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Search Results: 1 - 10 of 1252 matches for " Tsuyoshi Matsumura "
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Bacterial Cells as Model Factories  [PDF]
Ichiro Matsumura
American Journal of Operations Research (AJOR) , 2013, DOI: 10.4236/ajor.2013.31A007
Abstract:

Bacteria, like industrial engineers, must manage processes that convert low value inputs into high value outputs. Bacteria are not intelligent, so they utilize self-organizing production systems to accelerate life-sustaining chemical processes. Here I explore two questions. First, can businesses apply the principles of self-organization? Second, can operations researchers contribute to our understanding of biological systems? I explain biochemical concepts in plain terms, illustrated with a few informative laboratory evolution experiments, and describe the organizing principles that underlie complex biological systems. I describe the new disciplines of synthetic biology and metabolic engineering, which offer opportunities for interdisciplinary collaboration between life scientists and operations researchers.

Clinical and pathobiological heterogeneity of asthma—Mechanisms of severe and glucocorticoid-resistant asthma  [PDF]
Yasuhiro Matsumura
Health (Health) , 2013, DOI: 10.4236/health.2013.52A046
Abstract:

It is increasingly recognized that asthma represents a syndrome, and there is clinical and pathobiological heterogeneity. Many genes are reported to be associated with asthma, and may be involved in the disease heterogeneity. Diverse cells, such as T helper 1 (Th1)-cells, Th2-cells, Th17-cells, airway epithelial cells, and innate and adaptive immunity associated cells, contribute to the pathobiology of asthma independently of each other or they can also coexist and interact. Although, generally, Th2 immunity is important in most asthma endotypes, non- Th2-driven inflammation tends to be difficult to manage. Recently, increased attention has been focused on severe asthma and glucocorticoid (GC)-resistant (GC-R) asthma, in which diverse inflammatory processes may be involved. Treatment approaches should take into account pathological differences.

Severe Hypoglycemia Accompanied with Thyroid Crisis
Yuki Nakatani,Tsuyoshi Monden,Minoru Sato,Nozomi Domeki,Mihoko Matsumura,Nobuyuki Banba,Takaaki Nakamoto
Case Reports in Endocrinology , 2012, DOI: 10.1155/2012/168565
Abstract: We report a 32-year-old Japanese women with severe hypoglycemia accompanied with thyroid crisis. She complained of dyspnea, general fatigue, and leg edema. She was diagnosed with hyperthyroidism with congestive heart failure and liver dysfunction. Soon after admission, sudden cardiopulmonary arrest occurred. She was then transferred to the intensive care unit. Her serum glucose level was 7 mg/dl. Intravenous glucose, hydrocortisone, diuretics, and continuous hemodiafiltration (CHDF) saved her. We considered that hypoglycemia occurred due to heart failure and liver dysfunction due to thyroid crisis.
Chromosome 4q;10q translocations; Comparison with different ethnic populations and FSHD patients
Tsuyoshi Matsumura, Kanako Goto, Gaku Yamanaka, Je Lee, Cheng Zhang, Yukiko K Hayashi, Kiichi Arahata
BMC Neurology , 2002, DOI: 10.1186/1471-2377-2-7
Abstract: To clarify the influence on the deletion of the repeats, we surveyed three different ethnic populations and FSHD patients using the BglII/BlnI dosage test.The frequency of translocation in 153 Japanese, 124 Korean, 114 Chinese healthy individuals and 56 Japanese 4q35-FSHD patients were 27.5%, 29.8%, 19.3%, and 32.1%, respectively. The ratio of '4 on 10' (trisomy and quatrosomy of chromosome 4) was higher than that of '10 on 4' (nullsomy and monosomy of chromosome 4) in all populations.The inter-chromosomal exchange was frequently observed in all four populations we examined, and no significant difference was observed between healthy and diseased groups.Facioscapulohumeral muscular dystrophy (FSHD) is a common form of muscular disorder with an autosomal dominant trait. FSHD is characterized by weakness and atrophy of facial, shoulder-girdle and humeral muscles, with occasional subsequent pelvic-girdle and lower limb involvement. More than 95% of patients with FSHD have a smaller (< 35 kb) EcoRI fragment on chromosome 4q35 detected by probe p13E-11 and are called 4q35-FSHD [1-3]. This EcoRI fragment in normal individuals contains tandem repeated 3.3-kb KpnI units (D4Z4) varying from 11 to 150 in number, while 4q35-FSHD patients showed less than ten units [2,3]. No responsible gene has been isolated within the FSHD gene region.Probe p13E-11 cross-hybridizes with chromosome 10q26, which contains highly homologous 3.3-kb KpnI repeated units. Since the BlnI restriction enzyme site exists exclusively within each unit derived from 10q26, but not in D4Z4 (an unit from 4q35), double enzyme digestion using EcoRI and BlnI can discriminate as 4q35 (BlnI-resistant) and 10q26 (BlnI-sensitive) units [4]. In a Dutch control population, subtelomeric translocations between chromosomes 4 and 10 were seen in about 20% of individuals [5-7]. Furthermore, somatic mosaicism was found in 40% of de novo FSHD families and 46% of these individuals had BlnI-resistant units on chromosome 10 [8].
Severe Hypoglycemia Accompanied with Thyroid Crisis
Yuki Nakatani,Tsuyoshi Monden,Minoru Sato,Nozomi Domeki,Mihoko Matsumura,Nobuyuki Banba,Takaaki Nakamoto
Case Reports in Endocrinology , 2012, DOI: 10.1155/2012/168565
Abstract: We report a 32-year-old Japanese women with severe hypoglycemia accompanied with thyroid crisis. She complained of dyspnea, general fatigue, and leg edema. She was diagnosed with hyperthyroidism with congestive heart failure and liver dysfunction. Soon after admission, sudden cardiopulmonary arrest occurred. She was then transferred to the intensive care unit. Her serum glucose level was 7?mg/dl. Intravenous glucose, hydrocortisone, diuretics, and continuous hemodiafiltration (CHDF) saved her. We considered that hypoglycemia occurred due to heart failure and liver dysfunction due to thyroid crisis. 1. Introduction Hypoglycemia occurs with diabetes treatment, anorexia nervosa, liver disease, and adrenal insufficiency. Hyperthyroidism usually induces impaired glucose tolerance. However, hyperthyroidism with congestive heart failure or liver dysfunction is considered to induce hypoglycemia, but this is very rare. We describe here a case of thyroid crisis accompanied with severe hypoglycemia. Although the patient’s heart arrested, combined and intensive treatment saved her. 2. Case Report A 32-year-old Japanese woman was admitted to our hospital in January because of dyspnea, general fatigue, and legs edema. She had been well until one month earlier and had not been diagnosed with hyperthyroidism. There was no family history of thyroid disease. On admission, she was 157?cm tall and weighed 68.4?kg. Her body temperature was 36.9°C, blood pressure was 120/80?mmHg, and pulse rate was 132/min with irregularities. She was alert and oriented (Glasgow Coma Scale 15/15). Exophthalmos was not observed, but a diffuse enlarged thyroid was detected. Conjunctiva was not anemic, but was slightly icteric. Marked edema was found in both legs. Cardiac symptoms were recognized as class four of the New York Heart Association classification. Laboratory data indicated hyperthyroidism (free T3: >30.0?pg/mL, free T4: >6.0?ng/dL). The anti-TSH receptor antibody was elevated to 23.6?IU/L (Table 1). Electrocardiogram showed atrial fibrillation and chest X-ray showed cardiomegaly (CTR = 65.2%) and effusion. Based on these findings, the patient was diagnosed with Graves’ disease complicated with severe cardiac failure. Her condition was recognized as thyroid crisis, as described by Burch and Wartofsky [1] and the Japanese Thyroid Association [2]. She was started on thiamazole, propranolol, and furosemide. In addition, we did not use steroid and iodine. Because her consciousness was clear, we thought her thyroid crisis was not severe. Her glucose level was relatively low (57?mg/dL)
Minocycline for Schizophrenia: A critical review  [PDF]
Tsuyoshi Miyaoka
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.224056
Abstract: Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestoractive or neuroprotective properties in various models of neurodegenerative diseases. In particular, it has been shown to delay motor alterations, inflammation and apoptosis in models of Huntington’s disease, amyotrophic lateral sclerosis and Parkinson’s disease. Despite controversies about its efficacy, the relative safety and tolerability of minocycline have led to the launching of various clinical trials. Previously, we reported the antipsychotic effects of minocycline in patients with schizophrenia. In a pilot investigation, we administered minocycline as an open-label adjunct to antipsychotic medication to patients with schizophrenia. The results of this trial suggested that minocycline might be a safe and effective adjunct to antipsychotic medications, and that augmentation with minocycline may prove to be a viable strategy for “boosting” antipsychotic efficacy and for treating schizophrenia. Recently, in randomized double-blind placebo-controlled clinical trials, the addition of minocycline to treatment as usual early in the course of schizophrenia predominantly improves negative symptoms. The present review summarizes the available data supporting the clinical testing of minocycline for patients with schizophrenia. In addition, we extend our discussion to the potential applications of minocycline for combining this treatment with cellular and molecular therapy.
A Theoretical Study on Van Der Pauw Measurement Values of Inhomogeneous Compound Semiconductor Thin Films  [PDF]
Toru Matsumura, Yuichi Sato
Journal of Modern Physics (JMP) , 2010, DOI: 10.4236/jmp.2010.15048
Abstract: The influence of intermixing heterogeneous regions that have different electrical properties from the base materials on van der Pauw measurement values was theoretically studied by computer simulation using the finite-element method. The measurement samples selected were thin films of inhomogeneous semiconductors. Calculated electrical properties, such as resistivity, carrier density, and mobility of the thin films, varied in predictable ways when heterogeneous regions were dispersed in wide ranges over the samples. On the other hand, the mobility of the thin films showed a different change when heterogeneous regions were locally concentrated in the measurement samples.
Measurement of Surface SH-Wave Velocities Generated on the Surface of Japanese Cypress Column  [PDF]
Masumi Hasegawa, Junji Matsumura
Open Journal of Acoustics (OJA) , 2014, DOI: 10.4236/oja.2014.44018
Abstract: Polyetherimide resin wedge transducers were used to generate a shear wave that was obliquely incident relative to the surface of a Japanese cypress column for measuring the surface SH-wave velocity. As the inter-transducer distance increased, the propagation time increased and the am-plitude became smaller. The propagation time and the amplitude were significantly correlated with the inter-transducer distance. The SH-wave velocity ranged from 1270 m/s to 1496 m/s. Surface SH-wave velocity was lower in the central part of the column and higher in the outer part. Velocity was negatively correlated with moisture content at 1% of significance level. These results suggest the accomplishment of the first target for applying the surface SH-wave acoustoelastic technique to nondestructive evaluation of drying stress in wood.
Electrodeposition of Bi-Sb alloy using Cu electrodes  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.37069
Abstract: Bi-Sb alloys were grown by means of an electrodeposition method using Cu electrodes. The alloys were studied with the help of an x-ray diffractometer and an electron probe microanalysis. The both investigations have shown no trace of Cu in the obtained alloys. It can be concluded that Cu electrodes can be used for the deposition of Bi-Sb alloys; which results in an advantage of availability of the electrode.
Scoping the Possibilities: Student Preferences towards Open Textbooks Adoption for E-Learning  [PDF]
Deepak Prasad, Tsuyoshi Usagawa
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.524227
Abstract: Many universities have begun implementing e-Learning systems due to their low cost. However, publishers of expensive textbooks stand in the way of e-Learning’s ability to provide a cost-effective educational delivery model. While many universities aim to overcome this opposition and replace traditional publishers’ textbooks with free open textbooks, such plans cannot be executed successfully unless students are open to their use. As such, a study into students’ preferences towards open textbook adoption is vital to provide clear indication as to their opinions regarding open textbook use. Thus, this study conducted a study of University of the South Pacific (USP) students’ preferences towards open textbook adoption for e-Learning using a survey administered during Semester 2, 2013 which generated 1077 responses. Areas examined include: Impacts of textbook costs on students’ academic careers; preferences towards open textbook adoption; perceived barriers to and motivations for adoption of open textbooks; and preferred digital features and reading devices. Results show that textbook prices adversely impact students. Furthermore, a high level of acceptance towards the adoption of open textbooks was found. The study revealed that the preference for reading printed material was the highest rated barrier to open textbook adoption, while the free availability of open textbooks was rated the greatest motivator. Study findings are being used to inform efforts to develop open textbooks at the USP and may assist other universities seeking to start similar projects.
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