally isolated in the serum of pregnant women. The aim of this study was to analyze the values of concentration of PAPP-A in assessment of progress and outcome of pregnancy in pregnant women diagnosed with threatening preterm delivery, preeclampsia and fetal growth restriction in relation to physiological pregnancy of the same gestational age. Methods. The study included 60 pregnant women that were divided into three groups according to gestational age and the diagnosis of imminent premature birth upon reception, preeclampsia and fetal growth restriction as follows: the group I from 28 to 32 weeks of gestation, a total of 25 pregnant women, the group II from 33 to 36 weeks of gestation, a total of 23 pregnant women, and the group III from 37 to 41 weeks of gestation, a total of 12 pregnant women. The control group consisted of 60 pregnant women without complications of pregnancy that were identically divided into three groups according to gestational age as in the sample. We performed quantitative determination of PAPP-A from the venous blood of patients by using commercial tests of the company Diagnostics Product Corporation (DPC), Los Angeles, California, USA. Results. There was a statistically significant difference in PAPP-A values in the examined groups in all gestational ages (p < 0.01). The value of the PAPP-A concentration in different gestational ages with equal statistical significance indicated the possibility of complications, which was examined during pregnancy in relation to the control group of pregnant women with physiological pregnancies. This study confirmed that there was a statistically significant difference in fetal body weight at birth (p < 0.05), Apgar score in 5 min after birth (p < 0.05), and gestational age at birth (p < 0.05), as parameters of the outcome of pregnancy course, between the examined groups of pregnant women in relation to the value of PAPP-A concentration. The age of pregnant women was not statistically different in the examined groups (p > 0.05). Conclusion. Differences in PAPP-A concentration should point out to the obstetrician the need for more intensive antepartum fetal surveillance in order to increase the chances of favorable perinatal outcome, regardless gestational age. [Acknowledgement. The authors would like to express their gratitude to the Ministry of Science and Technological Development of the Republic of Serbia for the Grant N°175014, out of which the clinical trial that served as the ba
The ultrasonographic diagnosis of fetal encephalocele at 13th gestational week
?orak Marija,?ivanovi? Aleksandar,VarjaiMirjana,Luki? Goran
Vojnosanitetski Pregled , 2010, DOI: 10.2298/vsp1001069s
Abstract: Background. Encephalocele presents a rare anomaly of central nervous system, developed as a consequence of neural tube closing defect during early embrional development, and it is described by a baggy formation which prolaborates through the pores of the scull, filled with brain tissue, cerebrospinal liquor and entwined with meninges. According to literature search, until this day, the earliest it can be ultrasonically detected is the 13th gestation week, with the appliance of three-dimensional ultrasound. Case report. We presented 25 years old patient, ultrasonically diagnosed with occipital fetal encephalocela at the 13th gestation week. A gestation sack was located in the right uteral corn of the two-corned uterus with one cervix. The diagnosis was confirmed also by trippled value of alpha-fetoprotein in maternal serum: 75,98 IU/mL. Conclusion. Ultrasonic examination is the method of choice for prenatal detection of a fetal anomaly. It is possible to diagnose encephalocele if it prominates above the limits of the scull.
Effects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pockets
Toski?-Radoji?i? Marija,Nonkovi? Zorka,Lon?ar Irma,Varjai? Milomir
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0508565t
Abstract: Introduction. Metronidazole is the drug of choice in the treatment of periodontal pockets up to 5 mm in depth. It is topically applied - directly into the periodontal pockets. There are no registred trademark preparations for this purpose in the market of Serbia and Montenegro. The aim of our latest research was to test the efficacy of newly formulated preparation containing 25% metronidazole suspended in a lipogel in vitro - in anaerobic cultures isolated from the periodontal pockets, and in vivo - by the direct application into periodontal pockets. Methods. Preparation efficacy was tested in a randomized controlled study involving 25 patients, and was confirmed by the membrane-free agar diffusion method on the anaerobic strains isolated from the periodontal pockets. The duration of the testing was 30 days. The preparation was applied twice - immediately after the taking of the first swab, and on day 15, when the control swab was taken for the assessment of the effects of the applied preparation. Results. Seven anaerobic strains were isolated and tested, and each was confirmed as highly susceptible to metronidazole. Anaerobic strains were not isolated in any of the pockets treated with metronidazole-containing lipogel. The strains isolated in the control pockets were the same as were those at the beginning of the study. Conclusion. Metronidazole, in a lipogel-type base applied in the concentration of 25%, provided an efficient treatment of anaerobic infection in the periodontal pockets.
Assessment of the feasibility of the formulation of preparation for the growth inhibition of metronidazole-resistant strains isolated from the periodontal pockets
Toski?-Radoji?i? Marija,Nonkovi? Zorka,Lon?ar Irma,Varjai? Milomir
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0506453t
Abstract: Introduction. Topical metronidazole benzoate preparations, applied directly into the space between the teeth and periodontal tissue, are the treatment of choice for periodontal pockets. Oleogels and hydrogels, as the biomucoadhesive bases for the manufacturing of these preparations, were developed in our previous trials. The aim of our latest research was to develop a preparation that would solve the problem of inhibiting the metronidazole-resistant anaerobic strains, isolated from the periodontal pockets. Methods. Metronidazole-resistant strains were isolated from the periodontal pocket swabs, using the established susceptibility testing. Further testing of the antimicrobial activity of the prepared formulations was performed by the membrane-free diffusion method in agar gel. Oleogels and hydrogels were tested with: tetracycline (2.5%), metronidazole (25%), and metronidazole benzoate (40%), as well as with oleogels and hydrogels containing the combination of 2.5% tetracycline and 40% metronidazole benzoate. Results. Satisfying results were achieved with the preparation containing 2.5% tetracycline along with metronidazole benzoate. The main fact revealed by this study was that there was no synergism in tetracycline and metronidazole benzoate activities, if the strain was susceptible to both active substances. Conclusion. The best results in the inhibition of the growth of metronidazole-resistant anaerobic strains were obtained by 2.5% tetracycline and metronidazole benzoate preparations in oleogel base.
Demographic features of old people in Belgrade
Deved?iMirjana
Glasnik Srpskog Geografskog Dru?tva , 2007, DOI: 10.2298/gsgd0702093d
Abstract: The process of demographic ageing is one of the most apparent features of the demographic development of Serbia. The increase of the percentage of aged population is also present in Belgrade, although Belgrade itself, being the center of immigration and the major urban agglomeration, has a specific population development. This paper analyzes the dynamics and demographic features of the citizens of Belgrade older than 60, in the period between 1981 and 2000. It discusses the changes in gender and age distribution of this population group, as well as the processes of ageing and feminization of the elders. It also indicates related differences between the municipalities of Belgrade, as well as between the City of Belgrade, the Settlement of Belgrade and the settlements of Belgrade outside the inner urban zone.
Feminization of migrations?
Morokva?iMirjana
Stanovni?tvo , 2010, DOI: 10.2298/stnv1002025m
Abstract: Women have always taken part in migrations, but their presence varied depending on their origins, on the labour market situation both in the areas of origin and in the target areas, as well as the migration policies in the immigration areas. Their presence was not always visible and did not attract as much scholarly and political attention as today. What happened, how can one explain such an interest lately, whereas only few years ago the subject was marginal, in the shadow of the "mainstream - malestream", i.e. migration as a phenomenon which focuses on geographic mobility of men, while women are not considered as equal protagonists, they either follow or remain at home. Could the so called "feminization" of migration explain the great and sudden interest for women and gender in migrations? This text critically examines the notion of "feminization" considered today as one of the main dimensions of global migration flows. Drawing on trends both globally and in specific countries, it shows that "feminization" is neither a new nor a sudden trend and entails variations depending on the origins, level of development and maturity of migration flows. In some groups men were primo-migrants and with a gradual feminization the flows reach a balanced sex ratio. There where women migrated first, or became numerically predominant, one observs the opposite trend: a "masculinization". Some authors rightly refer to "gender transition", the term which covers both trends. It is argued in the conclusion that the visibility and growing interest for women in migration and, more recently, for a gender perspective in migration, is not only due to the changing migration patterns and profile of migrants but also to the renewal of theoretical perspectives in migration and gender studies in a context that largely facilitated that renewal. The focus of our attention today on specific aspects of migration is triggered not only by genuine changes in migration trends, but it is also a result of a long process of visibilisation in the academic production on migration, women and gender. These trends may have existed earlier in the migration history but had remained in the shadow of categories defining, recording and analyzing migration.
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