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Mycobacterial culture of fine needle aspirate - A useful tool in diagnosing tuberculous lymphadenitis
Kishore Reddy V,Aparna S,Prasad C,Srinivas A
Indian Journal of Medical Microbiology , 2008,
Abstract: A prospective study was undertaken on suspected lymph node TB (LNTB) patients, to evaluate the diagnostic utility of mycobacterial culture of fine needle aspirate (FNA), in comparison with the cytological examination and acid fast staining. Eighty percent of 157 aspirates studied were positive by cytological examination; 18% by ZN smear and 45% were positive by culture. Twelve aspirates which were negative by cytological features yielded positive mycobacterial cultures; four out of these were from HIV positive patients. Our observations suggest that supplementing FNA cytology with mycobacterial culture would increase the sensitivity of diagnosing LNTB; in addition to giving a highly specific diagnosis.
Pulmonary tuberculosis: A comparative study of conventional methods and serological diagnosis
Mohammed Khaleel,N. K. Saxena,V. C. Kishore Reddy
Journal of Medical and Allied Sciences , 2011,
Abstract: The objective of the study was to evaluate mycobacterial identification and isolation rates obtained by different conventional methods. Sputum and serum samples were taken from 80 clinically diagnosed pulmonary tuberculosis (PTB) cases. Smear microscopy alone showed an efficacy of 85%, culture 90% and serology 72.5%, in diagnosis of PTB. The efficacy of smear microscopy increased by examining more than one sputum sample to about 98%. The correlation between smear, culture and serology was assessed. Further investigation of smear-negative cases with culture examination was done. Concomitant x-ray studies delineated the location and extent of the lesion, mostly exudative type confined to upper zone. The culture isolates subjected to drug susceptibility test, showed 27% multi-drug resistant strains.
A Stability Indicating UPLC Method for Finasteride and Its Related Impurities  [PDF]
Y. Koti Reddy, G. V. Subba Reddy, K. N. Jaya Veera, Kishore Kumar Hotha
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.311098
Abstract: The objective of the present research work is to develop a gradient, reversed-phase liquid chromatographic (RP-UPLC) method for the determination of Finasteride in pharmaceutical bulk drugs for assay and its related impurities. The chromatographic separation was achieved on a Waters ACQUITY UPLC BEH Phenyl Column (150 mm × 2.1 mm, 1.7 μm), The gradient LC method employs solutions A and B as mobile phase. The solution A Contains 2.5 mM ortho phosphoric acid (Buffer) and solution B contains a mixture of acetonitrile and water in the ratio of (90:10 v/v). The flow rate was 0.22 ml/min and the detection wavelength was 210 nm. In the developed UPLC method, the resolution between Finasteride and its potential impurities, namely Imp-1, Imp-2, Imp-3 and Imp-4 was found to be greater than 2.0. The drug was subjected to stress conditions of hydrolysis, oxidation, photolysis and thermal degradation. Considerable degradation was found to occur in alkaline medium and oxidative stress conditions. Degradation product formed during oxidative hydrolysis was found to be Imp-1. The stress samples were assayed against a qualified reference standard and the mass balance was found close to 99.5%. The developed RP-UPLC method was validated with respect to linearity, accuracy, precision and robustness. The limit of quantification of Imp-1, Imp-2, Imp-3 and Imp-4 were 0.06, 0.06, 0.05 and 0.036% (of analyte concentration, i.e. 0.5 mg/ml) with 1μl injection volume. The developed method was found to be linear in the range of 2.5 - 15 μg/mL with correlation coefficient of 0.999 for assay procedures and found to be linear in the range of 0.05 - 3 μg/mL with correlation coefficient of 0.999 for related impurities.
Modeling and simulation of thirty bus system with D-STATCOM for power quality improvement
P. Venkata Kishore,S. Rama Reddy,,P. V. Kishore
International Journal of Engineering Science and Technology , 2010,
Abstract: This work deals with power quality improvement of thirty bus system using D-STATCOM. The thirty bus system is modeled using the elements of simulink. This model is used for conducting the simulation studies. The simulation results of the thirty bus system with and without D-STATCOM are presented. Power Quality improvement is observed by adding D-STATCOM in the existing network.
A Frame Synchronization and Frequency Offset Estimation Algorithm for OFDM System and its Analysis
Kishore Ch Nanda,Reddy V Umapathi
EURASIP Journal on Wireless Communications and Networking , 2006,
Abstract: Orthogonal frequency division multiplexing (OFDM) is a parallel transmission scheme for transmitting data at very high rates over time dispersive radio channels. In an OFDM system, frame synchronization and frequency offset estimation are extremely important for maintaining orthogonality among the subcarriers. In this paper, for a preamble having two identical halves in time, a timing metric is proposed for OFDM frame synchronization. The timing metric is analyzed and its mean values at the preamble boundary and in its neighborhood are evaluated, for AWGN and for frequency selective channels with specified mean power profile of the channel taps, and the variance expression is derived for AWGN case. Since the derivation of the variance expression for frequency selective channel case is tedious, we used simulations to estimate the same. Based on the theoretical value of the mean and estimate of the variance, we suggest a threshold for detection of the preamble boundary and evaluating the probability of false and correct detections. We also suggest a method for a threshold selection and the preamble boundary detection in practical applications. A simple and computationally efficient method for estimating fractional and integer frequency offset, using the same preamble, is also described. Simulations are used to corroborate the results of the analysis. The proposed method of frame synchronization and frequency offset estimation is applied to the downlink synchronization in OFDM mode of wireless metropolitan area network (WMAN) standard IEEE 802.16-2004, and its performance is studied through simulations.
Effect of Y on the Properties of Sm-Doped Ceria for IT-SOFC Applications  [PDF]
V. Venkatesh, C. Vishnuvardhan Reddy
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.411181
Abstract:

The co-doped ceria-based materials with general composition formula Ce0.8-xYxSm0.2O2-δ (x = 0, 0.02, 0.04, 0.06) were prepared through the sol-gel method. The single phase of the prepared materials was confirmed by X-ray diffraction (XRD). The lattice parameters were determined by least square fitting of UNIT CELL programme. The linear variation of lattice parameter with concentration of Y into the samarium doped ceria (SDC) indicates the validity of Vegard’s law. The crystallite size of the samples obtained by using of Scherrer formula is in the range from 34 nm to 49 nm. The thermal expansion studies were carried out by using dilatometric technique in the temperature range from room temperature to 1000°C. It was observed that the thermal expansion increased linearly with increasing temperature for all the samples. The electrical conductivity was studied using impedance spectroscopy. It was observed that the composition Ce0.74Y0.06Sm0.2O2-

A Multi-Site Validation in India of the Line Probe Assay for the Rapid Diagnosis of Multi-Drug Resistant Tuberculosis Directly from Sputum Specimens
Neeraj Raizada, K. S. Sachdeva, D. S. Chauhan, Bharti Malhotra, Kishore Reddy, P. V. Dave, Yamuna Mundade, Pranav Patel, Ranjani Ramachandran, Ram Das, Rajesh Solanki, Douglas Fraser Wares, Suvanand Sahu, Rick O'Brien, C. N. Paramasivan, Puneet K. Dewan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088626
Abstract: Rifampicin (R) and isoniazid (H) are key first-line anti-tuberculosis drugs. Failure to detect resistance to these two drugs early results in treatment failure and poor clinical outcomes. The study purpose was to validate the use of the GenoType MTBDRplus line probe assay (LPA) to detect resistance to R and H in Mycobacterium tuberculosis strains directly from smear-positive sputum samples in India. Method Smear positive sputum specimens from 320 patients were subjected to LPA and results compared against those from conventional Lowenstein Jensen (LJ) culture and drug susceptibility testing (C&DST). All specimens with discordant R DST results were subjected to either sequencing of the rpoB gene and/or repeat DST on liquid culture (MGIT 960) at a National Reference Laboratory. Results Significantly higher proportion of interpretable results were observed with LPA compared to LJ C&DST (94% vs. 80%, p-value <0.01). A total of 248 patients had both LJ and LPA DST results available; 232 (93.5%) had concordant R DST results. Among the 16 discordant R DST results, 13 (81%) were resolved in agreement with LPA results. Final LPA performance characteristics were sensitivity 96% (CI: 90%–98%), specificity 99% (CI: 95%–99%), positive predictive value 99% (CI: 95%–99%), and negative predictive value 95% (CI: 89%–98%). The median turnaround testing time, including specimen transportation time, on LPA was 11 days as compared with 89 days for LJ C&DST. Conclusions LPA proved highly accurate in the rapid detection of R resistance. The reduction in time to diagnosis may potentially enable earlier commencement of the appropriate drug therapy, leading to some reduction of transmission of drug-resistant strains.
Development and validation of stability indicating HPLC method for the estimation of Telmisartan related substances in tablets formulation
Ch. Phani Kishore, V. Bhanuprakash Reddy, Dhanashri M Kale
International Journal of Research in Pharmaceutical Sciences , 2010,
Abstract: A sensitive HPLC method was developed and validated for the estimation of Telmisartan related impurities in tablets formulation. The highly polar molecule requires aqueous mobile phase for the elution and separation of Telmisartan and its impurities (Impurity A, B, E and F official in EP).The developed method is found to be specific, reproducible, and stability indicating. The X-Bridge C18 150x4.6mm 3.5μ column was used and mobile phase consisted of 25mM potassium dihydrogen phosphate (KH2PO4) and 10mM of 1-hexaneusulphonic acid, sodium salt monohydrate buffer to achieve good resolution and retention of the analyte and its impurities. The detector linearity was established from concentrations ranging from 0.08μg/mL to 500μg/mL for Telmisartan and from 0.017 to 3.0 μg/mL for related impurities with a correlation co-efficient of 0.997.The relative response factor (RRF) values of impurityA, impurityE, impurityF, impurityB, TEL2, Dimer acid and Chloro analogue determined from linearity plots were 1.27,0.43,0.83,1.02,0.81,0.80 and 0.84 respectively. The limit of detection (LOD) and limit of quantification (LOQ) found to be in the range of 0.023μg/mL to 0.190 μg/mL for Telmisartan and impurities respectively. The molecule is forced to all stress conditions such as acid, base, oxidation, heat and photolysis as per the recommendations of ICH guidelines. All degradants are well separated from the main analyte. The method is proved to be robust with respect to change in flow rate, pH, organic phase composition and column temperature. The proposed method is found to be sensitive, precise, rapid, reproducible, and offers good column life.
Expression of antixenosis and antibiosis components of resistance to spotted stem borer Chilo partellus in sorghum under greenhouse conditions
V Kishore Kumar,K Dharma Reddy,HC Sharma
Journal of SAT Agricultural Research , 2007,
Abstract:
Iodine catalyzed and tertiary butyl ammonium bromide promoted p reparation of b enzoxazaphosphininyl phenylboronates
K. R. Kishore K. Reddy,,C. Bhupendra Reddy,,K. Suresh Kumar,,C. Naga Raju
Organic Communications , 2009,
Abstract: Benzoxazaphosphininyl Phenylboronates were prepared by O-Phosphorylation of potassium salt ofphenylboronic acid with cyclic phosphoromonochloridates in the presence of stoichiometric amount of Iodineand catalytic amount of tertiary butyl ammonium bromide at 50-60 °C in dry toluene.
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