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La dimension sociale dans un master post-universitaire à distance : outils, animation et analyse des interactions The social dimension within an online post-graduate course: tools, simulation and interaction analysis
Valentina Lupi,Francesca Pozzi,Simone Torsani
ALSIC : Apprentissage des Langues et Systèmes d'Information et de Communication , 2008, DOI: 10.4000/alsic.853
Abstract: Les technologies de l'information et de la communication (TIC) dans la formation peuvent favoriser l'adoption de modèles éducatifs de type socioconstructiviste. Dans ces contextes de formation (computer-supported collaborative learning, CSCL), une attention particulière est consacrée à la création de la communauté d'apprentissage et aux relations qui s'instaurent entre ses membres.Le master de haute formation en traduction juridique de l'université de Gênes – projet F@rum (Poli et al., 2004), se base sur ces théories. Pour favoriser au maximum le développement de la présence sociale de la communauté d'apprentissage, un "jeu de simulation socio-professionnel" (Debyser, 1996 ; Rossi, 2002) a été organisé par l'équipe du master, à l'intérieur d'une plateforme dédiée.Dans cette étude, nous décrirons les initiatives destinées à encourager la présence sociale à l'intérieur du master. Nous chercherons à comprendre également si et dans quelle mesure ces initiatives ont influencé la présence sociale des participants ; si elles ont stimulé la création de la communauté d'apprentissage et si elles ont contribué à l'atteinte des objectifs cognitifs du master. Cette contribution se fonde en particulier sur les résultats de l'analyse des interactions des apprenants indiquant la présence sociale (Garrison et al., 1999). L'analyse des messages des forums repose sur un modèle d'évaluation dit "mixte" (quantitatif et qualitatif) à cinq dimensions (Pozzi et al., 2007) inspiré des "communities of inquiry" (Garrison & Anderson, 2003). The use of ICTs in the field of education can promote the adoption of "social constructivist" approaches to learning. In these contexts of education (computer-supported collaborative learning, CSCL), a particular attention is paid to the creation of the "learning community" and to the relationships the members of the community establish among them.The post-graduate course in legal translation of the University of Genoa – carried out within the F@rum project – is underpinned by these same theories. To foster at its maximum the development of social presence among the learners, a socio-professional simulation game (Debyser, 1996 ; Rossi, 2002) is usually offered by the course staff within the learning platform.In this study, we will describe the initiatives carried out within the course, which are able, in our opinion, to promote social presence. We will discuss on whether and to what extent such initiatives have influenced the participants' social presence, whether they have stimulated the creation of the learning community and, finally, whether
Contribution to the definition of the metabolic profile of farmed rainbow trout (Oncorhynchus mykiss)
Paola Lupi,Valentina Vigiani,Massimo Mecatti
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2006.63
Abstract: The haematic outline of 339 rainbow trout (Oncorhynchus mykiss)from two different farms in the Lucca province was studied for a preliminary assessment of the metabolic profile of this species and for the investigation of the influence of some endogenous and exogenous factors on the variability of the studied parameters. The sampling time, as well as the weight, appears to have caused significant variations on most of the parameters analysed. The present study gives the annual means and the seasonal trends for each farm where the study was carried out.
First haematic results for the sea bass (Dicentrarchus labrax) metabolic profile assessment
Paola Lupi,Valentina Vigiani,Massimo Mecatti,Riccardo Bozzi
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2005.167
Abstract: The assessment of blood reference ranges of farmed fish can be extremely useful in improving production and product quality. A first attempt to establish the normality ranges for the most important haematochemical parameters of farmed sea bass was carried out by analysing the trend of Haematocrit, Glucose, Total Protein, Albumin, Globulin, Total Cholesterol and some electrolytes in 353 sea bass farmed with two different farming systems within 1 year. A strong seasonal effect was found with regard to each parameter; the role of some environmental conditions was evaluated; and some reference ranges were proposed for the culturing methods considered.
Dynamic Rendering of the Heterogeneous Cell Response to Anticancer Treatments
Francesca Falcetta,Monica Lupi,Valentina Colombo,Paolo Ubezio
PLOS Computational Biology , 2013, DOI: 10.1371/journal.pcbi.1003293
Abstract: The antiproliferative response to anticancer treatment is the result of concurrent responses in all cell cycle phases, extending over several cell generations, whose complexity is not captured by current methods. In the proposed experimental/computational approach, the contemporary use of time-lapse live cell microscopy and flow cytometric data supported the computer rendering of the proliferative process through the cell cycle and subsequent generations during/after treatment. The effects of treatments were modelled with modules describing the functional activity of the main pathways causing arrest, repair and cell death in each phase. A framework modelling environment was created, enabling us to apply different types of modules in each phase and test models at the complexity level justified by the available data. We challenged the method with time-course measures taken in parallel with flow cytometry and time-lapse live cell microscopy in X-ray-treated human ovarian cancer cells, spanning a wide range of doses. The most suitable model of the treatment, including the dose-response of each effect, was progressively built, combining modules with a rational strategy and fitting simultaneously all data of different doses and platforms. The final model gave for the first time the complete rendering in silico of the cycling process following X-ray exposure, providing separate and quantitative measures of the dose-dependence of G1, S and G2M checkpoint activities in subsequent generations, reconciling known effects of ionizing radiations and new insights in a unique scenario.
E. U. Customs Obligation  [PDF]
Marco Lupi
Beijing Law Review (BLR) , 2019, DOI: 10.4236/blr.2019.101002
Abstract: In a world that is increasingly globalized and open to trade, customs law has become increasingly central to businesses and consumers. From 1 May 2016 there has been a real revolution in customs: in fact, many of the provisions contained in the EU regulation no. 952/2013 which established the new EU Customs Code. The new simplifications are based on a more intense digitalization of the dialogue between the company and customs and they aim to both reduce the time spent on customs clearance, and also to provide external users with the traceability of the entire import/export cycle and the carrying out of controls connected. The transition to the new one, however, was not clear, but in order to protect the legitimate interests of the economic operators and to guarantee the validity of the decisions taken and the authorizations issued in force of the previous Union customs legislation, a transitional period was envisaged, until 1 May 2019, to allow the adaptation of these decisions and authorizations to the new legal provisions (reassessment). This contribution analyzes, in light of the new rules of the code, the conditions in relation to which the customs debt and the taxable persons required to fulfil the obligations arise. Finally, brief elements are dedicated to the settlement of customs duties, such as the classification of goods, having regard to the indications provided by the Common Customs Tariff, the origin and value of products. This electronic document is a “live” template. The various components of your paper [title, text, heads, etc.] are already defined on the style sheet, as illustrated by the portions given in this document.
The Molecular Assembly of Amyloid Aβ Controls Its Neurotoxicity and Binding to Cellular Proteins
Claudia Manzoni, Laura Colombo, Paolo Bigini, Valentina Diana, Alfredo Cagnotto, Massimo Messa, Monica Lupi, Valentina Bonetto, Mauro Pignataro, Cristina Airoldi, Erika Sironi, Alun Williams, Mario Salmona
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024909
Abstract: Accumulation of β-sheet-rich peptide (Aβ) is strongly associated with Alzheimer's disease, characterized by reduction in synapse density, structural alterations of dendritic spines, modification of synaptic protein expression, loss of long-term potentiation and neuronal cell death. Aβ species are potent neurotoxins, however the molecular mechanism responsible for Aβ toxicity is still unknown. Numerous mechanisms of toxicity were proposed, although there is no agreement about their relative importance in disease pathogenesis. Here, the toxicity of Aβ 1–40 and Aβ 1–42 monomers, oligomers or fibrils, was evaluated using the N2a cell line. A structure-function relationship between peptide aggregation state and toxic properties was established. Moreover, we demonstrated that Aβ toxic species cross the plasma membrane, accumulate in cells and bind to a variety of internal proteins, especially on the cytoskeleton and in the endoplasmatic reticulum (ER). Based on these data we suggest that numerous proteins act as Aβ receptors in N2a cells, triggering a multi factorial toxicity.
Terahertz Spectroscopy of Novel Superconductors
Stefano Lupi
Advances in Condensed Matter Physics , 2011, DOI: 10.1155/2011/816906
Abstract: Through the coupling of Synchrotron Radiation and Michelson interferometry, one may obtain in the terahertz (THz) range transmittance and reflectivity spectra with a signal-to-noise ratio (S/N) up to 103. In this paper we review the application of this spectroscopic technique to novel superconductors with an increasing degree of complexity: the single-gap boron-doped diamond; the isotropic multiband V3Si, where superconductivity opens two gaps at the Fermi energy; the CaAlSi superconductor, isostructural to MgB2, with a single gap in the hexagonal ab plane and two gaps along the orthogonal c axis. 1. Introduction After the discovery of high-Tc cuprates in 1986 that renewed the interest on superconducting materials, many new superconductors with different transport and magnetic properties have been synthesized in recent years. Among them one may cite A-doped (A = K, Rb, Na) C60, NaxCoO2 codoped with H2O; MgB2 and CaAlSi, and Boron-doped diamond and the new Iron pnictides. The magnetic, transport, and electrodynamics properties of a superconductor are intimately related to few parameters: the critical temperature Tc, the value and the symmetry in the k space of the superconducting gap Δ(k), the critical magnetic fields HC1, and HC2, and the penetration depth λ. The main issue about a new superconductor concerns if these properties can be described through the mean-field Bardeen-Cooper-Schrieffer (BCS) theory (which well-captures the properties of conventional superconducting metals), or a different, more exotic, theory should be considered. For instance, strongly covalent bonds, high-concentration of impurities, and high-phonon frequencies make B-doped diamond much different from the conventional metals where the BCS model holds. Moreover, after the discovery of MgB2, multiple-band unconventional-coupling superconductivity has been put forward and the properties of known materials like V3Si, with several electronic bands crossing the Fermi energy (EF), and recently discovered CaAlSi with anisotropic lattice properties, have been investigated in this scenario. The presence of a gap in the electronic excitations near the Fermi level for , is one of the main effect induced by superconductivity [1]. If the Cooper pairs are in a spherically symmetric s-state this gap opens along all directions of the Brillouin zone. When more bands cross EF, they can be characterized by different superconducting gaps if a low interband scattering is present. However, if a p or a d type band (or a linear combination) defines the electronic properties of the system, the gap
Doen?as pri?nicas: avalia??o dos riscos envolvidos na utiliza??o de produtos de origem bovina
Lupi, Omar;
Anais Brasileiros de Dermatologia , 2003, DOI: 10.1590/S0365-05962003000100002
Abstract: a prion is a protein that is capable of self replication, thereby altering a cell's metabolism. it is responsible for a number of human and animal diseases (prionic diseases), all of which are always lethal. these diseases have enormous variability in their incubation periods, ranging from a few months to forty years. prions accumulate and destroy nerve cells, causing spongiform encephalopathy. we discuss the clinical picture, epidemiology, and historical background of prionic diseases. the major focus of the discussion lies, however, on the theoretical possibility of iatrogenic transmission of prion infection due to topical formulations using ceramides (cerebrosides) or placenta of bovine origin, as well as the risk represented by some dermatological procedures such as skin grafts and collagen implants.
Imunoprofilaxia anti-herpética utilizando vírus geneticamente modificado: vacina DISC
Lupi, Omar;
Anais Brasileiros de Dermatologia , 2003, DOI: 10.1590/S0365-05962003000300011
Abstract: antiherpetic vaccines are administered to either act as a prophylactic or therapeutic against herpes simplex infection. several kinds of vaccines have been evaluated but with little result, such as live-attenuated viral vaccines and subunit glycoprotein vaccines. the new disabled infectious single cycle (disc) vaccines are designed to combine the safety and advantages of inactivated vaccines with the immunogenic activity of live viral vaccines. the gene for glycoprotein h was removed to disable the virus that can infect human cells much the same as native virus and viral progeny are produced but are defective and can no longer replicate. these viral particles are nonpathogenic and are capable of inducing broad cytotoxic t-cell and humoral response against herpetic antigens.
Squilibri della tassazione degli immobili e prospettive di riforma
R. Lupi
Aestimum , 1998,
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