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Search Results: 1 - 10 of 1914 matches for " Uwe Wollina "
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Pyoderma gangrenosum – a review
Uwe Wollina
Orphanet Journal of Rare Diseases , 2007, DOI: 10.1186/1750-1172-2-19
Abstract: The treatment of PG is a challenge. Randomized, double-blinded prospective multicenter trials for PG are not available. The best documented treatments are systemic corticosteroids and ciclosporin A. Combinations of steroids with cytotoxic drugs are used in resistant cases. The combination of steroids with sulfa drugs or immunosuppressants has been used as steroid-sparing modalities. Anti-tumor necrosis alpha therapy in Crohn's disease showed a rapid response of PG. Skin transplants and the application of bioengineered skin is useful in selected cases as a complement to the immunosuppressive treatment. Topical therapy with modern wound dressings is useful to minimize pain and the risk of secondary infections. Despite recent advances in therapy, the prognosis of PG remains unpredictable.Pyoderma gangrenosumPyoderma gangrenosum (PG) is a primarily sterile inflammatory neutrophilic dermatosis. It is characterized by recurrent cutaneous ulcerations with mucopurulent or hemorrhagic exudate. These very painful ulcers present with undermined bluish borders with surrounding erythema. In many cases, PG is associated with inflammatory bowel disease, rheumatic disorder or neoplasia [1-3].Powell et al. [4] suggested a classification of PG into four major clinical types [see Table 1].Accurate epidemiological data on PG are missing. The peak of incidence occurs between the ages of 20 to 50 years with women being more often affected than men [2,6]. Cases in infants and adolescents account for only 4% of PG. PG in elderly people has occasionally been reported [7]. The general incidence has been estimated to be between 3 and 10 per million per year [8].PG occurs most commonly on the lower legs with preference for the pretibial area [Fig. 1 &2]. PG has been reported on other sites of the body as well, including breast, hand, trunk, head and neck, and peristomal skin [Fig. 3 &4]. Extracutaneous manifestations include involvement of upper airway mucosa, eye [9-12], genital mucosa [13],
Peat: A natural source for dermatocosmetics and dermatotherapeutics
Wollina Uwe
Journal of Cutaneous and Aesthetic Surgery , 2009,
Abstract: In recent years the interest for natural substances in dermatotherapy and cosmetics has increased. Peat is a complex natural source of humic substances that are of potential interest in both dermatology and cosmetology. Humic substances in peat have been partially characterized and pharmacologic and biologic activities have been documented. Possible clinical applications are outlined.
Treatment of facial skin laxity by a new monopolar radiofrequency device
Wollina Uwe
Journal of Cutaneous and Aesthetic Surgery , 2011,
Abstract: Background : Acquired facial skin laxity seems to be a result of the combination of intrinsic and extrinsic processes. For treatment of facial ageing, non-invasive procedures have become popular. Aim : We wanted to investigate the effect of a new 2.2-MHz radiofrequency (RF) device on acquired facial skin laxity. Setting : Outpatient clinic associated with an academic teaching hospital. Materials and Methods : We performed an open trial with the RF-ReFacing device (Meyer-Haake Medical Innovations, Wehrheim/ Germany) in the monopolar mode with a power of 8-12 W, two passes per session and repetition three times after 2 weeks without treatment. Results : A total of 20 Caucasian female patients were included (age range, 34-73 years). The procedure was performed without any analgesia. We did not see any adverse effect. The procedure was scored as most convenient or convenient by all patients. Improvement in skin laxity and fine wrinkles was seen after the second treatment in 19 of the 20 patients and after the third treatment in 100% of the patients. On a scale from 0 to 3, improvement in the lower lid, Crow′s feet and jowl line was scored 2.6±0.7 by the patients; improvement in the overall appearance of the face was scored 2.3±0.5. Blinded assessment of the photographs rated the improvement as good or better in 15 of the 20 patients, moderate in 3 patients, no change in 1 patient. Conclusions : RF-ReFacing treatment was effective in improvement in skin laxity. Patients′ satisfaction was high. Although RF-ReFacing treatment cannot substitute surgical procedure, it might prolong the time to the first surgical facial lift. The number of patients treated was small, and no quantitative measurements or histopathology was performed. Hence further studies with greater number of patients are necessary.
Conservative procedures in skin reconstitution
Wollina, Uwe
GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery , 2005,
Abstract: Skin exerts a number of essential protective functions ensuring homeostasis of the whole body. In the present review barrier function of skin and its expression of antimicrobial peptides are discussed. Barrier function is provided by the dynamic stratum corneum structure composed of lipids and corneocytes. Stratum corneum is a conditio sine qua non for terrestrial life. Impairment of barrier function can be due to injury and inflammatory skin diseases. Therapeutic options are discussed with special emphasis of radiodermatitis and irritant contact dermatitis in patients with hearing device. The use of antimicrobial peptides is illustrated by facial inflammatory skin diseases. In wound healing new developments include biotechnological developments of matrix- and growth factors and tissue-engineered skin substitutes. In everyday wound care of chronic wounds the concept of wound bed preparation (TIME) constitutes the base of successful treatment.
comment to the article: Acne inversa (Hurley clinical stage II ): case report
Uwe Wollina
Our Dermatology Online , 2011,
Riga-Fede-Like disease in a 70 year old woman
Wollina Uwe
Indian Journal of Dermatology , 2010,
Abstract: Riga-Fede disease (RFD) describes a benign, ulcerative lesion resulting from the repetitive trauma of contact of the oral mucosal surface of the tongue with the teeth. Although the name applies primarily to small children, similar clinical and histopathological findings can also be found in adults. We describe here a 70 year-old woman showing a painful tongue ulcer with elevated borders and whitish discoloration for the past four years. Repeated histological investigations revealed a benign leukoplakia without dysplasia. Replacement of an ill-fitting prosthesis led to complete remission within two weeks. RDF-like disease is thus a problem in elderly patients for whom topical treatment is insufficient to induce healing.
Clinico-Epidemiological Profile And Factors Affecting Severity Of Atopic Dermatitis In North Indian Children
Wollina Uwe
Indian Journal of Dermatology , 2004,
Abstract: Liposomes are lamellar structures composed of a lipid bilayer. They are used as carriers for different drugs. The present paper reviews the use of intravenous liposomal anticancer drugs in dermato-oncology. The broadest application is found today for liposomal anthracyclines, i.e., doxorubicin and daunorubicin. The practical experiences with liposomal drugs in skin cancer are still limited. There is clear evidence for liposomal drug efficacy and safety in AIDS- related Kaposia€ s sarcoma. Their use in other conditions, such as cutaneous T-cell lymphoma, malignant melanoma and cutaneous angiosarcoma, has been investigated in uncontrolled trials. The preliminary data, however, are promising in particular for cutaneous T-cell lymphoma.
Epithelial Tumors Of The Outer Nose
Wollina Uwe
Indian Journal of Dermatology , 2003,
Abstract: The central part of the face is characterized by peculiarities in embryology and tissue composition. The outer nose is the most prominent part of the mid face exposed to UV- irradiation and sunlight. Tumors of the outer nose are not uncommon. There is a variety of nevi that may occur on the nose, but benign tumors and malignancies are also not uncommon. The most frequent malignant tumor of the region is basal cell carcinoma that needs micrographic control in case of surgical excision since frequent relapses can lead to an ulcus terebrans that may completely destroy the mid face. Most tumors need a diagnostic excision to diagnosis, some need radical excision.
Facial rejuvenation for middle-aged women: a combined approach with minimally invasive procedures
Alberto Goldman, Uwe Wollina
Clinical Interventions in Aging , 2010, DOI: http://dx.doi.org/10.2147/CIA.S13215
Abstract: cial rejuvenation for middle-aged women: a combined approach with minimally invasive procedures Review (5044) Total Article Views Authors: Alberto Goldman, Uwe Wollina Published Date September 2010 Volume 2010:5 Pages 293 - 299 DOI: http://dx.doi.org/10.2147/CIA.S13215 Alberto Goldman1, Uwe Wollina2 1Clinica Goldman, Porto Alegre, RS, Brazil; 2Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany Abstract: Facial rejuvenation is a significant process involved in restoring youthfulness. The introduction of less invasive procedures has increased acceptance of such procedures. Often a combination of different techniques allows individualized treatment with optimal outcomes. Furthermore, this leads to a natural look without a significant downtime. We report herein the use of such a combined approach in middle-aged women with particular emphasis on botulinum toxin type A, dermal fillers, and chemical peels.
Reconstruction of a large scalp defect by the sequential use of dermal substitute, self-filling osmotic tissue expander and rotational flap
Wollina Uwe,Bayyoud Yousef
Journal of Cutaneous and Aesthetic Surgery , 2010,
Abstract: Large scalp defects pose a challenge for the surgeon. Here, we present a 31-year-old male patient with a soft tissue defect on the temple with exposed bone. To allow reconstruction, we placed a self-filling osmotic expander in the subgaleal pocket for 12 weeks. The final volume of the tissue expander was 300 mL. In the last step, a rotational flap was created after removal of the tissue expander from its pocket. Thereby, a tension-free suturing was possible. The post-surgical healing was uncomplicated. Osmotic tissue expanders are a valuable tool for the closure of large tissue defects without the necessity of repeated filling procedures.
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