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Plasma Zinc Levels in Normotensive and Hypertensive Adults: A Comparative Study in Tehran Heart Center
S Aalami,V Nikoui,M Irani,A Bakhtiarian
Tehran University Medical Journal , 2012,
Abstract: Background: There are conflicting reports about zinc, a trace element, in the pathogenesis of hypertension and other cardiovascular diseases. The aim of this study was to evaluate the role of zinc in high blood pressure.Methods: We conducted this study on 80 patients with primary (idiopathic) hypertension and 80 normotensive people with similar age who attended to Tehran Heart Center between 2007 and 2008. We examined the effect of zinc concentration on blood pressure in both sexes in four age groups (41-50, 51-60, 61-70 and 71-80 years old). We measured plasma zinc concentration by atomic absorption.Results: The mean plasma zinc concentrations were 0.456±0.04 μg/ml and 0.551±0.055 μg/ml in patients with hypertension and in normotensive people, respectively, (P≤0.05). Nevertheless, the mean plasma zinc concentrations were 0.494 μg/ml and 0.486 μg/ml in men with and without hypertension, respectively. The mean plasma zinc concentrations of women with and without hypertension, respectively were 0.415 μg/ml and 0.596 μg/ml, showing a significant difference between two groups (P≤0.001). Moreover, there was a significant difference in plasma zinc concentration between hypertensive and normotensive people in 51 to 60 years age group (P≤0.05), but difference were not significant between other age groups.Conclusion: The results of this study revealed the relationship between the decrease in plasma zinc concentration and increase in blood pressure in women and in the men aged 51 to 60 years.
Teratogenic Effects of Caffeine and Clomipramine on Rat Fetus
N Takzare,V Nikoui,S Ostadhadi,SMA Nabavi
Tehran University Medical Journal , 2012,
Abstract: Background: Obsessive-compulsive disorders and depression have a high prevalence during pregnancy; therefore, pregnant women may take clomipramine and also take other drugs or consume foods that contain caffeine. As investigations about the teratogenic effects of clomipramine and its concurrent administration with caffeine during organogenesis period are scarce, we aimed to study the teratogenicity of simultaneous administration of clomipramine and caffeine in rat fetus.Methods: After dividing 42 pregnant rats to several case and control groups, we injected different doses of caffeine and clomipramine to the animals. All the injections were performed on the eighth until the 15th day of pregnancy. We removed the fetuses on the 17th day of pregnancy and studied the morphological features and apparent anomalies of the fetuses macroscopically. Results: We found a significant rate of mortality, apparent anomalies, abnormal torsion, shrinkage of skin and subcutaneous bleeding in fetuses of rats receiving high doses of caffeine or a combination of caffeine and clomipramine. Statistical analysis of the data revealed a significant increase (P?0.001) in teratogenicity of high doses of caffeine and its combination with clomipramine. Conclusion: This study implies simultaneous intake of high amounts of caffeine and clomipramine lead to teratogenicity. We recommend pregnant women to avoid uncontrolled consumption of foods that contain caffeine or drugs that contain high amounts of this substance. They should not also take clomipramine with caffeine in the first trimester of pregnancy.
Effects of diazoxide on rat isolated atria
V Nikoui,H Pazoki Toroudi,S Ostadhadi,A Rahmani
Tehran University Medical Journal , 2012,
Abstract: Background: It is generally accepted that the selective adenosine triphosphate-dependent potassium channel openers (KATP openers) have a dramatic role in the treatment of some cardiovascular disorders. The aim of this study was to investigate the effects of diazoxide, a potent ATP-related potassium channel opener, on spontaneously beating isolated rat atria to achieve more accurate approaches to treat cardiovascular diseases, such as atrial related disorders including atrial arrhythmias.Methods: After induction of anesthesia, we exsected the heart and isolated the atria of 48 male Wistar rats. Later, we recorded the beating and contractile force of the atria by a physiograph. Subsequently, we studied the effects of diazoxide (2 to 100 μg/mL) on beating and contractile force of the isolated atria 5, 10, 15 and 20 minutes after applying the drug onto the atria.Results: Diazoxide administration (2 to 100 μg/mL) showed a significant decrease (7% to 49% depending on concentration) in atrial beatings (P≤0.001) and in contractile force (1.5% to 67% depending on concentration), (P≤0.001). The effects began several minutes after applying the drug onto the tissues.Conclusion: This study revealed that diazoxide has a direct concentration-dependent effect on cardiac performance and leads to reduction in beating rates and contractile force of the heart. This effect seems to be related to the activation of mitochondrial or sarcolemmal KATP channels. Since the inhibitory action of diazoxide on the heart was very remarkable and prompt, this agent may also exhibit antiarrhythmic properties.
Preoperative pulmonary function tests in different surgical approaches of adolescent idiopathic scoliosis
Ameri Mahabadi E,Qomashi I,Mirzade Javaheri M,Nikoui F
Tehran University Medical Journal , 2011,
Abstract: "nBackground: Scoliosis is one of the most common spinal deformities with subsequent decrease in pulmonary function. The effects of surgical correction on the pulmonary function of patients with adolescent idiopathic scoliosis are controversial. The purpose of the present study was to compare the postoperative pulmonary function changes in different surgical approaches chosen for its correction."n "nMethods: Sixty-five patients with adolescent idiopathic scoliosis who had undergone corrective spinal surgery in Shafa Yahyaian Hospital since 1997 to 2007 and had documented preoperative pulmonary function test report, included in our study. The patients had documented preoperative pulmonary function tests and were divided into three groups based on their surgical approach. The first group was comprised of 25 patients who had undergone posterior spinal fusion (PSF), the second group included 29 patients who had anterior and posterior spinal fusion (ASF+PSF), and the third group consisted of 10 patients who had posterior spinal fusion and thoracoplasty (PSF+ thoracoplasty). The preoperative and the final follow-up values of absolute and percent predicted forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were compared and their relations with the undertaken surgical approach were evaluated."n "nResults: There were no significant correlations between the surgical approaches and changes in the pulmonary function tests (P>0.05). FVC and FEV1 values were similar to preoperative values in all groups after a minimum follow-up of two years."n "nConclusion: There were no significant differences between different surgical approaches for adolescent idiopathic scoliosis regarding the pulmonary function test results after at least two years of follow-up.
Evaluation of Analgesic Effects of Hydroalcoholic Extract of Marrubium parviflorum by Formalin Test in Mice
Mahnaz Khanavi,Mohammad-reza Delnavazi,Vahid Nikoui,Sattar Ostadhadi
Asian Journal of Plant Sciences , 2012,
Abstract: In this research, hydroalcoholic extract obtained from the aerial parts of Marrubium parviflorum (Lamiaceae) was subjected to evaluation of analgesic effects using formalin test at the doses of 50, 100 and 200 mg kg-1 in mice. Duration of licking and biting time (min) of the injected paw was recorded at 5 min intervals for 40 min after formalin injection as a pain index. Results of study showed that the dose of 100 mg kg-1 of the extract decreased duration of licking and biting time between 15 and 40 min, but this effect was not statistically significant (p>0.05), while the dose of 200 mg kg-1 of extract showed significant analgesic effects (p<0.05) in the chronic phase (15-40 min) of formalin induced pain that this analgesic effect was equal to morphine. Considering that chronic phase of formalin induced pain is a secondary response to formalin induced inflammation, results of study introduce the M. parviflorum as a valuable analgesic herbal medicine that can be used in treatment of inflammatory painful disease. It is possible to assume that phytochemical contents of M. parviflorum reduce inflammatory pain by inhibiting the formation of inflammatory mediators such as prostaglandins followed by inhibiting COX-II enzyme.
Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses
Azam Bakhtiarian,Nasrin Takzare,Mehdi Sheykhi,Narges Sistany,Farahnaz Jazaeri,Mario Giorgi,Vahid Nikoui
Advances in Pharmacological Sciences , 2014, DOI: 10.1155/2014/132034
Abstract: Objective. Depression during pregnancy is a relatively common problem. Since little is known about the teratogenic effects of concomitant administration of fluoxetine and olanzapine during the organogenesis period, the aim of the present study was to evaluate the teratogenic effects of coadministration of fluoxetine and olanzapine on rat fetuses. Method. Forty-two pregnant rats were divided into seven groups, randomly. The first group received 0.5?mL of normal saline as the control. The second and third groups received fluoxetine at doses of 9?mg/kg and 18?mg/kg, respectively. Olanzapine was injected at 3?mg/kg and 6?mg/kg to the fourth and fifth groups, respectively. The sixth group received 9?mg/kg fluoxetine and 3?mg/kg olanzapine. Finally, the seventh group was administrated with fluoxetine and olanzapine at 18?mg/kg and 6?mg/kg, respectively. Drugs were injected intraperitoneally between day eight and day 15 of the pregnancy. On the 17th day of pregnancy, the fetuses were removed and micro-/macroscopically studied. Results. Fetuses of rats receiving high doses of these drugs showed a significant rate of cleft palate development, premature eyelid opening and torsion anomalies, compared to the control group ( ). It is concluded that these drugs can lead to teratogenicity, so their concomitant use during pregnancy should be avoided, or if necessary their doses must be decreased. 1. Introduction One of the most used antidepressant drugs is fluoxetine. This active ingredient belongs to the SSRIs (selective serotonin reuptake inhibitors) class. It increases serotonin levels in synaptic clefts and is used for treatment of depression [1]. It is also used for obsessive-compulsive disorder (OCD), a prevalent disease of enhanced anxiety that has been diagnosed in around 2% of world population. Estrogen and progesterone imbalance and its influence on cerebrospinal fluid partly explain the incidence of psychological problems including OCD during pregnancy [2, 3]. Researchers have shown that OCD can be triggered during fertility periods like menstruation, pregnancy, or postparturition times. Its rate can be decreased by early diagnosis and appropriate treatment [4]. Maina and colleagues have demonstrated the precipitating effect that pregnancy and parturition can have for OCD which leads to postparturition problems for both mother and baby [5]. Leckman and colleagues found that oxytocin secretion during pregnancy increases intracerebral pressure (ICP) and can also lead to OCD [6]. Olanzapine is an atypical antipsychotic drug for treating schizophrenia and other
Nonsmooth Optimization Algorithms in Some Problems of Fracture Dynamics  [PDF]
V. V. Zozulya
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.211073
Abstract: Mathematical statement of elastodynamic contact problem for cracked body with considering unilateral restrictions and friction of the crack faces is done in classical and weak forms. Different variational formulations of unilateral contact problems with friction based on boundary variational principle are considered. Nonsmooth optimization algorithms of Udzawa’s type for solution of unilateral contact problem with friction have been developed. Convergence of the proposed algorithms has been studied numerically.
Precessing Ball Solitons as Self-Organizing Systems during a Phase Transition in a Ferromagnet  [PDF]
V. V. Nietz
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.410A3010
Abstract:

Precessing ball solitons (PBS) in a ferromagnet during the first order phase transition is induced by a magnetic field directed along the axis of anisotropy, while the action of the periodic field perpendicular to the main magnetic field has been analyzed. Under these conditions, the characteristics of arising equilibrium PBS are uniquely determined by the frequency of the periodic field, but the solitons with other frequencies are impossible. For such structure, the entropy increase connected with dissipation is compensated by the decrease of the entropy due to the external periodic field. It is shown that the equilibrium PBS are essentially the “self-organizing systems” that can arise spotaneously in a metastable state of ferromagnet.

Movement of Self-Organizing Solitons in Ferromagnet  [PDF]
V. V. Nietz
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.610155
Abstract: Precessing ball solitons (PBS) in a ferromagnet during the first order phase transition induced by a magnetic field directed along the axis of anisotropy, while the additional action of high-frequency field perpendicular to the main magnetic field, are analyzed. It is shown that the spatial motion of solitons, associated with thermal fluctuations in the crystal, does not destroy the equilibrium of self-organized PBS.
Lα Line of Dark Positronium as a Nongravitational Detection of DM  [PDF]
V. Burdyuzha, V. Charugin
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.613187
Abstract: An attempt to predict the new atomic dark matter lines is done on the example of a dark lepton atom-positronium. Its Layman-alpha line with the energy near 3 GeV may be observable if the appropriate conditions are realized. For this we have studied a γ-ray excess in the center of our galaxy. In principle, this excess may be produced by the Lα line of a dark positronium in the medium with Compton scattering. The possibility of observations of an annihilation line (E~300 TeV) of dark positronium is also predicted. Other proposals to observe the atomic dark matter are shortly described. Besides, Hα line (1.3μ) of usual positronum must be observable in the direction on the center of our galaxy.
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