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Epilepsy is one of the
most frequent neurological disorders. In these circumstances, more than 25% of the patients are women of
reproductive age. The aim of our research was to analyze the effectiveness and
safety of antiepileptic therapy in women with epilepsy during pregnancy and to
analyze the pregnancies’ outcomes. We included in our research 121 pregnancies
of 101 women aged at the moment of childbearing about 26.9 ± 4.57 years old.
Idiopathic forms of epilepsy were predominant among all causes—47.1% (р < 0.01). Of all cases, 65.4%
remained seizure-free from generalized tonic-clonic seizures (GTCS), including
69.6% of all idiopathic epilepsy cases and 68.6% among symptomatic ones. The
antiepileptic drugs (AED) dosages were exceeding teratogenic level at the
moment of conception in 54.7% of the cases. Worse control of epileptic seizures
was associated with Benzobarbital (66.7%) and Lamotrigine (50.0%). Women with
epilepsy did not receive specialized neurological therapy before conception in
most cases, which leaded to the usage of AED teratogenic doses and less
effectiveness of AED during pregnancy. It is necessary to plan the pregnancy
and prescribe rational treatment for epilepsy starting at the stage of planning
and during gestation in order to obtain a better seizures control and to
decrease congenital disorders risk in fetus.
Precessing ball solitons (PBS) in a ferromagnet during the first order phase transition is induced by a magnetic field directed along the axis of anisotropy, while the action of the periodic field perpendicular to the main magnetic field has been analyzed. Under these conditions, the characteristics of arising equilibrium PBS are uniquely determined by the frequency of the periodic field, but the solitons with other frequencies are impossible. For such structure, the entropy increase connected with dissipation is compensated by the decrease of the entropy due to the external periodic field. It is shown that the equilibrium PBS are essentially the “self-organizing systems” that can arise spotaneously in a metastable state of ferromagnet.