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Search Results: 1 - 10 of 162304 matches for " Víctor Luis; Marrero Delange "
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Estudios organolépticos, fisicoquímicos, microbiológicos e interacción con excipientes farmacéuticos de un extracto purificado de cera de Apis mellifera
González Canavaciolo,Víctor Luis; Martínez álvarez,Luis; Marrero Delange,David; Sierra Pérez,Roxana Caridad;
Revista Cubana de Farmacia , 2010,
Abstract: the d002, an antioxidant active ingredient extracted from the apis mellifera bees wax was characterized from the physicochemical point of view analyzing its interaction with excipients of pharmaceutical interest. the d-002 is a creamy white odourless fluid powder with losses by £ 1 % dry; it is water and ethanol insoluble and very slightly soluble in other organic solvents. its composition, determined by gas chromatography was: 1-tetracosanol (6-15 %), 1-hexacosanol (7-20 %), 1-octacosanol (12-20 %), 1-triacontanol (25-35 %, 1-dotriacontanol (18-25 %) and 1-tetratriacontaol (£ 7,5 %) for 3 85 % of purity. it remained stable during 5 years in the iv climatic zone and its analysis by differential scanning calorimetry showed 2 fusion transitions at 59.0 and 81.1 °c. without decomposition, a high thermal stability up to 200 °c, as well as a lack of interactions with lactose, starch, sodium croscarmelosa, polyvinylpyrrolidone, microcrystalline cellulose, and magnesium stearate allowing the use of these excipients in tablets formula.
Estudios organolépticos, fisicoquímicos, microbiológicos e interacción con excipientes farmacéuticos de un extracto purificado de cera de Apis mellifera Organoleptic, physicochemical and microbiological studies and its interaction with pharmaceutical excipients of a purified extract from Apis mellifera wax
Víctor Luis González Canavaciolo,Luis Martínez álvarez,David Marrero Delange,Roxana Caridad Sierra Pérez
Revista Cubana de Farmacia , 2010,
Abstract: El D-002, ingrediente activo antioxidante extraído de la cera de abejas Apis mellifera, fue caracterizado desde el punto de vista físicoquímico, de igual forma se analizó su interacción con excipientes de interés farmacéutico. El D-002 es un polvo fluido inodoro de color blanco a crema, con pérdidas por secado £ 1 %; es insoluble en agua y etanol, y muy ligeramente soluble en otros disolventes orgánicos. Su composición, determinada por cromatografía de gases, fue: 1-tetracosanol (6-15 %), 1-hexacosanol (7-20 %), 1-octacosanol (12-20 %), 1-triacontanol (25-35 %) 1-dotriacontanol (18-25 %) y 1-tetratriacontanol (£ 7,5 %), para una pureza 3 85 %. Fue estable durante 5 a os en la zona climática IV y su análisis por calorimetría diferencial de barrido mostró 2 transiciones de fusión a 59,0 y 81,1 °C sin descomposición, una alta estabilidad térmica hasta 200 °C, así como la ausencia de interacciones con lactosa, almidón, croscarmelosa sódica, polivinil pirrolidona, celulosa microcristalina y estearato de magnesio, lo que posibilita el empleo de estos excipientes en la formulación de las tabletas. The D002, an antioxidant active ingredient extracted from the Apis mellifera bees wax was characterized from the physicochemical point of view analyzing its interaction with excipients of pharmaceutical interest. The D-002 is a creamy white odourless fluid powder with losses by £ 1 % dry; it is water and ethanol insoluble and very slightly soluble in other organic solvents. Its composition, determined by gas chromatography was: 1-tetracosanol (6-15 %), 1-hexacosanol (7-20 %), 1-octacosanol (12-20 %), 1-triacontanol (25-35 %, 1-dotriacontanol (18-25 %) and 1-tetratriacontaol (£ 7,5 %) for 3 85 % of purity. It remained stable during 5 years in the IV climatic zone and its analysis by differential scanning calorimetry showed 2 fusion transitions at 59.0 and 81.1 °C. without decomposition, a high thermal stability up to 200 °C, as well as a lack of interactions with lactose, starch, sodium croscarmelosa, polyvinylpyrrolidone, microcrystalline cellulose, and magnesium stearate allowing the use of these excipients in tablets formula.
Determinación de alcoholes grasos en el ingrediente activo D004 por cromatografía de gases-espectrometría de masas
Marrero Delange,David; Rodríguez Leyes,Eduardo Antonio; González Canavaciolo,Víctor Luis; Adames Fajardo,Yuliamny; Vicente Murillo,Roxana;
Revista Cubana de Plantas Medicinales , 2012,
Abstract: introduction: d004, a new lipid extract purified from the cuban royal palm (roystonea regia [kunth] f. cook) fruits, has been shown to be effective in experimental models of prostate hyperplasia, and to exhibit antioxidant and anti-inflammatory effects. objectives: to identify the fatty alcohols that could be present in d004 active ingredient using gas chromatography-mass spectrometry. methods: samples of nine batches of d004 were submitted to saponification with koh/etoh solution and the unsaponifiable fractions were extracted with n-hexane. the alcohols were analyzed as trimetilsilil derivatives, which were obtained by reaction with mstfa. the quantification was carried out by the internal standard method using 1-eicosanol. results: the total content of alcohols in d004 ranged from 0.18 to 5.10 %. this fraction was mainly composed of 1-octacosanol (52.94 %), 1-triacontanol (25.91 %), and 1-hexacosanol (14.40 %); whereas the minority components were 1-docosanol, 1-tricosanol, 1-tetracosanol, 1-pentacosanol, 1-heptacosanol, 1-nonacosanol, 1-dotriacontanol 1-tetratriacontanol, 1-tetradecanol, 1-pentadecanol, 1-hexadecanol, 1-octadecanol and 1-eicosanol were minor components, being the last six alcohols present in trace levels. conclusions: fatty alcohols were identified and quantified in d004 active ingredient by gas chromatography-mass spectrometry. the major components were 1-octacosanol, 1-triacontanol and 1-hexacosanol.
Determinación de esteroles en la fracción insaponificable del aceite de los frutos de la palma real cubana (Roystonea regia) Determination of sterols determination in unsaponifiable fraction from Cuban royal palm (Roystonea regia) fruit oil
David Marrero Delange,Eduardo Antonio Rodríguez Leyes,Víctor Luis González Canavaciolo,Carmen Luisa Morales Rico
Revista Cubana de Farmacia , 2013,
Abstract: Introducción: los esteroles han sido ampliamente estudiados por su importancia nutricional y farmacéutica. Sin embargo, para nuestro conocimiento, la composición de esteroles del aceite de los frutos de la palma real cubana (Roystonea regia) no ha sido determinada hasta el momento. Objetivos: determinar la composición de esteroles que pudieran estar presentes en la fracción insaponificable del aceite de R. regia mediante CG-EM. Métodos: muestras de dos lotes de aceite de R. regia fueron sometidas al procedimiento para la determinación de esteroles establecido por el del Instituto de Nutracéuticos de los EE.UU., el cual consiste, fundamentalmente, en una saponificación con disolución de KOH/EtOH y posterior extracción con n-hexano de las fracciones insaponificables. Las fracciones obtenidas fueron analizadas por CG-EM como derivados TMS e identificadas por comparación de sus espectros con los de patrones comerciales y los de la base de espectros Wiley. Para la cuantificación se utilizó el colestano como patrón interno. Resultados: en la fracción insaponificable del aceite de R. regia se encontró un contenido total de esteroles de 66,1%; lo que representa un 0,14 % del aceite. La fracción de esteroles, estuvo compuesta principalmente por a -sitosterol (51,2 %), estigmasterol (9,6 %), campesterol (9,2 %), 24-metilen-cicloartanol (9,2 %), 5-avenasterol (8,9 %), cicloartanol (7,5 %); además de otros componentes minoritarios como cicloartenol, -sitosterol y colesterol. Conclusiones: se identificaron y se cuantificaron mediante CG-EM los esteroles de la fracción insaponificable del aceite de R. regia, en la cual el a-sitosterol resultó el componente mayoritario. Estos resultados son una contribución al estudio de la composición química de dicho aceite y pudieran avalar su posible utilidad nutricional y seguridad. Introduction: sterols have been widely studied because of their pharmaceutical and nutritional importance. However, to our knowledge, the sterol composition of the oil from the Cuban Royal Palm fruits (Roystonea regia (Kunth) F. Cook), has not been yet identified Objectives: to determine by GC-MS the sterols that could be present in the unsaponifiable fraction of R. regia oil. Methods: samples of two batches of R. regia oil were subjected to the established procedure of the US Institute for Nutraceutical Advancement to determine sterols, which mainly consists of saponification with KOH/EtOH solution and a subsequent extraction of the unsaponifiable fractions by using n-hexane. These fractions were analyzed by GC-MS as TMS derivatives and they were id
Determinación de alcoholes grasos en el ingrediente activo D004 por cromatografía de gases-espectrometría de masas Determination of fatty alcohols in D-004 active ingredient by using gas chromatography-mass spectrometry
David Marrero Delange,Eduardo Antonio Rodríguez Leyes,Víctor Luis González Canavaciolo,Yuliamny Adames Fajardo
Revista Cubana de Plantas Medicinales , 2012,
Abstract: Introducción: el D004, nuevo extracto lipídico purificado a partir de los frutos de la palma real cubana (Roystonea regia [Kunth] F. Cook), ha mostrado ser efectivo en modelos experimentales de hiperplasia prostática, y ha mostrado efectos antioxidantes y antiiflamatorios. Objetivos: identificar los alcoholes que pudieran estar presentes en el ingrediente activo D004 utilizando la cromatografía de gases acoplada a espectrometría de masa. Métodos: muestras de 9 lotes de D004 se sometieron a saponificación con una disolución de KOH/EtOH y las fracciones insaponificables fueron extraídas con n-hexano. Los alcoholes se analizaron como derivados trimetilsilil, obtenidos por reacción con N-metil, N-trimetilsilil trifluoroacetamida. La cuantificación se basó en el empleo de 1-eicosanol como patrón interno. Resultados: el D004 presenta un contenido total de alcoholes entre 0,18 y 5,10 %. Esta fracción está compuesta principalmente por 1-octacosanol (52,94 %), 1-triacontanol (25,91 %) y 1-hexacosanol (14,40 %); y presenta como componentes minoritarios: 1-docosanol, 1-tricosanol, 1-tetracosanol, 1-pentacosanol, 1-heptacosanol, 1-nonacosanol, 1-dotriacontanol, 1-tetratriacontanol, 1-tetradecanol, 1-pentadecanol, 1-hexadecanol, 1-octadecanol y 1-eicosanol, los seis últimos en niveles de trazas. Conclusiones: se identificaron y se cuantificaron mediante cromatografía de gases acoplada a espectrometría de masa los alcoholes grasos en el ingrediente activo D004. Los componentes mayoritarios fueron 1-octacosanol, 1-triacontanol y 1-hexacosanol. Introduction: D004, a new lipid extract purified from the Cuban royal palm (Roystonea regia [Kunth] F. Cook) fruits, has been shown to be effective in experimental models of prostate hyperplasia, and to exhibit antioxidant and anti-inflammatory effects. Objectives: to identify the fatty alcohols that could be present in D004 active ingredient using gas chromatography-mass spectrometry. Methods: samples of nine batches of D004 were submitted to saponification with KOH/EtOH solution and the unsaponifiable fractions were extracted with n-hexane. The alcohols were analyzed as trimetilsilil derivatives, which were obtained by reaction with MSTFA. The quantification was carried out by the internal standard method using 1-eicosanol. Results: the total content of alcohols in D004 ranged from 0.18 to 5.10 %. This fraction was mainly composed of 1-octacosanol (52.94 %), 1-triacontanol (25.91 %), and 1-hexacosanol (14.40 %); whereas the minority components were 1-docosanol, 1-tricosanol, 1-tetracosanol, 1-pentacosanol, 1-heptacosanol, 1-no
Estudios preliminares de estabilidad de un extracto lipídico de los frutos de Roystonea regia en frascos de vidrio ámbar
Sierra Pérez,Roxana de la Caridad; Rodríguez Leyes,Eduardo Antonio; González Canavaciolo,Víctor Luis; Marrero Delange,David; Vicente Murillo,Roxana;
Revista Cubana de Farmacia , 2010,
Abstract: the d004 is a new active ingredient extracted from the cuban real palm (roystonea regia), promising in the treatment of the benign prostatic hyperplasia. to determine its stability in amber glass flasks studies were conducted where samples underwent different conditions. in stress situations d004 is sensitive to the thermal and oxidative degradation. under accelerated conditions (40 ± 2 oc ad 75 ± 5 % of relative humidity) there weren't significant changes in any assessed parameters during 12 months allowing predicting a useful life time of at least 2 years under less drastic conditions. it was corroborated under climatic conditions ii (25 ± 2oc and 60± 5% of relative humidity and iv (30 ± 2 oc and 70 ± 5 % of relative humidity).
Estudios preliminares de estabilidad de un extracto lipídico de los frutos de Roystonea regia en frascos de vidrio ámbar Preliminary studies of a lipid extract stability from the fruits of Roystonea regia in amber glass flasks
Roxana de la Caridad Sierra Pérez,Eduardo Antonio Rodríguez Leyes,Víctor Luis González Canavaciolo,David Marrero Delange
Revista Cubana de Farmacia , 2010,
Abstract: El D004 es un nuevo ingrediente activo extraído de los frutos de la palma real cubana (Roystonea regia), promisorio en el tratamiento de la hiperplasia prostática benigna. Para determinar su estabilidad en frascos de vidrio ámbar, se realizaron estudios donde las muestras se sometieron a diferentes condiciones. En condiciones de estrés se observó que el D004 es susceptible a la degradación térmica y oxidativa. En condiciones aceleradas (40 ± 2 oC y 75 ± 5 % humedad relativa) no se observaron cambios significativos en ninguno de los parámetros evaluados durante 12 meses, lo que permitió predecir un tiempo de vida útil de al menos 2 a os en condiciones menos drásticas. Esto fue corroborado en las condiciones de las zonas climáticas II (25 ± 2 oC y 60 ± 5 % humedad relativa) y IV (30 ± 2 oC y 70 ± 5 % humedad relativa). The D004 is a new active ingredient extracted from the Cuban real palm (Roystonea regia), promising in the treatment of the benign prostatic hyperplasia. To determine its stability in amber glass flasks studies were conducted where samples underwent different conditions. In stress situations D004 is sensitive to the thermal and oxidative degradation. Under accelerated conditions (40 ± 2 oC ad 75 ± 5 % of relative humidity) there weren't significant changes in any assessed parameters during 12 months allowing predicting a useful life time of at least 2 years under less drastic conditions. It was corroborated under climatic conditions II (25 ± 2oC and 60± 5% of relative humidity and IV (30 ± 2 oC and 70 ± 5 % of relative humidity).
Caracterización preliminar del aceite obtenido del fruto completo de Roystonea regia (Kunth) O. F. Cook
Rodríguez Leyes,Eduardo A.; González Canavaciolo,Víctor L.; Marrero Delange,David; Adames Fajardo,Yuliamny; Vicente Murillo,Roxana;
Revista Cubana de Plantas Medicinales , 2008,
Abstract: introduction: the cuban royal palm tree oil, roystonea regia (kunth) o.f. cook, has possibilities to be used as raw material in the cuban pharmaceutical industry. objectives: to characterize the cuban royal palm tree oil and to study its fatty acid composition. methods: the official methods described in usp 27 were used and the composition of fatty acids was estimated by gas chromatography. results: relative density was 0.874 - 0.970 g/ml; refraction index 1.454 - 1.463; the saponification index ranged 190.0 to 221.8; the acidity index ranged 5.2 to 26.4; iodine index was 49.2 to 55.8; and the contents of non-saponificable material ranged 2.0 to 13.4 %. the total of fatty acids in the analyzed oils varied from 74.4 to 89.4 %. the composition of fatty acids standardized at 100 % was given by the following concentrations: c8:0 y c10:0 (0.1-0.9 %); c12:0 (17.9-27.8 %); c14:0 (9.3-12.7 %); c16:0 (9.3-15.0 %); c16:1 (0.1-0.6 %); c18:0 (2.5-3.7 %); c18:1 (27.3-37.3 %); c18:2 (12.8-17.4 %); y c18:3 (0.1-0.5 %). conclusions: some of the physical and chemical characteristics of r. regia fruit oil were studied in this paper.
Contenidos de aceite y de los ácidos láurico y mirístico en frutos maduros de Roystonea regia colectados durante dos a?os
Rodríguez Leyes,Eduardo A.; González Canavaciolo,Víctor L.; Marrero Delange,David; Adames Fajardo,Yuliamny; Vicente Murillo,Roxana;
Revista Cubana de Plantas Medicinales , 2010,
Abstract: introduction: d004, an promissory active ingredient in treatment and prevention of begnin prostatic hyperplasia, is obtained from the fruit oil of roystonea regia (kunth) o.f. cook. it is composed by a mixture of free fatty acids including lauric and myristic acids, both very important by their pharmacological effects. objective: to determine the potential influence of harvest season on the oily content and the concentration of lauric and myristic acids from r. regia fruits. methods: each month for two years, it was possible to collect mature fruits from r. regia in a selected group. in dry and milled samples it was determined the oily content in a gravimetric way and that of fatty acids by gas chromatography. results: there were differences statistically significant in oily contents and of lauric and myristic acids; however, the contents determined in all the cases remained within the quality specifications established for the plant material. conclusions: the plant material collected for all the year may be used in obtaining of r. regia oil, raw material used in the production of d004.
Fracciones lipídicas obtenidas a partir de frutos de Serenoa repens recolectados en Cuba
Rodríguez Leyes,Eduardo A; González Canavaciolo,Víctor L; Marrero Delange,David; Leiva Sánchez,ángela T;
Revista Cubana de Plantas Medicinales , 2012,
Abstract: introduction: lipid extracts from the fruits of serenoa repens, a native palm from the united states of america, are used to treat benign prostate hyperplasia. although this species was introduced in the national botanic garden of cuba some years ago, the lipid extracts of its fruits had not been studied yet. objective: to determine the main organoleptic, physical and chemical characteristics of lipid extracts from the fruits of s. repens harvested in cuba. methods: dried fruits and fresh ripe fruits of s. repens were harvested. fresh fruits were dried at room temperature and at 80 oc. the three groups of dried fruits were grounded and extracted with hexane in s?xhlet equipment. the main characteristics of the dried lipid extracts were determined. the studied components were determined by gas chromatography, in some cases with mass spectrometry detection. results: organoleptic and physical characteristics as well as the contents of fatty acids (major components) and ethyl esters of the studied extracts agreed with that described in literature, whereas those of sterols and fatty alcohols were higher than those previously reported for this species. some fatty alcohols not previously reported in these extracts, that is, 1-eicosanol, 1-docosanol, 1-heptacosanol, 1-nonacosanol, 1-dotriacontanol and 1-tetratriacontanol.were also identified. conclusions: generally speaking, the lipid extracts from the fruits of s. repens harvested in cuba presented characteristics similar to those reported for the extracts of this species, although some differences were also found, such as the content of sterols and fatty alcohols and the presence of some fatty alcohols not previously reported in the literature.
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