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Search Results: 1 - 10 of 131290 matches for " Valery V. Kukharchuk "
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Identification of Patients at High Cardiovascular Risk
Igor V. Sergienko, PhD, ScD,Saule J. Urazalina, PhD,Valery V. Kukharchuk, PhD, ScD,Yuri A. Karpov, PhD, ScD
International Journal of BioMedicine , 2012,
Abstract: Objective: To identify individuals at high cardiovascular risk (CVR) to check for an additional estimate of CVR with the use of the ESH/ESC Guidelines (2003, 2007) in patients earlier classified as being at low and moderate risk on SCORE . Material and methods: The study included 600 people (155 men and 445 women) with low and moderate cardiovascular risk on the SCORE scale. All patients were examined with duplex scanning of the carotid arteries (DSCA) to the determined of the thickness of the intima – media (IMT), the presence of atherosclerotic plaques (ASP); it has also been performed sphygmographic computer (SC) with automatic estimation of brachial-ankle pulse wave velocity (baPWV), biochemical analysis of blood lipid spectrum. Results: The frequency of ASP was 59.5% (357 out of 600), and a thickening of thecomplex "intima-media" (IMT)> 0.9 mm was detected in only 5% of the cases (28 persons out of 600), that indicated a slight contribution to the magnitude of the risk of such parameters as the IMT. The total number of patients with signs of preclinicallesions of the arterial wall (the presence of ASP and/or increased baPWV) was 337 (56% of 600). Our results showed that the presence of subclinical atherosclerosis is in itself a risk factor. Conclusion: The usage of instrumental methods of research (DSCA, SC) allowed to detect 32% of individuals with high CVR from 600 previously classified as low and moderate risk on SCORE scale. In our opinion, the proposed algorithm is convenient and easy to use for transfer of the patients into high-risk group.
Black Holes or Dark Stars—What Follows from the General Relativity Theory  [PDF]
Valery V. Vasiliev
Journal of Modern Physics (JMP) , 2017, DOI: 10.4236/jmp.2017.87070
Abstract: The paper is concerned with spherically symmetric static problem of the Classical Gravitation Theory (CGT) and the General Relativity Theory (GRT). First, the Dark Stars, i.e. the objects that are invisible because of high gravitation preventing the propagation of light discovered in the 18th century by J. Michel and P. Laplace are discussed. Second, the Schwarzchild solution which was obtained in the beginning of the 20th century for the internal and external spaces of the perfect fluid sphere is analyzed. This solution results in singular metric coefficients and provides the basis of the Black Holes. Third, the general metric form in spherical coordinates is introduced and the solution of GRT problem is obtained under the assumption that gravitation does not affect the sphere mass. The critical sphere radius similar to the Black Hole horizon of events is found. In contrast to the Schwarzchild solution, the radial metric coefficient for the sphere with the critical radius referred to as the Dark Star is not singular. For the sphere with radius which is less than the critical value, the GRT solution becomes imaginary. The problem is discussed within the framework of the phenomenological theory which does not take into account the actual microstructure of the gravitating objects and, though the term “star” is used, the analysis is concerned with a model fluid sphere rather than with a real astrophysical object.
The assessment of effects of combined therapy with mildronate on lipid profile, inflammatory factors and endothelium function in patients with ischemic heart disease
I.V. Sergienko,V.V. Kukharchuk,S.A. Gabrusenko,V.V. Malakhov
Rational Pharmacotherapy in Cardiology , 2007,
Abstract: Aim. To study the effect of treatment with metabolic corrector mildronate on lipid profile, inflammatory factors and endothelium function in patients with ischemic heart disease (IHD).Material and methods. 60 patients with IHD (stable exertional angina, II-IV functional class) were included in to the study. They were split in two groups. Patients of the main group (n=30) were treated with mildronate (1000 mg per day during 3 months) combined with standard therapy. Patients of the second group (n=30) received the standard therapy only. Total cholesterol (TC), triglycerides (TG), cholesterol of low density lipoproteid (LDL-C), cholesterol of high density lipoproteid (HDL-C), aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), creatine kinase (CK), C-reactive protein (CRP), interleukin-6 (IL-6), lipoprotein (α) (Lp(α)), NO3 were determined. Besides endothelium dependent vasodilatation of brachial artery was studied.Results. TC, HDL-C and TG levels did not differ before and after treatment with mildronate, but LDL-C level significantly reduced (from 3.06±1.32 to 2.7±1.0 mmol/l, p<0.05) in IHD patients after 3 months of mildronate treatment. There was significant decrease in CRP level (from 1.5±1.8 to 1.0±1.1 mg/l, р<0.01) and absent of IL-6 level difference (before treatment — 3.7±2.3 and after treatment — 3.4±1.8 pgml, p>0.05). The significant change of Lp(α) was not found in both groups. Increase in endothelium dependent vasodilatation was noted after mildronate treatment. Besides increase in NO3 level in blood was detected (from 33.5±10.0 to 44.1±32.3 μmol/l, р<0.05).Conclusion. Data of the study demonstrated that metabolic correctors exert positive influence on lipid profile and inflammatory factors in patients with IHD.
To the Schwarzschild Solution in General Relativity  [PDF]
Valery V. Vasiliev, Leonid V. Fedorov
Journal of Modern Physics (JMP) , 2018, DOI: 10.4236/jmp.2018.914160
Abstract: The paper is concerned with the history of the spherically symmetric static problem solution of General Relativity found in 1916 by K. Schwarzschild [1] [2] which is interpreted in modern physics as the background of the objects referred to as Black Holes. First, the modern interpretation this solution which does not exactly coincide with original solution obtained by K. Schwarzschild is discussed. Second, the basic equations of the original Schwarzschild solution are presented in modern notations allowing us to compare existing and original solutions. Finally, a modification of the Schwarzschild approach is proposed allowing us to arrive at the exact solution of the Schwarzschild problem.
Two types of systems and three types of paradigms in systems philosophy and system science  [PDF]
Valery M. Eskov, Valery V. Eskov, Olga E. Filatova, Michael A. Filatov
Journal of Biomedical Science and Engineering (JBiSE) , 2012, DOI: 10.4236/jbise.2012.510075
Abstract: Now it is evident that nature and society have a great number of special systems which very differ from traditional objects (systems) of physics, chemists and engineering. For such special (synergetic-chaotic) systems we are proposed the special third paradigm and construct five basic properties of (unique) systems and on 13 differences in the methods, basic concepts about such systems. The introduction of such basic properties and differences are presented in the article. We postulate the humanity evolution, dynamic of social and political systems, biosphere of Earth, the human organism and his functional systems and many other systems (Universe at all) have all five such properties and must be described according to special synergetic paradigm. Now the authors presents all these special properties and the special table where the differences between deterministic-stochastic systems (and its theoretical approaches) and the synergetic systems (complexity, self-organization systems) were presented more conveniently.
Chaotic approach in biomedicine: Individualized medical treatment  [PDF]
Valery M. Eskov, Alexander A. Khadartsev, Valery V. Eskov, Olga E. Filatova, Diana U. Filatova
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.68103
Abstract: According to classic deterministic-stochastic approaches, we don’t have any possibility for realization of the basic principle in medicine because every human organism has its own specific features. It is evident for us that requirement of medical personification includes two procedures: individual (with uninterrupted procedure of human organism state measurement) diagnostics and the second part which is connected with uninterrupted control of the efficiency of medical treatment and measurements of human organism parameters. We conduct the diagnostics according to behavior of state vector of human organism in phase space of states according to every coordinates of human’s state vector and with calculation of quasiattractors. We can present the results of our observations: what may be good for one person is not necessarily good for another. We present new bioinformational methods and software for calculation of quasiattractors parameters for dissolving such contradictions between deterministic-stochastic medicine and the use of theory of chaos self-organization where the state vector of human organism demonstrates uninterrupted movements. The practical results of such procedure are also presented according to the theory of chaos-self-organization. So there are great distinctions between the classic deterministic-stochastic approach (based on traditional medicine requirements) and the new theory of chaos self-organization which considers every human organism as a unique system with individual properties.
Quantitative Registration of the Degree of the Voluntariness and Involuntariness (of the Chaos) in Biomedical Systems  [PDF]
Valery M. Eskov, Alexander A. Khadartsev, Valery V. Eskov, Olga E. Filatova
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2013, DOI: 10.4236/jasmi.2013.32008

What does it mean: certainty and uncertainty, chaos and order? The understanding of such definition and real interpretation of chaotic behavior the third type of systems in nature was presented. The practical realization of different medical problems was presented too.

Western civilization in comparative historical views of historical multiculturalizm founders
Valery V. Shaparenko
European Researcher , 2011,
Abstract: The article brings in comparative analysis of American political scientist S. Huntington and Russian scientist N.Ya. Danilevsky views of Western Civilization cultural roots.
Human and social virtues in Francis Fukuyama’s theory of historical prosperity
Valery V. Shaparenko
European Researcher , 2011,
Abstract: The article analyses Human and Social virtues the theory of Francis Fukuyama’s historical prosperity.
Odessa Scientists as the Passengers of The Philosophy Steamer
Valery V. Levchenko
Bylye Gody , 2013,
Abstract: The article, basing on a wide range of document data and scientific literature, examines the expulsion of scientists from Odessa, which was part of the campaign on dissident intellectuals’ expulsion in 1922, memorized as “The Philosophy Steamer”. The determination of the degree of problem examination in the history showed that this theme wasn’t analyzed by Ukrainian and Russian historiography thoroughly. The previous publications contained only separate details of the campaign and the names of only few of the scientists were mentioned, which didn’t provide the full picture of the events. The article presents the previously unknown facts, introduces the forgotten names of the scientists and their fates for scientific use
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