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Search Results: 1 - 10 of 149938 matches for " Ulrika H. Englund "
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A Voltage Dependent Non-Inactivating Na+ Channel Activated during Apoptosis in Xenopus Oocytes
Ulrika H. Englund, Jens Gertow, Katarina K?gedal, Fredrik Elinder
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088381
Abstract: Ion channels in the plasma membrane are important for the apoptotic process. Different types of voltage-gated ion channels are up-regulated early in the apoptotic process and block of these channels prevents or delays apoptosis. In the present investigation we examined whether ion channels are up-regulated in oocytes from the frog Xenopus laevis during apoptosis. The two-electrode voltage-clamp technique was used to record endogenous ion currents in the oocytes. During staurosporine-induced apoptosis a voltage-dependent Na+ current increased three-fold. This current was activated at voltages more positive than 0 mV (midpoint of the open-probability curve was +55 mV) and showed almost no sign of inactivation during a 1-s pulse. The current was resistant to the Na+-channel blockers tetrodotoxin (1 μM) and amiloride (10 μM), while the Ca2+-channel blocker verapamil (50 μM) in the bath solution completely blocked the current. The intracellular Na+ concentration increased in staurosporine-treated oocytes, but could be prevented by replacing extracellular Na+ whith either K+ or Choline+. Prevention of this influx of Na+ also prevented the STS-induced up-regulation of the caspase-3 activity, suggesting that the intracellular Na+ increase is required to induce apoptosis. Taken together, we have found that a voltage dependent Na+ channel is up-regulated during apoptosis and that influx of Na+ is a crucial step in the apoptotic process in Xenopus oocytes.
Growth and Structure of ZnO Nanorods on a Sub-Micrometer Glass Pipette and Their Application as Intracellular Potentiometric Selective Ion Sensors
Muhammad H. Asif,Omer Nur,Magnus Willander,Peter Str?lfors,Cecilia Br?nnmark,Fredrik Elinder,Ulrika H. Englund,Jun Lu,Lars Hultman
Materials , 2010, DOI: 10.3390/ma3094657
Abstract: This paper presents the growth and structure of ZnO nanorods on a sub-micrometer glass pipette and their application as an intracellular selective ion sensor. Highly oriented, vertical and aligned ZnO nanorods were grown on the tip of a borosilicate glass capillary (0.7 μm in diameter) by the low temperature aqueous chemical growth (ACG) technique. The relatively large surface-to-volume ratio of ZnO nanorods makes them attractive for electrochemical sensing. Transmission electron microscopy studies show that ZnO nanorods are single crystals and grow along the crystal’s c-axis. The ZnO nanorods were functionalized with a polymeric membrane for selective intracellular measurements of Na +. The membrane-coated ZnO nanorods exhibited a Na +-dependent electrochemical potential difference versus an Ag/AgCl reference micro-electrode within a wide concentration range from 0.5 mM to 100 mM. The fabrication of functionalized ZnO nanorods paves the way to sense a wide range of biochemical species at the intracellular level.
Women Who Develop Diabetes Later in Life Have Diabetes-Associated Complications during Preceding Pregnancies  [PDF]
Ulrika Moll, H?kan Olsson, Mona Landin-Olsson
Journal of Diabetes Mellitus (JDM) , 2014, DOI: 10.4236/jdm.2014.44047
Abstract: Aims: The aim of this study was to explore the outcome of previous pregnancies in women who later developed diabetes. Method: A Swedish population based cohort of 23,524 women from 1990 aged 45 - 85 yr in 2000 when they self reported health status in a questionnaire. To identify which women who delivered we matched it towards the Swedish Medical Birth Register (SMBR). We identified 14,856 women who appeared in both registers and a total of 30,559 new birth registrations. Among these women 216 had developed diabetes after their pregnancy (ies) and additional twelve women were reported to have gestational diabetes in SMBR. These 228 women and their 455 pregnancies were compared with women without diabetes. Results: Women who developed diabetes later in life were already heavier before the pregnancy (ies) (69.2 ± 13.9 vs. 63.2 ± 10.3 kg; p < 0.001) but had less weight gain during pregnancy (13.3 ± 5.4 vs. 14.1 ± 4.6 kg; p = 0.03) compared to women without diabetes. Newborns to women with diabetes diagnosed any time after pregnancy had higher birth weight (3602 vs. 3507 g; p < 0.001), were more often large for gestational age (10.5% vs. 3.1%; p < 0.001), were more often delivered by caesarean section (4.8% vs. 2.7%; p = 0.005) and had lower Apgar scores. Conclusion: Women who developed diabetes after pregnancy had hyperglycaemia-associated complications during their pregnancy (ies). We therefore postulated that women with Type 2 diabetes are mainly recruited from women with earlier GDM. A general screening for GDM should identify these women and enable life style intervention that may prevent or at least delay diabetes.
Causes of Death in Patients with Aortic Aneurysmal Disease (1987-2014)  [PDF]
Raymond Englund
Surgical Science (SS) , 2017, DOI: 10.4236/ss.2017.81001
Abstract: Introduction: This study examined the cause of death of patients with aortic aneurysms treated for this disease between 1987 and 2014 to understand the current natural history of this condition. Methods: This study results from analysis of a prospectively maintained data base of patients treated by the author. Data points were obtained from practice records and supplemented by data made available through CHeRL (Centre for electronic Health Record Linkage). Six hundred and twenty two patients were treated consecutively between 1987 and 2014. At closure of the study in 2014, 402 patients had died and date of death was available. Cause of death was available by ICD (International Classification of Diseases) 9 or 10 in 89% of patients. Method of treatment of aneurysmal disease was available in all patients. Ethics approval for this study was obtained from the Centre for Health Research, Cancer Institute, New South Wales Department of Health. Statistical analysis was conducted by comparison of mean ±95% conference interval. Where appropriate contingency table analysis was constructed. Statistical significance was accepted at P < 0.05. Results: Mean age at presentation was 75.6 years (95%C.I. 74.8 - 76.3). Mean age at death was 81 years (95%C.I. 80.2 - 81.7). Predicted age at death based on Australian Bureau of Statistics life tables was 86.25 years (95%C.I. 85.8 - 86.8). Between 1987 and 1999, mean age at presentation was 74.5 years (95%C.I. 73.3 - 75, n = 304, Females = 78). Between 2000 and 2014, mean age at presentation was 75.3 years (95%C.I. 74.1 - 75, n = 318, females = 54). The difference for females presenting 1987 to 1999 compared 2000 to 2014 was significant, p < 0.01. Death was due to the following causes unknown 11%, cardiovascular disease 27.7%, pulmonary related disease 9.7% and aortic related disease 20.6%. Patients died of aortic related causes significantly earlier (within 2 years) compared to patients with other causes of death (5 to 8 years) due to presentation with ruptured aortic aneurysm. Cardiovascular related causes of death, malignancy and pulmonary related causes of death accounted for the majority of deaths post-treatment. There was no significant difference in length of survival among patients dying from these causes. Conclusion: Patients with successfully treated aneurysmal disease can expect to survive 5 - 8 years post-treatment. Presentation with aortic aneurysm rupture results in significantly shortened life expectancy. Patients presenting in the ninth
Towards a Classification of Left Common Iliac Vein Compression Based on Triplanar Phlebography  [PDF]
Raymond Englund
Surgical Science (SS) , 2017, DOI: 10.4236/ss.2017.81003
Abstract: Introduction: There is currently no consistent classification of the extent of left common iliac vein compression syndromes such that clinicians working in the area have a common terminology. Hypothesis: To create a classification of left common iliac vein compression based on the end point of triplanar pelvic phlebogrpahy. Methods: Based on 61 consecutive patients found to have left common iliac vein compression on triplanar phlebography in the course of treatment of venous disease, clinical presentation and symptomatology were retrospectively used to create a classification of left common iliac vein compression. Treatment of left common iliac vein compression was also retrospectively correlated with staging. Results: The following classification was arrived at: Stage 0, no compression and no intraluminal fibrous bands; Stage 1, evidence of compression by surrounding anatomical structures with or without the presence of fibrous bands; Stage 2: evidence of compression with or without fibrous bands as evidenced by cross-pelvic collaterals; Stage 3: compression of the left common iliac vein. Fibrous bands replaced by localised occlusion, with collateralisation and no involvement of adjacent venous segments; Stage 4a: as for Stage 3 but with the addition of thrombotic involvement of adjacent venous segments; Stage 4b: as for Stage 4a but with involvement of distal venous segments, femoral and popliteal. Stages 3, 4a or 4b correlated well with clinical presentations of DVT, PE, venous ulceration, vulval or cross-pelvic collaterals, ipsilateral limb swelling and claudication. The presence of varicose veins or recurrent varicose veins was a common finding amongst all groups. Conclusion: Acceptance of this classification system would provide a common terminology to allow more transparent assessment of modalities of treatment for this condition.
Review of Thoracic Endovascular Aneurysm Repair (TEVAR), Spinal Cord Ischemia (SCI), Cerebrospinal Fluid (CSF) Drainage and Blood Pressure (BP) Augmentation  [PDF]
R. Englund
Surgical Science (SS) , 2017, DOI: 10.4236/ss.2017.82009
Abstract: The object of this review is to examine the role of TEVAR in causing SCI. The anatomy and physiology of blood flow to the spinal cord is examined. The role of auto regulation of blood flow within the spinal cord is also examined. This review examines the reported results from the scientific literature of the effect of thoracic aortic aneurysm repair on spinal cord blood flow. In the light of the-se findings several conclusions can reasonably be reached. These conclusions are that the development of SCI can reasonably be predicted based on complexity and extent of the TEVAR procedure performed and BP augmentation and CSF drainage can significantly reduce the impact of SCI.
In Vivo Evaluation of Functionalized Biomimetic Hydroxyapatite for Local Delivery of Active Agents  [PDF]
Johan Forsgren, Ulrika Brohede, Sonya Piskounova, Albert Mihranyan, Sune Larsson, Maria Str?mme, H?kan Engqvist
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2011, DOI: 10.4236/jbnb.2011.22019
Abstract: This study was carried out to investigate the biological response in vivo to biomimetic hydroxyapatite implant coatings functionalized with bisphosphonates and bone morphogenetic proteins. The functionalization was carried out by a simple soaking procedure in the operating room immediately prior to surgery. Cylindrical titanium samples with and without coatings were implanted in the distal femoral epiphysis of sheep and retrieved after 6 weeks. The histological analysis proved that all samples were integrated well in the tissue with no signs of intolerance. Fewer osteoclasts were observed in the vicinity of bisphosphonate-functionalized samples and the bone was denser around these samples compared to the other samples. Samples functionalized with bone morphogenetic protein induced more bone/implant contact but showed a more inconsistent outcome with reduced bone density around the samples. This study demonstrates a simple method to functionalize implant coatings, which provides surgeons with an option of patient-specific functionalization of implants. The observed biological impact due to the delivery of active molecules from the coatings suggests that this strategy may also be employed to deliver antibiotics from similar coatings.
Endovascular Repair of Abdominal Aortic Aneurysm May Not Provide Long-Term Survival Benefit  [PDF]
R. Englund, N. Katib
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.77045
Abstract: Purpose: To investigate the long term survival benefit for the treatment of abdominal aortic aneurysmal (AAA) disease with Endovascular Aneurysm Repair (EVAR). Our hypothesis is that patients undergoing EVAR have an equivalent survival to an age matched population. Methods: Between 1997 and 2014 all patients treated for an AAA with EVAR by a single surgeon were prospectively followed and at 12 monthly intervals ultrasonography was utilised to assess the size of the aorta after treatment. Data from the Births, Deaths and Marriages was also collected regarding the survival of these patients. As of 2003 all patients with AAA were treated electively with EVAR. Results: There were a total of 145 patients treated with EVAR for AAA during the study period, 143 who survived the 30-day post-operative period. The long-term survival following EVAR at one year was 95% (95% C.I.: 88% to 97%), at 5 years 56% (95% C.I.: 42% to 64%), and at 10 years 28% (95% C.I.: 17% to 42%). Compared to an age-matched population the EVAR group had a lower than expected long term survival (P < 0.0001). Discussion: EVAR for the treatment of abdominal aortic aneurysms can be achieved with acceptable 30 day survival and freedom from aneurysm related death. However selection of patients for EVAR may significantly effect long-term survival if patients are fit for EVAR but not open operation. The question arises as to whether EVAR should be performed in patients with questionable long-term survival, even if they are fit for this procedure.
Gender Relations in African-Language Literature: Interpretative Politics and Possibilities
Harri Englund
African Sociological Review / Revue Africaine de Sociologie , 2004,
The university as an encounter for deliberative communication - creating cultural citizenship and professional responsibility
Tomas Englund
Utbildning & Demokrati : Tidsskrift f?r Didaktik och Utbildningspolitik , 2008,
Abstract: How can higher and professional education contribute to the development of responsible citizenship and professional responsibility? In recent discussions on the role of the educational system, the idea of “deliberative communication” has been brought into focus and stands for communication in which different opinions and values can be set against each other in educational settings. It implies an endeavour by each individual to develop his or her view by listening, deliberating, seeking arguments and valuing, coupled to a collective and cooperative endeavour to find values and norms which everyone can accept, at the same time as pluralism is acknowledged. Within higher education deliberative communication might explicitly be used to develop professional responsibility and analysing consequences of different ways of solving problems. To what extent are and can universities become public spaces for encounters dealing with controversial questions of how to solve different problems and analyse different ways of professional acting? Can universities recreate their selective traditions, “institutionalize dissensus”, and “make the university a site of public debate” through deliberative communication?
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