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Search Results: 1 - 10 of 865 matches for " Toma? Accetto "
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Inability of Prevotella bryantii to Form a Functional Shine-Dalgarno Interaction Reflects Unique Evolution of Ribosome Binding Sites in Bacteroidetes
TomaAccetto, Gorazd Avgu?tin
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022914
Abstract: The Shine-Dalgarno (SD) sequence is a key element directing the translation to initiate at the authentic start codons and also enabling translation initiation to proceed in 5′ untranslated mRNA regions (5′-UTRs) containing moderately strong secondary structures. Bioinformatic analysis of almost forty genomes from the major bacterial phylum Bacteroidetes revealed, however, a general absence of SD sequence, drop in GC content and consequently reduced tendency to form secondary structures in 5′-UTRs. The experiments using the Prevotella bryantii TC1-1 expression system were in agreement with these findings: neither addition nor omission of SD sequence in the unstructured 5′-UTR affected the level of the reporter protein, non-specific nuclease NucB. Further, NucB level in P. bryantii TC1-1, contrary to hMGFP level in Escherichia coli, was five times lower when SD sequence formed part of the secondary structure with a folding energy -5,2 kcal/mol. Also, the extended SD sequences did not affect protein levels as in E. coli. It seems therefore that a functional SD interaction does not take place during the translation initiation in P. bryanttii TC1-1 and possibly other members of phylum Bacteroidetes although the anti SD sequence is present in 16S rRNA genes of their genomes. We thus propose that in the absence of the SD sequence interaction, the selection of genuine start codons in Bacteroidetes is accomplished by binding of ribosomal protein S1 to unstructured 5′-UTR as opposed to coding region which is inaccessible due to mRNA secondary structure. Additionally, we found that sequence logos of region preceding the start codons may be used as taxonomical markers. Depending on whether complete sequence logo or only part of it, such as information content and base proportion at specific positions, is used, bacterial genera or families and in some cases even bacterial phyla can be distinguished.
Toma ?.
Sport si Societate : Revista de Educatie Fizica, Sport si Stiinte Conexe , 2013,
Abstract: Among the many diseases in humans caused by parasites, hydatid disease, Echinococcosis or hydatid cyst is mostly part of those who have the most severe and varied implications both pathology and among public health problems. Physical therapy as a means of recovery adjuvant drug therapy and psychological diagnoses of hydatid cyst, positive influence symptom relief with effects: objective, demonstrable by clinical examination and subjective characterized by a state of "good "expressed by patients.Material and methodsResearch type case study was conducted over 12 months in 2011 through the practical application of the requirements of the general state of the patient at the time of initial evaluation.ResultsThe patient, aged 52 years presented with a prescription for physical therapy with a diagnosis of bilateral pulmonary hydatid cyst surgery.Kinetic recovery is to minimize the functional disability, as well as facilitation of socio-professional enrollment. Medical history: debut 12 months ago predominant occurrence in environments with high concentrations of dust and post virus.ConclusionsBilateral hydatid cyst is indicated median sternotomy with solving both cysts in one surgical session. For kinetic program to have the best results, patients should be cooperative, to follow the directions and tasks received, be conscientious and not least will have an undeniable. Because results are reflected in the very quality of their lives, their kinetic abilities and skills.
Clinical Implication of Pulse Wave Analysis
Rok Accetto,Barbara Salobir,Jana Brguljan,Karla Rener
Acta Facultatis Medicae Naissensis , 2010,
Abstract: Systemic Pulse wave velocity (PWV) is a useful marker of target organ damage in hypertensive patients. It is used as a gold standard because of large body of evidence demonstrating its association with incident cardiovascular disease independently of traditional risk factors. Central blood pressure values (systolic, diastolic blood pressure, augmentation index) could be used in decision making what antihypertensive agent should we use. There are several techniques, most popular of which is applanation tonometry. Recently, normal and reference values have been published.
Recurrent Malignant Hypertension Treated with Angiotensin II Receptor Blocker (ARB) and ACE Inhibitor
Rok Accetto,Olga Pirc-?er?ek,Andreja Marn-Pernat
Acta Facultatis Medicae Naissensis , 2010,
Abstract: The prognosis of malignant hypertension without treatment is poor, with more than 80% mortality in two years. It is unusual to see it on more than one occasion in the same patient. We demonstrated clinical course, response to treatment and outcome of a patient presenting with recurrent malignant hypertension. In this patient, we did not see high renin as expected, but hypotensive effect of ARB and ACE inhibitor with normal salt diet was good. This is not surprising, since it has been shown that dual renin-aldosteron system blockade is more effective than doubling the usual dose of an ARB. Dual renin-angiotensin system blockade was effective in controlling blood pressure and restoring organ damage with regression of left ventricular hypertrophy and restoring renal function.
Limnological study of Dokan, Derbendikhan and Duhok lakes, Kurdistan region of Iraq  [PDF]
Janan Jabbar Toma
Open Journal of Ecology (OJE) , 2013, DOI: 10.4236/oje.2013.31003

The present study deals with the assessment of physico-chemical characteristics of Dokan, Derbendikhan and Duhok lakes. The physico-chemical characteristics of these lakes have been studied and analyzed for a year, during January-April-July and October 2009. Seasonal variations of two sampling sites of the lakes have been observed. Various parameters including air temperature, water temperature, electrical conductivity, TDS, pH, total alkalinity, total hardness, dissolved oxygen, calcium, magnesium, sodium, potassium, sulfate, chloride, nitrite and phosphate have been analyzed. The study has revealed that there are significant seasonal variations in some physico-chemical parameters and as a whole most of the parameters are different in the three lakes.

Specific Differential Equations for Generating Pulse Sequences
Ghiocel Toma
Mathematical Problems in Engineering , 2010, DOI: 10.1155/2010/324818
Abstract: This study presents nonlinear differential equations capable to generate continuous functions similar to pulse sequences. First are studied some basic properties of second-order differential equations with time-dependent coefficients generating bounded oscillating functions similar to test-functions (the function and its derivative  being equal to zero at the same time moments). The necessary intercorrelations between the phase of generated oscillations and the time-dependent coefficients is presented, being shown also that the external command function should be set to a constant value at these time moments so as to determine the amplitude and the sign of generated oscillations. Then some possibilities of using previous differential equation for generating positive-definite functions with null values for the function and its derivative at the same time moments and with constant slope for its amplitude are presented, being shown that the corresponding external command function should present also alternating components. Finally all previous results are used for determining a set of second-order differential equations with time dependent coefficients and a set of external command and corrective functions for generating a pulse sequence useful for modelling time series.
Advanced Signal Processing and Command Synthesis for Memory-Limited Complex Systems
Cristian Toma
Mathematical Problems in Engineering , 2012, DOI: 10.1155/2012/927821
Abstract: This paper presents advanced signal processing methods and command synthesis for memory-limited complex systems. For accurate measurements performed on limited time interval, some specific methods should be added. For signal processing, a robust filtering and sampling procedure performed on a specific working interval is required, so as the influence of low-amplitude and high-frequency fluctuations to be diminished. This study shows that such a signal processing method for the case of memory-limited complex systems requires the use of certain differentiation/integration procedures performed by oscillating systems, so as robust results suitable for efficient command synthesis to be available. A brief comparison with uncertainty aspects in modern physics (where quantum aspects can be considered as features of complex systems) is also presented.
Display of targets in multiple sclerosis
Tudor Toma
Genome Biology , 2002, DOI: 10.1186/gb-spotlight-20020507-01
Abstract: Lock et al. compared gene expression in acute and chronic MS lesions obtained at autopsy. They observed increased transcripts of genes encoding inflammatory cytokines, particularly interleukin-6 and -17, interferon-? and associated downstream pathways.In addition they chose two of these gene products as targets for therapy in experimental autoimmune encephalomyelitis (EAE), a murine model with similarities to MS. They observed that knocking out granulocyte colony-stimulating factor (upregulated in acute MS lesions) ameliorated EAE in the acute phase. In contrast, knocking out the immunoglobulin Fc receptor common ?chain (upregulated in chronic MS lesions) had the greatest effect on chronic disease."This is the first description supporting molecular differences in the two types of lesions, and provides data that could ultimately influence the choice of treatment for acute versus chronic stages of the disease" write Stephen Tompkins and Stephen Miller of Northwestern University Medical School, Chicago, Illinois, in an accompanying News & Views article.
Neurogenin works in two ways
Tudor Toma
Genome Biology , 2001, DOI: 10.1186/gb-spotlight-20010222-01
Abstract: In the 9 February issue of Cell, Yi Sun and colleagues show how the transcription factor neurogenin (Ngn1) is involved in cell-fate specification (Cell 2001, 104:365-376). Working on cortical stem cells from rats, the researchers demonstrate that the bHLH transcription factor Ngn1, in addition to inducing neurogenesis, inhibits the differentiation of neural stem cells into astrocytes. Ngn1 promotes neurogenesis by functioning as a transcriptional activator. In inhibiting astrocyte differentiation, Ngn1 sequesters the CBP-Smad1 transcription complex away from astrocyte differentiation genes, preventing the activation of the STAT transcription factors necessary for gliogenesis.Thus, two distinct mechanisms employed by the same transcription factor are involved in the activation and suppression of genes during neuronal cell-fate specification.
A virulence marker for Enterococcus faecium
Tudor Toma
Genome Biology , 2001, DOI: 10.1186/gb-spotlight-20010316-01
Abstract: Willems et al. used DNA probes based on the esp virulence gene from E. faecalis, and screened (by Southern blotting) chromosomal digests of 120 VREF isolates associated with hospital outbreaks in the US, Europe and Australia. These were compared with 45 non-epidemic isolates. A particular subpopulation of E. faecium was associated with epidemic outbreaks in all three continents, and these epidemic strains carried a variant of the esp gene. The variant was not present in non-epidemic and animal isolates.Esp is a cell-surface protein in E. faecalis, required for attachment of the bacteria to gut cells. The variant esp gene might be a marker of epidemic strains and could be used as a target for drugs to eradicate the epidemic VREF subpopulation from the gastrointestinal tract of carriers and help prevent the spread of VREF in Europe.
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