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Search Results: 1 - 10 of 1521 matches for " Tomomi Ueda "
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A Case of Serous Tubal Intraepithelial Carcinoma Diagnosed by Cytology during the Operation  [PDF]
Kenji Niwa, Tsuneo Ishihara, Yoko Ueda, Motoki Takenaka, Tomomi Shiga, Sakae Mori, Keigo Kuwabara, Yoshio Yamaguchi, Takuji Tanaka
Open Journal of Pathology (OJPathology) , 2018, DOI: 10.4236/ojpathology.2018.83008
Abstract: We experienced a case of serous tubal intraepithelial carcinoma (STIC), which is the earliest morphologically recognizable precursor of pelvic high grade serous carcinoma, diagnosed by cytology during the operation. A 48-year-old Japanese woman visited to our department because of abnormal cytological result and the left adnexal mass on female cancer screening. Pre-operatively, she was diagnosed as cervical intraepithelial neoplasia (CIN) 3, adenomyosis, and the left adnexal cystic lesion with papillary growth. At laparotomy, the left adnexal tumor turned out to be cystic fallopian tube with small papillary growth on the inner surface, but abnormal findings were not present on bilateral ovaries. The cytology of the imprint smears from the papillary projection and ascitic fluid showed positive, suggesting serous adenocarcinoma. Histopathological examination of the lesion revealed the left fallopian tube lesion was STIC with immunohistochemically positive reactivity against p53. No metastases including disseminated lesions were noted. The patient received four courses of systemic chemotherapy, and had no recurrent signs 10 months after the operation.
Resolvins as Regulators of the Immune System
Hiroyuki Seki,Takaharu Sasaki,Tomomi Ueda,Makoto Arita
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.72
Increased Apoptosis of Myoblasts in Drosophila Model for the Walker-Warburg Syndrome
Morio Ueyama,Yoshihiro Akimoto,Tomomi Ichimiya,Ryu Ueda,Hayato Kawakami,Toshiro Aigaki,Shoko Nishihara
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011557
Abstract: Walker-Warburg syndrome, a progressive muscular dystrophy, is a severe disease with various kinds of symptoms such as muscle weakness and occasional seizures. The genes of protein O-mannosyltransferases 1 and 2 (POMT1 and POMT2), fukutin, and fukutin-related protein are responsible for this syndrome. In our previous study, we cloned Drosophila orthologs of human POMT1 and POMT2 and identified their activity. However, the mechanism of onset of this syndrome is not well understood. Furthermore, little is known about the behavioral properties of the Drosophila POMT1 and POMT2 mutants, which are called rotated abdomen (rt) and twisted (tw), respectively. First, we performed various kinds of behavioral tests and described in detail the muscle structures by using these mutants. The mutant flies exhibited abnormalities in heavy exercises such as climbing or flight but not in light movements such as locomotion. Defective motor function in mutants appeared immediately after eclosion and was exaggerated with aging. Along with motor function, muscle ultrastructure in the tw mutant was altered, as seen in human patients. We demonstrated that expression of RNA interference (RNAi) for the rt gene and the tw mutant was almost completely lethal and semi-lethal, respectively. Flies expressing RNAi had reduced lifespans. These findings clearly demonstrate that Drosophila POMT mutants are models for human muscular dystrophy. We then observed a high density of myoblasts with an enhanced degree of apoptosis in the tw mutant, which completely lost enzymatic activity. In this paper, we propose a novel mechanism for the development of muscular dystrophy: POMT mutation causes high myoblast density and position derangement, which result in apoptosis, muscle disorganization, and muscle cell defects.
Association between Children’s Appetite Patterns and Maternal Feeding Practices  [PDF]
Tomomi Ainuki, Rie Akamatsu
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.23032
Abstract: This study explored associations between children’s appetites and maternal feeding practices. The participants, 614 parents of 3- to 6-year-old children from kindergartens in Tokyo, Japan, completed self-administered questionnaires. The children’s appetites were measured using the Enjoyment of Food (EF) and Food Responsiveness (FR) scales of the Child Eating Behaviour Questionnaire. Using cluster analysis, we examined three appetite patterns (“both low,” “high EF and low FR,” and “both high”). The three appetite patterns were associated with children’s obesity index. The “both low” pattern was associated with the highest maternal pressure to eat. The “high EF and low FR” patterns were related to an established snack time. The “both high” pattern was associated with higher maternal instrumental feeding compared with the “high EF and low FR” types. The results of this study will facilitate the development of targeted interventions and better parental guidance on maternal feeding practices and their association with children’s eating behaviours.
Effects of Curing Conditions and Formulations on Residual Monomer Contents and Temperature Increase of a Model UV Gel Nail Formulation  [PDF]
Kentaro Taki, Tomomi Nakamura
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2011, DOI: 10.4236/jcdsa.2011.14017
Abstract: Recently, the application of ultraviolet (UV) curable monomers to human nails, (also known as UV gel nails) has become a popular decoration technique for women’s nails. However, the unreacted layer, the depletion of residual monomers from the cured UV gel nails, which can cause allergy and asthma, and the increase in temperature during curing process, are major concerns. In this study, the thickness of the unreacted layer, the increase in temperature, and the residual contents in cured film of UV gel nail treatment were measured for the first time. The results of this study indicated that the thickness of unreacted layer was not affected by the cast thickness; however, the intensity of UV light and the photoinitiator concentration had significant effect on the thickness of the unreacted layer. To reduce the thickness of the unreacted layer, the intensity of the UV light and the photoinitiator concentration should be increased. However, the maximum temperature observed during the curing of UV gel nails increases with an increase in the intensity of the UV light and the photoinitiator concentration. A suitable cast thickness range (21 ~ 150 μm), which resulted in the formation of a cured film and without producing temperatures that exceed that of the human body, was identified. The mass fraction of the residuals in the cured layer decreased with an increase in the exposure time, the UV intensity, and the photoinitiator concentration.
Heart Rate Variability Predicts Emotional Flexibility in Response to Positive Stimuli  [PDF]
Tomomi Fujimura, Kazuo Okanoya
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.38086
Abstract: Flexible adaptation to constantly changing environments is linked to mental health and psychological functioning. Heart rate variability (HRV), an index of autonomic flexibility, has been implicated in emotional flexibility, the ability to generate contextually dependent emotional responses in accordance with situational demands. The current study investigated whether HRV during rest is associated with experienced emotion, one of the measures of emotional flexibility. To assess experienced emotion in response to changing events, three types of stimuli sets were created by presenting two stimuli successively. First, two stimuli represented the same valence (i.e., negative/negative or positive/positive). Second, two stimuli represented opposite valences (i.e., negative/positive or positive/negative). Third, a neutral stimulus was followed by negative or positive stimulus (i.e., neutral/negative or neutral/positive). Psychological ratings for experienced emotion to the second stimulus were collected with regard to valence and arousal. The results showed that subjects with lower resting HRV experienced more aroused states in response to successive positive stimuli. Resting HRV may be a proxy of emotional flexibility indexed by subjective arousal states to positive events.
Interaction of Bubbles with Vortex Ring Launched into Bubble Plume  [PDF]
Tomomi Uchiyama, Sou Kusamichi
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.34027
Abstract: This study is concerned with an experimental exploration for the interactions of bubbles with a vortex ring launched vertically upward into a bubble plume. A vortex ring launcher, composed of a cylinder and a piston, is mounted at the bottom of a water tank. Small hydrogen bubbles are released into still water from a cathode, which is wound around the cylinder outlet, by the electrolysis of water. The bubbles rise by the buoyant force and induce a bubble plume. The water in the cylinder is discharged into the bubble plume by the piston, resulting in a laminar vortex ring convecting along the central axis of the plume. Just after the launch of the vortex ring, the bubbles are spirally entrained into the vortex ring with the roll up of the shear layer. The void fraction within the vortex ring increases with the convection of the vortex ring until a certain displacement of the vortex ring, where the reduction occurs. The vortex ring convects with a constant velocity higher than that in still water. The entrained bubbles reduce the strength of the vortex ring.
Mitochondrial DNA Markers for PCR-Based Phylogenetic Analysis of Ark Shells  [PDF]
Tomomi Tanaka, Futoshi Aranishi
Open Journal of Marine Science (OJMS) , 2013, DOI: 10.4236/ojms.2013.34021

Arcidae species are commercially important bivalves in Japan and are commonly referred to as bloody ark due to their red blood. They have thick shells with distinct radiating ribs, and the numbers of these ribs are important morphological features for species discrimination. However, some Arcidae species are morphologically indistinguishable, with a similar number of the ribs in adults and deficient rib formation, particularly among juveniles. Thus, we developed a reliable molecular marker to genetically discriminate between 7 Arcidae species belonging to Scapharca, Anadara, and Tegillarca based on species-specific polymorphic segments of mitochondrial DNA. PCR amplification of partial COI, 16S rRNA, 12S rRNA, and Cyt b genes was performed on 7 species using 8 primer sets. Only the set of Scapharca-specific forward primer and universal reverse primer for the partial COI gene successfully yielded single PCR products from all 7 species examined. Thus, nucleotide sequences of 481 bp portion of these PCR products were determined, and the degrees of nucleotide substitutions ranged from 0.4% between S. broughtonii and T. granosa to 20.2% between S. satowi and A.

Genetic Variability and Population Structure of Ark Shell in Japan  [PDF]
Tomomi Tanaka, Futoshi Aranishi
Open Journal of Marine Science (OJMS) , 2014, DOI: 10.4236/ojms.2014.41002

Ark shell Scapharca kagoshimensis is one of the commercially important bivalve resources in East Asia. In Japan, the mass production method for its natural seedlings was developed in the 1880s, and they had been transplanted to an array of the major fishing areas. It has been therefore concerned with its genetic disturbance among not only current but also former fishing areas in Japan. This study was undertaken to ascertain its genetic diversity and population structure in East Asia by means of nucleotide sequence analysis of a 555-bp portion of the mitochondrial DNA COI gene. Of 225 individuals collected from 8 populations and 1 population in Japan and Korea, respectively, a total of 59 haplotypes, including 14 common haplotypes, were found, and Japan and Korea shared 3 common haplotypes. In Japan, the haplotype diversity and nucleotide diversity ranged from 0.65 to 0.93 and from 0.22% to 0.59%, respectively, reflecting relatively high levels of genetic diversity. The values in Korea were determined to be 0.45% and 0.19%, respectively, indicating significantly lower genetic diversity compared with that in Japan. Mismatch distribution analysis and neutrality tests showed a recent history of multiple types of reproduction and signals of demographic change in each population. These results suggest that S. kagoshimensis has experienced rapid population growth or reduction in population size such as a bottleneck in a short period.

Public health nurse observations of behavioral characteristics of fathers who contribute to the emotional instability of mothers, as presented in cases of infant abuse  [PDF]
Izumi Ueda
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.33041

The objective of this study is to look at the understanding and perceptions of public health nurses (PHNs) related to behavioral characteristics of fathers that contribute to emotional instability in mothers by reviewing abuse cases involving infants and very young children. A qualitative descriptive design was applied to the data analysis, based on a semi-structured interview administered to three experienced PHNs who had been in charge of maternal and child health services for at least five years at a public health department or health center; with the data obtained in the interview narratives analyzed. In the observations of the experienced PHNs, the behavioral characteristics of fathers who are instigators of child abuse can be classified into five categories, fathers who are: “Talking to others about marital problems without attempting to solve these by themselves”, “Working on learning about childcare seeking to correct childcare methods”, “Taking the initiative in childcare at cross purposes with mothers”, “Stressing the effort they (the fathers) put into childcare”, and “Failing to notice the own family situation and problems”. The findings of the study suggest the necessity for PHNs to understand fathers, to be aware of the difficulty of building a supportive relationship with fathers, and to improve skills enabling the PHNs to help fathers form good relationships with other family members.

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