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Search Results: 1 - 10 of 4587 matches for " Valérie Collado "
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Conscious Sedation Procedures Using Intravenous Midazolam for Dental Care in Patients with Different Cognitive Profiles: A Prospective Study of Effectiveness and Safety
Valérie Collado, Denise Faulks, Emmanuel Nicolas, Martine Hennequin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071240
Abstract: The use of midazolam for dental care in patients with intellectual disability is poorly documented. This study aimed to evaluate the effectiveness and safety of conscious sedation procedures using intravenous midazolam in adults and children with intellectual disability (ID) compared to dentally anxious patients (DA). Ninety-eight patients with ID and 44 patients with DA programmed for intravenous midazolam participated in the study over 187 and 133 sessions, respectively. Evaluation criteria were success of dental treatment, cooperation level (modified Venham scale), and occurrence of adverse effects. The mean intravenous dose administered was 8.8±4.9 mg and 9.8±4.1 mg in ID and DA sessions respectively (t-test, NS). 50% N2O/O2 was administered during cannulation in 51% of ID sessions and 61% of DA sessions (NS, Fisher exact test). Oral or rectal midazolam premedication was administered for cannulation in 31% of ID sessions and 3% of DA sessions (p<0,001, Fisher exact test). Dental treatment was successful in 9 out of 10 sessions for both groups. Minor adverse effects occurred in 16.6% and 6.8% of ID and DA sessions respectively (p = 0.01, Fisher exact test). Patients with ID were more often very disturbed during cannulation (25.4% ID vs. 3.9% DA sessions) and were less often relaxed after induction (58.9% ID vs. 90.3% DA) and during dental treatment (39.5% ID vs. 59.7% DA) (p<0.001, Fisher exact test) than patients with DA. When midazolam sedation was repeated, cooperation improved for both groups. Conscious sedation procedures using intravenous midazolam, with or without premedication and/or inhalation sedation (50% N2O/O2), were shown to be safe and effective in patients with intellectual disability when administered by dentists.
A national cross-sectional survey of dental anxiety in the French adult population
Emmanuel Nicolas, Valérie Collado, Denise Faulks, Brigitte Bullier, Martine Hennequin
BMC Oral Health , 2007, DOI: 10.1186/1472-6831-7-12
Abstract: A convenience sample of 2725 adults (mean age = 47 years, SD16, minimum = 16, maximum = 101 years), representative of the French population with regard to age and urban distribution, completed a French version of the Corah Dental Anxiety scale (DAS) and a questionnaire relating to their dental appointments.Moderate dental anxiety (14≥DAS≥13) was revealed for 172 persons (6.2%), while 195 (7.3%) had severe dental anxiety (DAS≥15), giving an overall prevalence of dental anxiety of 13.5%. Prevalence was lower proportionally with age (P < 0.001) and was higher in French overseas territories and in the countryside (P < 0.01). Farmers and low skilled workers were significantly more anxious than executives and shopkeepers (P < 0.001). Anxiety was associated with avoidance of care (p < 0.001) and lack of regular dental appointments (p < 0.001).Dental anxiety in France appears to concern a similar proportion of the population as in other industrialised European, Australasian or North American countries. Recommendations for prevention and management of dental anxiety are made with reference to dental education and health care services in France.Dental anxiety partially limits, or completely prevents, utilisation of oral health care services [1,2]. It increases the prevalence of dental disease [2,3]. Anxious persons present more damaged or missing teeth and less restored teeth [4]. Regular and conventional care is bypassed by dentally anxious persons, who rely on self-care, use of emergency services, and occasionally use of traditional or parallel remedies to relieve pain. The oral health and quality of life of this population are affected [5]. When professional care is provided, it is often given under general anaesthesia without consideration for the aetiological factors behind dental fear. Ideally, the management of patients with dental anxiety requires psycho-behavioural and sedation procedures [6,7] as alternatives to general anaesthesia. Such techniques have been shown t
Neuroendocrine Differentiation in the Progression of Prostate Cancer: An Update on Recent Developments  [PDF]
Valérie Perrot
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.223032
Abstract: Neuroendocrine (NE) differentiation, either benign or malignant, is the hallmark of prostate cancer (PCa). Clusters of malignant NE cells are found in most prostate cancer cases. NE differentiation is among the non-mutually exclusive theories proposed to explain the progression to androgen independence of PCa. NE differentiation is usually associated with an increased aggressivity and invasiveness of prostate tumors and a poor prognosis. This review aims to present an overview of current knowledge on neuroendocrine differentiation in PCa to improve our understanding of tumour progression and androgen independence. The NE component represents an important therapeutic axis. Development of new generation of drugs that selectively target NE-like cells may lead to the development of new therapeutic modalities for advanced and hormone-refractory PCa.
Bordetella holmesii: Comparison of Two Isolates from Blood and a Respiratory Sample  [PDF]
Valérie Bouchez, Nicole Guiso
Advances in Infectious Diseases (AID) , 2013, DOI: 10.4236/aid.2013.32020

Interest in Bordetella holmesii is increasing, but very little is known about this bacterium, which can be isolated from both blood and respiratory samples. In this study, we compared a B. holmesii isolate from the blood sample of an adult with bacteremia with another isolate from a nasopharyngeal swab from an adult with whooping cough syndrome. Genetic analysis was carried out, targeting relevant genes, and virulence properties were studied in cellular and animal models. Our genomic analysis provided no evidence of traits specific to either blood or respiratory isolates of B. holmesii. Neither isolate was cytotoxic to human tracheal epithelial cells. Both isolates were only weakly invasive and they did not persist within epithelial cells for less than 48 h.

Evaluation of safe and effective administration of nitrous oxide after a postgraduate training course
Valérie Collado, Emmanuel Nicolas, Denise Faulks, Corinne Tardieu, Marie-Cécile Manière, Dominique Droz, Peter Onody, Martine Hennequin
BMC Pharmacology and Toxicology , 2008, DOI: 10.1186/1472-6904-8-3
Abstract: 45 practitioners were trained between 2002 and 2004. They carried out 826 sessions of inhalation sedation in 662 patients. The clinical competency of this group was compared with an expert group.There was no difference between trainees and experts in ability to complete the planned dental treatment under sedation (89.6% vs 93.2%). Trainees were less successful than experts for patients with intellectual disability (87.4% vs 94.2%, p < 0.01). For both groups, the degree of cooperation improved between initial induction and each perioperative step (Wilcoxon test, p < 0.01). However, for trainees, Venham behaviour scores varied with the type of patient (Kruskal Wallis test, p < 0.001). No major adverse effects were recorded. Trainees reported more minor adverse effects than experts (13% vs. 5.3% respectively, Fisher exact test, p < 0.001)The trainee practitioners provided effective and safe inhalation sedation. This challenges the current French restriction of the 50% nitrous oxide in oxygen premix to the hospital setting. Further emphasis is required on the teaching of behaviour management skills for patients with intellectual disability.In September 2002, four French dental faculties (Clermont-Ferrand, Marseille, Nancy and Strasbourg) set up the first one-year collaborative training course in conscious sedation for dental care. The course objectives were the acquisition of the knowledge, skills and attitudes necessary for the practice of all techniques of conscious sedation relevant to dentistry. This course was evaluated over the first two years in order to validate a minimum training requirement for dentists to ensure safe and effective conscious sedation. Reservations expressed by non-dental professionals, including anaesthetists, could then be addressed [1]. Harmonisation of practices and dental training between European countries could also be improved, as conscious sedation techniques (in particular inhalation and intravenous sedation) have been declared to be
Effect of Pulsed Ultraviolet Light on the Total Phenol Content of Elderberry (Sambucus nigra) Fruit  [PDF]
Ramesh Murugesan, Valérie Orsat, Mark Lefsrud
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.36104
Abstract: The changes in total polyphenolics in elderberry (Sambucus nigra) following treatment with various doses of pulsed ultraviolet rays (UV) were investigated. Four pulsed UV durations (5, 10, 20, 30 seconds) at three energy dosages (4500, 6000, 11,000 J/m2/pulse) were considered for the research. All treated elderberry fruits were incubated for 24 h at room temperature (25℃) following treatment to ensure enough response duration for enhanced development of polyphenols by the berries. The highest increase in total phenolics around 50% was found with 11,000 J/m2/pulse for a 10 seconds treatment while nearly 40% increase in total phenolics was found at an energy dosage of 11,000 J/m2/pulse after 5 seconds exposure. Even though most of the treatments indicated an increase in total polyphenols, some treatment expressed a decrease in phenolics content when compared to untreated fruits.
The Unconscious Experimentally Demonstrated by Means of Hypnosis  [PDF]
Edoardo Casiglia, Valérie Tikhonoff, Enrico Facco
Psychology (PSYCH) , 2016, DOI: 10.4236/psych.2016.74048

Although taken for granted today by people and by some experts, the unconscious has never been experimentally demonstrated. Even for the psychoanalysts, the unconscious is nothing more than a model. The unconscious, if anything, is normally obscured by conscious activities and can only express itself in response to conditions leading to non-ordinary mental expressions, for instance during hypnosis. For many years, we have been using hypnosis in variegating experimental setting, and we think one of the evidences coming from our tests is the experimental demonstration that the unconscious exists and can be forced to respond to solicitations the participant is not aware of. We administered hypnotic suggestions to highly-hypnotizable normal participants with the aim of inducing hallucination of body heating, alexia, amusia, spatial neglect, focused analgesia, general anaesthesia, and age regression. Following such suggestions, participants actually experienced a sensation of heat, incapability to read, lack of interest in a side of the world, indifference to painful stimuli, and revivification of infantile age, respectively. But this is not all. Through the above-mentioned suggestions we also obtained some physical reactions that could only be defined as unconscious, i.e. increase of the stroke volume and of the mesenteric artery flow following hallucinated body heating, reduction of reaction times to incongruent color words in a Stroop task following alexia, prolongation of ipsilateral reaction times following spatial neglect, reduction of mismatch negativity to deviant stimuli following hypnotic amusia, coherent modifications of the sympathetic/parasympathetic balance to trigeminal and non-trigeminal pain during analgesia and anaesthesia, reduction of Raven score and Raven-induced stress during age regression. These responses evoked during hypnosis in response to mental images are clearly non-voluntary and non-conscious, and demonstrate in experimental setting with the tools that are typical of human physiology—the existence of unconscious to perceive and react.

A Critical Evaluation of Single Extractions from the SMT Program to Determine Trace Element Mobility in Sediments
Valérie Cappuyns
Applied and Environmental Soil Science , 2012, DOI: 10.1155/2012/672914
Abstract: Two commonly applied single extractions procedures, namely extractions with ammonium-EDTA and acetic acid, were evaluated based on the analysis of 72 samples from alluvial sediments. For most trace elements (Cu, Zn, Cd, Ni, As, and Pb), a significant linear relationship could be established between their ammonium-EDTA or acetic acid extractable concentrations and their total concentrations, the organic carbon content, pH, and Fe , Al, and/or Ca content in the sediments. The scientific understanding of trace element partitioning in the complex soil-water system with these simple models is rather limited, but they offer the opportunity to use data from single extractions in a more comprehensive way. Despite the fact that these extractions cannot directly be related to the bioavailability of elements, they can provide input data for use in risk assessment models. Additionally, they also offer possibilities to perform a fast screening of the mobilizable pool of elements in soils and/or sediments. 1. Introduction The contamination of soils and sediments is widespread and is a potential threat for the environment in the short and long term. The impact of trace elements in soils and sediments on the environment depends on their speciation, mobility, and bioavailability. Over the past decades, the term “heavy metals” has increasingly been used, without any consistency to denote trace element contamination of environmental media. An overview of the use of the term “heavy metals” in scientific dictionaries and relevant literature can be found in Duffus [1]. Since “heavy metals” is a poor scientific term and many alternatives exit [2], we will use the term “trace elements” in the present study to refer to As, Cd, Cu, Cr, Ni, Pb, and Zn. Talking about trace metals would be incorrect because arsenic is actually a metalloid. Before discussing the different methods for determination of “trace element” availability in soils and/or sediments and before addressing the pros and cons of single and sequential extraction procedures, the difference between soils and sediments will be clarified, as well as the terminology used throughout this paper. 1.1. Soils versus Sediments Soils and sediments are different matrixes from many viewpoints, especially under the environmental context. “Soil” can be defined as a “three-dimensional body with properties that reflect the impact of climate, vegetation, fauna, and topography on soils parent material over a variable time span. Soils are still in a process of change. As a result of “soil formation” or “pedogenesis,” soil profiles show
The chicken as a model to study microchromosomes in birds: a review
Valérie Fillon
Genetics Selection Evolution , 1998, DOI: 10.1186/1297-9686-30-3-209
Chungará (Arica) , 2004, DOI: 10.4067/S0717-73562004000300011
Abstract: how to carry out a comparative study between human groups distinguished by the means of subsistence and their territories? the example of comparison of the lithic industries of the maritimes hunters from seno otway (bahia colorada, englefield 1), the riesco island (ponsonby), the strait of magellan (bahía buena, punta santa ana), the beagle channel (lancha packewa?a) and the terrestrial hunters from fell's cave show us clearly how the lithic technology is a privileged means to answer regional issue of cultural characterization. the results are given with a view to showing methodically how the study has been adjusted to the context and how many questions pertaining to the data comparison have been sorted. in view of a global approach, the author will explain the choices of a technological and typological analysis, and the importance of the economic and cultural patterns constitutions that enhance the concepts ("way of seeing") and also the technical behaviours ("way of doing") used by the inhabitants of those different sites. finally the interpretation and the accuracy of the results in terms of cultural signification will be discussed
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