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Search Results: 1 - 10 of 123017 matches for " Tsang-En Wang "
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Is an estimated glomerular filtration rate better than creatinine to be incorporated into the end-stage liver disease score?
Yu-Wei Chen,Ching-Wei Chang,Chen-Wang Chang,Tsang-En Wang
World Journal of Hepatology , 2012, DOI: 10.4254/wjh.v4.i11.291
Abstract: AIM: To incorporate estimated glomerular filtration rate (eGFR) into the model for end-stage liver disease (MELD) score to evaluate the predictive value. METHODS: From January 2004 to October 2008, the records of 4127 admitted cirrhotic patients were reviewed. Patients who survived and were followed up as outpatients were defined as survivors and their most recent available laboratory data were collected. Patients whose records indicated death at any time during the hospital stay were defined as non-survivors (in-hospital mortality). Patients with incomplete data or with cirrhosis due to a congenital abnormality such as primary biliary cirrhosis were excluded; thus, a total of 3857 patients were enrolled in the present study. The eGFR, which was calculated by using either the modification of diet in renal disease (MDRD) equation or the chronic kidney disease epidemiology collaboration (CKD-EPI) equation, was incorporated into the MELD score after adjustment with the original MELD equation by logistic regression analysis [bilirubin and international normalized ratio (INR) were set at 1.0 for values less than 1.0]. RESULTS: Patients defined as survivors were significantly younger, had a lower incidence of hepatoma, lower Child-Pugh and MELD scores, and better renal function. The underlying causes of cirrhosis were very different from those in Western countries. In Taiwan, most cirrhotic patients were associated with the hepatitis virus, especially hepatitis B. There were 16 parameters included in univariate logistic regression analysis to predict in-hospital mortality and those with significant predicting values were included in further multivariate analysis. Both 4-variable MDRD eGFR and 6-variable MDRD eGFR, rather than creatinine, were significant predictors of in-hospital mortality. Three new equations were constructed (MELD-MDRD-4, MELD-MDRD-6, MELD-CKD-EPI). As expected, original MELD score was a significant predictor of in-hospital mortality (odds ratio = 1.25, P < 0.001). MELD-MDRD-4 excluded serum creatinine, with the coefficients refit among the remaining 3 variables, i.e., total bilirubin, INR and 4-variable MDRD eGFR. This model represented an exacerbated outcome over MELD score, as suggested by a decrease in chi-square (2161.45 vs 2198.32) and an increase in -2 log (likelihood) (2810.77 vs 2773.90). MELD-MDRD-6 included 6-variable MDRD eGFR as one of the variables and showed an improvement over MELD score, as suggested by an increase in chi-square (2293.82 vs 2198.32) and a decrease in -2 log (likelihood) (2810.77 vs 2664.79). Finally, when s
Difference between CKD-EPI and MDRD equations in calculating glomerular filtration rate in patients with cirrhosis
Yu-Wei Chen,Han-Hsiang Chen,Tsang-En Wang,Ching-Wei Chang
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i40.4532
Abstract: AIM: To evaluate the difference between the performance of the (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations in cirrhotic patients. METHODS: From Jan 2004 to Oct 2008, 4127 cirrhotic patients were reviewed. Patients with incomplete data with respect to renal function were excluded; thus, a total of 3791 patients were included in the study. The glomerular filtration rate (GFR) was estimated by the 4-variable MDRD (MDRD-4), 6-variable MDRD (MDRD-6), and CKD-EPI equations. RESULTS: When serum creatinine was 0.7-6.8 mg/dL and 0.6-5.3 mg/dL in men and women, respectively, a significantly lower GFR was estimated by the MDRD-6 than by the CKD-EPI. Similar GFRs were calculated by both equations when creatinine was > 6.9 mg/dL and > 5.4 mg/dL in men and women, respectively. In predicting in-hospital mortality, estimated GFR obtained by the MDRD-6 showed better accuracy [81.72%; 95% confidence interval (CI), 0.94-0.95] than that obtained by the MDRD-4 (80.22%; 95%CI, 0.96-0.97), CKD-EPI (79.93%; 95%CI, 0.96-0.96), and creatinine (77.50%; 95%CI, 2.27-2.63). CONCLUSION: GFR calculated by the 6-variable MDRD equation may be closer to the true GFR than that calculated by the CKD-EPI equation.
Gastric carcinoid tumor in a patient with a past history of gastrointestinal stromal tumor of the stomach
Chien-Yuan Hung, Ming-Jen Chen, Shou-Chuan Shih, Tsang-Pai Liu, Yu-Jan Chan, Tsang-En Wang, Wen-Hsiung Chang
World Journal of Gastroenterology , 2008,
Abstract: Gastrointestinal stromal tumor is the most common mesenchymal tumor in the gastrointestinal tract. It may coexist with other type of cancers, and if so, the tumors usually involve the stomach. The most common associated cancers are gastrointestinal carcinomas. We report a 65-year-old woman with a history of gastric gastrointestinal stromal tumor who had undergone subtotal segmental gastrectomy. New polypoid lesions were detected on a follow-up gastroscopy one year later. The lesions were biopsied and found to be carcinoid tumors. There was serum hypergastrinemia, and type 1 gastric carcinoid tumor was diagnosed. A total gastrectomy was performed. Pathologic examination revealed both carcinoid tumors and a recurrent gastrointestinal stromal tumor.
Acute transient hepatocellular injury in cholelithiasis and cholecystitis without evidence of choledocholithiasis
Chen-Wang Chang, Wen-Hsiung Chang, Ching-Chung Lin, Cheng-Hsin Chu, Tsang-En Wang, Shou-Chuan Shih
World Journal of Gastroenterology , 2009,
Abstract: AIM: To investigate acute transient hepatocellular injury in patients with cholelithiasis and cholecystitis but no evidence of choledocholithiasis.METHODS: The medical records of patients with cholelithiasis who underwent cholecystectomy between July 2003 and June 2007 were retrospectively reviewed. Imaging studies to detect common bile duct (CBD) stones were performed in 186 patients, who constituted the study population. Biochemical liver tests before and after surgery, and with the presence or absence of CBD stones were analyzed.RESULTS: In 96 patients with cholelithiasis and cholecystitis without evidence of CBD stones, 49 (51.0%) had an alanine aminotransferase level elevated to 2-3 times the upper limit of normal, and 40 (41.2%) had an elevated aspartate aminotransferase level. Similar manifestations of hepatocellular injury were, as would be expected, even more obvious in the 90 patients with CBD stones. These markers of hepatocellular injury resolved almost completely within 2 wk to 1 mo after cholecystectomy. Compared to 59 patients with histologically less severe cholecystitis in the group undergoing urgent surgery (total 74 patients), the 15 patients with a gangrenous gallbladder had a higher mean level of total bilirubin (1.14 ± 1.27 mg/dL vs 2.66 ± 1.97 mg/dL, P < 0.001) and white cell count (9480 ± 4681/μL vs 12840 ± 5273/μL, P = 0.018).CONCLUSION: Acute hepatocellular injury in cholelithiasis and cholecystitis without choledocholithiasis is mild and transient. Hyperbilirubinemia and leukocytosis may predict severe inflammatory changes in the gallbladder.
Oral Glutamine Supplement Inhibits Ascites Formation in Peritoneal Carcinomatosis Mouse Model
Ming-Jen Chen,Tsang-En Wang,Shu-Jung Tsai,Ching-Chung Lin,Chia-Yuan Liu,Horng-Yuan Wang,Shou-Chuan Shih,Yu-Jen Chen
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/814054
Abstract: Background. Peritoneal carcinomatosis (PC) accompanied with ascites formation causes several distressing symptoms, resulting in poor quality of life. Methods. Twenty BALB/c nude mice generated by direct orthotopic injection of human pancreatic cancer PANC-1 cells were randomized to receive either a stock laboratory diet or a stock diet supplemented with glutamine. Half of the mice were sacrificed at day 76 to measure the amount of ascitic fluid and pancreatic tumor volume. The remaining mice were subject to survival analysis. Serum albumin levels were estimated every 2 weeks. Results. At day 76, the average amount of ascitic fluid measured in the control group was ?mL compared to ?mL from the glutamine-supplemented mice ( ). The volume of pancreatic tumor was ?cm3 in the control group and ?cm3 in glutamine-supplemented mice ( ). The mean survival time of glutamine-supplemented mice was prolonged from to days ( ). Mean serum albumin levels were higher in the glutamine-supplemented group. Conclusions. This preclinical study showed that oral supplementation of glutamine may provide ascites-reducing activity in pancreatic cancer patients with PC, via a cell-mediated immunity-independent mechanism. 1. Introduction Peritoneal carcinomatosis (PC) is well established as a terminal feature of advanced primary or secondary neoplasms involving the peritoneum. PC is a challenging complication associated with a poor prognosis and limited treatment options [1]. Locally advanced pancreatic cancer is one of the most common diseases causing PC and subsequent ascites formation. Terminal stage cancer patients with PC have an estimated median survival of 3–6 months [2]. At this terminal stage, quality of life, rather than the prolonging of survival, is considered the most crucial issue in palliative care. Nevertheless, the importance of life-prolonging palliative care is gaining recognition in the new era of cancer management. Because PC-associated ascites develops due to hydrostatic pressure factors rather than osmotic factors, the current management of the condition includes abdominal paracentesis, diuretics administration, and salt restriction. Nutrition support represents an alternative strategy to improve the general well-being after management for ascites. However, the value of nutrition support in patients with PC remains controversial with inconclusive survival benefits [3] and concerns that it may accelerate tumor growth [4, 5]. The pathogenesis of ascites formation in PC is unclear. It is thought to be a correlation between endothelial cells, angiogenesis, and
Comparison of coplanar and noncoplanar intensity-modulated radiation therapy and helical tomotherapy for hepatocellular carcinoma
Chen-Hsi Hsieh, Chia-Yuan Liu, Pei-Wei Shueng, Ngot-Swan Chong, Chih-Jen Chen, Ming-Jen Chen, Ching-Chung Lin, Tsang-En Wang, Shee-Chan Lin, Hung-Chi Tai, Hui-Ju Tien, Kuo-Hsin Chen, Li-Ying Wang, Yen-Ping Hsieh, David YC Huang, Yu-Jen Chen
Radiation Oncology , 2010, DOI: 10.1186/1748-717x-5-40
Abstract: Nine patients with unresectable HCC and PVT underwent step and shoot coplanar IMRT with intent to deliver 46 - 54 Gy to the tumor and portal vein. The volume of liver received 30Gy was set to keep less than 30% of whole normal liver (V30 < 30%). The mean dose to at least one side of kidney was kept below 23 Gy, and 50 Gy as for stomach. The maximum dose was kept below 47 Gy for spinal cord. Several parameters including mean hepatic dose, percent volume of normal liver with radiation dose at X Gy (Vx), uniformity index, conformal index, and doses to organs at risk were evaluated from the dose-volume histogram.HT provided better uniformity for the planning-target volume dose coverage than both IMRT techniques. The noncoplanar IMRT technique reduces the V10 to normal liver with a statistically significant level as compared to HT. The constraints for the liver in the V30 for coplanar IMRT vs. noncoplanar IMRT vs. HT could be reconsidered as 21% vs. 17% vs. 17%, respectively. When delivering 50 Gy and 60-66 Gy to the tumor bed, the constraints of mean dose to the normal liver could be less than 20 Gy and 25 Gy, respectively.Noncoplanar IMRT and HT are potential techniques of radiation therapy for HCC patients with PVT. Constraints for the liver in IMRT and HT could be stricter than for 3DCRT.Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide [1] and is the third most common cause of cancer mortality in the recent year [2]. The 5-year survival rate of individuals with liver cancer reported by the American Cancer Society in the United States is less than 10% despite aggressive conventional therapy. In addition, comparing 1991 and 2005, liver cancer is not only one of the three cancers with an increasing death rate, but also the fastest growing death rate (27%) in the United States [3]. Portal vein thrombosis (PVT) is a common complication in patients with advanced-stage HCC, occurring in 20%-80% of these patients [4-6]. PVT may alter the correc
Diatomic remains in sediments of Le An River flowing into Po Yang Lake
Chang Tsang Pi,
Chang Tsang Pi
,Wang Wenhua

环境科学学报(英文版) , 1996,
Abstract: This study has shown the concentration of diatomas and heavy metal ions (Cu , Pb,Zn and Cd) in the sediment samples from Le An River,a main tributary to Po Yang Lake. 38 diatom species in 19 genera were microscopically found on the sample slides prepared from the sediment of 4 ecologically characterized sites along this river.The occurrence of diatoms might be associated with the local water quality which was determined from the concentration of organic halogen-sub-stances and heavy metal ions,particular Cu and Pb contained in the seditnent samples.
Application and projects approved for fundamental research on integrated traditional Chinese and Western medicine in National Natural Science Foundation of China from 2000 to 2004
WANG Chang-En
Zhong Xi Yi Jie He Xue Bao , 2005,
Abstract: From 2000 to 2004, the National Natural Science Foundation of China (NSFC) accepted 1 171 applications and funded 160 projects for fundamental research on integrated traditional Chinese and Western medicine. The success rate is 13.64%. Being supported by NSFC, a number of achievements well known in China and abroad have been made, such as acupuncture complementary anaesthesia, treatment of leukemia, viral hepatitis, cardio-cerebrovascular diseases, acute abdomen, burns and fracture with integrated traditional Chinese and Western medicine and their therapeutic mechanisms, and some new concepts and theories have been put forward, such as the theories of activating blood to resolve stagnation, simultaneous treatment of bacteria and toxin, etc. But there still exit some problems in the research of the funded projects. The research ways are mainly combination of different methods instead of integration of both traditional Chinese and Western medicine. The research results are mainly confirmation of traditional Chinese medical theories instead of exploration of their innate regularities. The relationship among disease, syndrome and symptom is not clearly explored. The principal-subordinate relationship between macro- and micro-differentiation of syndromes is not clear. Academic research is short of new ideas. Improper or biased explanation of the theories of traditional Chinese medicine still exists. On analysis of above problems, some preferable aspects of projects for fundamental research on integrated traditional Chinese and Western medicine funded by NSFC in future are suggested in this article.
A high-throughput VLSI design for JPEG2000 9/7discrete wavelet transform
Wang Jianxin, Zhu En
- , 2015, DOI: 10.3969/j.issn.1003-7985.2015.01.004
Abstract: To achieve high parallel computation of discrete wavelet transform(DWT)in JPEG2000, a high-throughput two-dimensional(2D)9/7 DWT very large scale integration(VLSI)design is proposed, in which the row processor is based on flipping structure. Due to the difference of the input data flow, the column processor is obtained by adding the input selector and data buffer to the row processor. Normalization steps in row and column DWT are combined to reduce the number of multipliers, and the rationality is verified. By rearranging the output of four-line row DWT with a multiplexer(MUX), the amount of data processed by each column processor becomes half, and the four-input/four-output architecture is implemented. For an image with the size of N×N, the computing time of one-level 2D 9/7 DWT is 0.25N2+1.5N clock cycles. The critical path delay is one multiplier delay, and only 5N internal memory is required. The results of post-route simulation on FPGA show that clock frequency reaches 136 MHz, and the throughput is 544 Msample/s, which satisfies the requirements of high-speed applications.
Comparative In Vitro Osteoinductivity Study of CaP Ceramics (HA, α-TCP, β-TCP) using 10T1/2 Cells with Different Controls and Possible Correlations with Other Systems  [PDF]
Juliana Tsz Yan Lee, Kefeng Wang, Wai Hung TSANG, King Lau Chow
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2011, DOI: 10.4236/jbnb.2011.22021
Abstract: In this study, we use a pluripotent mesenchymal stem cell (MSC) model, C3H/10T1/2, to evaluate three calcium phos-phate (CaP) materials, namely the hydroxyapatite (HA), α-tricalcium phosphate (α-TCP) and β-tricalcium phosphate (β-TCP). 10T1/2 cell was chosen as it has advantages over its counterparts in terms of ease of maintenance, free of ethical concerns and also more reproducible results. ALP enzymatic assay, RT-qPCR, DAPI staining and SEM were employed to assess the osteoinductivity of these materials. A good reference material which also acts as a scientific control is necessary for comparisons of results from different experimental batches and hence other materials such as titanium, Nunclon plastic surface, BD Falcon plastic surface and gold coated porous HA were also tested. The results show that ceramics induce a more sustained osteo-differentiation state as compared with plastics. Inductivity was found to be acting in descending order of strength with HA > β-TCP > α-TCP, which is reversed in terms of their impact on proliferation rate (HA < TCP). This is also consistent with the results observed in SBF study in terms of calcium phosphate precipitate area coverage (HA > TCP) and in vivo osteoinductivity in terms of incidence and quality of bone described previously (HA > β-TCP > α-TCP). These confirm the suitability of using 10T1/2 cells in cell culture assay of osteoinductivity.
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