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Search Results: 1 - 10 of 211759 matches for " Ulrich Welge-Lüssen "
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Preventive Effects of Omega-3 and Omega-6 Fatty Acids on Peroxide Mediated Oxidative Stress Responses in Primary Human Trabecular Meshwork Cells
Theofilos Tourtas, Marco T. Birke, Friedrich E. Kruse, Ulrich-Christoph Welge-Lüssen, Kerstin Birke
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031340
Abstract: Pathologic processes in glaucoma include increased apoptosis, accumulation of extracellular material in the trabecular meshwork and optic nerve, condensations of the cytoskeleton and precocious cellular senescence. Oxidative stress was shown to generate these alterations in primary ocular cells. Fatty acids omega-3 and -6 are alleged to constitute a prophylaxis against these deleterious effects. Here, we tested actual preventive effects omega-3 and -6 against peroxide induced stress responses in primary human trabecular meshwork cells. Changes of mitochondrial activity, proliferation, heat shock proteins, extracellular matrix components, and inflammatory markers were evaluated. Alterations of the cytoskeleton were evaluated by phalloidin labeling. Here we report a repressive effect of omega-6 on metabolic activity and proliferation, which was not detected for omega-3. Both agents were able to prevent the anti-proliferative effect of H2O2, but only omega-3 prevented metabolic repression. Expression of heat shock protein 27 was unaltered by both fatty acids, whereas heat shock protein 90 was significantly induced by both. Omega-6 increased fibronectin and connective tissue growth factor synthesis, as well as the amount of secreted fibronectin. Omega-3, instead, induced plasminogen activator inhibitor 1 synthesis. H2O2 further increased fibronectin production in omega-6 supplemented cells, which was not the case in omega-3 treated cells. H2O2 stimulation of plasminogen activator inhibitor 1 and connective tissue growth factor was repressed by both fatty acids. Both fatty acids appeared to abolish H2O2 mediated stimulation of nuclear factor κB and IL-6, but not IL-1α and IL-8. H2O2 induced formation of cross-linked actin networks and stress fibers, which was reduced by preemptive application of omega-3. Omega-6, in contrast, had no protective effect on that, and even seemed to promote condensation. Based on the observed side effects of omega-6, omega-3 appears to be the more beneficial fatty acid in respect of prophylactic intake for prevention of a glaucomatous disease.
Re-establishment of olfactory and taste functions
Welge-Lüssen, Antje
GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery , 2005,
Abstract: The incidence of olfactory disorders is appoximately 1-2% and they can seriously impact on the quality of life. Quantitative disorders (hyposmia, anosmia) are distinguished from qualitative disorders (parosmia, phantosmia). Olfactory disorders are classified according to the etiology and therapy is planned according to the underlying pathophysiology. In ENT patients olfactory disorders caused by sinonasal diseases are the most common ones, followed by postviral disorders. Therapy consists of topical and systemic steroids, whereas systemic application seems to be of greater value. It is very difficult to predict the improvement of olfactory function using surgery, moreover, the long term - success in surgery is questionable. Isolated taste disorders are rare and in most often caused by underlying diseases or side effects of medications. A meticulous history is necessary and helps to choose effective treatment. In selected cases zinc might be useful.
Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma
Leonieke M. E. van Koolwijk equal contributor,Wishal D. Ramdas equal contributor,M. Kamran Ikram,Nomdo M. Jansonius,Francesca Pasutto,Pirro G. Hysi,Stuart Macgregor,Sarah F. Janssen,Alex W. Hewitt,Ananth C. Viswanathan,Jacoline B. ten Brink,S. Mohsen Hosseini,Najaf Amin,Dominiek D. G. Despriet,Jacqueline J. M. Willemse-Assink,Rogier Kramer,Fernando Rivadeneira,Maksim Struchalin,Yurii S. Aulchenko,Nicole Weisschuh,Matthias Zenkel,Christian Y. Mardin,Eugen Gramer,Ulrich Welge-Lüssen,Grant W. Montgomery,Francis Carbonaro,Terri L. Young,The DCCT/EDIC Research Group,Céline Bellenguez,Peter McGuffin,Paul J. Foster,Fotis Topouzis,Paul Mitchell,Jie Jin Wang,Tien Y. Wong,Monika A. Czudowska,Albert Hofman,Andre G. Uitterlinden,Roger C. W. Wolfs,Paulus T. V. M. de Jong,Ben A. Oostra,Andrew D. Paterson,Wellcome Trust Case Control Consortium 2,David A. Mackey,Arthur A. B. Bergen,André Reis,Christopher J. Hammond,Johannes R. Vingerling,Hans G. Lemij,Caroline C. W. Klaver,Cornelia M. van Duijn
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002611
Abstract: Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic factors which determine IOP are largely unknown. We performed a genome-wide association study for IOP in 11,972 participants from 4 independent population-based studies in The Netherlands. We replicated our findings in 7,482 participants from 4 additional cohorts from the UK, Australia, Canada, and the Wellcome Trust Case-Control Consortium 2/Blue Mountains Eye Study. IOP was significantly associated with rs11656696, located in GAS7 at 17p13.1 (p = 1.4×10?8), and with rs7555523, located in TMCO1 at 1q24.1 (p = 1.6×10?8). In a meta-analysis of 4 case-control studies (total N = 1,432 glaucoma cases), both variants also showed evidence for association with glaucoma (p = 2.4×10?2 for rs11656696 and p = 9.1×10?4 for rs7555523). GAS7 and TMCO1 are highly expressed in the ciliary body and trabecular meshwork as well as in the lamina cribrosa, optic nerve, and retina. Both genes functionally interact with known glaucoma disease genes. These data suggest that we have identified two clinically relevant genes involved in IOP regulation.
Biological Effects of Cigarette Smoke in Cultured Human Retinal Pigment Epithelial Cells
Alice L. Yu, Kerstin Birke, Johannes Burger, Ulrich Welge-Lussen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048501
Abstract: The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured human RPE cells were exposed to 2, 4, 8, and 12% of CSE concentration for 24 hours. Cell loss was detected by cell viability assay. Lipid peroxidation was assessed by loss of cis-parinaric acid (PNA) fluorescence. Senescence-associated ?-galactosidase (SA-?-Gal) activity was detected by histochemical staining. Expression of apolipoprotein J (Apo J), connective tissue growth factor (CTGF), fibronectin, and laminin were examined by real-time PCR, western blot, or ELISA experiments. The results showed that exposure of cells to 12% of CSE concentration induced cell death, while treatment of cells with 2, 4, and 8% CSE increased lipid peroxidation. Exposure to 8% of CSE markedly increased the number of SA-?-Gal positive cells to up to 82%, and the mRNA expression of Apo J, CTGF, and fibronectin by approximately 3–4 fold. Treatment with 8% of CSE also increased the protein expression of Apo J and CTGF and the secretion of fibronectin and laminin. Thus, treatment with CSE can induce cell loss, senescent changes, and ECM synthesis in primary human RPE cells. It may be speculated that cigarette smoke could be involved in cellular events in RPE cells as seen in age-related macular degeneration.
Educación y desigualdad salarial en México.
Ulrich Láchler
Perfiles educativos , 1998,
The non-linearity between and induced by the acceptance of fluorescence telescopes
R. Ulrich,L. Cazon
Physics , 2012, DOI: 10.1016/j.astropartphys.2012.09.001
Abstract: The measurement of the average depth of the shower maximum is the most commonly used observable for the possible inference of the primary cosmic-ray mass composition. Currently, different experimental Collaborations process and present their data not in the same way, leading to problems in the comparability and interpretation of the results. Whereas is expected to be proportional to in ideal conditions, we demonstrate that the finite field-of-view of fluorescence telescopes plus the attenuation in the atmosphere can introduce a non-linearity into this relation, which is specific for each particular detector setup.
Construction of a free Lévy process as high-dimensional limit of a Brownian motion on the Unitary group
Micha?l Ulrich
Mathematics , 2014, DOI: 10.1142/S0219025715500186
Abstract: It is well known that freeness appears in the high-dimensional limit of independence for matrices. Thus, for instance, the additive free Brownian motion can be seen as the limit of the Brownian motion on hermitian matrices. More generally, it is quite natural to try to build free L\'evy processes as high-dimensional limits of classical matricial L\'evy processes. We will focus here on one specific such construction, discussing and generalizing a work done previously by Biane, who has shown that the (classical) Brownian motion on the Unitary group U\left(d\right) converges to the free multiplicative Brownian motion when d goes to infinity. We shall first recall that result and give an alternative proof for it. We shall then see how this proof can be adapted in a more general context in order to get a free L\'evy process on the dual group (in the sense of Voiculescu) U\langle n\rangle. This result will actually amount to a truly noncommutative limit theorem for classical random variables, of the which Biane's result constitutes the case n=1.
Ore revisited: an algorithmic investigation of the simple commutator promise problem
James L. Ulrich
Mathematics , 2006,
Abstract: Motivated by a desire to test the security of the pubic key exchange protocol of I. Anshel, M. Anshel, and D. Goldfeld, (``An Algebraic Method for Public-Key Cryptography'', Mathematical Research Letters, vol. 6, pp. 1-5, 1999), we study algorithmic approaches to the simple commutator decision and promise problems (SCDP/SCPP) for the braid groups B_n. We take as our point of departure a seminal paper of O. Ore, (``Some Remarks on Commutators'', Proceedings of the American Mathematical Society, Vol. 2, No. 2, pp.307-314, 1951), which studies the SCPP for the symmetric groups. Our results build on the work of H. Cejtin and I. Rivin, (``A Property of Alternating Groups'', arXiv:math.GR/0303036).


物理学报 , 1988,
Abstract: 本文利用脉冲紫外激光(UV)选择激发氨分子到?1A″2电子激发态的两个最低振动能级ν′2=0和ν′2=1(ν2振动),然后检测新生态H原子的飞行谱(TOF),研究了氨分子的光碎片动力学。光谱证实了最近所测的离解能D00(H-NH2)=4.645eV;绝大多数生成的NH2(X2B1)基处于非振动激发,但是具有围绕a惯性轴的高度转动激发。通过NH3(?)的ν′2=1光离解产生的NH2(X)基具有较高的内部激发,并且显示了在N=Ka转动能级上的反转布居。
Mathematical Rotordynamic Model Regarding Excitation Due to Elliptical Shaft Journals in Electrical Motors Considering the Gyroscopic Effect  [PDF]
Ulrich Werner
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.48A009

The paper presents a mathematical rotordynamic model regarding excitation due to elliptical shaft journals in sleeve bearings of electrical motors also considering the gyroscopic effect. For this kind of excitation, a mathematical rotordynamic model was developed considering the influence of the oil film stiffness and damping of the sleeve bearings, the stiffness of the end-shields and bearing housings, the stiffness of the rotor, the electromagnetic stiffness in the air gap of the electrical motor and the mass moment of inertia of the rotor and therefore also considering the gyroscopic effect. The solution of the linear differential equation system leads to the mathematical description of the absolute orbits of the shaft centre, the shaft journals and the bearing housings and to the relative orbits between the shaft journals and the bearing housings. Additionally, the bearing housing velocities can also be derived with this mathematical rotordynamic model.

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