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Autopsies of the real: Resurrecting the dead
Valis, No?l
Asclepio : Revista de Historia de la Medicina y de la Ciencia , 2011,
Abstract: The sense of the real, or the material—the dead body—as an inextricable part of the sacred does not disappear in the secular environment of the nineteenth and twentieth centuries. This article analyzes specific humanitarian narratives centered on the practice of autopsy and mummification, in which the traces of Catholicism act as a kind of spectral discourse of the imagination, where the real is configured in forms of the uncanny, the monstrous or the sacred. El sentido de lo real, de lo material —el cuerpo sin vida— como una inextricable parte de lo sagrado, no desaparece del ambiente secular de los siglos XIX y XX. En los relatos analizados en este artículo se estudia cómo en determinadas narrativas humanitarias centradas en la práctica de la autopsia y la momificación, las huellas del catolicismo actúan como una suerte de discurso espectral de la imaginación, en que lo real se configura en formas de lo siniestro, lo monstruoso o lo sagrado.
Impulse control disorder associated with dopaminergic therapy in Parkinson’s disease – a case report
Martin Valis,Jiri Masopust,Ales Urban,Dita Kalnicka
Neuropsychiatria i Neuropsychologia , 2009,
Abstract: Parkinson’s disease is regularly associated with nonmotorsymptoms that are often not sufficientlydiagnosed and treated. We describe development of animpulse control disorder in relation to the administrationof dopamine agonist pramipexole to a 61 year-old malewith Parkinson’s disease. Behavioral disturbances in thepatient evolved gradually after the initiation ofpramipexole therapy in a dose of 2.1 mg pro die anddisappeared within several weeks after pramipexole dailydose reduction to 0.54 mg. The case demonstrates thenecessity for careful monitoring of adverse effects ofdopaminergic treatment in patients with Parkinson’sdisease. Differential diagnosis of symptoms andtreatment options are discussed.
Erythrocyte and Porcine Intestinal Glycosphingolipids Recognized by F4 Fimbriae of Enterotoxigenic Escherichia coli
Annelies Coddens, Erik Valis, John Benktander, Jonas ?ngstr?m, Michael E. Breimer, Eric Cox, Susann Teneberg
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023309
Abstract: Enterotoxigenic F4-fimbriated Escherichia coli is associated with diarrheal disease in neonatal and postweaning pigs. The F4 fimbriae mediate attachment of the bacteria to the pig intestinal epithelium, enabling an efficient delivery of diarrhea-inducing enterotoxins to the target epithelial cells. There are three variants of F4 fimbriae designated F4ab, F4ac and F4ad, respectively, having different antigenic and adhesive properties. In the present study, the binding of isolated F4ab, F4ac and F4ad fimbriae, and F4ab/ac/ad-fimbriated E. coli, to glycosphingolipids from erythrocytes and from porcine small intestinal epithelium was examined, in order to get a comprehensive view of the F4-binding glycosphingolipids involved in F4-mediated hemagglutination and adhesion to the epithelial cells of porcine intestine. Specific interactions between the F4ab, F4ac and F4ad fimbriae and both acid and non-acid glycosphingolipids were obtained, and after isolation of binding-active glycosphingolipids and characterization by mass spectrometry and proton NMR, distinct carbohydrate binding patterns were defined for each fimbrial subtype. Two novel glycosphingolipids were isolated from chicken erythrocytes, and characterized as GalNAcα3GalNAc?3Gal?4Glc?1Cer and GalNAcα3GalNAc?3Gal?4GlcNAc?3Gal?4Glc?1C?er.These two compounds, and lactosylceramide (Gal?4Glc?1Cer) with phytosphingosine and hydroxy fatty acid, were recognized by all three variants of F4 fimbriae. No binding of the F4ad fimbriae or F4ad-fimbriated E. coli to the porcine intestinal glycosphingolipids occurred. However, for F4ab and F4ac two distinct binding patterns were observed. The F4ac fimbriae and the F4ac-expressing E. coli selectively bound to galactosylceramide (Gal?1Cer) with sphingosine and hydroxy 24:0 fatty acid, while the porcine intestinal glycosphingolipids recognized by F4ab fimbriae and the F4ab-fimbriated bacteria were characterized as galactosylceramide, sulfatide (SO3-3Gal?1Cer), sulf-lactosylceramide (SO3-3Gal?4Glc?1Cer), and globotriaosylceramide (Galα4Gal?4Glc?1Cer) with phytosphingosine and hydroxy 24:0 fatty acid. Finally, the F4ad fimbriae and the F4ad-fimbriated E. coli, but not the F4ab or F4ac subtypes, bound to reference gangliotriaosylceramide (GalNAc?4Gal?4Glc?1Cer), gangliotetraosylceramide (Gal?3GalNAc?4Gal?4Glc?1Cer), isoglobotriaosylceramide (Galα3Gal?4Glc?1Cer), and neolactotetraosylceramide (Gal?4GlcNAc?3Gal?4Glc?1Cer).
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