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Search Results: 1 - 10 of 939 matches for " Tsuyoshi Yoshimoto "
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Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia
Masayuki Miyazaki,Masatake Tanaka,Akihiro Ueda,Tsuyoshi Yoshimoto
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i44.4928
Abstract: Drug-induced hypersensitivity syndrome (DIHS) is a severe reaction usually characterized by fever, rash, and multiorgan failure, occurring 2-6 wk after drug introduction. It is an immune-mediated reaction involving macrophage and T-lymphocyte activation and cytokine release. A 54-year-old woman was diagnosed with rheumatic arthritis and initiated salazosulfapyridine by mouth. About 10 d later, she had a high fever, skin rash and liver dysfunction. She was admitted to hospital and diagnosed with a drug eruption. She was treated with oral prednisolone 30 mg/d; however, she developed high fever again and her blood tests showed acute liver failure and cytopenia associated with hyperferritinemia. She was diagnosed with acute liver failure and hemophagocytosis caused by DIHS. She was transferred to the Department of Medicine and Bioregulatory Science, Kyushu University, where she was treated with arterial steroid injection therapy. Following this treatment, her liver function improved and serum ferritin immediately decreased. We hypothesized that an immune-mediated reaction in DIHS may have generated over-activation of macrophages and T-lymphocytes, followed by a cytokine storm that affected various organs. The measurement of serum ferritin might be a useful marker of the severity of DIHS.
Comparison of tissue pressure and ablation time between the LeVeen and cool-tip needle methods
Makoto Nakamuta, Motoyuki Kohjima, Shusuke Morizono, Tsuyoshi Yoshimoto, Yuzuru Miyagi, Hironori Sakai, Munechika Enjoji, Kazuhiro Kotoh
Comparative Hepatology , 2006, DOI: 10.1186/1476-5926-5-10
Abstract: A block of pig liver sealed in a rigid plastic case was used as a model of an HCC tumor with a capsule. The multi-step method with the LeVeen electrode resulted in the lowest pressure as compared with the single-step or cool-tip methods. There was no significant difference in the ablation time between the multi-step and cool-tip ablation methods, although the single-step methods had longer ablation times than the other ablation procedures. In HCC cases, the multi-step method had a significantly shorter ablation time than the single-step or cool-tip methods.We demonstrated that the multi-step method was useful to reduce the ablation time and to suppress the increase in pressure. The multi-step method using a LeVeen needle may be a clinically applicable procedure for RFA.Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Most of HCC patients suffer from virus-induced liver injury and most have underlying liver cirrhosis [1]. Percutaneous ethanol injection therapy (PEIT) has been used widely for the treatment of unresectable HCC [2]. Many reports showed that the efficacy of PEIT for small HCC tumors was comparable to that of hepatic resection; however, PEIT demands multiple sessions to achieve complete necrosis, resulting in protracted hospitalization [3]. Furthermore, many patients suffer from local recurrence after PEIT, which is attributable to intra-tumor septa that prevent the injected ethanol from infiltrating the entire tumor [4,5]. We reported that local recurrence after PEIT should be prevented as much as possible because it is one of the most important negative prognostic factors for HCC patients [6].It has been reported that radio frequency ablation (RFA) is an effective procedure for hepatocellular carcinoma (HCC) as well as for metastatic liver tumors [7,8]. However, it has also been shown that it is not uncommon for RFA to cause various complications [9,10]. During or just after the procedure, peritoneal bleeding, hepatic abscess,
Comparison of Hemodynamic Responses Associated with Tracheal Intubation Under Various Induction Doses of Remifentanil and Propofol  [PDF]
Toru Goyagi, Masashi Yoshimoto
Open Journal of Anesthesiology (OJAnes) , 2012, DOI: 10.4236/ojanes.2012.24035
Abstract: .Background: The optimal dose of propofol and remifentanil induction to minimize the cardiovascular response associated with tracheal intubation may exist. We investigated the cardiovascular response associated with tracheal intubation when various continuous induction doses of remifentanil in combination with propofol were used. Methods: Seventy- five patients were randomly allocated into 1 of 3 groups: the R-0.4 P-1 group (remifentanil 0.4 μg/kg/min and propofol 1 mg/kg); the R-0.5 P-1 group (remifentanil 0.5 μg/kg/min and propofol 1 mg/kg); and the R-0.4 P-2 group (remifentanil 0.4 μg/kg/min and propofol 2 mg/kg). One minute after remifentanil infusion commenced, a bolus of propofol was injected. Rocuronium 1 mg/kg was administered 1 min after propofol injection following loss of consciousness. Controlled ventilation was then performed for 2 min, and the trachea was intubated 4 min after the start of the remifentanil infusion. The infusion rate of remifentanil was decreased to 0.1 μg/kg/min after intubation. Blood pressure (BP) and heart rate (HR) were measured during this period until 5 min after tracheal intubation. Results: The changes in BP response due to tracheal intubation in the R-0.4 P-1 group were greater than those in the other 2 groups, whereas the HR responses to tracheal intubation were similar among the 3 groups. Conclusion: The combination of remifentanil 0.4 μg/kg/min and propofol 1 mg/kg led to an exaggerated cardiovascular response to tracheal intubation compared with the other combination groups.
Minocycline for Schizophrenia: A critical review  [PDF]
Tsuyoshi Miyaoka
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.224056
Abstract: Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestoractive or neuroprotective properties in various models of neurodegenerative diseases. In particular, it has been shown to delay motor alterations, inflammation and apoptosis in models of Huntington’s disease, amyotrophic lateral sclerosis and Parkinson’s disease. Despite controversies about its efficacy, the relative safety and tolerability of minocycline have led to the launching of various clinical trials. Previously, we reported the antipsychotic effects of minocycline in patients with schizophrenia. In a pilot investigation, we administered minocycline as an open-label adjunct to antipsychotic medication to patients with schizophrenia. The results of this trial suggested that minocycline might be a safe and effective adjunct to antipsychotic medications, and that augmentation with minocycline may prove to be a viable strategy for “boosting” antipsychotic efficacy and for treating schizophrenia. Recently, in randomized double-blind placebo-controlled clinical trials, the addition of minocycline to treatment as usual early in the course of schizophrenia predominantly improves negative symptoms. The present review summarizes the available data supporting the clinical testing of minocycline for patients with schizophrenia. In addition, we extend our discussion to the potential applications of minocycline for combining this treatment with cellular and molecular therapy.
On the Dependence of the Limit Functions on the Random Parameters in Random Ergodic Theorems
Takeshi Yoshimoto
Abstract and Applied Analysis , 2013, DOI: 10.1155/2013/503689
Melting of MgO studied using a multicanonical ensemble method combined with a first-principles calculation
Yoshihide Yoshimoto
Physics , 2009, DOI: 10.1143/JPSJ.79.034602
Abstract: Melting of MgO was studied using a multicanonical ensemble method combined with a first-principles calculation. This approach has been successively performed by using a rather simple functional form for a model inter-atomic potential that is determined from first-principles and a novel approximation treating auxiliary degrees of freedom, such as electron thermal excitations, within a multicanonical ensemble method. Although a rather simple model potential was used, this approach could distinguish differences due to the exchange-correlation potential used in the first-principles calculations. The pressure dependence of the melting point, latent heat, and volume change during melting were studied. The obtained dependence was similar to that reported by Alfe which differs from experimental results. This dependence did not change even with the PBEsol exchange-correlation potential.
Influence of Underlying Diseases and Age on the Association between Obesity and All-Cause Mortality in Post-Middle Age  [PDF]
Kazuki Yoshimoto, Tatsuya Noda, Tomoaki Imamura
Health (Health) , 2018, DOI: 10.4236/health.2018.109089
Abstract: Background: Studies on the association between obesity and all-cause mortality have found that the degree of obesity is directly proportional to all-cause mortality. In contrast, there have been studies indicating that obese people with underlying diseases have a higher survival rate. We hypothesized that age and underlying diseases lead to such contrasting results. Therefore, we conducted a study to clarify the influence of post-middle age obesity and underlying diseases on all-cause mortality. Methods: This study used data from longitudinal studies in the United States, which conducted follow-up for 19 years on 33,708 participants in different age groups: ≥45, 45 - 64, and ≥65 years. Hazard ratio (HR) was determined using the Cox proportional hazards model to analyze a group consisting of all participants, a group of those with underlying diseases, and a group of those without underlying diseases, considering age, gender, education history, marital status, household income, smoking history, and BMI category as covariates. Results: In the group aged ≥65 without underlying diseases, HR was almost 1 in those with BMI 25 - <30, 30 - <35, and BMI > 35 kg/m2. Further, HR was higher in the 45 - 64 age group without underlying diseases if BMI was >35 kg/m2. However, HR was approximately 1 in the ≥65 age group. Conclusions: The study revealed that among individuals aged ≥65 years without underlying diseases, there was no association between obesity and all-cause mortality. Among individuals without underlying diseases, HR was higher in the 45 - 64 age group with BMI > 35 kg/m2 but was approximately 1 among those aged ≥65 years. Therefore, an interaction based on age was detected. These findings may lead to recommendations regarding the need to modify the advice and education provided to obese individuals in different age groups.
Electrodeposition of Bi-Sb alloy using Cu electrodes  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.37069
Abstract: Bi-Sb alloys were grown by means of an electrodeposition method using Cu electrodes. The alloys were studied with the help of an x-ray diffractometer and an electron probe microanalysis. The both investigations have shown no trace of Cu in the obtained alloys. It can be concluded that Cu electrodes can be used for the deposition of Bi-Sb alloys; which results in an advantage of availability of the electrode.
Scoping the Possibilities: Student Preferences towards Open Textbooks Adoption for E-Learning  [PDF]
Deepak Prasad, Tsuyoshi Usagawa
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.524227
Abstract: Many universities have begun implementing e-Learning systems due to their low cost. However, publishers of expensive textbooks stand in the way of e-Learning’s ability to provide a cost-effective educational delivery model. While many universities aim to overcome this opposition and replace traditional publishers’ textbooks with free open textbooks, such plans cannot be executed successfully unless students are open to their use. As such, a study into students’ preferences towards open textbook adoption is vital to provide clear indication as to their opinions regarding open textbook use. Thus, this study conducted a study of University of the South Pacific (USP) students’ preferences towards open textbook adoption for e-Learning using a survey administered during Semester 2, 2013 which generated 1077 responses. Areas examined include: Impacts of textbook costs on students’ academic careers; preferences towards open textbook adoption; perceived barriers to and motivations for adoption of open textbooks; and preferred digital features and reading devices. Results show that textbook prices adversely impact students. Furthermore, a high level of acceptance towards the adoption of open textbooks was found. The study revealed that the preference for reading printed material was the highest rated barrier to open textbook adoption, while the free availability of open textbooks was rated the greatest motivator. Study findings are being used to inform efforts to develop open textbooks at the USP and may assist other universities seeking to start similar projects.
Comparison between Amorphous and Tandem Silicon Solar Cells in Practical Use  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.54002
Abstract: Solar cells are now widely used as a clean method for electric energy generation. Among various type of solar cells, we compared the ability between amorphous and tandem (amorphous and polycrystalline) silicon solar cells by means of simultaneous running test. This kind of comparison is of importance practically, because the comparison of only inherent characteristics cannot include environmental parameters such as temperature totally. It was concluded that both types of solar cells provided almost the same energy for one year. The amorphous silicon solar cell provided more energy in summer while the tandem solar cell was advantageous in winter. It is due to the fact that the decrease in energy conversion at the higher cell temperature is more noticeable in tandem solar cells.
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