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Search Results: 1 - 10 of 211479 matches for " Vanesa Martín-Palanco "
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Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia
Amaia Vilas–Zornoza,Xabier Agirre,Vanesa Martín-Palanco,José Ignacio Martín-Subero,Edurne San José-Eneriz,Leire Garate,Sara álvarez,Estíbaliz Miranda,Paula Rodríguez-Otero,José Rifón,Antonio Torres,María José Calasanz,Juan Cruz Cigudosa,José Román-Gómez,Felipe Prósper
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017012
Abstract: Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). Using methylation bead arrays we analyzed the methylation status of 807 genes implicated in cancer in a group of ALL samples at diagnosis (n = 48). We found that 154 genes were methylated in more than 10% of ALL samples. Interestingly, the expression of 13 genes implicated in the TP53 pathway was downregulated by hypermethylation. Direct or indirect activation of TP53 pathway with 5-aza-2′-deoxycitidine, Curcumin or Nutlin-3 induced an increase in apoptosis of ALL cells. The results obtained with the initial group of 48 patients was validated retrospectively in a second cohort of 200 newly diagnosed ALL patients. Methylation of at least 1 of the 13 genes implicated in the TP53 pathway was observed in 78% of the patients, which significantly correlated with a higher relapse (p = 0.001) and mortality (p<0.001) rate being an independent prognostic factor for disease-free survival (DFS) (p = 0.006) and overall survival (OS) (p = 0.005) in the multivariate analysis. All these findings indicate that TP53 pathway is altered by epigenetic mechanisms in the majority of ALL patients and correlates with prognosis. Treatments with compounds that may reverse the epigenetic abnormalities or activate directly the p53 pathway represent a new therapeutic alternative for patients with ALL.
Germinación de Grindelia ventanensis (Asteraceae), una especie endémica del sistema de Ventania (Buenos Aires)
Negrin,Vanesa Lorena; Zalba,Sergio Martín;
Bolet?-n de la Sociedad Argentina de Bot??nica , 2008,
Abstract: in this paper the potential for sexual propagation of grindelia ventanensis (asteraceae) is evaluated. it is an endemic shrub of ventania mountains (buenos aires province) considered critically endangered and with potential economic value as ornamental species. percentage and media term of germination of seeds were estimated from cultivated and wild populations, exposed and not exposed to cold conditions, and the effect of storage on these variables was determined. percentage of germination of seeds from wild populations was greater (67%) than that of seeds from cultivated populations (16%), and no effect of cold was detected. changes in the media term of germination were neither detected when considering the origin of seeds nor the application of cold. time of storage tested (nine to ten months) significantly reduced the percentage of germination and increased its media term. reduction in the percentage of germination associated with storage could be result of a loss of viability or an induction of a secondary dormancy. our results indicate that g. ventanensis is a species with a good potential for its cultivation from seeds. this knowledge could contribute to the conservation of this species.
Germinación de Grindelia ventanensis (Asteraceae), una especie endémica del sistema de Ventania (Buenos Aires) Germination of Grindelia ventanensis (Asteraceae), an endemic species from the Ventania Mountains (Buenos Aires)
Vanesa Lorena Negrin,Sergio Martín Zalba
Boletín de la Sociedad Argentina de Botánica , 2008,
Abstract: Este trabajo evalúa la capacidad de propagación por semillas de Grindelia ventanensis (Asteraceae), un subarbusto endémico del sistema de Ventania (provincia de Buenos Aires). La especie es considerada en peligro crítico de extinción y presenta potencial económico como ornamental. Se estimaron el porcentaje y tiempo medio de germinación de semillas de poblaciones cultivadas y silvestres, tratadas o no con frío y se evaluó el efecto del almacenamiento sobre estas variables. El porcentaje de germinación de semillas de poblaciones silvestres (67%) resultó mayor que el de las cultivadas (16%), pero no se hallaron diferencias asociadas al tratamiento con frío. Tampoco se observaron cambios en el tiempo medio de germinación teniendo en cuenta el origen de las semillas ni la aplicación de frío. El tiempo de almacenamiento testeado (nueve a diez meses) reduce significativamente el porcentaje y la velocidad de germinación. La reducción del porcentaje de germinación asociada al almacenamiento podría atribuirse a una pérdida de viabilidad o a la inducción de una segunda dormancia. Nuestros resultados indican que G. ventanensis es una especie con buen potencial para el cultivo a través de semillas. Esta información puede contribuir a su conservación. In this paper the potential for sexual propagation of Grindelia ventanensis (Asteraceae) is evaluated. It is an endemic shrub of Ventania Mountains (Buenos Aires province) considered critically endangered and with potential economic value as ornamental species. Percentage and media term of germination of seeds were estimated from cultivated and wild populations, exposed and not exposed to cold conditions, and the effect of storage on these variables was determined. Percentage of germination of seeds from wild populations was greater (67%) than that of seeds from cultivated populations (16%), and no effect of cold was detected. Changes in the media term of germination were neither detected when considering the origin of seeds nor the application of cold. Time of storage tested (nine to ten months) significantly reduced the percentage of germination and increased its media term. Reduction in the percentage of germination associated with storage could be result of a loss of viability or an induction of a secondary dormancy. Our results indicate that G. ventanensis is a species with a good potential for its cultivation from seeds. This knowledge could contribute to the conservation of this species.
Saponificación cadavérica parcial
Sibón Olano,A.; Martínez-García,P.; Romero Palanco,JL.;
Cuadernos de Medicina Forense , 2004, DOI: 10.4321/S1135-76062004000400005
Abstract: the processes of cadaverous decomposition hinder, in a very important way, the work of the forensic pathologist in the clarification of the cause of the death. we can state that this difficulty is directly proportional at the time lapsed between the death and the finding of the corpse or the autopsy practice. sometimes, however, the conservative phenomenae of the cadaver appear and may, in a natural way, retard or impede the development of the decomposition, allowing the forensic investigation. the natural processes conservatives of the cadaver are the mummification, saponification and leathery. in the case presented, the accusation alleged in the tribunal lapsed ten months from the death, being then performed the exhumation and later forensic autopsy. the corpse suffered a partial saponification that helped the forensic investigation.
Muerte por Ahorcadura
Sibón Olano,A.; Martínez-García,P.; Palacios Granero,RJ.; Romero Palanco,JL.;
Cuadernos de Medicina Forense , 2005, DOI: 10.4321/S1135-76062005000200007
Abstract: the death by hanging or suspension is generally suicidal and with less frequency accidental. the homicidal hanging is unusual, being described like mechanism to disguise the true cause of the death. the presence of vital signs allow us to distinguish between a vital suspension and another postmortal. in this paper, we are going to present images of some signs of hanging discussing its vital origin. the standardized autopsy of the neck, sometimes, does not show macroscopic signs of vitality, reason why we will have to perform histopathological studies. this is the reason why we include in this section (mainly macroscopic) microscopical images.
Síndrome de Asfixia Sumersión
Sibón Olano,A.; Martínez-García,P.; Vizcaya Rojas,MA.; Romero Palanco,JL.;
Cuadernos de Medicina Forense , 2005, DOI: 10.4321/S1135-76062005000300006
Abstract: the finding of a corpse in water always raise doubts for a proper diagnosis: are we before a corpse thrown or fallen into the water? was the death due to causes different from drowning, including naturals?. it is a true death by drowning?. the use of complementary examinations in the diagnosis of drowning has undergone diverse ups and downs. the biochemical determinations have been confronted with the artefacts related to the putrefaction which has favoured the appearance of certain very controverted methods of diagnosis. in addition, the experiments made in animals not always must be applied to the human's beings, since the absorbed amount of water by air passages seems to be much smaller for the latest's. the diagnosis of death by drowning will be made, therefore, establishing a correlation between the typical findings of the submersion observed in the autopsy and the different complementary laboratory tests.
Intoxicación por Monóxido de Carbono
Sibón Olano,A.; Martínez-García,P.; Vizcaya Rojas,MA.; Romero Palanco,JL.;
Cuadernos de Medicina Forense , 2007, DOI: 10.4321/S1135-76062007000100007
Abstract: several authors recommend to perform a toxicological analysis in practically every forensic autopsy, specifically when the macroscopical examination does not reveal sufficiently the cause of death. the absence of pathognomonic findings in the majority of poisonings support this recommendation. however; in some cases autopsy findings are indicative of the causative agent. for instance, the red cherry coloration from livor mortis are suggestive of a carbon monoxide or cyanide poisoning.
Síndrome de Asfixia Sumersión Asphyxia Drowning Syndrome
A. Sibón Olano,P. Martínez-García,MA. Vizcaya Rojas,JL. Romero Palanco
Cuadernos de Medicina Forense , 2005,
Abstract: El hallazgo de un cadáver en el agua siempre nos plantea dudas diagnósticas: Estamos ante un cadáver arrojado o caído al agua? El sujeto ha fallecido por causas distintas a la sumersión, incluidas las de origen natural? Se trata de una verdadera muerte por sumersión?. La utilización de exámenes complementarios en el diagnóstico de asfixia por sumersión ha sufrido diversos avatares. Las determinaciones bioquímicas han tropezado con los artefactos debidos a la putrefacción, lo que ha llevado a la aparición de determinados métodos de diagnóstico muy controvertidos. Además, los experimentos realizados en animales no siempre son extrapolables al ser humano, dado que hasta la cantidad de agua absorbida por vía aérea, parece ser mucho menor para estos últimos. El diagnóstico de muerte por sumersión se realizará, por lo tanto, estableciendo una correlación entre los hallazgos propios de la sumersión observados en la autopsia y las diferentes pruebas analíticas realizadas en el laboratorio. The finding of a corpse in water always raise doubts for a proper diagnosis: Are we before a corpse thrown or fallen into the water? Was the death due to causes different from drowning, including naturals?. It is a true death by drowning?. The use of complementary examinations in the diagnosis of drowning has undergone diverse ups and downs. The biochemical determinations have been confronted with the artefacts related to the putrefaction which has favoured the appearance of certain very controverted methods of diagnosis. In addition, the experiments made in animals not always must be applied to the human's beings, since the absorbed amount of water by air passages seems to be much smaller for the latest's. The diagnosis of death by drowning will be made, therefore, establishing a correlation between the typical findings of the submersion observed in the autopsy and the different complementary laboratory tests.
Intoxicación por Monóxido de Carbono Poisoning by carbon monoxide
A. Sibón Olano,P. Martínez-García,MA. Vizcaya Rojas,JL. Romero Palanco
Cuadernos de Medicina Forense , 2007,
Abstract: Numerosos autores recomiendan la realización de análisis toxicológico, prácticamente en todos los casos forenses, especialmente, cuando tras el examen macroscópico no aparece suficientemente aclarada la causa de la muerte. La ausencia de lesiones patognomónicas en la mayoría de las intoxicaciones avalan la recomendación anterior; sin embargo, en algunos casos los hallazgos en la autopsia son indicativos del agente causal. Así vemos como la coloración rojo cereza de las livideces cadavéricas van a ser muy sugestivas de intoxicación por monóxido de carbono o cianuro. Several authors recommend to perform a toxicological analysis in practically every forensic autopsy, specifically when the macroscopical examination does not reveal sufficiently the cause of death. The absence of pathognomonic findings in the majority of poisonings support this recommendation. However; in some cases autopsy findings are indicative of the causative agent. For instance, the red cherry coloration from livor mortis are suggestive of a carbon monoxide or cyanide poisoning.
Muerte por Ahorcadura Death by Hanging
A. Sibón Olano,P. Martínez-García,RJ. Palacios Granero,JL. Romero Palanco
Cuadernos de Medicina Forense , 2005,
Abstract: La muerte por ahorcadura, suspensión o colgamiento, es generalmente suicida y con menos frecuencia accidental. El ahorcamiento homicida es inusual, estando descrito como mecanismo para disimular la verdadera causa de la muerte. La presencia de signos vitales van a permitir distinguir entre una suspension vital y otra postmortal. En este número, vamos a mostrar imágenes de algunos signos de ahorcadura discutiendo su origen vital. La autopsia reglada del cuello, en ocasiones, no muestra signos macroscópicos de vitalidad, por lo que tendremos que recurrir a la microscopía para la detección de los mismos. Esta es la causa de que incluyamos en esta sección (esencialmete macroscópica) imágenes microscópicas. The death by hanging or suspension is generally suicidal and with less frequency accidental. The homicidal hanging is unusual, being described like mechanism to disguise the true cause of the death. The presence of vital signs allow us to distinguish between a vital suspension and another postmortal. In this paper, we are going to present images of some signs of hanging discussing its vital origin. The standardized autopsy of the neck, sometimes, does not show macroscopic signs of vitality, reason why we will have to perform histopathological studies. This is the reason why we include in this section (mainly macroscopic) microscopical images.
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