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Search Results: 1 - 10 of 303 matches for " Ufuk USTA "
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A Rare Case of Angiomyxolipoma: Differential Diagnosis From Other Vascular and Myxoid Tumors
Trakya Universitesi Tip Fakultesi Dergisi , 2010,
Abstract: A case of angiomyxolipoma in the posterior neck region of a 36-year-old man is presented. Although lipomatous tumors are very frequent among benign soft tissue neoplasms, angiomyxolipoma has been reported only in seven case studies before. We present a new case of a typical angomyxolipoma. Histopathologically, admixture of mature adipocytes, poorly cellular myxoid spindle cell areas and abundant vascular structures are the striking components of this tumor. Myxoid spindle cell lipoma, vascular spindle cell lipoma, myxoid liposarcoma, myxolipoma, angiolipoma and pseudoangiomatous spindle cell lipoma can be considered in the differential diagnosis of angiomyxolipoma. Immunohistochemistry is usually helpful in the diagnosis of this extremely rare entity. In our case, positive staining for vimentin and sparse positivity for CD34, in the absence of reactivity for SMA, desmin, S-100 protein and HMB45 in the spindle cells, are the most important immunohistochemical features that help in the differential diagnosis.
Verrucous Carcinoma of Urinary Bladder
Trakya Universitesi Tip Fakultesi Dergisi , 2006,
Abstract: Verrucous carcinoma is a very rare entity in the urinary bladder, and it is usually associated with Condyloma accuminatum and schistosomiasis. Though chronic irritation is accepted as a common etiological factor in few rare cases, bladder stone has not been demonstrated among irritative etiologic agents. Verrucous carcinoma in the bladder of a man of 54 years, who underwent three surgical interventions in the last 20 years because of bladder stone, is presented. The histopathological diagnosis of the specimen from the third operation was verrucous carcinoma of the bladder. Recently the fourth operation; a transurethral resection was performed, as the verrucous carcinoma relapsed.
Adrenal Ectopia Within the Wall of an Ovarian Serous Cystadenoma
Trakya Universitesi Tip Fakultesi Dergisi , 2006,
Abstract: Ectopic adrenal tissue is a relatively common finding, especially in children. The most common localization is the male genital system, especially the spermatic cord. Female genital tract is also a common site for ectopic adrenal tissue but, ovarian localization is very rare. A 21-year-old woman presented with complaints of abdominal swelling, pelvic pain and menstrual irregularity. Ultrasonographic examination revealed a 25 cm cystic mass in the left ovarian region. The cyst which was removed surgically, was filled with serous fluid and there was a 0.2 cm yellowish nodule within the wall. Serous cubic epithelium was lining the inner portion of the cyst. The nodule within the cyst wall was well defined and consisted of adrenal tissue.
Evaluation of Cytological Alterations in Normal-Appearing Oral Mucosal Epithelia of Smokers and Non-Smokers Via AgNOR Counts and Nuclear Morphometry
Ufuk Usta,Ufuk Berberoglu,Ercument Helvaci,Semsi Altaner
Trakya Universitesi Tip Fakultesi Dergisi , 2008,
Abstract: Objectives: We planned this study to evaluate the proliferative activity of the oral mucosal epithelial cells of smokers and non-smokers via nuclear morphometry and AgNOR counts.Patients and Methods: Smears were collected from normal-appearing mouth floor mucosa of 40 non-smokers and 40 smokers between ages of 50 and 70. AgNORs were counted in the first 50 well-fixed, nucleated squamous cells and nuclear areas were calculated via computerized image analyzing system.Results: Statistically mean AgNOR numbers per nucleus in the nonsmoking group (3.47±0.30) was lower than the smoking group (4.22±0.39, p<0.001), and mean nuclear areas of squamous cells of smokers (94.32±10.08) was also significantly higher than non-smokers (87±9.4, p<0.05). The mean number of nuclei having more than 5 AgNORs was 14.6% and 36.8% in non-smokers and smokers, respectively.Conclusion: Our results support that smoking is a severe risk factor for oral mucosal proliferative lesions and exfoliative cytology can be the preferred method for screening of oral mucosal lesions.
Glomus Tumor of the Stomach
Trakya Universitesi Tip Fakultesi Dergisi , 2007,
Abstract: A sixty-four-year old male patient presented to the emergency room with massive upper gastrointestinal tract bleeding. During distal gastrectomy, a submucosal, well demarcated mass with a diameter of 2.4 cm was palpable in the antral region of the lesser curvature. Histopathological examination of the mass revealed uniform tumor cells with clear cytoplasms and round nuclei, forming nests, strands and sheets between dense, irregularly branching, thin-walled vessels. Immunohistochemistry was positive for vimentin and SMA and negative for cytokeratin, CD34, synaptophysin, chromogranin A, NSE, CD117 (C-kit) and S-100 protein. Electron microscopy demonstrated tumor cells with clear cytoplasms and round nuclei with coarsely dispersed chromatin, forming groups around vascular structures. Clinical findings, gross appearance, tumor pattern, immunohistochemical findings and electronmicroscopic findings were all consistent with a glomus tumor.
A Rare Case of Schwannoma Arising From a Diverticulum in the First Portion of Duodenum
Atakan SEZER,Ahmet HAT?PO?LU,Ufuk USTA
Trakya Universitesi Tip Fakultesi Dergisi , 2009,
Abstract: A case of duodenal schwannoma, a rare tumor arising from schwannian cells of peripheral nerves is presented. A 57-year-old woman was admitted with abdominal pain and fever during investigation of anemia. Physical examination revealed tenderness in the right side of the upper abdomen. Laboratory tests showed no abnormality except for leucocytosis of 15 300/l. All tumor markers were negative. Ultrasonography revealed a hypoechoic mass adjacent to the duodenum. Computed tomography and magnetic resonance imaging showed a 4x3 cm mass in the same region and an abscess with dimensions of 8x11x12 cm in the right lobe of liver. Hepatic abscess drainage and duodenal diverticulectomy was performed. Histopathological examination revealed a tumorous mass composed of interlacing bundles of spindle cells, showing mild variations in nuclear shape and size. Immunohistochemically tumor cells were positive for S100 protein, thus, schwannoma of the duodenum was diagnosed. The postoperative course was uneventful and the patient was discharged on the eighth day of operation.
Retroperitoneal Ganglioneuroma
Tevfik AKTOZ,Mustafa KAPLAN,Ufuk USTA,?rfan Hüseyin ATAKAN
Trakya Universitesi Tip Fakultesi Dergisi , 2009,
Abstract: Neuroblastoma, ganglioneuroblastoma and ganglioneuroma are tumors of varying maturity derived from the primordial neural crest cells that form the sympathetic nervous system. A primary extraadrenal retroperitoneal ganglioneuroma was found incidentally in a 12-year-old boy during a series of examinations for abdominal distension, left upper quadrant pain and diarrhoea.
Fibro-Osseous Pseudotumor of the Digits
Ufuk USTA,Murat BAS,Nasuhi Engin AYDIN,Servet GURESCI
Trakya Universitesi Tip Fakultesi Dergisi , 2007,
Abstract: Fibro-osseous pseudotumor of the digits is a conflicting and rare benign lesion leading to serious problems and conflicts in differential diagnosis, especially with extraskeletal osteosarcoma. A 57-year-old man presented with a painful swelling in the proximal phalange of his left index finger. Direct radiography taken on admission revealed a soft tissue swelling with suspicious calcification in the proximal phalange palmar aspect of the index finger of left hand The excised specimen of, 2x1.5x0.7 cm was gray-white with a rough, somewhat irregular outer surface. Microscopic examination revealed a mesenchimal tumorous lesion with a partially degenerated and partially calcified/ ossified myxoid stroma. There were cellular areas composed of fibroblastic spindle cells, with mild-moderate nuclear atypia and moderate mitotic activity. Those cellular areas also contained osteoclast like multinucleated giant cells forming disordered groups. The final diagnosis based on histopathologic, radiographic and clinical findings was fibro-osseous pseudotumor of the digits.
Adrenal insufficiency caused by bilateral adrenal
?rfan ????N,Sernaz UZUNO?LU,Hakan KARAG?L,Ufuk USTA
Turkish Journal of Oncology , 2008,
Abstract: A 42-year-old male with symptoms of weight loss, fatigue, hyponatremia, hypoglycemia, hypotension and fever was referred to our hospital. A computed tomographic scan of the abdomen and pelvis showed multiple solid masses in the liver, thickened wall of sigmoid colon and bilateral solid adrenal masses, 7x5x3 cm on the right side and 6x4.5x3.5 cm on the left side. A colonoscopic examination showed tumoral mass originating from the sigmoid colon. A biopsy was performed and adenocarcinoma was diagnosed. The patient was suspected of having primary adrenal insufficiency due to bilateral adrenal macrometastases. The diagnosis of adrenal insufficiency was confirmed by levels of ACTH serum, cortisol and ACTH stimulation test. Adrenal metastases are well-recognized, but compared with the prevalence of adrenal metastases, adrenocortical insufficiency in patients with cancer seems to be rare. We report the case of a patient with both bilateral surrenal macrometastases, which is rare in colorectal cancer, and subsequent adrenal insufficiency.
Evaluation of Proliferative-Apoptotic Activity in Inactive, Proliferative, Hyperplastic Endometria and Endometrioid Carcinomas
Ufuk USTA,Mehmet Naci EDALI,Nasuhi Engin AYDIN
Trakya Universitesi Tip Fakultesi Dergisi , 2007,
Abstract: Objectives: The role of proliferative and apoptotic mechanisms in various endometrial pathologies and in proliferative and atrophic endometria was assessed by immunohistochemical methods.Patients and Methods: A total of 55 cases consisting of 13 endometrioid carcinomas, eight cases of endometrial hyperplasia, 15 cases of disordered proliferation, 12 cases with proliferative and seven with inactive/athrophic endometria gathered from the local archives were included in the study. Immunohistochemical markers and stains, namely bcl-2, an antiapopitotic marker, and Ki-67, a proliferative marker were applied to the sections of selected diagnostic tissue blocks. Additionally, mitotic counts per 10 high power fields were obtained in cases of hyperplasia and carcinoma.Results: Mean H-score value for bcl-2 reaction was 0.48 for endometrioid carcinoma. Mean H-score values for cases of hyperplasia, disordered proliferation, proliferation and atrophy were calculated as 1.93, 1.62, 1.5 and 1.0, respectively. Ki-67 proliferation index for endometrioid carcinoma was 48.9%. This index was 32%, 29%, 31.5% and 8.4% for hyperplasia, disordered proliferation, proliferation and atrophy, respectively.Conclusion: Staining with bcl–2 peaked in cases of hyperplasia, and lost its intensity as nuclear atypia became evident. Weakest staining was observed in cases with grade II and III endometrioid carcinomas. In contrast, proliferative indexes increased with increasing grades of carcinoma.
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