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Search Results: 1 - 10 of 781 matches for " Umberto Volta "
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Delayed diagnosis of coeliac disease increases cancer risk
Marco Silano, Umberto Volta, Anna Mecchia, Mariarita Dessì, Rita Di Benedetto, Massimo De Vincenzi, the collaborating centers of the Italian registry of the complications of coeliac disease
BMC Gastroenterology , 2007, DOI: 10.1186/1471-230x-7-8
Abstract: The study population consists of patients (n = 1968) diagnosed with CD at 20 Italian gastroenterology referral Centers between 1st January 1982 and 31st March 2005.The SIR for all cancers resulted to be 1.3; 95% CI = 1.0–1.7 p < 0.001. The specific SIRs for non Hodgkin lymphoma was 4.7; 95% CI = 2.9–7.3 p < 0.001, for the small bowel carcinoma 25; 95% CI = 8.5–51.4 p < 0.001, for non Hodgkin lymphoma 10; 95% CI = 2.7–25 p = 0.01, finally for the stomach carcinoma 3; 95% CI = 1.3–4.9 p < 0.08. The mean age at diagnosis of CD of patients that developed sooner or later a neoplasm was 47,6 ± 10.2 years versus 28.6 ± 18.2 years of patients who did not.Coeliac patients have an increased risk of developing cancer in relation to the age of diagnosis of CD. This risk results higher for malignancies of the gastro-intestinal sites. An accurate screening for tumors should be performed in patients diagnosed with CD in adulthood and in advancing age.Coeliac disease (CD) is a permanent autoimmune enteropathy triggered by the ingestion of gluten, the storage protein complex of wheat, rye and barley. Gluten causes, in genetically determined individuals carryng the HLA-DQ2/DQ8 haplotype, an inflammatory response of the small bowel mucosa, resulting in villous atrophy, infiltration of T-lymphocytes and hyperplasia of the cripts. The only known treatment for this disorder is the life – long withdrawn from the diet of the above mentioned cereals. CD occurs worldwide and its prevalence is estimated about 1/150 individuals [1-3].The association between CD and neoplasms has been long established [4]. In the '60s, a population-based study has already reported a 100-fold increased risk of non-Hodgkin's lymphoma in patients affected by CD [5]. More recently, this risk has been resized to 3-fold by an Italian study and 9-fold by a study from States [6,7].It has been also noted that CD patients have a higher risk of developing a small bowel adenocarcinoma respect to the general population and t
Spectrum of gluten-related disorders: consensus on new nomenclature and classification
Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano
BMC Medicine , 2012, DOI: 10.1186/1741-7015-10-13
Abstract: Wheat, rice and maize are the most widely consumed food grains in the world. Wheat, the most widely grown crop, is immensely diverse, with more than 25,000 different cultivars having been produced by plant breeders worldwide. Much of the world's production of wheat is consumed after it has been processed into bread, other baked goods, pasta and noodles, and, in the Middle East and North Africa, bulgur and couscous. In addition, the wide availability of wheat flour and the functional properties of gluten proteins provide the rationale for their wide use as an ingredient in food processing.Gluten is the main structural protein complex of wheat with equivalent toxic proteins found in other cereals, including rye and barley. The toxic protein fractions of gluten include gliadins and glutenins, with gliadins containing monomeric proteins and glutenins containing aggregated proteins. Possibly the introduction of gluten-containing grains, which occurred about 10,000 years ago with the advent of agriculture, represented an evolutionary challenge that created the conditions for human diseases related to gluten exposure, the best known of which are mediated by the adaptive immune system: wheat allergy (WA) and celiac disease (CD). In both conditions the reaction to gluten is mediated by T-cell activation in the gastrointestinal mucosa. However, in WA it is the cross-linking of immunoglobulin (Ig)E by repeat sequences in gluten peptides (for example, serine-glutamine-glutamine -glutamine-(glutamine-)proline-proline-phenylalanine) that triggers the release of chemical mediators, such as histamine, from basophils and mast cells [1]. In contrast, CD is an autoimmune disorder, as demonstrated by specific serologic autoantibodies, most notably serum anti-tissue transglutaminase (tTG) and anti-endomysial antibodies (EMA).Besides CD and WA, there are cases of gluten reactions in which neither allergic nor autoimmune mechanisms are involved. These are generally defined as gluten sensi
PROgnosticating COeliac patieNts SUrvivaL: The PROCONSUL Score
Federico Biagi, Annalisa Schiepatti, Georgia Malamut, Alessandra Marchese, Christophe Cellier, Sjoerd F. Bakker, Chris J. J. Mulder, Umberto Volta, Fabiana Zingone, Carolina Ciacci, Anna D’Odorico, Alida Andrealli, Marco Astegiano, Catherine Klersy, Gino R. Corazza
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084163
Abstract: Introduction It has been shown that mortality rates of coeliac patients correlate with age at diagnosis of coeliac disease, diagnostic delay for coeliac disease, pattern of clinical presentation and HLA typing. Our aim was to create a tool that identifies coeliac patients at higher risk of developing complications. Methods To identify predictors of complications in patients with coeliac disease, we organised an observational multicenter case-control study based on a retrospective collection of clinical data. Clinical data from 116 cases (patients with complicated coeliac disease) and 181 controls (coeliac patients without any complications) were collected from seven European centres. For each case, one or two controls, matched to cases according to the year of assessment, gender and age, were selected. Diagnostic delay, pattern of clinical presentation, HLA typing and age at diagnosis were used as predictors. Results Differences between cases and controls were detected for diagnostic delay and classical presentation. Conditional logistic models based on these statistically different predictors allowed the development of a score system. Tertiles analysis showed a relationship between score and risk of developing complications. Discussion A score that shows the risk of a newly diagnosed coeliac patient developing complications was devised for the first time. This will make it possible to set up the follow-up of coeliac patients with great benefits not only for their health but also for management of economic resources. Conclusions We think that our results are very encouraging and represent the first attempt to build a prognostic score for coeliac patients.
The recent invasion of Rutilus rutilus (L.) (Pisces: Cyprinidae) in a large South- Alpine lake: Lago Maggiore
Pietro VOLTA,Niels JEPSEN
Journal of Limnology , 2008, DOI: 10.4081/jlimnol.2008.163
Abstract: Very recently, a common cyprinid fish species at northern latitude, the roach (Rutilus rutilus L.) has been observed in the large south-alpine Lago Maggiore for the first time. The colonization of the lake has the characteristics of an invasion. In order to investigate this new fish population, benthic multi-mesh and commercial gill nets were used to sample fish in a wide gulf in the central part of the lake (Golfo Borromeo) from February to October 2006. In total 779 roach (TL: 5.5 – 38.8 cm) were caught, aged, sexed and stomach analyzed. Fecundity was assessed by counting the eggs in ripe gonads of females of age 3 and 4. The roach have become clearly the dominant species in the catches, constituting over 70% of the biomass and 70% of the numbers caught. None of the roach exceeded 8 years in age. They grow very fast (Φ' = 2.55) and have high fecundity (Fabs = 13740 ±4700 S.D. at age 3 and Fabs = 14768 ±5642 S.D. at age 4). The diet spectrum is wide and characterized by a strong seasonality. In early spring algae (benthic and planktonic algae), benthos and detritus prevail, whereas in summer zooplankton is the most frequent food item. In autumn roach switch back to benthos and detritus. Algae occur more frequently in young specimens while zooplankton, benthos and detritus in adults. The roach population is practically unimpacted by fishing. The minimum legal mesh size (25 mm) of gillnets, used by commercial fishermen, selects roach at the mean LT of 21.2 cm, which is over its length at maturity. The results suggest that roach established a viable population in Lago Maggiore less than a decade ago and rapidly became one of the dominant (if not the dominant) fish species. The possible consequence for the fish fauna in general and for the ecological status of the whole lake is briefly discussed.
Beyond Customer Churn: Generating Personalized Actions to Retain Customers in a Retail Bank by a Recommender System Approach  [PDF]
Michele Gorgoglione, Umberto Panniello
Journal of Intelligent Learning Systems and Applications (JILSA) , 2011, DOI: 10.4236/jilsa.2011.32011
Abstract: Customer churn may be a critical issue for banks. The extant literature on statistical and machine learning for customer churn focuses on the problem of correctly predicting that a customer is about to switch bank, while very rarely consid-ers the problem of generating personalized actions to improve the customer retention rate. However, these decisions are at least as critical as the correct identification of customers at risk. The decision of what actions to deliver to what customers is normally left to managers who can only rely upon their knowledge. By looking at the scientific literature on CRM and personalization, this research proposes a number of models which can be used to generate marketing ac-tions, and shows how to integrate them into a model embracing both the analytical prediction of customer churn and the generation of retention actions. The benefits and risks associated with each approach are discussed. The paper also describes a case of application of a predictive model of customer churn in a retail bank where the analysts have also generated a set of personalized actions to retain customers by using one of the approaches presented in the paper, namely by adapting a recommender system approach to the retention problem.
Numerical Study of the Injection of Carbon Dioxide in a Homogeneous Porous Media  [PDF]
Luiz Umberto Rodrigues Sica
Open Journal of Fluid Dynamics (OJFD) , 2018, DOI: 10.4236/ojfd.2018.81009
Abstract:
This work proposes a locally conservative and less restrictive algorithm to solve the problem dealt with in [1], i.e. a two-phase flow in a homogeneous porous medium (water and CO2), with mass absorption between the fluid phases and reaction between the CO2 phase and the rock. The latter is modeled by two non-linear hyperbolic equations that represent the transport of the flowing phases for a given velocity field (equations of saturation and concentration). From the numerical point of view, we use the operator splitting technique to properly treat the time scale of each physical phenomenon and a high-order non-oscillatory central-scheme finite volume method for nonlinear hyperbolic equations proposed by [2] that was extended for a system of equations with source terms to treat the equations that govern the saturation and concentration of phases. In addition, with respect to source terms, the mass flux between fluid phases was handled using the flash methodology, whereas kinetic theory was applied for reproducing the changes in porosity and permeability that are caused by the reaction of CO2 with the rock. The same physical trends observed in [1] were obtained in our numerical results which indicate a good predictive capability. Furthermore, this method avoids the difficulties that arise when adopting small time steps enforced by CFL stability restrictions. Finally, the results obtained show that the applicability of the KT method is beyond just a single nonlinear conservation law with the absence of source terms.
INSIGHT INTO THE MOLECULAR AND GENETIC CHANGES IN HEART FAILURE
Sergio Dalla–Volta, MD, PhD
European Journal of Cardiovascular Medicine , 2010,
Abstract: n the last fifteen years much progress has been made on the knowledge of the mechanisms controlling the genetic and molecular activities of the mammalian (with special emphasis on the human) heart in chronic cardiac insufficiency.This increased knowledge has greatly influenced the understanding and treatment of heart failure, helping to prolong duration of life; even if clear evidence of a long lasting improvement of the syndrome is lacking.The causes of heart failure are numerous and different, but the common feature depends on the modest regenerative capacity of the human heart after any important injury damaging the myocardium. Therefore, the more frequent consequence is the appearance of scar tissue, with collagen deposition and tissue remodelling. Even is some proliferation of cardiac myocites has been noted, this process is unable to overcome the destruction of normal cells observed in the several cardiac disorders, so that the only efficient response is usually the cellular hypertrophy.
On Orbit Equivalence and Permutation groups defined by unordered relations
F. Dalla Volta,J. Siemons
Mathematics , 2010,
Abstract: For a set $\Omega$ an unordered relation on $\Omega$ is a family R of subsets of $\Omega.$ If R is such a relation we let G(R) be the group of all permutations on $\Omega$ that preserves R, that is g belongs to G(R) if and only if x in R implies x^{g}\in R. We are interested in permutation groups which can be represented as G=G(R) for a suitable unordered relation R on $\Omega.$ When this is the case, we say that G is defined by the relation R, or that G is a relation group. We prove that a primitive permutation group different from the Alternating Group and of degree bigger or equal to 11 is a relation groups. The same is true for many classes of finite imprimitive groups, and we give general conditions on the size of blocks of imprmitivity, and the groups induced on such blocks, which guarantee that the group is defined by a relation. This property is closely connected to the orbit closure of permutation groups. Since relation groups are orbit closed the results here imply that many classes of imprimitive permutation groups are orbit closed.
On solvable minimally transitive permutation groups
Francesca Dalla Volta,Johannes Siemons
Mathematics , 2007,
Abstract: We investigate properties of finite transitive permutation groups $(G, \Omega)$ in which all proper subgroups of $G$ act intransitively on $\Omega.$ In particular, we are interested in reduction theorems for minimally transitive representations of solvable groups.
A Combination of Tanacetum parthenium, Griffonia simplicifolia and Magnesium (Aurastop) as Symptomatic Acute Treatment for Migraine Aura: A Retrospective Cohort Study  [PDF]
Paola Zavarise, Giorgio Dalla Volta
Open Access Library Journal (OALib Journal) , 2017, DOI: 10.4236/oalib.1103660
Abstract:
Background: effective treatments for migraine aura and related symptoms are not yet well established. In the last years, several herbal and/or nutraceutical preparations have been proposed as potential treatment. We report the results of a retrospective analysis on the synergistic effect of three nutraceutical components (Tanacetum parthenium, Griffonia simpliciofila and Magnesium, Aurastop) as symptomatic treatment of migraine aura and related symptoms. Method: Forty-nine subjects with headache with aura were recruited from the headache Center of the Istituto Clinico Citta’ di Brescia to enter the studied that consist to treat the first 3 aura attacks as usual and the next 3 taking a tablet of Aurastop at the beginning of the aura phenomena. They had to describe aura and headache characteristics of previous three attacks (t1) and the modification of these parameters with the assumption of Aurastop for the following three attacks (t2). Results: A significant reduction (>50%) in aura duration (t1 = 33.6 ± 10.1 minutes vs. t2 = 9.4 ± 6.2 minutes, p < 0.01 FWER corrected) as well as in overall disability (median [interquartile range]) (t1 = 5[4 - 5] vs. t2 = 1[1 - 2], p < 0.01 FWER corrected) was evident. Furthermore, modification of aura type as well as a series of parameters more related to headache (number of headache attacks, duration, intensity, utilization of analgesics and response to symptomatic treatment) was influenced by Aurastop utilization (p < 0.01 FWER corrected). No significant adverse effects were recorded after the assumption of Aurastop. Conclusions: the combined and synergistic effect of Tanacetum parthenium, Griffonia simpliciofila and Magnesium (Aurastop) highlights the idea that symptomatic treatment potentially modulating cortical spreading depression could deserve attention to mitigate aura and related symptoms (migraine as well as long-lasting discomfort). Further blinded, placebo-controlled studies on larger groups are warranted.
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