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Search Results: 1 - 10 of 200887 matches for " V. I. Aleshin "
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Testis-specific glyceraldehyde-3-phosphate dehydrogenase: origin and evolution
Mikhail L Kuravsky, Vladimir V Aleshin, Dmitrij Frishman, Vladimir I Muronetz
BMC Evolutionary Biology , 2011, DOI: 10.1186/1471-2148-11-160
Abstract: A dataset of GAPD sequences was assembled from public databases and used for phylogeny reconstruction by means of the Bayesian method. Since resolution in some clades of the obtained tree was too low, syntenic analysis was carried out to define the evolutionary history of GAPD more precisely. The performed selection tests showed that selective pressure varies across lineages and isoenzymes, as well as across different regions of the same sequences.The obtained results suggest that GAPD-1 and GAPD-2 emerged after duplication during the early evolution of chordates. GAPD-2 was subsequently lost by most lineages except lizards, mammals, as well as cartilaginous and bony fishes. In reptilians and mammals, GAPD-2 specialized to a testis-specific protein and acquired the novel N-terminal proline-rich domain anchoring the protein in the sperm tail cytoskeleton. This domain is likely to have originated by exonization of a microsatellite genomic region. Recognition of the proline-rich domain by cytoskeletal proteins seems to be unspecific. Besides testis, GAPD-2 of lizards was also found in some regenerating tissues, but it lacks the proline-rich domain due to tissue-specific alternative splicing.Glyceraldehyde-3-phosphate dehydrogenase (GAPD, EC is a homotetrameric glycolytic enzyme providing phosphorylation of 3-phosphoglyceraldehyde to 1,3-diphosphoglycerate coupled with reduction of NAD+ to NADH. Mammals are known to possess two tissue-specific GAPD isoenzymes: somatic (GAPD-1) and testis-specific (GAPD-2, GAPDS). For Homo sapiens, their protein sequences are 68% identical. Besides the two isoenzymes, a vast amount of GAPD pseudogenes was found in the genomes of primates and rodents [1,2].Mammalian GAPD-1 is a well-studied protein, a high concentration of which in cells (5-15% of all cytoplasmic proteins) confirms its functional significance. Recent studies established that GAPD-1 is not simply a classical metabolic protein involved in glycolytic energy product
A self-confined Fermi-gas model for nuclear collective motion
V. P. Aleshin
Physics , 2008,
Abstract: The main result of this study consists in working out a microscopic description of collective motion in hot nuclei, allowing to express the parameters of a phenomenological collective model in terms of nucleonic quantities.
力学进展 , 1984, DOI: 10.6052/1000-0992-1984-3-J1984-039
Abstract: 本文所提出的土壤中水和热交换的数学模型,预期可以解决农田中水和热状况的预测与控制等实际问题。此模型可用于确定所计划的土壤改良系统的参数,选择灌溉的方法,并制定出农田作物生产过程中的综合动态模型。
The Paradigm of the Seismic Zonation Continuality  [PDF]
A. S. Aleshin
World Journal of Engineering and Technology (WJET) , 2015, DOI: 10.4236/wjet.2015.33C051

Basic concepts of seismic zonation in Russia are the degree of intensity and soil categories that correspond to discrete structure in the ratio “seismic impact-ground reaction”. Meanwhile, the parameters of seismic effects, and the parameters of soil properties are continuous in the space. The report expounds the basic theory, adequately representing the above mentioned continuality. Thus, many the concepts of seismic zonation, used now, become either more correct, or unnecessary.

The New Formula of Seismic Rigidity Method  [PDF]
Alexandr S. Aleshin
Open Journal of Civil Engineering (OJCE) , 2018, DOI: 10.4236/ojce.2018.83025
Abstract: This publication is a revised version of the previous article. Seismic rigidity method despite its widespread use is the object of harsh criticism from scientists who oppose it to the methodology and results of seismological registration of earthquakes and microseisms. The article substantiates the original approach based on the solution of the direct problem of seismic microzonation for the model of real soil thickness. A new formula of the seismic rigidity method is proposed, taking into account the lithological, hydrogeological and spectral features of the soil mass, as well as the position of the new seismic scale of the SSI. The formula was tested on the example of the correct description of the features of macroseismic effects on the territory of Leninakan at the Spitak earthquake in 1988. Linear estimates according to the formula of seismic rigidity in the seismic microzoning area represent changes in seismic intensity in the most contrast way. It is shown that the real estimates of seismic intensity under strong seismic effects (by I > VII degree) will not exceed those given by the formula of the seismic rigidity method.
A Simulation Technology for a Full Cycle of Steel Line Pipe Manufacturing Operations
Vladimir V. Aleshin,Viacheslav V. Kobyakov,Vadim E. Seleznev
Advances in Mechanical Engineering , 2011, DOI: 10.1155/2011/765739
Abstract: At present day, pipe mill engineers have to deal with challenging technological problems of heavy-wall and high-strength line pipe manufacturing. Numerical analysis of welded large-diameter pipe manufacturing stages is the most efficient way to solve these problems. Corresponding computational technologies and applied software were developed at Physical & Technical Center. Numerical structural analysis of steel plates at various stages of line pipe manufacturing is performed by the finite element method, accounting for geometric and material nonlinearities. The only thing to be done by the engineer in such analysis is to specify required input parameters. All the further process is software controlled. The discrepancy between the numerical analysis results and measured data in the overwhelming majority cases did not exceed 1%. 1. Introduction The fast growth of energy consumption in the world guaranties a stable growth of demand for welded large-diameter pipes, which are used in the construction of oil and gas trunk lines. Most of such pipes are made from steel plates by the so-called UOE process. UOE stands for a series of three basic steel plate forming processes in pipe manufacturing: U for forming the steel sheet to the U-shape (U-ing), O for forming the U-shape to the O-shape (O-ing), and E for expanding the formed and welded pipe to the specified diameter (expansion). The characteristic feature of this process is elastic-plastic deformation of cold steel plates at each process stage. In addition, longitudinal welding is accompanied by the formation of hot spots in pipe walls. Thus, each manufactured line pipe possesses some nonuniform residual stress state. Such residual stress state determines the key measures of pipe quality, such as deviations from specified diameter and specified wall thickness, out-of-roundness of cross-sections, straightness of longitudinal sections, end squareness, and so forth. A large number of trans- and intercontinental trunk lines are being constructed today for oil and natural gas transmission. Such trunk lines contain a large number of segments, which are laid in tough locations. Such tough locations include, first of all, high-mountain and seismically active regions, permafrost regions, seas, and oceans. In order to meet applicable safety standards, pipeline system segments laid in critical areas are usually assigned higher design safety margins. In addition, pipes supplied for the construction of such segments are subject to more stringent standard dimensional requirements. In order to satisfy such strict
On possibility of realization NEUTRINO-4 experiment on search for oscillations of the reactor antineutrino into a sterile state
A. P. Serebrov,A. K. Fomin,V. G. Zinoviev,V. G. Ivochkin,Yu. E. Loginov,G. A. Petrov,V. A. Solovey,A. V. Chernyi,O. M. Zherebtsov,R. M. Samoylov,V. P. Martemyanov,V. G. Tsinoev,V. G. Tarasenkov,V. I. Aleshin,A. L. Petelin,S. V. Pavlov,M. N. Svyatkin,A. L. Izhutov,S. A. Sazontov,D. K. Ryazanov,M. O. Gromov,V. V. Afanasiev,V. I. Rykalin
Physics , 2013,
Abstract: One has investigated possibility of performing NEUTRINO-4 experiment on search for reactor neutrino oscillations into a sterile state at research reactors. The simulated experiment has been conducted at 16 MW reactor WWR-M in PNPI with the purpose of implementing a full scale experiment with the help of 100 MW reactor SM-3 in RIAR. Background conditions for making such an experiment have been examined at both reactors. The conclusion has been made on possible implementation of a full scale experiment NEUTRINO-4 at the reactor SM-3 in RIAR.
Modeling of Spray System Operation under Hydrogen and Steam Emissions in NPP Containment during Severe Accident
Vadim E. Seleznev,Vladimir V. Aleshin,Sergey N. Pryalov
Science and Technology of Nuclear Installations , 2011, DOI: 10.1155/2011/284274
Abstract: The paper describes one of the variants of mathematical models of a fluid dynamics process inside the containment, which occurs in the conditions of operation of spray systems in severe accidents at nuclear power plant. The source of emergency emissions in this case is the leak of the coolant or rupture at full cross-section of the main circulating pipeline in a reactor building. Leak or rupture characteristics define the localization and the temporal law of functioning of a source of emergency emission (or accrued operating) of warmed up hydrogen and steam in the containment. Operation of this source at the course of analyzed accident models should be described by the assignment of the relevant Dirichlet boundary conditions. Functioning of the passive autocatalytic recombiners of hydrogen is described in the form of the complex Newton boundary conditions.
Dynamic and Quasistatic Trajectories in Quasifission Reactions and Particle Emission
V. P. Aleshin,M. Centelles,X. Vi?as,N. G. Nicolis
Physics , 2000, DOI: 10.1016/S0375-9474(00)00371-7
Abstract: We show that the quasifission paths predicted by the one-body dissipation dynamics, in the slowest phase of a binary reaction, follow a quasistatic path, which represents a sequence of states of thermal equilibrium at a fixed value of the deformation coordinate. This establishes the use of the statistical particle-evaporation model in the case of dynamical time-evolving systems. Pre- and post-scission multiplicities of neutrons and total multiplicities of protons and alpha particles in fission reactions of 63Cu+92Mo, 60Ni+100Mo, 63Cu+100Mo at 10 MeV/u and 20Ne+144,148,154Sm at 20 MeV/u are reproduced reasonably well with statistical model calculations performed along dynamic trajectories whose slow stage (from the most compact configuration up to the point where the neck starts to develop) lasts some 35x10^{-21} s.
Creation of a neutrino laboratory for search for sterile neutrino at SM-3 reactor
A. P. Serebrov,V. G. Ivochkin,R. M. Samoylov,A. K. Fomin,V. G. Zinoviev,P. V. Neustroev,V. L. Golovtsov,N. V. Gruzinsky,V. A. Solovey,A. V. Cherniy,O. M. Zherebtsov,V. P. Martemyanov,V. G. Zinoev,V. G. Tarasenkov,V. I. Aleshin,A. L. Petelin,S. V. Pavlov,A. L. Izhutov,S. A. Sazontov,D. K. Ryazanov,M. O. Gromov,V. V. Afanasiev,L. N. Matrosov,M. Yu. Matrosova
Physics , 2015,
Abstract: In connection with the question of possible existence of sterile neutrino the laboratory on the basis of SM-3 reactor was created to search for oscillations of reactor antineutrino. A prototype of a neutrino detector with scintillator volume of 400 l can be moved at the distance of 6-11 m from the reactor core. The measurements of background conditions have been made. It is shown that the main experimental problem is associated with cosmic radiation background. Test measurements of dependence of a reactor antineutrino flux on the distance from a reactor core have been made. The prospects of search for oscillations of reactor antineutrino at short distances are discussed.
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