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Search Results: 1 - 10 of 181 matches for " Turhan Caskurlu "
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A Novel Technique for Treatment of Distal Ureteral Calculi: Early Results
Bayram Guner,Cenk Gurbuz,Turhan Caskurlu
Urology Journal , 2013,
Abstract: No Abstract
The Use of PSA Doubling Time to Predict Prognosis and the Use of PSA Response to Assess the Success for Prostate Cancer Patients Undergoing Docetaxel Chemotherapy  [PDF]
Sarp K. Keskin, Asif Yildirim, Cengiz Canakci, Ismail Ulus, Ramazan Gokhan Atis, Turhan Caskurlu
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.78062
Abstract: In the targeted therapy era, it is critical to know the certain points to start or discontinue chemotherapy for patients with castration resistant metastatic prostate cancer. The prognostic factors to determine this response are still not clear yet. We tried to find out if the PSA doubling time helps us to predict the patients who will benefit from docetaxel chemotherapy most, and also to question the value of the PSA response to chemotherapy. Retrospectively, 70 patients who had hormone refractory metastatic prostate cancer that were given at least 4 cycles of docetaxel chemotherapy between 2002 and 2015 were evaluated. After the onset of docetaxel, PSA response to therapy and overall survival rates were analyzed to figure out if these parameters were related to PSA doubling time. The only statistically significant prognostic parameter affecting overall survival was the best PSA response rate to docetaxel chemotherapy being over or under 50%. The most significant parameter that affects the PSA doubling time was the clinical stage at the time of diagnosis. PSA doubling time is not a useful predictive tool for predicting response to docetaxel. By means of overall survival, the clinical stage at the time of diagnosis was the best predictive tool for our cohort. The best PSA response rate to docetaxel chemotherapy was found to be a valuable parameter. The study being retrospective and the low number of patients included in this cohort can be the main weaknesses of this study. Further studies to determine which other factors can be useful are needed.
Reducing infectious complications after transrectal prostate needle biopsy using a disposable needle guide: is it possible?
Gurbuz, Cenk;Canat, Lutfi;Atis, Gokhan;Caskurlu, Turhan;
International braz j urol , 2011, DOI: 10.1590/S1677-55382011000100010
Abstract: purpose: to investigate whether the use of a disposable needle guide results in a decreased incidence of infectious complication after transrectal prostate needle biopsy (tpnb). materials and methods: fifty five patients who underwent 10-core tpnb were randomized into two groups. a pre-biopsy blood and urine examination was performed in both groups. group 1 (25 patients) underwent biopsy with disposable biopsy needle guide and group 2 (30 patients) underwent biopsy with reusable biopsy needle guide. all patients had a blood and negative urine culture before the procedure. the patients received ciprofloxacin 500 mg twice a day beginning the day before the biopsy and continued for 3 days after. serum c-reactive protein levels and urine and blood specimens were obtained 48h after the biopsy. primary endpoint of the study was to determine the effect of needle guide on the bacteriologic urinary tract infection (uti) rate and secondary end point was to determine symptomatic uti. results: the mean age of the patients was 63.46 (range 55 to 68) years. there were no significant differences regarding the prostate-specific antigen level, prostate size, existence of comorbidity in two groups before the procedure. bacteriologic and symptomatic uti was detected in 4% vs. 6.6% and 4% vs. 3.9% in group 1 and 2 relatively (p > 0.05). conclusion: the use of a disposable needle guide does not appear to minimize infection risk after tpnb. large scale and randomized studies are necessary to determine the effect of disposable needle guide on infection rate after tpnb.
Laparoscopic Unroofing and Aspiration-Sclerotherapy in the Management of Symptomatic Simple Renal Cysts
Serdar Arisan,Ayhan Dalkilinc,Turhan Caskurlu,Nurettin Cem Sonmez
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.358
Tissue Reaction of the Rat Urinary Bladder to Synthetic Mesh Materials
Gokhan Atis,Serdar Arisan,Aysim Ozagari,Turhan Caskurlu
The Scientific World Journal , 2009, DOI: 10.1100/tsw.2009.120
Efficacy of three different alpha 1-adrenergic blockers and hyoscine N-butylbromide for distal ureteral stones
Gurbuz, M. Cenk;Polat, Haci;Canat, Lutfi;Kilic, Mert;Caskurlu, Turhan;
International braz j urol , 2011, DOI: 10.1590/S1677-55382011000200006
Abstract: purpose: to evaluate hyoscine n-butyl bromide (hbb) and three different alpha-1 blockers in the treatment of distal ureteral stones. materials and methods: a total of 140 patients with stones located in the distal tract of the ureter with stone diameters of 5 to 10mm were enrolled in the present study and were randomized into 4 equal groups. group 1 received hbb, group 2 received alfuzosin, group 3 received doxazosin and group 4 received terazosin. the subjects were prescribed diclofenac injection (75 mg) intramuscularly on demand for pain relief and were followed-up after two weeks with x-rays of the kidneys, ureters, bladder and urinary ultrasonography every week. the number of pain episodes, analgesic dosage and the number of days of spontaneous passage of the calculi through the ureter were also recorded. results: the average stone size for groups 1, 2, 3 and 4 was comparable (6.13, 5.83, 5.59 and 5.48 mm respectively). stone expulsion was observed in 11%, 52.9%, 62%, and 46% in groups 1, 2, 3 and 4 respectively. the average time to expulsion was 10.55 ± 6.21 days in group 1, 7.38 ± 5.55 days in group 2, 7.85 ± 5.11 days in group 3 and 7.45 ± 5.32 days in group 4. alpha blockers were found to be superior to hbb (p < 0.05). conclusions: medical treatment of distal ureteral calculi with alfuzosin, doxazosin and terazosin resulted in a signi?cantly increased stone-expulsion rate and decreased expulsion time when compared with hbb. hbb seems to have a negative effect on stone-expulsion rate.
Primary Leiomyosarcoma of the Adrenal Gland: A Case Report with Immunohistochemical Study and Literature Review
Murat Tolga Gulpinar,Asif Yildirim,Berrin Gucluer,Ramazan Gokhan Atis,Cengiz Canakci,Cenk Gurbuz,Turhan Caskurlu
Case Reports in Urology , 2014, DOI: 10.1155/2014/489630
Abstract: Primary adrenal leiomyosarcoma is extremely rare tumor. We report a case with adrenal leiomyosarcoma. Our case was a 48-year-old man who presented with lower urinary tract symptoms. Ultrasonography and magnetic resonance imaging revealed approximately 9?cm solid mass originating from right adrenal gland. He underwent right adrenalectomy. Pathology of the specimen showed histologic and immunohistochemical features of adrenal leiomyosarcoma. 1. Introduction Primary leiomyosarcoma of the adrenal gland is a malignant tumor very rarely encountered in the literature and is without any specific findings by laboratory tests and radiologic imaging modalities. Herein, we present a rare case of primary leiomyosarcoma of the right adrenal gland in a 48-year-old male patient who presented with lower urinary tract symptoms. We aim to present a case with a definitive diagnosis of adrenal leiomyosarcoma, which was histopathologically established based on the microscopic examination and immunohistochemical staining of the specimen from the time of diagnosis to its treatment. A review of the recent literature is also presented. 2. Case A 48-year-old male patient consulted an outpatient urology clinic with complaints of frequent urination and awaking during night hours due to the need to urinate. During his physical examination, a mass was palpated on the upper right abdominal quadrant. Upon ultrasonography, a right adrenal mass measuring ?mm was detected, and the patient was hospitalized for further investigation and treatment. The mass was evaluated by the endocrinology department for identification. Upon abdominal magnetic resonance imaging (MRI), a ?mm hypervascular solid mass originating from the right adrenal gland and extending to the right hepatic lobe was observed, with intense contrast uptake on postcontrast images (Figures 1(a) and 1(b)). Figure 1: Magnetic resonance images of a 9?cm right adrenal leiomyosarcoma. T1-weighted images in coronal section (a) and transverse section show a homogenous solid mass in the right suprarenal area. (c) Macroscopic appearance of roundish, fibrous neoplasia. (d) Six months after right adrenalectomy, postoperative abdominal computerized tomography demonstrated no signs of local recurrence. The rectal examination findings and PSA values of the patient, whose father had been diagnosed with prostatic carcinoma, were within the normal limits. A routine laboratory examination and chest X-ray findings were unremarkable. To evaluate the endocrine activity of the mass, the 24-hour vanyl-mandelic acid, metanephrine, and normetanephrine
miR-1 and miR-133b Are Differentially Expressed in Patients with Recurrent Prostate Cancer
Omer Faruk Karatas, Esra Guzel, Ilknur Suer, Isin D. Ekici, Turhan Caskurlu, Chad J. Creighton, Michael Ittmann, Mustafa Ozen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098675
Abstract: Prostate cancer (PCa) is currently the most frequently diagnosed malignancy in the western countries. It is more prevalent in older men with 75% of the incident cases above 65 years old. After radical prostatectomy, approximately 30% of men develop clinical recurrence with elevated serum prostate-specific antigen levels. Therefore, it is important to unravel the molecular mechanisms underlying PCa progression to develop novel diagnostic/therapeutic approaches. In this study, it is aimed to compare the microRNA (miRNA) profile of recurrent and non-recurrent prostate tumor tissues to explore the possible involvement of miRNAs in PCa progression. Total RNA from 41 recurrent and 41 non-recurrent PCa tissue samples were used to investigate the miRNA signature in PCa specimens. First of all, 20 recurrent and 20 non-recurrent PCa samples were profiled using miRNA microarray chips. Of the differentially expressed miRNAs, miR-1, miR-133b and miR-145* were selected for further validation with qRT-PCR in a different set of 21 recurrent and 21 non-recurrent PCa samples. Data were statistically analyzed using two-sided Student's t-test, Pearson Correlation test, Receiver operating characteristic analysis. Our results demonstrated that miR-1 and mir-133b have been significantly downregulated in recurrent PCa specimens in comparison to non-recurrent PCa samples and have sufficient power to distinguish recurrent specimens from non-recurrent ones on their own. Here, we report that the relative expression of miR-1 and mir-133b have been significantly reduced in recurrent PCa specimens in comparison to non-recurrent PCa samples, which can serve as novel biomarkers for prediction of PCa progression.
On Partial Vertex Cover on Bipartite Graphs and Trees
Bugra Caskurlu,K. Subramani
Computer Science , 2013,
Abstract: It is well-known that the Vertex Cover problem is in P on bipartite graphs, however; the computational complexity of the Partial Vertex Cover problem on bipartite graphs is open. In this paper, we first show that the Partial Vertex Cover problem is NP-hard on bipartite graphs. We then identify an interesting special case of bipartite graphs, for which the Partial Vertex Cover problem can be solved in polynomial-time. We also show that the set of acyclic bipartite graphs, i.e., forests, and the set of bipartite graph where the degree of each vertex is at most 3 fall into that special case. Therefore, we prove that the Partial Vertex Cover problem is in P on trees, and it is also in P on the set of bipartite graphs where the degree of each vertex is at most 3.
Some Results on the Differential Geometry of Spacelike Curves in De-Sitter Space  [PDF]
Tunahan Turhan, Nihat Ayyildiz
Journal of Applied Mathematics and Physics (JAMP) , 2013, DOI: 10.4236/jamp.2013.13009

The differential geometry of curves on a hypersphere in the Euclidean space reflects instantaneous properties of spherecal motion. In this work, we give some results for differential geometry of spacelike curves in 3-dimensional de-Sitter space. Also, we study the Frenet reference frame, the Frenet equations, and the geodesic curvature and torsion functions to analyze and characterize the shape of the curves in 3-dimensional de-Sitter space.

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