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Search Results: 1 - 10 of 8360 matches for " VANESSA; RODRIGUEZ "
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EFECTO DEL CONTENIDO DE SODIO EN LA OBTENCIóN DE Na+-b-ALúMINA UTILIZANDO EL MéTODO DE PRECURSOR POLIMéRICO
RUIZ,VANESSA; RODRIGUEZ,JORGE;
DYNA , 2011,
Abstract: in this work was utilized the polymeric precursor method to synthesis ceramic powders of na+-b-alúmina. we were interested in determinate the initial quantity from sodium precursor and its effect on crystalline phase obtained. powders obtained were characterized using infrared spectroscopy (ftir), x-ray diffraction (xrd) and scanning electron microscopy (sem). the effect of the initial quantity of sodium in the sample was very important in the nature of the final product. if we used one stoichiometric quantity of naoh, to obtain naal11o17 compound, we obtained a-alúmina as finish product (1450oc). on the other hand, b-alúmina and/or na2al2xo3x-1 were obtained in samples treated thermicalment from 1000oc to 1350oc. when we used a higher quantity of naoh, sample non-stoichiometric, a solid with naal11o17 as majority phase was obtained.
EFECTO DEL CONTENIDO DE SODIO EN LA OBTENCIóN DE Na+ -B-ALúMINA UTILIZANDO EL MéTODO DE PRECURSOR POLIMéRICO
VANESSA RUIZ,JORGE RODRIGUEZ
DYNA , 2011,
Abstract: En este trabajo se muestran los resultados obtenidos al emplear el metodo de precursor polimerico (Pechini) para sintetizar polvos ceramicos de Na + B àalumina, utilizando sales inorganicas, tomando como parametro de estudio la cantidad inicial del precursor de sodio y su efecto sobre la fase cristalina obtenida al final del proceso. Los polvos fueron caracterizados utilizando espectroscopia Infrarroja (FTIR), Difraccion de Rayos X (DRX) y Microscopia Electronica de Barrido (MEB). Se encontro que el efecto de la cantidad de sodio inicial en la muestra es determinante en la naturaleza del producto final obtenido. Utilizando la cantidad estequiometrica de NaOH requerida, para la obtencion del compuesto NaAl11O17, se obtuvo al final del proceso (1450oC) a-alumina y B-alumina y/o Na2Al2xO3x1 en muestras tratadas termicamente entre 1000oC y 1350oC. Cuando se uso una mayor cantidad de NaOH, muestra no estequiometrica, se obtuvo un solido con el compuesto NaAl11O17 como fase mayoritaria.
Effect of velocity on roll/slip for low and high load conditions in polymer composite
Sukumaran, Jacob,Ando, Matyas,Rodriguez Fereira, Vanessa,De Baets, Patrick
Sustainable Construction & Design , 2011,
Abstract:
Roughness measurement problems in tribological testing
Rodriguez Fereira, Vanessa,Sukumaran, Jacob,Ando, Matyas,De Baets, Patrick
Sustainable Construction & Design , 2011,
Abstract:
Sparstolonin B Inhibits Pro-Angiogenic Functions and Blocks Cell Cycle Progression in Endothelial Cells
Henry R. Bateman, Qiaoli Liang, Daping Fan, Vanessa Rodriguez, Susan M. Lessner
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070500
Abstract: Sparstolonin B (SsnB) is a novel bioactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. Angiogenesis, the process of new capillary formation from existing blood vessels, is dysregulated in many pathological disorders, including diabetic retinopathy, tumor growth, and atherosclerosis. In functional assays, SsnB inhibited endothelial cell tube formation (Matrigel method) and cell migration (Transwell method) in a dose-dependent manner. Microarray experiments with human umbilical vein endothelial cells (HUVECs) and human coronary artery endothelial cells (HCAECs) demonstrated differential expression of several hundred genes in response to SsnB exposure (916 and 356 genes, respectively, with fold change ≥2, p<0.05, unpaired t-test). Microarray data from both cell types showed significant overlap, including genes associated with cell proliferation and cell cycle. Flow cytometric cell cycle analysis of HUVECs treated with SsnB showed an increase of cells in the G1 phase and a decrease of cells in the S phase. Cyclin E2 (CCNE2) and Cell division cycle 6 (CDC6) are regulatory proteins that control cell cycle progression through the G1/S checkpoint. Both CCNE2 and CDC6 were downregulated in the microarray data. Real Time quantitative PCR confirmed that gene expression of CCNE2 and CDC6 in HUVECs was downregulated after SsnB exposure, to 64% and 35% of controls, respectively. The data suggest that SsnB may exert its anti-angiogenic properties in part by downregulating CCNE2 and CDC6, halting progression through the G1/S checkpoint. In the chick chorioallantoic membrane (CAM) assay, SsnB caused significant reduction in capillary length and branching number relative to the vehicle control group. Overall, SsnB caused a significant reduction in angiogenesis (ANOVA, p<0.05), demonstrating its ex vivo efficacy.
Technological Perspectives in Phylogeny Research: Revisiting Comparative Analysis of Complete Mitochondrial Genomes for Time-Extended Lineages  [PDF]
Tommy Rodriguez
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.55057
Abstract:

This article seeks to emphasize a simplified approach to phylogeny research using complete mitochondrial genomes alone, while touching upon a number of technological perspectives, such as algorithmic selection, which can help improve accuracy and performance in comparative analysis. My results will show that reliable estimations can be obtained by using mitochondrial markers, even among time-extended taxonomical rankings. Six distinct mammalian groups of taxa were selected for comparison. In all cases, mtDNA models generated reliable phylogeny approximations when compared against other independent data, while rendering exceptional computational performance.


Behavioral and Experiential Self-Regulations in Psychological Well-Being under Proximal and Distal Goal Conditions  [PDF]
Peter Horvath, Vanessa McColl
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.412141
Abstract:

This study examined the relationship of goal-related components of cybernetic, behavioral, and experiential self-regulations to psychological well-being under two types of conditions, the pursuit of intrinsic goals in general and specific intrinsic goals for the academic term. In an online survey, undergraduates (N = 186) completed global measures of psychological well-being, behavioral and experiential self-regulations, and rated themselves on goal-related self-regulatory components. Correlations indicated that most of the cybernetic, behavioral and experiential self-regulatory variables were associated with each other and with well-being. In terms of the goal-related self-regulatory components, when pursuing intrinsic goals more generally, the experiential self-regulatory component of enjoyment of the activity predicted well-being. However, when pursuing intrinsic term goals, the cybernetic self-regulatory component of perceived goal progress and the behavioral self-regulatory component of self-reinforcement for goal progress predicted well-being. The findings extend theoretical conceptualizations of psychological well-being by integrating compatibilities between cybernetic, behavioral, experiential self-regulatory processes and motivational conditions.

Peptides identify multiple hotspots within the ligand binding domain of the TNF receptor 2
Ku-chuan Hsiao, Renee E Brissette, Pinger Wang, Paul W Fletcher, Vanessa Rodriguez, Michael Lennick, Arthur J Blume, Neil I Goldstein
Proteome Science , 2003, DOI: 10.1186/1477-5956-1-1
Abstract: Here we describe the use of complex and high diversity phage display libraries to isolate peptides (called Hotspot Ligands or HSPLs) which sub-divide the ligand binding domain of the tumor necrosis factor receptor 2 (TNFR2; p75) into multiple hotspots. We have shown that these libraries could generate HSPLs which not only subdivide hotspots on protein and non-protein targets but act as agonists or antagonists. Using this approach, we generated peptides which were specific for human TNFR2, could be competed by the natural ligands, TNFα and TNFβ and induced an unexpected biological response in a TNFR2-specific manner.To our knowledge, this is the first report describing the dissection of the TNFR2 into biologically active hotspots with the concomitant identification of a novel and unexpected biological activity.Hotspots have been defined as the minimal functional protein:protein interaction domains through which biological activity can be modulated [1-3]. A novel strategy called Phenogenix? has been developed as a means for studying these interactions. To enable Phenogenix?, we use large and diverse phage display libraries consisting of randomized 20 mer and 40 mer amino acid peptides with > 1011 independent clones. Because of their ability to modulate protein: protein interactions, the resulting peptides are called Hotspot Ligands (HSPLs). Using this approach, we have successfully identified peptide agonists and antagonists for a number of biologically important molecules including growth hormone receptor, insulin receptor and the insulin-like growth factor receptor [2,3].In this report, we describe the use of Phenogenix? to identify the critical protein:protein interactions underlying the TNF/TNFR axis. TNFα and TNFβ have been extensively studied and are involved in immune and pro-inflammatory responses, playing an important role in host defenses against infection and other disease states [4-7]. The biological effects of TNFα and TNFβ are mediated through the two me
miR-203 Regulates Cell Proliferation through Its Influence on Hakai Expression
Vanessa Abella, Manuel Valladares, Teresa Rodriguez, Mar Haz, Moisés Blanco, Nuria Tarrío, Pilar Iglesias, Luís A. Aparicio, Angélica Figueroa
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052568
Abstract: Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of E-cadherin, a major component of adherens junctions in epithelial cells and a potent tumour suppressor. Recent data have provided evidence that Hakai affects cell proliferation in an E-cadherin-independent manner, thus revealing a role for Hakai in the early stages of tumour progression. Furthermore, Hakai is highly up-regulated in human colon adenocarcinomas compared to normal tissues. However, the molecular mechanisms that regulate Hakai abundance are unknown. We identified two putative sites of miR-203 interaction on the Hakai mRNA, in its 3′-untranslated region (UTR). In several human carcinoma cell lines tested, overexpression of a miR-203 precursor (Pre-miR-203) reduced Hakai abundance, while inhibiting miR-203 by using an antisense RNA (Anti-miR-203) elevated Hakai levels. The repressive influence of miR-203 on the Hakai 3′-UTR was confirmed using heterologous reporter constructs. In keeping with Hakai's proliferative influence, Anti-miR-203 significantly increased cell number and BrdU incorporation, while Pre-miR-203 reduced these parameters. Importantly, the growth-promoting effects of anti-miR-203 required the presence of Hakai, because downregulation of Hakai by siRNA suppressed its proliferative action. Finally, in situ hybridization showed that miR-203 expression is attenuated in colon tumour tissues compared to normal colon tissues, suggesting that miR-203 could be a potential new prognostic marker and therapeutic target to explore in colon cancer. In conclusion, our findings reveal, for the first time, a post-transcriptional regulator of Hakai expression. Furthermore, by lowering Hakai abundance, miR-203 also reduces Hakai-regulated-cell division.
Mass Spectrum in the Minimal Supersymmetric 3-3-1 Model  [PDF]
Marcos Cardoso Rodriguez
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.210149
Abstract: We consider the minimal supersymmetric extension of the 3-3-1 model. We study the mass spectrum of this model in the fermionic and gauge bosons sectors without the antisextet. We also present some phenomenological consequences of this model at colliders such as Large Hadron Collider (LHC) and International Linear Collider (ILC).
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