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A rare cause of dilated cardiomyopathy; Alstr m syndrome
Cihan Unlu,Ihsan Ustun,Fahrettin Akay,Umuttan Dogan
Anadolu Kardiyoloji Dergisi , 2008,
P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke
Umuttan Dogan, Ebru Apaydin Dogan, Mehmet Tekinalp, Osman Serhat Tokgoz, Alpay Aribas, Hakan Akilli, Kurtulus Ozdemir, Hasan Gok, Betigul Yuruten
International Journal of Medical Sciences , 2012,
Abstract: Background: Detection of paroxysmal atrial fibrillation (PAF) in acute ischemic stroke patients poses diagnostic challenge. The aim of this study was to predict the presence of PAF by means of 12-lead ECG in patients with acute ischemic stroke. Our hypothesis was that P-wave dispersion (Pd) might be a useful marker in predicting PAF in patients with acute ischemic stroke. Methods: 12-lead resting ECGs, 24-hour Holter recordings and echocardiograms of 400 patients were analyzed retrospectively. PAF was detected in 40 patients on 24-hour Holter monitoring. Forty out of 360 age and gender matched patients without PAF were randomly chosen and assigned as the control group. Demographics, P-wave characteristics and echocardiographic findings of the patients with and without PAF were compared. Results: Maximum P-wave duration (p=0.002), Pd (p<0.001) and left atrium diameter (p=0.04) were significantly higher in patients with PAF when compared to patients without PAF. However, in binary logistic regression analysis Pd was the only independent predictor of PAF. The cut-off value of Pd for the detection of PAF was 57.5 milliseconds (msc). Area under the curve was 0.80 (p<0.001). On a single 12-lead ECG, a value higher than 57.5 msc predicted the presence of PAF with a sensitivity of 80% and a specificity of 73%. Conclusion: Pd on a single 12-lead ECG obtained within 24 hours of an acute ischemic stroke might help to predict PAF and reduce the risk of recurrent strokes.
Oral anticoagulation in atrial fibrillation: are the problems solved?
Umuttan Do?an
Anadolu Kardiyoloji Dergisi , 2010,
The Evaluation of the Patients with Clefts in Aegean Region in Turkey between the Years 2000 to 2011  [PDF]
Ege Dogan, Erdal Is?ksal, Servet Dogan
Open Journal of Stomatology (OJST) , 2014, DOI: 10.4236/ojst.2014.46042
Abstract: Purpose: The evaluation of the patients with clefts; the number, type, distribution by gender, etiological factors in Aegean region in Turkey between the years 2000 to 2011. Material and Method: The patients with clefts who referred to Ege University from different cities were evaluated. The number of the clefts, the type of the clefts, and the causative etiological factors which were known, were recorded for each year separately, from 2000 to 2011. At the same time, the distribution of the gender was made for each year. Chi-square test is used for the statistical evaluation. Results: According to the results of the study, the numbers of the patients with clefts were increased day by day. Totally 741 (49.6% female, 50.4% male) patients with clefts were identified. Unilateral complete cleft lip and palate appeared in the left side was seen more in males (23.8%), while seconder palate cleft was seen more in females (16.7%). Drugs, which were used in the first trimester of the pregnancy, were the most seen etiological factors for the clefts (42.5%), while genetic was 23.3% only. Conclusion: The prevention for one of the mostly seen congenital anomaly; cleft lip and palate is still unknown. For this reason, the determination of the newborn babies with cleft lip and palate has an important role in order to give these patients more effective treatment.
Structural and Electrical Properties of Niobium Doped Y0.6Gd0.4Ba2-xNbxCu3O7-y Superconductors  [PDF]
Mucahit Yilmaz, Oguz Dogan
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.28147
Abstract: Polycrystalline samples of Y0.6Gd0.4Ba2-xNbxCu3O7-y(YGBNCO) with different Nb contents (x = 0.05, 0.10, 0.15, 0.20, and 0.25) were prepared using the usual solid state reaction technique. The structure for all samples was characterized by XRD and SEM. The electrical properties were measured by the FPP method in the temperature range from 70 to 130 K. The lattice constant of b remains almost unchanged and a and c increases with the increase of Nb content with x ≤ 0.10. The zero resistance transition temperature and Jc decrease with increasing Nb content. But superconductivity did not suppress. As the Nb content in the samples increases, it gives a diffused phase indicating a niobium perovskite phase and it is a small amount of unidentified phase.
Vazoactive Effects of Oxidative Stress Elicited by Hydrogen Peroxide in the Human Umbilical Artery: An in Vitro Study  [PDF]
Ipek Duman, Necdet Dogan
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.24045
Abstract: The vasoactive effects of oxidative stress induced by hydrogen peroxide (H2O2) on human umbilical artery strips as well as the possible mechanisms involved are studied. Contraction responses to cumulative H2O2 (10–7 M-3 × 10–2 M) in endothelium intact and denuded umbilical arteries and responses to cumulative H2O2 after incubation with L-NAME (10–4 M) (n = 8), indomethacin (10–5 M) (n = 8) and verapamil (10–6) (n = 8) were recorded. Responses elicited with cumulative H2O2 in Ca2+ free extracellular medium and the responses to cumulative Ca2+ (10–4 M-2 × 10–3 M) after H2O2 (10–3 M) induced contraction were also studied. The Emax for each experiment was calculated. p <0.05 was considered as significant. H2O2 elicited contraction was greater in endothelium denuded artery strips compared to endothelium intact strips (p < 0.05). Compared to control, incubation with L-NAME significantly augmented (p < 0.05), while verapamil and indomethacin inhibited the contractions elicited by cumulative H2O2 (p < 0.05). Ca2+ free extracellular medium caused decreases in cumulative H2O2 elicited contractions and cumulative Ca2+ caused concentration dependent increases in the contraction caused by a single bolus of H2O2 (p < 0.05). Exposure to H2O2 causes concentration-dependent constriction in human umbilical arteries. The presence of the endothelium and NOS enzyme activation influences the H2O2 responses. Removal of the endothelium increases the H2O2 elicited contractions more than incubation with L-NAME suggesting beside NO, other endothelial vasodilators are also involved in vascular tonus of the umbilical arteries. Both intracellular and extracellular Ca2+ ions and constrictor cyclooxygenase metabolites play a
Comparison of the arch forms and dimensions in various malocclusions of the Turkish population  [PDF]
Sultan Olmez, Servet Dogan
Open Journal of Stomatology (OJST) , 2011, DOI: 10.4236/ojst.2011.14023
Abstract: Objectives: The aim of this study is to determine the distribution of morphological differences in the cli- nical mandibular arch forms seen in Angle Class I, II and III malocclusions in Turkish population and to examine the effect of gender on arch dimension pa- rameters. Material and methods: This study has been conducted on pretreatment mandibular study models of 600 individuals (362 girls, 238 boys) aged between 14 and 19. On the photocopies derived from these models, 4 linear and 2 proportional measurements have been made. The samples have been evaluated as square, ovoid and tapered (OrthoForm-3M Unitek) arch form templates. Results: The most frequent arch form encountered among all the groups was the ta- pered one (62.5%) followed by the ovoid (27.3%) and the square one (10.2%). Gender difference influences on morphological structure was apparent. Generally, compared with girls, arch width and depth were found to be more in boys. Conclusion: The most fre- quent arch form seen in Angle malocclusion groups was the tapered one, followed by the less frequent ovoid and square ones.
A Military Doctor Pioneer of the Preventive Medicine in Turkey: Colonel Dr. Huseyin Remzi Bey
Dogan Ceyhan
TAF Preventive Medicine Bulletin , 2008,
Abstract: One of the most important turning points in Turkish History of Medicine is the transfer of Western / European medical knowledge to Ottoman medicine in 19th century. This knowledge is mostly transferred by government employed Ottoman citizens and aimed at improving the health status of the Ottoman State s elites, troops and people. Most important contributions of transferring and popularizing the concepts of microbe and vaccination to Ottoman medicine, concerning both disease and preventive medicine, were made by a military doctor, Colonel Dr. Huseyin Remzi Bey . He served in a large spectrum of military and civilian health services from field medicine to professorship in higher educational institutes and made important contributions for education of modern medicine in Turkish language. He was a part of the Ottoman team visiting Pasteur to learn the rabies vaccine and given credit to be one of the first users of microbiological knowledge and applications in Ottoman Country. He also tried to disseminate the knowledge about health amongst people and wrote more than 50 manuscripts, most of them published as books or newspaper periodicals. He is a figure who made important contributions of the accumulation and distribution of modern medical knowledge, including preventive medicine, in Turkey. [TAF Prev Med Bull. 2008; 7(4): 347-350]
Traditionally used wild edible greens in the Aegean Region of Turkey
Yunus Dogan
Acta Societatis Botanicorum Poloniae , 2012, DOI: 10.5586/asbp.2012.037
Abstract: Turkey has the largest coastal area in the Mediterranean, possesses an extraordinarily rich flora, and a great traditional knowledge. This diversity of plants naturally affects the traditional use of plants and is reflected in the rich Turkish cuisine. Consequently, the Mediterranean Diet (whose typical components are wild greens) constitutes one of the important elements of Turkish cuisine. For this reason, the aim of this study was to determine the consumption of wild edible green plants for the Aegean Region of Turkey and to establish the similarities to or differences from consumption in other regions and other cuisine in the Mediterranean Basin. This study compiles and evaluates the ethnobotanical data currently available. There were 111 taxa that were identified as wild edible greens in the study area belonging to 26 different families. Asteraceae (21 taxa) were the most commonly consumed as food. It was followed by Boraginaceae with 19 taxa, Apiaceae with 15 taxa and Lamiaceae with 7 taxa, respectively. Rumex and Erodium were the most represented genera with 4 species. Tamus communis and Asparagus acutifolius, Mediterranean elements and distributed in all of the Mediterranean Basin, are among the most widely consumed wild plants in the area. Wild edible plants are consumed in a variety of ways. The most common type of consumption (79 taxa) was in salads. The fact that the majority of the plants used in the area are consumed in salads shows the close relationship between the local diet and the concept of the Mediterranean Diet. As a result, very promisingly, there is a renewed or increasing interest in consuming wild food plants as part of this diet.
Paraneoplastic Limbic Encephalitis (Case Report)
Trakya Universitesi Tip Fakultesi Dergisi , 2010,
Abstract: Paraneoplastic limbic encephalitis (PLE) is a result of an autoimmune reaction in patients who have an apparent or an occult malignancy. Patients often present to hospitals with subacute psychiatric symptoms, memory disturbances and epileptic seizures. Diagnosis was made by the elimination of other possibilities presenting similar symptomatology, cerebral radiologic findings, EEG and CSF examination and most importantly detecting the primary tumor. Our case presented to hospital with multiple epileptic seizures, confusion, and was diagnosed as PLE after radiologic, electrophysiologic and laboratory examination. We thougt that it is worth to report this rare case and discuss it under the light of literature.
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