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Search Results: 1 - 10 of 130386 matches for " V. Agache "
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Management of hypersensivity pneumonitis
Ioana O Agache, Liliana Rogozea
Clinical and Translational Allergy , 2013, DOI: 10.1186/2045-7022-3-5
Abstract:
Alteration of superconductivity of suspended carbon nanotubes by deposition of organic molecules
M. Ferrier,A. Yu. Kasumov,V. Agache,L. Buchaillot,A-M. Bonnot,C. Naud,V. Bouchiat,R. Deblock,M. Kociak,M. Kobylko,S. Gueron,H. Bouchiat
Physics , 2005, DOI: 10.1103/PhysRevB.74.241402
Abstract: We have altered the superconductivity of a suspended rope of single walled carbon nanotubes, by coating it with organic polymers. Upon coating, the normal state resistance of the rope changes by less than 20 percent. But superconductivity, which on the bare rope shows up as a substantial resistance decrease below 300 mK, is gradualy suppressed. We correlate this to the suppression of radial breathing modes, measured with Raman Spectroscopy on suspended Single and Double-walled carbon nanotubes. This points to the breathing phonon modes as being responsible for superconductivity in carbon nanotubes.
Dysfunctional breathing phenotype in adults with asthma - incidence and risk factors
Ioana Agache, Cristina Ciobanu, Gabriela Paul, Liliana Rogozea
Clinical and Translational Allergy , 2012, DOI: 10.1186/2045-7022-2-18
Abstract: Adult patients aged 17–65 with diagnosed asthma were screened for DB using the Nijmegen questionnaire (positive predictive score >23) and confirmed by progressive exercise testing. The following were evaluated as independent risk factors for DB in the multiple regression analysis: female sex; atopy, obesity, active smoker, moderate/severe rhinitis, psychopathology, GERD, arterial hypertension; severe asthma, asthma duration > 5 years, lack of asthma control, fixed airway obstruction, fast lung function decline, frequent exacerbator and brittle asthma phenotypes; lack of ICS, use of LABA or LTRA.91 adults with asthma, mean age 35.04 ±1.19 years, 47(51.65%) females were evaluated. 27 (29.67%) subjects had a positive screening score on Nijmegen questionnaire and 16(17.58%) were confirmed by progressive exercise testing as having DB. Independent risk factors for DB were psychopathology (p = 0.000002), frequent exacerbator asthma phenotype (p = 0.01) and uncontrolled asthma (p < 0.000001).Dysfunctional breathing is not infrequent in asthma patients and should be evaluated in asthma patients presenting with psychopathology, frequent severe asthma exacerbations or uncontrolled asthma. Asthma medication (ICS, LABA or LTRA) had no significant relation with dysfunctional breathing.Dysfunctional breathing (DB) is defined as chronic or recurrent changes in breathing pattern that cannot be attributed to a specific medical diagnosis, causing respiratory and non-respiratory complaints such as anxiety, light headedness and fatigue. Symptoms of DB include dyspnea with normal lung function, chest tightness, chest pain, deep sighing, exercise-induced breathlessness, frequent yawning and hyperventilation [1-6]. There is no gold standard for the diagnosis of DB beyond the clinical description. The Nijmegen Questionnaire can be used to discriminate dysfunctional breathers from normal individuals in adults [7]. For moderate to severe asthma a positive Nijmegen score might overestimate the
Antinuclear Antibodies in Asthma Patients- A Special Asthma Phenotype?
Ioana Agache,Liliana Duca,Mariana Anghel,Gheorghe Pamfil
Iranian Journal Of Allergy, Asthma and Immunology , 2009,
Abstract: Several studies reported the appearance of asthma and autoimmune conditions in the same patient, but the clinical significance of this association was not yet assessed. One hundred asthmatic patients were observed for one year evolution with death, severe exacerbations, intake of > 1000 micrograms of beclometasone or equivalent (high ICS) and FEV1 decline >100 ml, in relation with ANA (ELISA), sputum and blood eosinophilia (EO), NSAID intolerance, BMI >25, chronic rhinosinusitis, smoking status and FEV1 <30% predicted (low FEV1). After 1 year of observation, there were 5 deaths, 28 severe asthma exacerbations requiring hospitalisations, 24 cases requiring high inhaled corticosteroid intake, and 19 patients with fast FEV1 decline (>100 ml/year). Multiple regression analysis pointed out several different independent risk factors for severe asthma evolution: for death presence of ANA (P=0.037), NSAID intolerance (P<0.001) and low FEV1 (P=0.021); for evolution with severe exacerbations ANA (p=0.011), sputum EO (P<0.001), smoking (P=0.044) and NSAID intolerance (P=0.022); for high ICS intake ANA (P=0.036), sputum EO (P=0.026) and low FEV1 (P=0.006); for FEV1 decline >100 ml ANA (P=0.006), sputum EO (P=0.037), BMI>25 (P=0.046) and NSAID intolerance (P=0.017)The presence of ANA is an independent risk factor in asthma for evolution with death, severe exacerbations, high inhaled corticosteroid intake and FEV1 decline >100 ml.
Antitumor Effects of Combining Docetaxel (Taxotere) with the Antivascular Action of Ultrasound Stimulated Microbubbles
David E. Goertz, Margarita Todorova, Omid Mortazavi, Vlad Agache, Branson Chen, Raffi Karshafian, Kullervo Hynynen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052307
Abstract: Ultrasound stimulated microbubbles (USMB) are being investigated for their potential to promote the uptake of anticancer agents into tumor tissue by exploiting their ability to enhance microvascular permeability. At sufficiently high ultrasound transmit amplitudes it has also recently been shown that USMB treatments can, on their own, induce vascular damage, shutdown blood flow, and inhibit tumor growth. The objective of this study is to examine the antitumor effects of ‘antivascular’ USMB treatments in conjunction with chemotherapy, which differs from previous work which has sought to enhance drug uptake with USMBs by increasing vascular permeability. Conceptually this is a strategy similar to combining vascular disrupting agents with a chemotherapy, and we have selected the taxane docetaxel (Taxotere) for evaluating this approach as it has previously been shown to have potent antitumor effects when combined with small molecule vascular disrupting agents. Experiments were conducted on PC3 tumors implanted in athymic mice. USMB treatments were performed at a frequency of 1 MHz employing sequences of 50 ms bursts (0.00024 duty cycle) at 1.65 MPa. USMB treatments were administered on a weekly basis for 4 weeks with docetaxel (DTX) being given intravenously at a dose level of 5 mg/kg. The USMB treatments, either alone or in combination with DTX, induced an acute reduction in tumor perfusion which was accompanied at the 24 hour point by significantly enhanced necrosis and apoptosis. Longitudinal experiments showed a modest prolongation in survival but no significant growth inhibition occurred in DTX–only and USMB-only treatment groups relative to control tumors. The combined USMB-DTX treatment group produced tumor shrinkage in weeks 4–6, and significant growth inhibition and survival prolongation relative to the control (p<0.001), USMB-only (p<0.01) and DTX-only treatment groups (p<0.01). These results suggest the potential of enhancing the antitumor activity of docetaxel by combining it with antivascular USMB effects.
A Formal Approach for the Development of Service-Oriented Applications
Lorina Negreanu,Cristian Giumale,Alexandru Agache,Mihnea Muraru,Matei Popovici,Ciprian Dobre
Computer Science , 2012,
Abstract: Please cite this as "Lorina Negreanu, Cristian Giumale, Alexandru Agache, Mihnea Muraru, Matei Popovici, Ciprian Dobre, A Formal Approach for the Development of Service-Oriented Applications, in Proc. of 18th International Conference on Control Systems and Computer Science (CSCS-18), Bucharest, Romania, 2011, pp. 804-810, ISSN: 2066-4451, Politehnica Press"
Optimization of Liquid DiElectroPhoresis (LDEP) Digital Microfluidic Transduction for Biomedical Applications
Rapha?l Renaudot,Vincent Agache,Bruno Daunay,Pierre Lambert,Momoko Kumemura,Yves Fouillet,Dominique Collard,Hiroyuki Fujita
Micromachines , 2011, DOI: 10.3390/mi2020258
Abstract: Digital microfluidic has recently been under intensive study, as an effective method to carry out liquid manipulation in Lab-On-a-Chip (LOC) systems. Among droplet actuation forces, ElectroWetting on Dielectric (EWOD) and Liquid DiElectroPhoresis (LDEP) are powerful tools, used in many LOC platforms. Such digital microfluidic transductions do not require integration of complex mechanical components such as pumps and valves to perform the fluidic operations. However, although LDEP has been proved to be efficient to carry and manipulate biological components in insulating liquids, this microfluidic transduction requires several hundreds of volts at relatively high frequencies (kHz to MHz). With the purpose to develop integrated microsystems μ-TAS (Micro Total Analysis System) or Point of Care systems, the goal here is to reduce such high actuation voltage, the power consumption, though using standard dielectric materials. This paper gives key rules to determine the best tradeoff between liquid manipulation efficiency, low-power consumption and robustness of microsystems using LDEP actuation. This study leans on an electromechanical model to describe liquid manipulation that is applied to an experimental setup, and provides precise quantification of both actuation voltage Vth and frequency fc thresholds between EWOD and LDEP regimes. In particular, several parameters will be investigated to quantify Vth and fc, such as the influence of the chip materials, the electrodes size and the device configurations. Compared to current studies in the field, significant reduction of both Vth and fc is achieved by optimization of the aforementioned parameters.
A direct comparison of efficacy between desloratadine and rupatadine in seasonal allergic rhinoconjunctivitis: a randomized, double-blind, placebo-controlled study
Lukat KF, Rivas P, Roger A, Kowalski ML, Botzen U, Wessel F, Sanquer F, Agache I, Izquierdo I
Journal of Asthma and Allergy , 2013, DOI: http://dx.doi.org/10.2147/JAA.S39496
Abstract: direct comparison of efficacy between desloratadine and rupatadine in seasonal allergic rhinoconjunctivitis: a randomized, double-blind, placebo-controlled study Original Research (766) Total Article Views Authors: Lukat KF, Rivas P, Roger A, Kowalski ML, Botzen U, Wessel F, Sanquer F, Agache I, Izquierdo I Published Date February 2013 Volume 2013:6 Pages 31 - 39 DOI: http://dx.doi.org/10.2147/JAA.S39496 Received: 23 October 2012 Accepted: 06 December 2012 Published: 22 February 2013 KF Lukat,1 P Rivas,2 A Roger,3 ML Kowalski,4 U Botzen,5 F Wessel,6 F Sanquer,7 I Agache,8 I Izquierdo9 Investigators working group clinical trial 1Institute Respiratory Science, Dusseldorf, Germany; 2Hospital Viladecans, ENT Department, Barcelona, Spain; 3Hospital Universitario “German Trias i Pujol,” Badalona, Spain; 4Medical University of Lodz, Immunology, Rheumatology, and Allergy, Lodz, Poland; 5ENT, private consult, Solingen, Germany; 6Allergologist, Private Practice, Nantes, France; 7Allergologist, Private Practice, Bordeaux, France; 8Medical Clinical SC Radoi Mariana SRL, Brasov, Romania; 9Clinical Research and Development, J Uriach y Compa ia, SA Barcelona, Spain Background: H1-antihistamines are recommended as the first-line symptomatic treatment of allergic rhinitis. The objective of this study was to evaluate the effects of rupatadine (RUP) versus desloratadine (DES) in subjects with seasonal allergic rhinitis (SAR). Method: To assess the efficacy and safety of RUP in SAR in comparison with placebo (PL) and DES. A randomized, double-blind, multicenter, international, and PL-controlled study was carried out. The main selection criteria included SAR patients over 12 years old with a positive prick test to a relevant seasonal allergen for the geographic area. Symptomatic patients at screening with a nasal symptom sum score of ≥6 points (nasal discharge, nasal obstruction, sneezing, and nasal pruritus), a non-nasal score of ≥3 points (ocular pruritus, ocular redness, and tearing eyes), and a rhinorrhea score of ≥2 points with laboratory test results and electrocardiography within acceptable limits were included in the study. Change from baseline in the total symptom-score (T7SS) over the 4-week treatment period (reflective evaluation) was considered the primary efficacy variable. Secondary efficacy measures included total nasal symptom score (T4NSS) and conjunctival symptom score (T3NNSS), both of which are reflective and instantaneous evaluations. Furthermore questions related to quality of life (eg, sleep disturbances or impairment of daily activities) have also been evaluated. Safety was assessed according to adverse events reported, as well as laboratory and electrocardiography controls. Results: A total of 379 patients were randomized, of which 356 were included and allocated to PL (n = 122), RUP (n = 117), or DES (n = 117). Mean change of T7SS over the 4-week treatment period was significantly reduced in the RUP ( 46.1%, P = 0.03) and DES ( 48.9%, P = 0.
Nonsmooth Optimization Algorithms in Some Problems of Fracture Dynamics  [PDF]
V. V. Zozulya
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.211073
Abstract: Mathematical statement of elastodynamic contact problem for cracked body with considering unilateral restrictions and friction of the crack faces is done in classical and weak forms. Different variational formulations of unilateral contact problems with friction based on boundary variational principle are considered. Nonsmooth optimization algorithms of Udzawa’s type for solution of unilateral contact problem with friction have been developed. Convergence of the proposed algorithms has been studied numerically.
Precessing Ball Solitons as Self-Organizing Systems during a Phase Transition in a Ferromagnet  [PDF]
V. V. Nietz
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.410A3010
Abstract:

Precessing ball solitons (PBS) in a ferromagnet during the first order phase transition is induced by a magnetic field directed along the axis of anisotropy, while the action of the periodic field perpendicular to the main magnetic field has been analyzed. Under these conditions, the characteristics of arising equilibrium PBS are uniquely determined by the frequency of the periodic field, but the solitons with other frequencies are impossible. For such structure, the entropy increase connected with dissipation is compensated by the decrease of the entropy due to the external periodic field. It is shown that the equilibrium PBS are essentially the “self-organizing systems” that can arise spotaneously in a metastable state of ferromagnet.

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