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Search Results: 1 - 10 of 39595 matches for " Van Waes Oscar JF "
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Treatment of penetrating trauma of the extremities: ten years’ experience at a dutch level 1 trauma center
Van Waes Oscar JF,Van Lieshout Esther MM,Hogendoorn Wouter,Halm Jens A
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2013, DOI: 10.1186/1757-7241-21-2
Abstract: Background A selective non-operative management (SNOM) has found to be an adequate and safe strategy to assess and treat patients suffering from penetrating trauma of the extremities (PTE). With this SNOM comes a strategy in which adjuvant investigations or interventions are not routinely performed, but based on physical examination only. Methods All subsequent patients presented with PTE at a Dutch level I trauma center from October 2000 to June 2011 were included in this study. In-hospital and long-term outcome was analysed in the light of assessment of these patients according to the SNOM protocol. Results A total of 668 patients (88.2% male; 33.8% gunshot wounds) with PTE presented at the Emergency Department of a level 1 traumacenter, of whom 156 were admitted for surgical treatment or observation. Overall, 22 (14%) patients that were admitted underwent exploration of the extremity for vascular injury. After conservative observation, two (1.5%) patients needed an intervention to treat (late onset) vascular complications. Other long-term extremity related complications were loss of function or other deformity (n = 9) due to missed nerve injury, including 2 patients with peroneal nerve injury caused by delayed compartment syndrome treatment. Conclusion A SNOM protocol for initial assessment and treatment of PTE is feasible and safe. Clinical examination of the injured extremity is a reliable diagnostic 'tool' for excluding vascular injury. Repeated assessments for nerve injuries are important as these are the ones that are frequently missed and result in long-term disability. Level of evidence: II / III, retrospective prognostic observational cohort study Key words Penetrating trauma, extremity, vascular injury, complications.
Harmonization of rules for VCU testing of maize in comparable agro ecological regions
van Waes J.
Genetika , 2004, DOI: 10.2298/gensr0401001v
Abstract: In the European Community, a new variety of an agricultural crop must submit official trials for DUS (Distinctness, Uniformity, Stability) and VCU (Value for Cultivation and Use) before commercialisation. The guidelines for those tests are summarized in the European directive 70/457/EU (1970), revised in 2002 (2002/53/EU). The result of the VCU-tests is the admission on the national variety catalogue of new varieties, which are better than the best existing ones. Better varieties in the market can increase the income of the farmers. The progress in breeding can be measured by comparison the level of recent with older (10 - 15 years ago) varieties. Incorporation of new varieties in the culture plan is only justified if they are better than existing varieties and if they have no great weaknesses. Therefore the farmers need criteria for cultivation security and high return (output, yield). The two most important factors for cultivation security are resistance to lodging and to stalk rot. In addition earliness is another important factor for silage maize to attain a sufficient dry matter of the total plant and for corn maize to attain a low moisture content in the grains. Important factors for cost-effectiveness are total dry matter yield and quality for silage and grain yield for corn maize. Until now each EU- country has a separate system for VCU testing. The aim of the VCU-research is to predict the agronomical and technological value of a new variety on a reliable way in comparison with standard varieties. For this purpose there is the necessity for a high number of field trials and analyses; this implicates high national experimentation costs. But the costs for experimentation are only a small fraction of the benefits for the farmers. International cooperation for VCU-testing will become necessary to reduce the costs for the national variety testing systems. However the aim of the research must still be to predict the agronomical value of a new variety with the same reliability as at national level. For the future variety testing should be realized on the basis of comparable agro-ecological regions with the same crop husbandry and use of the crop. These regions must be clearly defined so that the release of varieties corresponds to the high demands for harvest security and good conservation possibilities of the harvested material. The most important criteria for evaluation should be: harvest security, disease resistance, yield and quality. The basis for a good success for international cooperation is a good knowledge of the national systems: searching
Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
Reza Ehsanian, Carter Van Waes, Stephan M Feller
Cell Communication and Signaling , 2011, DOI: 10.1186/1478-811x-9-13
Abstract: Quinacrine (IUPAC name 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine) is a heterocyclic three-ring compound (Figure 1A), and an acridine (Figure 1B) derivative (9-aminoacridine). It is readily available as quinacrine dihydrochloride, the dihydrochloride salt of quinacrine, for clinical use. The interest in quinacrine stems from its long history of therapeutic uses, as will be discussed in the following sections, and in particular its potential antineoplastic activities.Quinacrine formulations and isomers are known by numerous designations some of which are: acrichine, Atabrine?, atebrine, atebrin, mepacrine, quinacrine dihydrochloride, quinacrine dihydrochloride dihydrate, quinacrine dihyrochloride (R)-isomer, quinacrine dihyrochloride (S)-isomer, quinacrine dimesylate, quinacrine hydrochloride, quinacrine monoacetate, quinacrine monohydrochloride, quinacrine monomesylate, quinacrine (R)-isomer, quinacrine (S)-isomer, and 6-chloro-9-[[4-(diethylamino)-1 methylbutyl]amino]-2-methoxyacridine. The most commonly used designations for quinacrine are mepacrine, quinacrine hydrochloride, quinacrine dihydrochloride, and the registered name Atabrine?. Quinacrine is one of several known aminoacridines which include, for example, acridine orange, acriflavine, aminacrin, amsacrine, ethacridine, nitracrine, proflavine and tacrine and which have a range of biological and therapeutic applications. Table 1 summarizes some of the key biological and therapeutic applications of these compounds.Originally developed as pigments and dyes, the pharmalogical properties of acridine compounds were first investigated by Ehrlich and Benda in 1912, as antiprotozoal agents that act upon trypanosome parasites and developed further by Carl Browning as antibacterial agents [1-3]. The use of acridines as antibacterial agents fell out of favor in the 1940's after the discovery and wide spread availability of penicillin to combat bacterial infections. However, from the 1940's
Coordinating sentence composition with error correction: A multilevel analysis
Leijten, M.,De Maeyer, S.,Van Waes, L.
Journal of Writing Research , 2011,
Abstract: Error analysis involves detecting and correcting discrepancies between the 'text produced so far' (TPSF) and the writer's mental representation of what the text should be. While many factors determine the choice of strategy, cognitive effort is a major contributor to this choice. This research shows how cognitive effort during error analysis affects strategy choice and success as measured by a series of online text production measures. We hypothesize that error correction with speech recognition software differs from error correction with keyboard for two reasons. Speech produces auditory commands and, consequently, different error types. The study reported on here measured the effects of (1) mode of presentation (auditory or visual-tactile), (2) error span, whether the error spans more or less than two characters, and (3) lexicality, whether the text error comprises an existing word. A multilevel analysis was conducted to take into account the hierarchical nature of these data. For each variable (interference reaction time, preparation time, production time, immediacy of error correction, and accuracy of error correction), multilevel regression models are presented. As such, we take into account possible disturbing person characteristics while testing the effect of the different conditions and error types at the sentence level.The results show that writers delay error correction more often when the TPSF is read out aloud first. The auditory property of speech seems to free resources for the primary task of writing, i.e. text production. Moreover, the results show that large errors in the TPSF require more cognitive effort, and are solved with a higher accuracy than small errors. The latter also holds for the correction of small errors that result in non-existing words.
Investigation of trace element mobility in river sediments using ICP-OES
PJ Botes, JF van Staden
Water SA , 2005,
Abstract: In this study, the column method was used to determine the leachable trace metals present in selected river sediments. In addition the sediments were investigated using a shaker method and these two methods were compared for reliability. For both these methods extract solutions associated with a sequential extraction method were used. However, the sediments were only subjected to one extractant solution and not to the whole sequential procedure. The river sediments were also subjected to a digestion procedure to determine the total trace metal content. Simulated pollution experiments were performed where the sediments were also spiked to give known concentrations of trace metals. These results were very useful, especially in cases where certain trace metals were not currently present in river sediments. From the results achieved in this study the general trace metal status of the sediments can be established. From the results achieved it was established that in the case of the less impacted rivers (Crocodile and Olifants Rivers) only slight changes in the river conditions are needed to mobilise the trace metals present. From the results of the Blesbokspruit it was seen that urgent attention is needed to prevent further damage to the system. Water SA Vol. 31 (2) 2005: pp.183-192
An improved technique for the determination of oxidised nitrogen in natural waters with a Sequential Injection Analysis (SIA) system
EB Naidoo, JF Van Staden
Water SA , 2001,
Abstract: An SIA system is proposed for the determination of oxidised nitrogen (nitrate + nitrite as N) in natural waters. A cadmium reductor, made of cadmium granules closely packed in a glass column reduces the nitrate to nitrite. The reduced nitrate and the nitrite present in the water samples is diazotised in the SIA system with sulphanilamide and coupled with N - (1-napthyl) ethylene diammoniumdichloride to form a highly coloured azo dye which is detected at 540 nm with a UV/Vis spectrophotometer. The proposed system is fully computerised and is able to monitor total oxidised nitrogen as nitrite at a frequency of 36 samples per hour with a standard deviation of < 1.2%. The calibration curve is linear up to 5 mg/l with a detection limit of 0.01 mg/l. WaterSA Vol.27(3) 2001: 355-360
Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex
Janee Gelineau-van Waes, Joyce R Maddox, Lynette M Smith, Michael van Waes, Justin Wilberding, James D Eudy, Linda K Bauer, Richard H Finnell
BMC Genomics , 2008, DOI: 10.1186/1471-2164-9-156
Abstract: Affymetrix microarray analysis of the relative gene expression profiles in whole E9.5 RFC1-/- vs. RFC1+/+ embryos identified 200 known genes that were differentially expressed. Major ontology groups included transcription factors (13.04%), and genes involved in transport functions (ion, lipid, carbohydrate) (11.37%). Genes that code for receptors, ligands and interacting proteins in the cubilin-megalin multiligand endocytic receptor complex accounted for 9.36% of the total, followed closely by several genes involved in hematopoiesis (8.03%). The most highly significant gene network identified by Ingenuity? Pathway analysis included 12 genes in the cubilin-megalin multiligand endocytic receptor complex. Altered expression of these genes was validated by quantitative RT-PCR, and immunohistochemical analysis demonstrated that megalin protein expression disappeared from the visceral yolk sac of RFC1-/- embryos, while cubilin protein was widely misexpressed.Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in the maternal-fetal transport of folate and other nutrients, lipids and morphogens such as sonic hedgehog (Shh) and retinoids that play critical roles in normal embryogenesis.Folate and vitamin B12 are essential vitamins derived from various food sources that play an important role in erythropoiesis, DNA biosynthesis, and embryogenesis. Nutritional deficiencies or genetic variations that impact folate and/or vitamin B12 homeostasis may result in megaloblastic anemia [1], and failure of maternal-fetal transport of these nutrients has been shown to adversely impact normal embryogenesis [2-5]. Folate is a vitamin derived from plant sources that consists of a pteridine ring structure attached to a para-aminobenzoic acid side chain. Tetrahydrofolate, the reduced form of folate, functions as an important co-factor for donating or accepting methyl groups. Adequate levels of fol
(In-)Stability of Singular Equivariant Solutions to the Landau-Lifshitz-Gilbert Equation
Jan Bouwe van den Berg,JF Williams
Mathematics , 2011,
Abstract: In this paper we use formal asymptotic arguments to understand the stability proper- ties of equivariant solutions to the Landau-Lifshitz-Gilbert model for ferromagnets. We also analyze both the harmonic map heatflow and Schrodinger map flow limit cases. All asymptotic results are verified by detailed numerical experiments, as well as a robust topological argument. The key result of this paper is that blowup solutions to these problems are co-dimension one and hence both unstable and non-generic. Solutions permitted to deviate from radial symmetry remain global for all time but may, for suitable initial data, approach arbitrarily close to blowup. A careful asymptotic analysis of solutions near blowup shows that finite-time blowup corresponds to a saddle fixed point in a low dimensional dynamical system. Radial symmetry precludes motion anywhere but on the stable manifold towards blowup. A similar scenario emerges in the equivariant setting: blowup is unstable. To be more precise, blowup is co-dimension one both within the equivariant symmetry class and in the unrestricted class of initial data. The value of the parameter in the Landau-Lifshitz-Gilbert equation plays a very subdued role in the analysis of equivariant blowup, leading to identical blowup rates and spatial scales for all parameter values. One notable exception is the angle between solution in inner scale (which bubbles off) and outer scale (which remains), which does depend on parameter values. Analyzing near-blowup solutions, we find that in the inner scale these solution quickly rotate over an angle {\pi}. As a consequence, for the blowup solution it is natural to consider a continuation scenario after blowup where one immediately re-attaches a sphere (thus restoring the energy lost in blowup), yet rotated over an angle {\pi}. This continuation is natural since it leads to continuous dependence on initial data.
Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status
Bin Yan, Guang Chen, Kunal Saigal, Xinping Yang, Shane T Jensen, Carter Van Waes, Christian J Stoeckert, Zhong Chen
Genome Biology , 2008, DOI: 10.1186/gb-2008-9-3-r53
Abstract: To address this question, we used a newly developed computational strategy, COGRIM (Clustering Of Gene Regulons using Integrated Modeling), to identify NF-κB regulons (a set of genes under regulation of the same transcription factor) for 1,265 genes differentially expressed by head and neck cancer cell lines differing in p53 status. There were 748 NF-κB targets predicted and individually annotated for RELA, NFκB1 or cREL regulation, and a prevalence of RELA related genes was observed in over-expressed clusters in a tumor subset. Using Ingenuity Pathway Analysis, the NF-κB targets were reverse-engineered into annotated signature networks and pathways, revealing relationships broadly altered in cancer lines (activated proinflammatory and down-regulated Wnt/β-catenin and transforming growth factor-β pathways), or specifically defective in cancer subsets (growth factors, cytokines, integrins, receptors and intermediate kinases). Representatives of predicted NF-κB target genes were experimentally validated through modulation by tumor necrosis factor-α or small interfering RNA for RELA or NFκB1.NF-κB globally regulates diverse gene programs that are organized in signal networks and pathways differing in cancer subsets with distinct p53 status. The concerted alterations in gene expression patterns reflect cross-talk among NF-κB and other pathways, which may provide a basis for molecular classifications and targeted therapeutics for heterogeneous subsets of head and neck or other cancers.The nuclear factor kappaB (NF-κB) family comprises a group of evolutionarily conserved signal-activated transcription factors (TFs) that have been shown to play a central role in the control of a large number of normal and stressed cellular processes [1,2]. NF-κB is involved in similar biological processes in cancers, as a critical modulator of genes that promote cell survival, inflammation, angiogenesis, tumor development, progression and metastasis [3-5]. We previously showed that NF-κB i
Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma
Bin Yan, Xinping Yang, Tin-Lap Lee, Jay Friedman, Jun Tang, Carter Van Waes, Zhong Chen
Genome Biology , 2007, DOI: 10.1186/gb-2007-8-5-r78
Abstract: Genome-wide cDNA microarray profiling of ten HNSCC cell lines revealed novel gene expression signatures that distinguished cancer cell subsets associated with p53 status. Three major clusters of over-expressed genes (A to C) were defined through hierarchical clustering, Gene Ontology, and statistical modeling. The promoters of genes in these clusters exhibited different patterns and prevalence of transcription factor binding sites for p53, nuclear factor-κB (NF-κB), activator protein (AP)-1, signal transducer and activator of transcription (STAT)3 and early growth response (EGR)1, as compared with the frequency in vertebrate promoters. Cluster A genes involved in chromatin structure and function exhibited enrichment for p53 and decreased AP-1 binding sites, whereas clusters B and C, containing cytokine and antiapoptotic genes, exhibited a significant increase in prevalence of NF-κB binding sites. An increase in STAT3 and EGR1 binding sites was distributed among the over-expressed clusters. Novel regulatory modules containing p53 or NF-κB concomitant with other transcription factor binding motifs were identified, and experimental data supported the predicted transcriptional regulation and binding activity.The transcription factors p53, NF-κB, and AP-1 may be important determinants of the heterogeneous pattern of gene expression, whereas STAT3 and EGR1 may broadly enhance gene expression in HNSCCs. Defining these novel gene signatures and regulatory mechanisms will be important for establishing new molecular classifications and subtyping, which in turn will promote development of targeted therapeutics for HNSCC.Numerous basic and clinical studies suggest that development and malignant progression of cancer is rarely due to a defect in a single gene or pathway. Multiple genetic alterations accumulate during carcinogenesis, potentially leading to aberrant activation or suppression of multiple pathways and downstream genes that have important functions in determining the
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