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Search Results: 1 - 10 of 1195 matches for " Tsuyoshi Noguchi "
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A Non-Neuronal Cardiac Cholinergic System Plays a Protective Role in Myocardium Salvage during Ischemic Insults
Yoshihiko Kakinuma, Tsuyoshi Akiyama, Kayo Okazaki, Mikihiko Arikawa, Tatsuya Noguchi, Takayuki Sato
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050761
Abstract: Background In our previous study, we established the novel concept of a non-neuronal cardiac cholinergic system–cardiomyocytes produce ACh in an autocrine and/or paracrine manner. Subsequently, we determined the biological significance of this system–it played a critical role in modulating mitochondrial oxygen consumption. However, its detailed mechanisms and clinical implications have not been fully investigated. Aim We investigated if this non-neuronal cardiac cholinergic system was upregulated by a modality other than drugs and if the activation of the system contributes to favorable outcomes. Results Choline acetyltransferase knockout (ChAT KO) cells with the lowest cellular ACh levels consumed more oxygen and had increased MTT activity and lower cellular ATP levels compared with the control cells. Cardiac ChAT KO cells with diminished connexin 43 expression formed poor cell–cell communication, evidenced by the blunted dye transfer. Similarly, the ChAT inhibitor hemicholinium-3 decreased ATP levels and increased MTT activity in cardiomyocytes. In the presence of a hypoxia mimetic, ChAT KO viability was reduced. Norepinephrine dose-dependently caused cardiac ChAT KO cell death associated with increased ROS production. In in vivo studies, protein expression of ChAT and the choline transporter CHT1 in the hindlimb were enhanced after ischemia-reperfusion compared with the contralateral non-treated limb. This local effect also remotely influenced the heart to upregulate ChAT and CHT1 expression as well as ACh and ATP levels in the heart compared with the baseline levels, and more intact cardiomyocytes were spared by this remote effect as evidenced by reduced infarction size. In contrast, the upregulated parameters were abrogated by hemicholinium-3. Conclusion The non-neuronal cholinergic system plays a protective role in both myocardial cells and the entire heart by conserving ATP levels and inhibiting oxygen consumption. Activation of this non-neuronal cardiac cholinergic system by a physiotherapeutic modality may underlie cardioprotection through the remote effect of hindlimb ischemia-reperfusion.
Minocycline for Schizophrenia: A critical review  [PDF]
Tsuyoshi Miyaoka
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.224056
Abstract: Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestoractive or neuroprotective properties in various models of neurodegenerative diseases. In particular, it has been shown to delay motor alterations, inflammation and apoptosis in models of Huntington’s disease, amyotrophic lateral sclerosis and Parkinson’s disease. Despite controversies about its efficacy, the relative safety and tolerability of minocycline have led to the launching of various clinical trials. Previously, we reported the antipsychotic effects of minocycline in patients with schizophrenia. In a pilot investigation, we administered minocycline as an open-label adjunct to antipsychotic medication to patients with schizophrenia. The results of this trial suggested that minocycline might be a safe and effective adjunct to antipsychotic medications, and that augmentation with minocycline may prove to be a viable strategy for “boosting” antipsychotic efficacy and for treating schizophrenia. Recently, in randomized double-blind placebo-controlled clinical trials, the addition of minocycline to treatment as usual early in the course of schizophrenia predominantly improves negative symptoms. The present review summarizes the available data supporting the clinical testing of minocycline for patients with schizophrenia. In addition, we extend our discussion to the potential applications of minocycline for combining this treatment with cellular and molecular therapy.
Engineering Management Framework to Achieve Safety of a Service of an Organization Based on Social Acceptance  [PDF]
Yuichi Otsuka, Hiroshi Noguchi
Open Journal of Safety Science and Technology (OJSST) , 2012, DOI: 10.4236/ojsst.2012.21003
Abstract: We aim at a management framework of an organization in order to achieve its safety in a limited case for a system in-volving the organization for the service, its users and the surrounding society. The proposed framework is possible to allow safety managers to specify tasks involving safety measures based on the concept of “a study of safety”. In the beginning, we discuss the definitions of safety and acceptance, which will be the target of safety management. Next, problems in which the hierarchy of components in the safety systems involves are noted. We then propose the following details of the management framework to achieve the safety of the service of the organization based on acceptance by the surrounding society. Applications of the components in the proposed framework are effectively demonstrated. The shown application can aid in visualizing a way of specification of the proposed concept in a target system.
Relationship between Abdominal Strength Measured by a Newly Developed Device and Abdominal Muscle Thickness  [PDF]
Takanori Noguchi, Shinichi Demura
Advances in Physical Education (APE) , 2014, DOI: 10.4236/ape.2014.42010

Although measurement of abdominal strength is important for evaluating trunk myofunction, adequate devices for these measurements have not been developed. As a consequence, the relationships between abdominal strength and abdominal muscle thickness have also not been determined. This study aimed to develop a new device for measuring abdominal strength and to examine the relationship between abdominal muscle strength and thickness. The subjects in the study included 50 young males (age, 19.1 ± 0.32 years; height, 171.0 ± 6.55 cm; weight, 69.5 ± 12.15 kg). The measurement of abdominal flexion strength had high reliability with an intra-class correlation coefficient (ICC) >0.9. The thickness of the rectus abdominis muscle was measured under two conditions using an ultrasound imaging method; relaxation and strength exertion. Abdominal muscle thickness was significantly thicker during exertion than during relaxation. Abdominal flexion strength showed a significant correlation with muscle thickness during both relaxation (r = 0.69) and strength exertion (r = 0.71). No significant difference was found between these correlation coefficients. In conclusion, the values of abdominal strength determined by our newly-developed measuring device had high reliability, with abdominal flexion strength showing a relatively close relationship with the thickness of the rectus abdominis during strength exertion and relaxation.

Generation of Induced Pluripotent Stem Cells from Human Nasal Epithelial Cells Using a Sendai Virus Vector
Mizuho Ono, Yuko Hamada, Yasue Horiuchi, Mami Matsuo-Takasaki, Yoshimasa Imoto, Kaishi Satomi, Tadao Arinami, Mamoru Hasegawa, Tsuyoshi Fujioka, Yukio Nakamura, Emiko Noguchi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042855
Abstract: The generation of induced pluripotent stem cells (iPSCs) by introducing reprogramming factors into somatic cells is a promising method for stem cell therapy in regenerative medicine. Therefore, it is desirable to develop a minimally invasive simple method to create iPSCs. In this study, we generated human nasal epithelial cells (HNECs)-derived iPSCs by gene transduction with Sendai virus (SeV) vectors. HNECs can be obtained from subjects in a noninvasive manner, without anesthesia or biopsy. In addition, SeV carries no risk of altering the host genome, which provides an additional level of safety during generation of human iPSCs. The multiplicity of SeV infection ranged from 3 to 4, and the reprogramming efficiency of HNECs was 0.08–0.10%. iPSCs derived from HNECs had global gene expression profiles and epigenetic states consistent with those of human embryonic stem cells. The ease with which HNECs can be obtained, together with their robust reprogramming characteristics, will provide opportunities to investigate disease pathogenesis and molecular mechanisms in vitro, using cells with particular genotypes.
Electrodeposition of Bi-Sb alloy using Cu electrodes  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.37069
Abstract: Bi-Sb alloys were grown by means of an electrodeposition method using Cu electrodes. The alloys were studied with the help of an x-ray diffractometer and an electron probe microanalysis. The both investigations have shown no trace of Cu in the obtained alloys. It can be concluded that Cu electrodes can be used for the deposition of Bi-Sb alloys; which results in an advantage of availability of the electrode.
Scoping the Possibilities: Student Preferences towards Open Textbooks Adoption for E-Learning  [PDF]
Deepak Prasad, Tsuyoshi Usagawa
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.524227
Abstract: Many universities have begun implementing e-Learning systems due to their low cost. However, publishers of expensive textbooks stand in the way of e-Learning’s ability to provide a cost-effective educational delivery model. While many universities aim to overcome this opposition and replace traditional publishers’ textbooks with free open textbooks, such plans cannot be executed successfully unless students are open to their use. As such, a study into students’ preferences towards open textbook adoption is vital to provide clear indication as to their opinions regarding open textbook use. Thus, this study conducted a study of University of the South Pacific (USP) students’ preferences towards open textbook adoption for e-Learning using a survey administered during Semester 2, 2013 which generated 1077 responses. Areas examined include: Impacts of textbook costs on students’ academic careers; preferences towards open textbook adoption; perceived barriers to and motivations for adoption of open textbooks; and preferred digital features and reading devices. Results show that textbook prices adversely impact students. Furthermore, a high level of acceptance towards the adoption of open textbooks was found. The study revealed that the preference for reading printed material was the highest rated barrier to open textbook adoption, while the free availability of open textbooks was rated the greatest motivator. Study findings are being used to inform efforts to develop open textbooks at the USP and may assist other universities seeking to start similar projects.
Comparison between Amorphous and Tandem Silicon Solar Cells in Practical Use  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.54002
Abstract: Solar cells are now widely used as a clean method for electric energy generation. Among various type of solar cells, we compared the ability between amorphous and tandem (amorphous and polycrystalline) silicon solar cells by means of simultaneous running test. This kind of comparison is of importance practically, because the comparison of only inherent characteristics cannot include environmental parameters such as temperature totally. It was concluded that both types of solar cells provided almost the same energy for one year. The amorphous silicon solar cell provided more energy in summer while the tandem solar cell was advantageous in winter. It is due to the fact that the decrease in energy conversion at the higher cell temperature is more noticeable in tandem solar cells.
Simulation Suggests Origin of Potential Induced Degradation of Solar Cell  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.56004
Abstract: Solar cells are well known as devices for sustainable electric energy generation. Nowadays the potential induced degradation has been brought up as an obstacle problem for practical use. In order to determine the cause of this kind of degradation, numerical simulation by a finite difference time domain method has been performed for computational electromagnetics in the case that the thunder attacks the solar modules. The results show that the dielectric breakdown in the glass covered over the solar cells triggered by the thunderstroke is critical. So it is helpful to protect the dielectric breakdown in the glass from the thunderstroke.
Effect of Parameters on Potential Induced Degradation of Solar Cell  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.56003
Abstract: Solar cells are widely used to generate electric energy even at homes. It surely has a great advantage of sustainability. However, the potential induced degradation has been found to be an obstacle problem for practical use. It was reported that the main cause is the dielectric breakdown in the glass covered over the solar cells triggered by the thunderstroke. In this paper, the effects of the parameters such as the position of thunderstroke, the wave form, the peak value and the front duration of the lightning current, were examined by means of numerical calculation. For the lightning current, a step-like waveform and an impulse waveform were examined. The effect of the induced voltage was found to be independent of the waveform. The peak value, the front duration of the lightning current greatly affects the induced voltage.
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