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Search Results: 1 - 10 of 63879 matches for " Tu Wen-Jun "
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Correlation Between Hypoglycemia and Positive Rate of Inborn Error of Metabolism in Neonatal Intensive Care Unit
Wen-jun Tu,Jian He,Ying Li
Iranian Journal of Pediatrics , 2012,
Abstract: Objective: To investigate the correlation between hypoglycemia and positive rate of inborn error of metabolism (IEM) in neonatal intensive care unit.Methods: 160 patients from a neonatal intensive care unit were enrolled. Blood glucose was measured by Roche Modular chemistry. The dry blood on filter papers, collected from 160 patients, was tested by tandem mass spectrometry to detect 35 inborn errors of metabolism. Clinical follow-up of all the patients was at leastin an interval of 12 months. The mean observation period was 13.5 months per child.Findings: Based on the ROC curve, the optimal cut-off value of hypoglycemia as an indicator for screening forIEMs was projected to be 2.8 mmol/L, which yielded a sensitivity of 71.4% and a specificity of 76.5%. The patients were divided into two groups: hypoglycemia group (48 cases) and the control group (112 cases).5(10.4%) of the 48 patients in the hypoglycemia group were positive, while only 2(1.8%) of the 112 patients in the control group were positive. The difference of the positive rate in the screening for IEMs between the two groups was significant (χ2=4.10, P<0.05); the relative risk (RR) was 5.83 (95% CI: 1.06-32.12).Conclusion: The risk of patients with hypoglycemia suffering from IEMs was significantly higher than that of the non-hypoglycemia patients in NICU, based on cut-off value of 2.8mmol/L.
Tuberous Sclerosis Complex in Autism
Xin Guo,Wen-Jun Tu,Xiao-Dong Shi
Iranian Journal of Pediatrics , 2012,
Abstract: Objective: To study the prevalence rate of tuberous sclerosis complex in autistic disorder.Methods: We studied one cohort of children followed up since 2005 until 2009, with autistic disorder, to determine the incidence of tuberous sclerosis complex. We established an autistic disorder registry in 2005 at China Rehabilitation Research Center. During the 4-year period (2005–2009), we collected a database of 429 children (390 boys and 39 girls; male to female ratio 10:1) with autistic disorder and pervasive developmental disorders. We routinely examined all children with autistic disorder for any features oftuberous sclerosis complex by looking for neurocutaneous markers such as depigmented spots. In those with infantile spasm or epilepsy, the clinical features of tuberous sclerosis complex were monitored regularly during follow-up.Findings: Of these, five had tuberous sclerosis complex. Thus, the prevalence rate of tuberous sclerosis complex in autistic disorder is 1.17%. All of these children were mentally retarded with moderate to severe grades. Their IQ or developmental quotient was less than 70.Conclusion: The prevalence rate of tuberous sclerosis complex in autistic disorder was 1.17% in our region;autism spectrum disorder is a condition that might be associated with development of tuberous sclerosis complex.
Prognostic value of copeptin in patients with acute ischemic stroke
Tu Wen-Jun,Chen Hui,Cui Li-Hua
Iranian Journal of Neurology , 2011,
Abstract: Stroke is the second leading cause of mortality in the Chinaand one of the leading causes of severe morbidity. An earlyrisk assessment with estimate of the severity of disease andprognosis is pivotal for optimized care and allocation ofhealthcare resources. Reliable prognostic markers availableduring the initial phase after acute stroke may aid clinicaldecision-making.Vasopressin (AVP) is a potent synergistic factor ofcorticotropin-releasing hormone as hypothalamic stimulator ofthe hypothalamo-pituitary-adrenal axis.1 Some studies foundincreased AVP levels in patients with ischemic stroke werecorrelated with stroke severity2 and outcome.3 Copeptin isreleased in an equimolar ratio to AVP, and is more stable inthe circulation and easy to measure.4We designed a preliminary prospective cohort study toevaluate the prognostic value of copeptin in acute strokepatients. Adult patients with a persistent neurological deficitdue to ischemic stroke were eligible. Sixty-ninenonconsecutive patients admitted at 3 hospitals with adiagnosis of acute ischemic stroke confirmed by CT scanningwere evaluated. All patients provided informed consent. Inpatients who died within 24 hours after admission or inpatients who were discharged, data from admission or untildischarge were collected. The National Institute of HealthStroke Scale (NIHSS) score was assessed on admission.Functional outcome was obtained on days 90 according to themodified Rankin Scale (mRS) blinded to copeptin levels. Poorfunctional outcome at 3 months was considered as a mRSscore > 2. Blood samples were collected on admission andimmediately centrifuged and sera stored at –70°C. Copeptinwas measured with a sandwich immunoluminometricassay.1 Discrete variables are summarized as counts(percentage), and continuous variables as medians andinterquartile ranges (IQRs). Two-group comparison of notnormally distributed data was performed using Mann–Whitney U test, and a Kruskal–Wallis one-way analysis ofvariance was used for multi-group comparisons.The median age of the 69 patients was 62 years (IQR,55 to 84), 61% were men and the median NIHSS score onadmission was 7 points (IQR, 3 to 12). In 38 patients(55%) with a poor functional outcome (13 patients died),copeptin levels were higher compared with those inpatients with a favorable outcome (23.5; IQR, 10.6 to 64.3pmol/L vs. 7.5; IQR, 3.8 to 13.6 pmol/L; P < 0.0001).Multivariate logistic regression analysis adjusted for ageand NIHSS score showed that copeptin was anindependent predictor of poor functional outcome (oddsratio = 3.12; 95%CI, 1.54–6.46). The area under the
Psychological Effects of False-Positive Results in Expanded Newborn Screening in China
Wen-Jun Tu, Jian He, Hui Chen, Xiao-Dong Shi, Ying Li
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036235
Abstract: Objectives As more families participate expanded newborn screening for metabolic disorders in China, the overall number of false positives increases. Our goal was to assess the potential impact on parental stress, perceptions of the child's health, and family relationships. Methods Parents of 49 infants with false-positive screening results for metabolic disorders in the expanded newborn screening panel were compared with parents of 42 children with normal screening results. Parents first completed structured interview using likert scales, closed and open questions. Parents also completed the parenting stress index. Results A total of 88 mothers and 41 fathers were interviewed. More mothers in the false-positive group reported that their children required extra parental care (21%), compared with 5% of mothers in the normal-screened group (P<0.001). 39% of mothers in the false-positive group reported that they worry about their child's future development, compared with 10% of mothers in the normal-screened group (P<0.001). Fathers in the false-positive group did not differ from fathers in the normal-screened group in reporting worry about their child's extra care requirements, and their child's future development. Children with false-positive results compared with children with normal results were triple as likely to experience hospitalization (27%vs 9%, respectively; P<0.001). Conclusions The results showing false-positive screening results may affect parental stress and the parent-child relationship. Parental stress and anxiety can be reduced with improved education and communication to parents about false-positive results.
An in vitro study on neuroprotective effects of serum containing Gengnianchun decoction and its main monomers against amyloid beta protein-induced cellular toxicity
Wen-jun WANG
Zhong Xi Yi Jie He Xue Bao , 2010,
Abstract: Obiective: To observe the effects of serum containing Gengnianchun (GNC) decoction, a compound traditional Chinese herbal medicine, and its monomers (paeoniflorin, berberine, timosaponin A-Ⅲ and icariin) on neurotoxicity in PC12 cells induced by amyloid beta-protein (Aβ).Methods: Injury of PC12 cells was induced by in incubating with Aβ25-35 in vitro. Ovariectomized rats were intragastrically administered with GNC decoction twice daily for 5 days and then sera were obtained. Different concentrations of serum containing GNC decoction and its main monomers including paeoniflorin, berberine, timosaponin and icariine and the monomer mixtures were cultured with PC12 cells to determine the best concentration of the drugs by methyl thiazolyl tetrazolium (MTT) method. The effective concentration of Aβ25-35 was detemined by culturing PC12 cells with different concentrations of Aβ25-35. Then, the activity of PC12 cells with Aβ25-35-induced injury was observed with MTT method. Cellular morphological change was observed by phase contrast microscopy. Flow cytometry and fluorescence microscopy were employed to observe the Aβ25-35-induced early apoptosis of PC12 cells.Results: After Aβ25-35 induction, the PC12 cells were fewer in number, less viable with shrinked cel1 body, many fragments, adhered less and nuclei shrinked. The cell proliferation was inhibited by Aβ25-35 concentration- and timedependently. Aβ25-35 at concentration of 20 μmol/ L was selected to construct the Alzheimer's disease model in vitro. The sera containing GNC decoction could reinforce PC12 cell activity, and concentration at 20% was better than other concentrations after 24-, 48- and 72-hour culture. The 20% serum containing GNC decoction, 0.1 μmol/L berberin and monomer mixture 3 including 1 mg/mL paeoniflorin, 1 μmol/L berberine, 1 μmol/L timosaponin and 1 ng/mL icariine could antagonize neurotoxicity induced by Aβ25-35. Moreover, they could inhibit Aβ25-35-induced early apoptosis of PC12 cells, with the effect of 20% serum containing GNC decoction better than 0.1 μmol/L berberine and monomer mixture 3.Conclusion: Serum containing GNC decoction at 20% concentration has the potential neuroprotective effect on Aβ-induced cellular impairment. The serum containing GNC decoction was found to be stronger in action than the main monomers.
An Empirical Study on the Overreaction of Shanghai Stock Market  [PDF]
Hu Lin, Sha Zi-Jun, Liu Xiu-Yi, Chen Wen-Jun
Chinese Studies (ChnStd) , 2013, DOI: 10.4236/chnstd.2013.21004

Based on both Chinese and non-Chinese research results, this study uses the research methods of De Bondt and Thaler, selects the trading data from January 2007 to June 2011 in stock market in Shanghai, and tests whether there has been overreaction in the stock market. The empirical result shows more abnormal return of loser portfolio than that of winner portfolio, which indicates over-reaction of the stock market. Moreover, the term is longer and the reversion degree of return is weaker. The result means that the risk difference between winner and loser portfolios does not adequately explain the over-reaction. The main reason for the overreaction we think is the institutional background and other constraining conditions of the stock market in the Chinese mainland.

Hormone-Sensitive Lipase Knockouts
Fredric B Kraemer, Wen-Jun Shen
Nutrition & Metabolism , 2006, DOI: 10.1186/1743-7075-3-12
Abstract: Free fatty acids (FFA) are a major energy source for most tissues in mammals. Circulating FFA in plasma are primarily derived from adipose tissue, which is the main repository for the storage of triacylglycerol. All treatments for obesity, including dietary restriction of carbohydrates, have a goal of reducing the storage of fat in adipocytes. The chief enzyme responsible for the mobilization of FFA from adipose tissue, i.e., lipolysis, was thought to be hormone-sensitive lipase (HSL). This review addresses some aspects of the organization of components of fat metabolism in the adipocyte, lipolysis and lipogenesis, and how genetic manipulation of the pathway of lipolysis affects fat metabolism in the adipocyte.HSL is an intracellular, neutral lipase that has broad substrate specificity, catalyzing the hydrolysis of triacylglycerol, diacylglycerol, monoacylglycerol, and cholesteryl esters, as well as retinyl esters; however, it possesses no phospholipase activity [1]. Its activity against diacylglycerol is about 10-fold and 5-fold higher than its activity against triacylglycerol and monoacylglycerol, respectively, whereas its activity against cholesteryl esters is about twice its activity toward triacylglycerol. The hydrolytic activity of HSL against triacylglycerol and cholesteryl esters, but not against diacylglycerol, is stimulated by phosphorylation mediated primarily by protein kinase A (PKA) [1].The regulation of lipolysis is complex and, although not completely understood, involves multiple mechanisms, including lipolytic (β-adrenergic agonists, ACTH, etc.) and anti-lipolytic (insulin, adenosine, etc.) hormones and their cognate receptors and signaling pathways, particularly involving cyclic AMP and PKA. Current working models for the mechanisms underlying lipolysis have focused on steps downstream of hormone receptors and signaling cascades, concentrating on lipid droplet-associated proteins, such as perilipins, and lipases, such as HSL and others, that appea
Lung tissue flap repairs esophagus defection with an inner chitosan tube stent
Gang Chen, Wen-Jun Shi
World Journal of Gastroenterology , 2009,
Abstract: AIM: To repair the partial esophagus defect with a chitosan stent, a new esophageal prosthesis made of pulmonary tissue with vascular pedicle.METHODS: Fifteen Japanese big ear white rabbits were divided into experimental group (n = 10) and control group (n = 5). Esophagus defect in rabbits of experimental group was repaired using lung tissue flap with a chitosan tube stent, gross and histological appearance was observed at week 2, 4 and 8 after operation, and barium sulphate X-ray screen was performed at week 10 after operation. Esophagus defect of rabbits in control group was repaired using lung tissue flap with no chitosan tube stent, gross and histological appearance was observed at week 2, 4 and 8 after operation, and barium sulphate X-ray screen was performed at week 10 after operation.RESULTS: In the experimental group, 6 rabbits survived for over two weeks, the lung tissue flap healed esophageal defection, and squamous metaplasia occurred on the surface of lung tissue flap. At week 10 after operation, barium sulphate examination found that barium was fluent through the esophagus with no stricture or back stream, the creeping was good. In the control group, 4 rabbits survived for two weeks, the lung tissue flap healed esophageal defection with fibrous tissue hyperplasia, barium sulphate examination found that barium was fluent through the esophagus with a slight stricture or back stream, and the creeping was not good at week 10 after operation.CONCLUSION: Esophagus defect can be repaired using lung tissue flap with an inner chitosan tube stent.
Research advances of traditional Chinese medicine in delaying skin aging
Ling ZHANG,Wen-jun WANG
Zhong Xi Yi Jie He Xue Bao , 2009,
Efficacy of Chinese patent medicine Tian Gui Capsule in patients with polycystic ovary syndrome: a randomized controlled trial
Susuana Kuek,Wen-jun Wang
Zhong Xi Yi Jie He Xue Bao , 2011,
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