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Search Results: 1 - 10 of 51325 matches for " Tokarnia Carlos Hubinger "
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Sobre o "ronca", doen?a de etiologia obscura em bovinos, caracterizada por respira??o ruidosa
Tokarnia, Carlos Hubinger;D?bereiner, Jürgen;
Pesquisa Veterinária Brasileira , 1998, DOI: 10.1590/S0100-736X1998000300001
Abstract: "ronca", a disease of cattle occurring in the states of piauí, rio de janeiro and mato grosso do sul, is also known by the popular names "roncadeira" or "ronqueira", what means snoaring disease. data on the disease were obtained through informations, own observations, clinical and postmortem examinations of 12 affected bovines, completed by histopathological examinations and chemical analyses of liver samples for microelements. the main symptoms are the snoaring sound during inspiration, which arises or is intensified the more one leades with the animal, irritability, continuous worsening of the nutritional state and death after a few months up to 2 years. blood examinations, performed during the studies in piauí, showed a normocytic and hypocromic condition; blood smears did not reveal any abnormality. at postmortem examination sometimes an orange discolouration of the liver and an orange-brown colour of the lymphnodes of the liver hilus was observed. careful examinations of the nasal cavity, especially of the turbinates, and of the larynx did not disclose any lesions. histopathological examinations revealed, as the main lesion, severe hemosiderosis of the liver, always seen, as well as of the spleen and lymphnodes. chemical analyses of liver samples revealed in all by "ronca" affected animals of the three regions very low copper and very high iron values. two bovines affected by "ronca" and transferred to a region where the disease does not occur, continued with the snoaring respiration during more than a year. at postmortem examination no lesions besides a few not related to the disease were found. histopathological examinations revealed hemosiderosis in liver, spleen and lymphnodes, but less pronounced than in the animals affected by "ronca" which stayed at the original farm. chemical anlyses of the liver samples of the two transferred animals revealed normal values for copper and high levels of iron, but these were lower than those found in the animals affected
INTOXICA??O EXPERIMENTAL PELAS SEMENTES TRITURADAS DE Ricinus communis (Euphorbiaceae) EM COELHOS
Brito, Marilene de Farias;Tokarnia, Carlos Hubinger;
Pesquisa Veterinária Brasileira , 1997, DOI: 10.1590/S0100-736X1997000100001
Abstract: the ground seeds of ricinus communis, given by stomach tube in single doses to rabbits, caused severe symptoms of poisoning, lethal in three rabbits which received the dose of 2 g/kg and in one of four rabbits which received 1 g/kg; the other three rabbits which received the lower dose, showed slight to moderate symptoms and recovered. three other rabbits, which received 0.5 g/kg, showed only slight symptoms. the period between administration of the seeds and death or recovery, varied from 12h47min to 68h08min, and from 3 to 6 days, respectively. first clinical symptoms after the administration of the seeds were observed about 8 hours in the lethal cases and in those where the animals showed more than slight symptoms, and about 24 hours in the cases with only slight symptoms. the course of the poisoning varied from 4 to 56 hours in the lethal cases and from 2 to 5 and half days in the cases with recovery. the clinical signs consisted mainly in digestive distress; the animals showed inappetence or anorexia. faeces were generally scarce, with bolus altered in form and size, dark, sometimes soft, with mucus. there were manifestations of colic. the most evident post-mortem findings were in the small intestine and cecum, which had liquid contents; its wall was congested and edematous, and fibrine covered the mucosa as pseudomembranes or was found in the lumen as flakes and or filaments. the most important histological changes were seen also in the small intestine and cecum. in the formar there was coagulative necrosis associated with congestion/ hemorrhages of the mucosa and submucosa which also showed edema. similar lesions were seen in the cecum, but these were less marked, with exception of the edema of the submucosa. in colon and rectum the changes were slight or absent. necrosis with marked caryorhexis of the macrophages, which migrated to the upper mucosal layer, was seen in the lymphoid follicles of the appendix vermiformis and in one case also of the rudimentary
IMUNIDADE CRUZADA PELAS SEMENTES DE Abrus precatorius E Ricinus communis EM BOVINOS
Tokarnia, Carlos Hubinger;D?bereiner, Jürgen;
Pesquisa Veterinária Brasileira , 1997, DOI: 10.1590/S0100-736X1997000100005
Abstract: five bovines immunized against the toxicity of the seeds of abrus precatorius l. (jequiriti bean) did not get poisoned or only slightly so when the seeds of ricinus communis l. (castor bean) were given in amounts that in bovines, which never before ingested the seeds of a. precatorius or r. communis, caused moderate to severe poisoning or even death. a sixth bovine, which was not well immunized against the toxic action of the seeds of a. precatorius, was severely poisoned when given a high dose of the seeds of r. communis. on the other side, from five bovines immunized against the toxic action of the seeds of r. communis four were severely poisoned and the fifth one moderately when the seeds of a. precatorius were given in doses that in bovines, which never before ingested seeds of r. communis or a. precatorius, caused slight to severe poisoning. it is concluded that bovines immunized against the toxic action of the seeds of a. precatorius are resistant to the toxic action of the seeds of r. communis, but that the contrary is not the case; this is, bovines immunized against the toxic action of the seeds of r. communis were not protected against the poisoning by a. precatorius. earlier studies by other authors had shown that the toxalbumins of the seeds of a. precatorius and r. communis, respectively abrin and ricin, are different as to their antigenic properties. a possible explanation for the difference in results can be.that in the present study polygastric animals were used which received the seeds orally, but in the earlier studies monogastric animals received the seeds or toxins by parenteral route. the administration of the fresh leaves or the pericarp of the fruits r. communis to bovines, which had been immunized against the action of the seeds of the plant, had the same toxic effect as to not immunized animals, showing that the immunity due to ricin does not give protection against the action of ricinin, the toxic principle of the leaves and the pericarp.
A importancia dos acidentes ofídicos como causa de mortes em bovinos no Brasil
Tokarnia, Carlos Hubinger;Peixoto, Paulo Vargas;
Pesquisa Veterinária Brasileira , 2006, DOI: 10.1590/S0100-736X2006000200001
Abstract: a review of the literature shows that opinions on the importance of snake bites as cause of cattle death in brazil are divergent among veterinarians; some think they are of no importance or of only minor significance, others are of the opinion that snake bites are frequent. however, the literature only reports two confirmed fatal cases by bothrops and none by crotalus in cattle in the country. a questionnaire which was submitted for appraisal to veterinary pathologists and clinicians in various states of brazil, revealed only suspected cases of fatal accidents by snakes in cattle. during our field and laboratory diagnostic work we never made a diagnosis of a snake bite accident. many "diagnoses" have apparently been made at a distance from where the animals died, without clinical and post-mortem examination, nor histological studies. by this way, the great majority of cases seems to be only supposition. in brazil there are only few snakes of the genus bothrops theoretically able to produce sufficient amounts of venom to kill an adult bovine. nevertheless, in experiments, only bothrops alternatus was able to cause the death of just one out of three bovines bitten, and this animal only weighed 279 kg. snakes of the genus crotalus can produce sufficient amounts of venom to kill an adult bovine; however it is known, that snakes of the genus crotalus as well as of bothrops generally inoculate only a part of their venom. these considerations indicate that the deaths suspected to have been caused by snake bites in cattle in brazil have to be studied more thoroughly. a diagnosis can only be confirmed by establishing the precise clinical and pathological picture. our current opinion is that fatal snake bites are much less frequent in cattle than often believed, and that their importance is generally much exaggerated.
IMUNIDADE CRUZADA PELAS SEMENTES DE Abrus precatorius E Ricinus communis EM BOVINOS
Tokarnia Carlos Hubinger,D?bereiner Jürgen
Pesquisa Veterinária Brasileira , 1997,
Abstract: Cinco bovinos imunizados contra a a o tóxica das sementes de Abrus precatorius L. ("tento", "jiquiriti") n o adoeceram ou somente levemente pela administra o das sementes de Ricinus communis L. ("mamona"), em doses que em bovinos que antes nunca ingeriram sementes de A. precatorius ou R. communis, causaram intoxica o de intensidade de grau moderado a acentuado ou até a morte. Um sexto bovino, que n o ficou bem imunizado contra a a o tóxica das sementes de A. precatorius, adoeceu em grau acentuado pela administra o de dose elevada das sementes de R. communis. Já dos cinco bovinos imunizados contra a a o tóxica das sementes de R. communis quatro adoeceram em grau acentuado, oquinto em grau moderado, pela administra o das sementes de A. precatorias em doses que em bovinos que antes nunca ingeriram sementes de R. communis ou A. precatorius causaram intoxica o de intensidade leve a acentuada. Estes resultados permitem concluir que bovinos imunizados contra a a o tóxica das sementes de A. precatorius s o resistentes à a o tóxica das sementes de R. communis, mas que o contrário n o ocorre, isto é, bovinos imunizados contra a a o tóxica das sementes de R. communis, n o se mostraram protegidos contra a intoxica o por A. precatorius. Estudos anteriores por outros autores mostraram que as toxalbuminas de A. precatorius e R. communis, respectivamente abrina e ricina, s o diferentes do ponto de vista antigênico. Uma explica o para a divergência desses resultados com os nossos poderia estar no fato de que no presente estudo foram usados poligástricos que receberam as sementes por via oral, enquanto que nos estudos anteriores foram usados monogástricos em que as sementes ou as toxinas foram aplicadas por via parenteral. A administra o de folhas frescas ou do pericarpo do fruto de R. communis a bovinos imunizados contra a a o das sementes desta planta tiveram o mesmo efeito tóxico que em animais n o imunizados, demonstrando que a imunidade conferida pela ricina n o inibe a a o da ricinina, o principio tóxico das folhas e do pericarpo.
INTOXICA O EXPERIMENTAL PELAS SEMENTES TRITURADAS DE Ricinus communis (Euphorbiaceae) EM COELHOS
Brito Marilene de Farias,Tokarnia Carlos Hubinger
Pesquisa Veterinária Brasileira , 1997,
Abstract: As sementes trituradas de Ricinus communis, administradas em doses únicas por sonda intragástrica a coelhos causou graves sintomas de intoxica o com êxito letal nos três coelhos que receberam a dose de 2 g/kg e em um dos quatro que receberam 1 g/kg. Os outros três coelhos que receberam 1g/kg desenvolveram sintomas discretos a moderados e se recuperaram, e os três que receberam 0,5g/kg só mostraram sintomas discretos. O período entre a administra o das sementes e a morte ou recupera o variou de 12h47min a 68h08min, e de 3 a 6 dias, respectivamente. Os primeiros sintomas após a administra o das sementes, foram observados dentro de cerca 8 horas nos casos letais e nos animais que adoeceram moderadamente, e dentro de cerca 24 horas nos casos com sintomatogia discreta. A evolu o da intoxica o variou de 4 a 56 horas nos casos letais e de 2 a 5 meio dias nos casos de recupera o. A sintomatologia consistiu principalmente de perturba es digestivas. Os animais apresentaram inapetência até anorexia. As fezes geralmente eram escassas, com forma e tamanho das síbalas alteradas, eram escuras, às vezes pastosas, com muco. Havia nítidas manifesta es de cólica. Os achados de necropsia mais evidentes foram constatados no intestino delgado e ceco. O conteúdo destes segmentos do intestino era líquido. A parede do intestino delgado apresentou congest o e edema e havia fibrina recobrindo a mucosa sob forma de pseudomembranas, ou na luz intestinal sob forma de flocos e/ou filamentos. No ceco havia edema da mucosa como também congest o da parede e fibrina aderida à mucosa ou encontrada em flocos e/ou filamentos no conteúdo. As altera es histológicas mais importantes foram verificadas no intestino delgado e ceco. No intestino delgado observou-se necrose de coagula o associada a congest o/hemorragias na mucosa. Havia ainda congest o/hemorragias e edema na submucosa. Les es semelhantes foram vistas no ceco onde porém, com exce o do edema da submucosa, eram menos acentuadas. No cólon e reto as les es eram leves ou ausentes. Foi verificado no apêndice vermiforme e em um caso também no ceco rudimentar, necrose com acentuada cariorrexia de macrófagos que migraram dos folículos linfóides para aparte superior da mucosa.
Sobre o "ronca", doen a de etiologia obscura em bovinos, caracterizada por respira o ruidosa
Tokarnia Carlos Hubinger,D?bereiner Jürgen
Pesquisa Veterinária Brasileira , 1998,
Abstract: S o apresentados os resultados de estudos realizados sobre uma doen a de evolu o cr nica em bovinos, de etiologia obscura, cuja caraterística principal é uma respira o ruidosa. Esta doen a é conhecida nos Estados do Piauí, Rio de Janeiro e Mato Grosso do Sul, onde a sua ocorrência foi verificada, pelos nomes populares de "ronca", "roncadeira" ou "ronqueira". Os dados mais importantes da doen a, baseados nos históricos, em observa es próprias, exames clínicos, necropsias de 12 bovinos, complementadas por exames histopatológicos e analises químicas de amostras de fígado para microelementos, s o a respira o ruidosa na inspira o, que aparece ou se intensifica a medida que se lida com os animais, irritabilidade, emagrecimento progressivo e morte após alguns meses até dois anos. Exames de sangue, realizados nos estudos no Piauí, revelaram uma condi o normo-cítica hipocr mica; esfrega os de sangue n o revelaram nada digno de nota. à necropsia se constatou às vezes colora o alaranjada do fígado e colora o alaranjada/marrom dos linfonodos do hilo do fígado. Exames da cavidade nasal, especialmente dos cornetos, e da laringe, n o revelaram nenhuma altera o. Os exames histopatológicos evidenciaram como les o principal hemossiderose acentuada do fígado, sempre presente, bem como do ba o e de linfonodos. Análises de amostras de fígado revelaram em todos os animais afetados pela doen a, nas três regi es, valores muito baixos de cobre e muito elevados de ferro. Dois bovinos afetados pela doen a, transferidos para regi o indene, continuaram com a respira o ruidosa durante mais de um ano. à necropsia destes animais n o foram encontradas les es, além de alguns achados n o relacionáveis com a doen a. Nos exames histopatológicos foi constatada hemosside-rose no fígado, ba o e em linfonodos, porém menos acentuada que nos casos de "ronca" examinados no local de sua procedência. As análises de amostras de fígado revelaram valores normais para cobre e de ferro ainda altos, mas menos acentuados que nos bovinos com "ronca" no local de sua procedência. Os estudos realizados n o permitiram desvendar a raz o da respira o ruidosa. é levantada a suspeita, que a deficiência de cobre tenha influência na patogênese do "ronca", em que, porém, devem estar envolvidos ainda outros fatores para a forma o do quadro.
Distúrbios comportamentais em ruminantes n?o associados a doen?as: origem, significado e importancia
Malafaia, Pedro;Barbosa, José Diomedes;Tokarnia, Carlos Hubinger;Oliveira, Carlos Magno Chaves;
Pesquisa Veterinária Brasileira , 2011, DOI: 10.1590/S0100-736X2011000900010
Abstract: the scientific study of animal behavior, especially when the animated or inanimated environment is changed, is the main objective of ethology. many diseases which occur in ruminants develop some degree of change in their behavior. professionals that work with ruminants should distinguish abnormal behavior due to environmental disturbance when their welfare is negatively affected (i.e. feedlots with high stock ratio, shade deficiencies in pastures, heat stress, and errors in nutritional management) from disease conditions or nutritional deficiencies (i.e. depraved appetite caused by sodium deficiency or by lack of physically effective fiber). the purpose of this paper is to discuss the main behavioral disturbances (i.e. abnormal herd behavior, stereotypies, cross-sucking, bar-biting) verified in ruminants raised under intensive or extensive conditions in brazil.
Fotossensibiliza??o hepatógena em eqüinos pela ingest?o de Brachiaria humidicola (Gramineae) no Estado do Pará
Barbosa, José Diomedes;Oliveira, Carlos Magno C. de;Tokarnia, Carlos Hubinger;Peixoto, Paulo Vargas;
Pesquisa Veterinária Brasileira , 2006, DOI: 10.1590/S0100-736X2006000300003
Abstract: data on the clinical-pathological aspects and on the epidemioloy of a disease in horses, characterized by phototsensitization, which occurs in northeastern of pará, brazil, are presented. of a total of 40 horses examined clinically, post-mortem examination was performed on seven. due to the characteristic lesions found on the non-pigmented skin, the macroscopic and histological alterations in the liver, and knowing that brachiaria grasses contain saponins with toxic properties, which cause liver lesions and photosensitization in cattle and sheep, it is concluded that this disease in horses is caused by grassing exclusively brachiaria humidicola.
Compara??o da sensibilidade de bovinos e búfalos à intoxica??o por Palicourea marcgravii (Rubiaceae)
Barbosa, José Diomedes;Oliveira, Carlos Magno Chaves de;Tokarnia, Carlos Hubinger;Riet-Correa, Franklin;
Pesquisa Veterinária Brasileira , 2003, DOI: 10.1590/S0100-736X2003000400005
Abstract: in order to verify if buffaloes are more resistant than cattle to poisoning by palicourea marcgravii, the plant was given per os simultaneously to buffaloes and cattle. seven buffaloes and three head of cattle were used. doses of 0.5, 1.0 and 2.0 g/kg did not cause signs of poisoning in buffaloes; but doses of 3.0, 4.0 and 6.0 g/kg caused death. in cattle 0.25 g/kg did not cause symptoms; but 0.5 and 2.0 g/kg were lethal. the influence of exercise on the onset of symptoms, the time which elapsed from the beginning of the administration of the plant to the appearance of symptoms, and the symptoms themselves, were similar in the two animal species. the clinical course was longer in buffaloes; whilst in cattle the period between the onset of severe symptoms and death lasted 9 to 17 minutes; in buffaloes it varied from 10 minutes to 1 hour 28 minutes. it can be concluded, that buffaloes are about six times more resistant than cattle to the toxic action of p. maracgravii. the lower incidence of deaths in buffaloes by poisonous plants in the amazon region is, at least in part, due the lower sensibility of buffaloes to poisoning by this plant. another factor responsible for the smaller number of buffaloes which die due to plant poisoning in the amazon region, is possibly that buffaloes prefer the lowlands, e.g. temporarily flooded areas, which are the habitat of arrabidaea bilabiata, the second most important poisonous plant of the amazon region. this plant is less poisonous than p. marcgravii, and its habitat are the higher not flooded areas. so it would be safer, in order to diminish losses, to breed buffaloes instead of cattle in areas where p. marcgravii occurs. the reason for the greater resistance of buffaloes should be further investigated as a possible prophylactic measure to avoid poisoning by p. marcgravii in cattle. on the other hand, australian investigators modified genetically the ruminal bacteria butyrivibrio fibrisolvens by introducing a gene, isolated from
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