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Search Results: 1 - 10 of 1150 matches for " Tsutomu Sawada "
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Case of endophthalmitis following intravitreal injections of bevacizumab
Shinya Komori, AkirA Sawada, Tsutomu Oguni, et al
Clinical Ophthalmology , 2010, DOI: http://dx.doi.org/10.2147/OPTH.S11379
Abstract: se of endophthalmitis following intravitreal injections of bevacizumab Case report (3944) Total Article Views Authors: Shinya Komori, AkirA Sawada, Tsutomu Oguni, et al Published Date July 2010 Volume 2010:4 Pages 773 - 775 DOI: http://dx.doi.org/10.2147/OPTH.S11379 Shinya Komori1, Akira Sawada1, Tsutomu Oguni1, Kiyofumi Mochizuki1, Kiyofumi Ohkusu2 1Department of Ophthalmology, 2Department of Microbiology, Gifu University Graduate School of Medicine, Gifu, Japan Purpose: We report a case of infectious endophthalmitis that developed after the third intravitreal injection of bevacizumab. The endophthalmitis was caused by Staphylococcus epidermidis. Methods: Observational case series. Results: This was a case of a 77-year-old man who had received three intravitreal injections of bevacizumab and developed infectious endophthalmitis. Polymerase chain reaction of an aqueous humor sample showed that the endophthalmitis was caused by S. epidermidis. The patient received intravitreal ceftazidime and vancomycin, and subconjunctival injection of vancomycin. After the intravitreal injections he was treated with topical levofloxacin and cefmenoxime hydrochloride, and intravenous cefpirome. Subsequently, the ocular inflammation gradually decreased and his visual acuity remained at 30/200. Conclusions: Our findings indicate that endophthalmitis can develop after intravitreal bevacizumab injections. Polymerase chain reaction is useful for differentiation from sterile endophthalmitis.
Case of endophthalmitis following intravitreal injections of bevacizumab
Shinya Komori,Akira Sawada,Tsutomu Oguni,et al
Clinical Ophthalmology , 2010,
Abstract: Shinya Komori1, Akira Sawada1, Tsutomu Oguni1, Kiyofumi Mochizuki1, Kiyofumi Ohkusu21Department of Ophthalmology, 2Department of Microbiology, Gifu University Graduate School of Medicine, Gifu, JapanPurpose: We report a case of infectious endophthalmitis that developed after the third intravitreal injection of bevacizumab. The endophthalmitis was caused by Staphylococcus epidermidis.Methods: Observational case series.Results: This was a case of a 77-year-old man who had received three intravitreal injections of bevacizumab and developed infectious endophthalmitis. Polymerase chain reaction of an aqueous humor sample showed that the endophthalmitis was caused by S. epidermidis. The patient received intravitreal ceftazidime and vancomycin, and subconjunctival injection of vancomycin. After the intravitreal injections he was treated with topical levofloxacin and cefmenoxime hydrochloride, and intravenous cefpirome. Subsequently, the ocular inflammation gradually decreased and his visual acuity remained at 30/200.Conclusions: Our findings indicate that endophthalmitis can develop after intravitreal bevacizumab injections. Polymerase chain reaction is useful for differentiation from sterile endophthalmitis.Keywords: endophthalmitis, bevacizumab, Staphylococcus, antibiotics
Shrinking stacking fault through glide of the Shockley partial dislocation in hard-sphere crystal under gravity
Atsushi Mori,Yoshihisa Suzuki,Shin-ichiro Yanagiya,Tsutomu Sawada,Kensaku Ito
Physics , 2006, DOI: 10.1080/00268970701348725
Abstract: Disappearance of a stacking fault in the hard-sphere crystal under gravity, such as reported by Zhu et al. [Nature 387 (1997) 883], has successfully been demonstrated by Monte Carlo simulations. We previously found that a less ordered (or defective) crystal formed above a bottom ordered crystal under stepwise controlled gravity [Mori et al. J. Chem. Phys. 124 (2006) 174507]. A defect in the upper defective region has been identified with a stacking fault for the (001) growth. We have looked at the shrinking of a stacking fault mediated by the motion of the Shockley partial dislocation; the Shockley partial dislocation terminating the lower end of the stacking fault glides. In addition, the presence of crystal strain, which cooperates with gravity to reduce stacking faults, has been observed.
Comparison of metal artifact in digital tomosynthesis and computed tomography for evaluation of phantoms  [PDF]
Tsutomu Gomi
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.67089
Abstract: We compared metal artifact in X-ray digital tomosynthesis (DT) and modern computed tomography (CT) reconstruction to improve the image quality. We compared the images of a prosthetic phantom (titanium) and a contrast-detail phantom obtained by DT using conventional filtered backprojection (FBP), metal artifact reduction (MAR) processing, and simultaneous iterative reconstruction technique (SIRT) methods and those obtained by CT using conventional FBP and adaptive statistical iterative reconstruction methods. The effectiveness of each method for enhancing the visibility of a prosthetic phantom was quantified in terms of the intensity profile and root mean square error, and the removal of ghosting artifacts was quantified in terms of the artifact spread function (ASF). In addition, low contrast resolution was evaluated in terms of the contrast-to- noise ratio. Image error was smaller in the MAR DT images in the near in-focus-plane, and the intensity profiles revealed the beam hardening effect. Streak artifacts were reduced in the SIRT DT and adaptive statistical iterative reconstruction CT images. The ASF performances of the algorithms were ranked in descending order: 1) MAR DT; 2) CT (adaptive statistical iterative reconstruction, and conventional FBP); 3) SIRT DT; and 4) conventional FBP DT. The low contrast resolution was higher in the CT images than in the DT images. In conclusion, a review of the results revealed that the metal artifact reduction was highest for tomosynthesis with MAR processing, and the low contrast resolution performance was highest for CT.
On the Pollen Detection with Photoacoustic Imaging  [PDF]
Tsutomu Hoshimiya
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.47A1005
Abstract:

A photoacoustic (PA) imaging that utilizes acoustic detection of sound generated by a specimen due to the absorption of modulated light was applied to measure the amount of the pollen of the Cryptomeria japonica, Asian allergic plant. High-sensitivity PA imaging can measure pollen particles with a large dynamic range from single particle to several hundred micrograms. The PA signal dependence on the amount of the pollen showed good correlation with the amount of pollen.

A Comparison of Reconstruction Algorithms Regarding Exposure Dose Reductions during Digital Breast Tomosynthesis  [PDF]
Tsutomu Gomi
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.78053
Abstract: This study compared reconstruction algorithms [filtered back projection (FBP) and simultaneous iterative reconstruction technique (SIRT)] with respect to radiation doses and image quality and suggested the possibility of decreasing the exposure dose in digital breast tomosynthesis (DBT). These two existing algorithms were implemented using a DBT system and experimentally evaluated using contrast-detail (CD) phantom measurements, such as contrast-to-noise ratio (CNR), root mean square error (RMSE), intensity profile, and artifact spread function (ASF), and the results obtained with FBP and SIRT were compared. The potential dose reduction, contrast improvement, quantum noise reduction, and artifact reduction in DBT were evaluated using different exposures and the two reconstruction techniques. The effectiveness of each technique for enhancing the visibility of a CD phantom was quantified with respect to CNR and RMSE, and artifact reduction was quantified with respect to the intensity profile and ASF. SIRT produced reconstructed images with CNR values indicative of high-contrast detection. Image error was smaller in the in-focus plane SIRT images, and artifacts were decreased in these images according to the determined intensity profiles and ASF. These results suggest that when using SIRT, the exposure dose could possibly be decreased to half.
Comparison of Different Reconstruction Algorithms for Decreasing the Exposure Dose during Digital Breast Tomosynthesis: A Phantom Study  [PDF]
Tsutomu Gomi
Journal of Biomedical Science and Engineering (JBiSE) , 2015, DOI: 10.4236/jbise.2015.88044
Abstract: We compared reconstruction algorithms [filtered back projection (FBP), maximum likelihood expectation maximization (MLEM), and the simultaneous iterative reconstruction technique (SIRT)] in terms of the radiation dose and image quality, for exploring the possibility of decreasing the radiation dose during digital breast tomosynthesis (DBT). The three algorithms were implemented using a DBT system and experimentally evaluated using measurements, such as signal difference-to-noise ratio (SDNR) and intensity profile, on a BR3D phantom (infocus plane image). The possible radiation dose reduction, contrast improvement, and artifact reduction in DBT were evaluated using different exposure levels and the three reconstruction techniques. We performed statistical analysis (one-way analysis of variance) of the SDNR data. The effectiveness of each technique for enhancing the visibility of the BR3D phantom was quantified with regard to SDNR (FBP versus MLEM, P < 0.05; FBP vs. SIRT, P < 0.05; MLEM vs. SIRT, P = 0.945); the artifact reduction was quantified with regard to the intensity profile. MLEM and SIRT produced reconstructed images with SDNR values indicative of low-contrast visibility. The SDNR value for the half-radiation dose MLEM and SIRT images was close to that of the FBP reference radiation dose image. Artifacts were decreased in the MLEM and SIRT images (in the infocus plane) according to the intensity profiles that we obtained. With MLEM and SIRT, the radiation dose may be decreased to half comparison with FBP.
Closed/Open-Cell Photoacoustic Imaging for Spectroscopic Measurements  [PDF]
Tsutomu Hoshimiya
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.48152
Abstract:
Photoacoustic imaging using a closed photoacoustic cell and an open photoacoustic cell with gas- microphone detection scheme was described. R/G/B LED light sources were used for the closed photoacoustic (PA) cell configuration. The colored specimen enclosed in a PA cell was imaged with R/G/B color light sources, and an image restored from the inverted PA images was compared with the original image. For open cell configuration, an open PA cell using a spheroidal acoustic resonator was applied to measure the amount of large-sized colored specimens. A calibration curve for a food red dye was obtained that apparently showed the ability of the present scheme to measure as a spectroscopic measurement tool.
Further Improvement of Reflection Efficiency of a Magnetic Mirror and Replenishment against Loss of Escaping Deuteron Ions  [PDF]
Mitsuaki Nagata, Keiichi Sawada
Journal of Modern Physics (JMP) , 2019, DOI: 10.4236/jmp.2019.102011
Abstract: We reported previously the idea to improve reflection-ability of a magnetic mirror by installing a cyclotron resonance space in the front part of the mirror. However, since the previous analysis was insufficient from the examination after that, we complement the following two things in this work: 1) A simpler procedure of design to make a supplemental magnetic mirror with the simplest magnetic configuration, compared with the procedure reported previously. 2) A peculiar characteristic arising only in reflection of a nonrelativistic charged particle (a deuteron ion).
Rib fracture after stereotactic radiotherapy on follow-up thin-section computed tomography in 177 primary lung cancer patients
Atsushi Nambu, Hiroshi Onishi, Shinichi Aoki, Tsuyota Koshiishi, Kengo Kuriyama, Takafumi Komiyama, Kan Marino, Masayuki Araya, Ryo Saito, Lichto Tominaga, Yoshiyasu Maehata, Eiichi Sawada, Tsutomu Araki
Radiation Oncology , 2011, DOI: 10.1186/1748-717x-6-137
Abstract: A total of 177 patients who had undergone SRT were prospectively evaluated for periodical follow-up thin-section CT with special attention to chest wall injury. The time at which CT findings of chest wall injury appeared was assessed. Related clinical symptoms were also evaluated.Rib fracture was identified on follow-up CT in 41 patients (23.2%). Rib fractures appeared at a mean of 21.2 months after the completion of SRT (range, 4 -58 months). Chest wall edema, thinning of the cortex and osteosclerosis were findings frequently associated with, and tending to precede rib fractures. No patients with rib fracture showed tumors > 16 mm from the adjacent chest wall. Chest wall pain was seen in 18 of 177 patients (10.2%), of whom 14 patients developed rib fracture. No patients complained of Grade 3 or more symptoms.Rib fracture is frequently seen after SRT for lung cancer on CT, and is often associated with chest wall edema, thinning of the cortex and osteosclerosis. However, related chest wall pain is less frequent and is generally mild if present.Stereotactic radiotherapy (SRT) for primary lung cancer has recently attracted attention because of its promising treatment effects [1-10]. A recent report demonstrated that SRT achieved a good survival rate for patients with non-small cell lung carcinoma, comparable to those of surgery [10]. SRT has now been applied not only to medically inoperable patients but also to operable ones. In the near future, SRT might become an alternative treatment to surgery for stage I non-small lung carcinoma.One major concern that must always been taken into consideration when selecting treatment methods is treatment sequelae. SRT is generally considered a safe treatment, with fewer complications than surgery. However, several studies have reported complications in SRT, such as radiation pneumonitis [11,12] and chest wall injury, including rib fracture [5-7,13-16]. Frequencies of rib fracture after SRT have already been reported in several inv
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