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OALib Journal期刊

ISSN: 2333-9721

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Human 14-3-3 Paralogs Differences Uncovered by Cross-Talk of Phosphorylation and Lysine Acetylation
Marina Uhart, Diego M. Bustos
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055703
Abstract: The 14-3-3 protein family interacts with more than 700 different proteins in mammals, in part as a result of its specific phospho-serine/phospho-threonine binding activity. Upon binding to 14-3-3, the stability, subcellular localization and/or catalytic activity of the ligands are modified. Seven paralogs are strictly conserved in mammalian species. Although initially thought as redundant, the number of studies showing specialization is growing. We created a protein-protein interaction network for 14-3-3, kinases and their substrates signaling in human cells. We included information of phosphorylation, acetylation and other PTM sites, obtaining a complete representation of the 14-3-3 binding partners and their modifications. Using a computational system approach we found that networks of each 14-3-3 isoform are statistically different. It was remarkable to find that Tyr was the most phosphorylatable amino acid in domains of 14-3-3 epsilon partners. This, together with the over-representation of SH3 and Tyr_Kinase domains, suggest that epsilon could be involved in growth factors receptors signaling pathways particularly. We also found that within zeta’s network, the number of acetylated partners (and the number of modify lysines) is significantly higher compared with each of the other isoforms. Our results imply previously unreported hidden differences of the 14-3-3 isoforms interaction networks. The phosphoproteome and lysine acetylome within each network revealed post-transcriptional regulation intertwining phosphorylation and lysine acetylation. A global understanding of these networks will contribute to predict what could occur when regulatory circuits become dysfunctional or are modified in response to external stimuli.
Lecciones aprendidas de la influenza aviar
Uhart,Marcela; Karesh,William; Smith,Kristine;
El hornero , 2008,
Abstract: avian flu, mainly natural to wild waterfowl, became famous in 2006 with the growing threat of a pandemic driven by the highly pathogenic strain h5n1. even though the feared pandemic has not yet occurred, a succession of events and neglects contribute to an ongoing stage of risk. avian influenza viruses are one of many pathogens which under appropriate conditions can affect the health of wildlife, humans, and domestic animals, as well as conservation, agriculture, food security, and the overall health of ecosystems. avian influenza is a global disease, which overcame species and geographical barriers, favoured by the lack of action. we would hope that avian influenza has taught us that an ounce of prevention is worth a ton of cure.
NUEVOS REGISTROS Y EXTENSIONES DE DISTRIBUCIóN DE MAMíFEROS PARA GUANAJUATO, MéXICO
Cynthia Elizalde-Arellano,Juan Carlos López-Vidal,Enrique Q. Uhart,José Ismael Campos-Rodríguez
Acta zoológica mexicana , 2010,
Abstract: La presente publicación tiene dos objetivos principales: 1. dar a conocer varias especies de mamíferos que son nuevos registros para Guanajuato y 2. mencionar localidades adicionales para algunas especies de mamíferos que han sido colectadas previamente en el estado, incrementando su distribución en la entidad. Los ejemplares se colectaron durante los a os 2003 a 2006 en varias localidades de la Reserva de la Biosfera "Sierra Gorda de Guanajuato" y se depositaron en la Colección de Mastozoología de la Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Además de los colectados, se incluyeron otros animales que ya se encontraban en dicha colección. Se presentan 11 nuevos registros y 14 especies que aumentan su distribución conocida en Guanajuato, representados por 364 especímenes de 5 familias, 14 géneros y 25 especies (20 roedores y 5 murciélagos). De estas especies destacan tres roedores endémicos de México (Peromyscus difficilis, P. levipes y P. melanophrys). De los murciélagos, Desmodus rotundus no había sido registrada previamente para el estado y Leptonycteris yerbabuenae fue la única especie que presentó algún estatus de protección. Las 25 especies de este escrito complementan y actualizan el conocimiento de la biodiversidad de la mastofauna, adicionándose a las 73 publicadas previamente dando un total de 98 especies registradas hasta el momento para Guanajuato.
Nuevos registros y extensiones de distribución de mamíferos para Guanajuato, México
ELIZALDE-ARELLANO, Cynthia;LóPEZ-VIDAL, Juan Carlos;UHART, Enrique Q.;CAMPOS-RODRíGUEZ, José Ismael;HERNáNDEZ-ARCIGA, Raúl;
Acta zoológica mexicana , 2010,
Abstract: this contribution has two objectives: 1. to publish some new records of mammal species for guanajuato and 2. to mention additional localities for mammal species that have been registered before in the state, increasing their distribution. specimens were colected from 2003 to 2006 in different sites of "sierra gorda de guanajuato" biosphere reserve and were deposited at mammal scientific collection at escuela nacional de ciencias biológicas, i.p.n. we included also some specimens colected some years ago and were in the same collection. we present 11 new registers and 14 species that extend their range in guanajuato, represented by 364 specimen within 5 families, 14 genera and 25 species (20 rodents and 5 bats). three species of rodents are endemic to mexico (peromyscus difficilis, p. levipes y p. melanophrys). about bats, desmodus rotundus had not been registered for guanajuato and leptonycteris yerbabuenae is the only species with a conservation status. the 25 species of this manuscript complete and actualize knowledge about mammalian biodiversity, plus 73 species previously published for the state we have a total of 98 species registered in guanajuato.
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