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Search Results: 1 - 10 of 227009 matches for " Vanessa R. Yingling "
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SHORT-TERM JUMP ACTIVITY ON BONE METABOLISM IN FEMALE COLLEGE-AGED NON-ATHLETES
Kohei Kishimoto,Ryan P. Lynch,Jamie Reiger,Vanessa R. Yingling
Journal of Sports Science and Medicine , 2012,
Abstract: There have been few studies examining the short-term effect of high-impact activities on bone metabolism measured by bone serum marker concentrations. The purpose of this study was to examine the effect of short-term high-impact jump activity on bone turnover in female college-aged non-athletes. Twenty six healthy females were randomly assigned to a control or jump group. The subjects jumped 5 days per week for 2 weeks. The participants completed 10 jumps per session. A general health questionnaire and a bone-specific physical activity assessment instrument (BPAQ) were completed. BPAQ scores were calculated based on the past history of exercise. Blood draws were taken in both groups before and after the two-week experimental period. The vertical ground reaction force (VGRF) of all jumps and jump height were measured for each subject daily and the osteogenic index (OI) was measured. Concentrations of serum osteocalcin (OC), Bone Specific Alkaline Phosphatase (BAP), C-Terminal Telopeptides of Type I Collagen (CTX) and plasma Tartrate-Resistant Acid Phosphatase (TRAP5b) were assessed pre and post jump protocol to measure bone formation and resoprtion respectively. A significant interaction (time x group) was found in TRAP5b, and BAP values (p < 0.05). There was a significant decrease in CTX and BAP values in the jump group (p < 0.05) after the two week jump protocol. No significant interactions or changes were observed in OC values for either the jump or the control group. Two weeks of jump activity consisting of 10 jumps/day for 5 days/week with a weekly osteogenic index of 52.6 significantly decreased markers of bone resorption (TRAP5b and CTX) and bone formation (BAP) in young female non- athletes.
Research on English Language Teaching Practice in Open Distance Learning
Yingling Gu
International Journal of English Linguistics , 2011, DOI: 10.5539/ijel.v1n1p247
Abstract: A new stage of development for modern distance education has been entered in China. The main signs are: One of the main tasks is a Plan of Action for the revitalization on modern distance education project as the 21st century education; the project of open educational pilot has been implemented by all Radio & TV University systems. Under such an educational situation, modern distance education pilot project developed in the English undergraduate students, in March 2000 in Changji. With the guidance of CCTV and Changji People's Government, 42 of undergraduate English students were recruited at the same year in August, the school began in September. Under the modern distance educational conditions, Teachers of TVU how to teach? Students how to learn? A variety of media technology how to combine the application? Distance learning how to improve the system of support services? And so on, new problems need to be recognized and explored by the TVU educators of the long-distance educational practice for decades. Practice is needed for theoretical guidance, theory is also needed to enrich in the practice of refining. According to the combination of experimental work, Xinjiang Changji TVU is led by the Ministry of Education in Xinjiang Institute of Research Group, research and experiment of English teaching mode is being carried out.
Vocabulary Teaching in Distance Learning
Yingling Gu
Theory and Practice in Language Studies , 2011, DOI: 10.4304/tpls.1.6.737-739
Abstract: Word is the basic function unit and foundation of English language. The ignorance of word memorization will make English study the water without a source. English vocabulary teaching is an important part of English teaching. In some way, foreign language ability of students depends on the vocabulary they mastered. the word insufficiency or inaccurateness is "the biggest obstacle" for students to study English. Therefore, it is the extremely important task for a teacher to scientifically enlarge students’ vocabulary according to the English new curriculum standard and the rules of memorization.
Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole
Shujun Chao,Yingling Wang
Journal of Chemistry , 2013, DOI: 10.1155/2013/568907
Abstract:
Application of an Integrated Statistical Design for Optimization of Culture Condition for Ammonium Removal by Nitrosomonas europaea
Bao yingling, Ye zhengfang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060322
Abstract: Statistical methodology was applied to the optimization of the ammonium oxidation by Nitrosomonas europaea for biomass concentration (CB), nitrite yield (YN) and ammonium removal (RA). Initial screening by Plackett-Burman design was performed to select major variables out of nineteen factors, among which NH4Cl concentration (CN), trace element solution (TES), agitation speed (AS), and fermentation time (T) were found to have significant effects. Path of steepest ascent and response surface methodology was applied to optimize the levels of the selected factors. Finally, multi-objective optimization was used to obtain optimal condition by compromise of the three desirable objectives through a combination of weighted coefficient method coupled with entropy measurement methodology. These models enabled us to identify the optimum operation conditions (CN = 84.1 mM; TES = 0.74 ml; AS = 100 rpm and T = 78 h), under which CB = 3.386×108 cells/ml; YN = 1.98 mg/mg and RA = 97.76% were simultaneously obtained. The optimized conditions were shown to be feasible through verification tests.
Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis
Vidya Ganapathy, Rongrong Ge, Alison Grazioli, Wen Xie, Whitney Banach-Petrosky, Yibin Kang, Scott Lonning, John McPherson, Jonathan M Yingling, Swati Biswas, Gregory R Mundy, Michael Reiss
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-122
Abstract: Both 1D11 and LY2109761 effectively blocked TGF-β-induced phosphorylation of receptor-associated Smads in all MDA-MB-231 subclones in vitro. Moreover, both antagonists inhibited TGF-β stimulated in vitro migration and invasiveness of MDA-MB-231 subclones, indicating that these processes are partly driven by TGF-β. In addition, both antagonists significantly reduced the metastatic burden to either lungs or bones in vivo, seemingly independently of intrinsic differences between the individual tumor cell clones. Besides inhibiting metastasis in a tumor cell autonomous manner, the TGF-β antagonists inhibited angiogenesis associated with lung metastases and osteoclast number and activity associated with lytic bone metastases. In aggregate, these studies support the notion that TGF-β plays an important role in both bone-and lung metastases of basal-like breast cancer, and that inhibiting TGF-β signaling results in a therapeutic effect independently of the tissue-tropism of the metastatic cells. Targeting the TGF-β pathway holds promise as a novel therapeutic approach for metastatic basal-like breast cancer.In aggregate, these studies support the notion that TGF-β plays an important role in both bone-and lung metastases of basal-like breast cancer, and that inhibiting TGF-β signaling results in a therapeutic effect independently of the tissue-tropism of the metastatic cells. Targeting the TGF-β pathway holds promise as a novel therapeutic approach for metastatic basal-like breast cancer.In the normal mammary gland, Transforming Growth Factor-β (TGF-β) controls tissue homeostasis by inhibiting cell cycle progression, inducing differentiation and apoptosis, and maintaining genomic integrity [1-3]. In addition, TGF-β orchestrates the response to tissue injury and mediates repair by inducing epithelial-to-mesenchymal transition (EMT) and cell migration in a time-and space-limited manner [4,5]. Following extracellular activation of TGF-β, the ligand binds to the type II TGF-β r
Médicos, viagens e intercambio científico na institucionaliza??o do combate ao cancer no Brasil (1941-1945)
Andrade, R?mulo de Paula;Lana, Vanessa;
História, Ciências, Saúde-Manguinhos , 2010, DOI: 10.1590/S0104-59702010000500007
Abstract: the article analyzes initiatives taken by physicians from both the private and public sectors who contributed to placing the fight against cancer on the federal government's agenda of public health policies, which became embodied in the 1941 creation of brazil's national cancer service. the text also aims to show that this historical process was directly related to the international context of scientific exchange between brazil and the united states that was encouraged under the good-neighbor policy of the 1940s. it calls attention to political disputes over the coordination of efforts to fight the disease at the federal level.
μ-1,2-Di-4-pyridylethane-κ2N:N′-bis[bis(N,N-diisopropyldithiocarbamato-κ2S,S′)zinc(II)]
Vanessa Avila,Edward R. T. Tiekink
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808010003
Abstract: In the dinuclear title compound, [Zn{S2CN(n-Pr)2}2{(NC5H4)CH2CH2(C5H4N)}] or [Zn2(C7H14NS2)4(C12H12N2)], each Zn atom adopts a distorted trigonal–bipyramidal ZnNS4 geometry. The crystal structure involves intermolecular C—H...S hydrogen bonds.
“White Cord Syndrome” of Acute Tetraplegia after Anterior Cervical Decompression and Fusion for Chronic Spinal Cord Compression: A Case Report
Kingsley R. Chin,Jason Seale,Vanessa Cumming
Case Reports in Orthopedics , 2013, DOI: 10.1155/2013/697918
Abstract:
Insights and relative effect of aspirin, naproxen and ibuprofen containing hydrogels: From design to performance as a functional dual capacity restorative material and build in free radical defense: In-vitro studies  [PDF]
Victoria Tamara Perchyonok, Vanessa Reher, Shengmiao Zhang, Sias R. Grobler, Theunis G. Oberholzer, Ward Massey
Open Journal of Stomatology (OJST) , 2014, DOI: 10.4236/ojst.2014.42013
Abstract:

Restorative materials in the new era aim to be “bio-active” and long-lasting. It has been suggested that the anti-inflammatory activity of some non-steroidal anti-inflammatory drugs (NSAIDs) may be partly due to their ability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as to inhibit the respiratory burst of neutrophils triggered by various activating agents. As a part of our continuous interest of developing functional dual action restorative materials capable of being “bio-active” and long-lasting, we design and evaluate novel chitosan hydrogels containing krill oil (antioxidant containing material), naproxen, ibuprofen (non steroidal anti-inflammatory medication), aspirin (pain relieve medication and free radical scavengers) and combinations thereof (chitosan-H-krill oil, chitosan-H-krill oil-aspirin and chitosan-H-naproxen, chitosan-H-naproxen-krill oil, chitosan-H-krill oil-ibuprofen and chitosan-H-ibuprofen) as functional additive prototypes for further development of “dual function restorative materials”; secondly, determine their effect on the dentin bond strength of a composite and thirdly, evaluate the capability of newly designed hydrogels to play an integral role of “build in” free radical defense mechanism by using BSA solubility as a “molecular prototype” of the site of free radical attack in vitro. Materials and Methods: The above mentioned hydrogels were prepared by dispersion of the corresponding component in glycerol and acetic acid

with the addition of chitosan gelling agent. The surface morphology (SEM), release behaviors (physiological pH and also in acidic conditions), stability of the therapeutic agent-antioxidant-chitosan and the effect of the hydrogels on the shear bond strength of dentin were also evaluated. Results: The release of aspirin, ibuprofen and naproxen confers the added benefit of synergistic action of a functional therapeutic delivery when comparing the newly designed chitosan-based hydrogel restorative materials to the commercially available products alone. Neither the release of aspirin, ibuprofen or naproxen nor the antioxidant stability was affected by storage over a 6- month period. The hydrogel formulations have a uniform distribution of drug content, homogenous texture and yellow color (SEM study). All chitosan dentin treated hydrogels gave significantly (P < 0.05; non-parametric ANOVA test) higher shear bond values (P <

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