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Search Results: 1 - 10 of 462305 matches for " Todorovi?-Rakovi? Nata?a "
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TGF-beta1 in breast cancer-estrogen regulation
Todorovi?-RakoviNataa,Ivanovi? Vesna,Demajo Miroslav A.,Ne?kovi? Borka
Archive of Oncology , 2002, DOI: 10.2298/aoo0203164t
Abstract: TGF-beta1 is a pluripotent cytokine with diverse effects in the normal development of mammary glands, and in the development of malignant tumors of the breast. The aim of the study was to determine the levels of TGF-beta1 in the group of advanced breast cancer, in which increased TGF-beta1 levels were most likely to be expected. TGF-beta1 levels were also compared with estradiol levels. Our results suggested that TGF-beta1 synthesis may be regulated by estrogen or anti-estrogen through ER. Finding of increased TGF-beta1 levels, due to its possible role in predicting invasive phenotype in later phases of tumor progression, may indicate the tendency of tumor tissue towards autonomy.
Elevated plasma levels of TGF-beta1 in patients with locally advanced breast cancer related to other clinical stages
Todorovi?-RakoviNataa,Ivanovi? Vesna,Demajo Miroslav A.,Ne?kovi?-Konstantinovi? Zora
Archive of Oncology , 2003, DOI: 10.2298/aoo0303131t
Abstract: Background: The application of plasma tumor markers is mainly during the follow-up of cancer patients and especially in monitoring of advanced disease. These biomarkers do not require surgical intervention and provide relatively simple monitoring at any time during the disease course. TGF-beta1 is a pluripotent cytokine, with diverse effects in normal physiology and a role in both normal mammary gland development and progression of breast cancer. In early stages of breast carcinomas TGF-beta1 acts as tumor suppressor, while in later stages, when tumor cells become resistant to growth inhibition by TGF-beta1, it acts as tumor promoter. For that reason, the aim of this study was to assess the stage-related TGF-beta1 elevation in circulation of breast cancer patients, during disease progression. Methods: We analyzed 52 breast cancer patients of different stages (I/II, III, IV) and 36 healthy donors. TGF-beta1 levels were determined by enzyme-linked immunosorbent assay (ELISA, R&D). Results Although there was no increase in plasma TGF-beta1 in stage I/II patients (n =10, median value = 0.89 ng/ml), statistically significant elevation of plasma TGF-beta1 was found in locally advanced breast cancer (stage III, n = 9, median value = 2.30 ng/ml) and also in metastatic breast cancer (stage IV, n = 33, median value = 2.46 ng/ml) in relation to healthy donors and stage I/II. Conclusion: This elevation of plasma TGF-beta1 in locally advanced breast cancer is probably the result of increased tumor mass and tumor-stromal interactions in this stage, as well as a possible cause of greater metastatic potential of tumor cells which lead to metastatic breast cancer. Prognostic role of TGF-beta1 is not fully understood, but from these results we could say that it could be a marker for monitoring patients disease course, as well as for understating the biology of breast cancer.
The influence of plasma TGF-beta1 levels on development of postradiotherapy fibrosis in breast cancer patients
Mladenovi? Jasmina,Borojevi? Nenad D.,Todorovi?-RakoviNataa,Ne?kovi?-Konstantinovi? Zora
Archive of Oncology , 2002, DOI: 10.2298/aoo0203171m
Cross-talk between ER and HER2 in breast carcinoma
Todorovi?-RakoviNataa,Ne?kovi?-Konstantinovi? Zora,Nikoli?-Vukosavljevi? Dragica
Archive of Oncology , 2006, DOI: 10.2298/aoo0604146t
Abstract: In tumors in which estrogen receptor (ER) and growth factor signaling pathways are simultaneously active, there is a bidirectional cross-talk that results in a positive feedback cycle of cell survival and proliferation stimuli. Beside the postulated inverse correlation between ER and HER2 (human epidermal growth factor receptor 2) as a consequence of repressive feedback signaling loop, there are also other mechanisms regarding ER-HER2 interactions. It seems that MAPK (mitogen-activated protein kinase) pathway has a central role in synergistic action between ER and HER2 in normal mammary gland development, as well in the breast cancer. MAPK pathway is hyperstimulated in cells that overexpress HER2 as a consequence of HER2 gene amplification. In ER+ tumors, MAPK phosphorylates and activates either ER itself or ER coregulators, enhancing the transcriptional activation potential of ER. ER and HER2 signaling could interact on multiple levels (genomic or non-genomic) and therefore might induce reduced ER expression or might increase ER function. Based on our own research, dominant effect of postulated cross-talk was not related to HER2-induced reduced expression of ER (no difference in quantitative levels of ER in ER+ tumors regarding their HER2 status and no difference in progression-free time between ER+HER2- and ER+HER2+ patients) as presented. The importance of understanding ER-HER2 cross-talk is not only because of its significance in breast cancer progression, but because it seems to be fundamental factor in endocrine resistance that can improve treatment strategies, especially targeting MAPK pathway. .
Immunoradiometric assay of cathepsin D: Estrogen regulated vs. non estrogen- regulated cathepsin D expression in relation to clinicopathological features of breast cancer
Nikoli?-Vukosavljevi? Dragica,Marki?evi? Milan,Kanjer Ksenija,Rakovi?-TodoroviNataa
Archive of Oncology , 2002, DOI: 10.2298/aoo0203115n
Abstract: Background: Cellular biomarkers may predict tumor cell behavior in breast cancer. One of the most paradoxical biomarker in breast cancer is cathepsin D. Patients and methods: The study includes 152 patients with histologically verified breast carcinoma. Clinicopathological findings were classified according to classical breast carcinoma-host features (age and menopausal status) and carcinoma features (lymph node status, tumor size type and grade). Estrogen and progesterone receptors were assayed in accordance with the recommendation of the EORTC. Cathepsin D concentrations were determined using immunoradiometric assay. The results were analyzed using non-parametric statistical methods. Results: All differences in the proportion of breast carcinoma classified as cathepsin D-positive and disagreements on the association of cathepsin D status with clinicopathological features of breast cancer are the result of varying cut-off values used by different authors. Using the cut-off value, which defines estrogen-regulated vs. nonestrogen-regulated cathepsin D expres sion, this study points to the cathepsin D status as a complementary biolog ical information to ER and PR status, and a dependent biomarker in relation to age of patients and lymph node status. Conclusion: The classification of tumors according to the cathepsin D status within ER and PR status could provide more information on the association between cathepsin D status and clinical-pathological features of breast cancer.
Prognostic significance of steroid hormone receptors (ER and PR) in primary operable breast cancer
Kanjer Ksenija,Todorovi?-RakoviNataa,Marki?evi? Milan,Ne?kovi?-Konstantinovi? Zora
Archive of Oncology , 2002, DOI: 10.2298/aoo0203155k
The importance of simultaneous determination of breast cancer biomarkers
Marki?evi? Milan,Todorovi?-RakoviNataa,Kanjer Ksenija,Nikoli?-Vukosavljevi? Dragica
Archive of Oncology , 2002, DOI: 10.2298/aoo0203165m
Abstract: It is shown that steroid hormone receptors by themselves are not sufficiently strong prognostic factors in management of breast cancer. For that reason, simultaneous consideration of different biomarkers seems to be more appropriate for clinical use, i.e. selections of patients with high/inter-mediate/low risk of disease outcome. However, the amount of tumor material available from breast carcinoma can preclude determination of estrogen- regulated biomarkers together with estrogen receptor and progesterone receptor. The aim of this study was to assess the possibility of estrogen receptor and progesterone receptor determination by a single-point instead of five-point biochemical method. Our results demonstrated that the correlation between measurements of estrogen and progesterone receptor contents obtained by the five-point and single-point assay in the total population was very high. Consequently, we could use the single-point assay instead of five-point assay for estrogen receptor and progesterone receptor determination, thus making possible determination of other molecular biomarkers from the same breast carcinoma.
Determinants of debt rescheduling in Eastern European countries
Lau?ev Jelena,Stojanovi? Aleksandar,TodoroviNataa
Economic Annals , 2011, DOI: 10.2298/eka1188007l
Abstract: This study utilizes Panel Logit Models applied to a set of macroeconomic, financial, and political variables to estimate the debt rescheduling probabilities of 15 Eastern European countries during the transition period from 1990-2005. These transition economies became a very attractive region for foreign investment. Specifically, the region became the largest recipient of net non-FDI flows among all emerging market regions in 2005. Therefore, it is relevant for policy makers and institutional and private foreign investors to investigate factors that influence debt rescheduling probabilities, as these may directly affect the size of and return on investments in these countries. Our findings suggest that policy efforts focused on reducing government expenditure, attracting foreign direct investment, increasing export revenues, and keeping a good repayment record result in low debt rescheduling probabilities and, in turn, decrease the cost of debt for these countries. This is a common finding for all countries in the sample, including those that have become EU members.
Hypoxic-ischemic encefalopathy: Clinical course and prognosis
?osi?-Cerovac Nataa,Todorovi? Slobodanka M.,Jovi? Neboj?a J.,Prostran Milica ?.
Vojnosanitetski Pregled , 2003, DOI: 10.2298/vsp0303291c
Abstract: Background. Establishing the value of neurological examination, and additional diagnostic methods (ultrasonography and magnetic resonance imaging of the brain) in the diagnosis and prognosis of hypoxic-ischemic encephalopathy and its treatment, tracking the clinical course, and making the prognosis of neurological development in newborn infants with hypoxic-ischemic encefalopathy. Methods. The group of 40 term newborn infants with suspected intrauterine asphyxia was examined. All the infants were prospectivelly followed untill the 3rd year of age at the Clinic for Neurology and Psychiatry for Children and Youth in order to estimate their neurological development and to diagnose the occurence of persistent neurological disorders. All the infants were analyzed by their gestational age and Apgar score in the 1st and the 5th minute of life. They were all examined neurologically and by ultrasonography in the first week of life and, repeatedly, at the age of 1, 3, 6, 9, 12, 18, as well as in the 24th month of life. They were treated by the standard methods for this disease. Finally, all the infants were examined neurologically and by magnetic resonance imaging of the brain in their 3rd year of age. On the basis of neurological finding infants were devided into 3 groups: infants with normal neurological finding, infants with mild neurological symptomatology, and infants with severe neurological disorders. Results. It was shown that neurological finding, ultrasonography and magnetic resonance imaging of the brain positively correlated with the later neurological development of the infants with hypoxic-ischemic encephalopathy. Conclusion. Only the combined use of these techniques had full diagnostic and prognostic significance emphasizing that the integrative approach was very important in the diagnosis of brain lesions in infants.
Dragoslav ?umarac,Maja Todorovi,Maja Djurovi? - Petrovi?,Nataa Tri?ovi?
Thermal Science , 2010, DOI: tsci100430017s
Abstract: In this paper, presented is the state of the art of Energy Efficiency (EE) of residential buildings in Serbia. Special attention is paid to energy efficiency in already existing buildings. The average energy consumption in residential buildings in Serbia is over 150 kWh/m2 per year, while in developed European countries it is about 50 kWh/m2 per year. In this paper examined is the contribution of ventilation losses, through the windows of low quality, regardless whether they are poorly made, or made from bad materials, or with no adequate glass. Besides ventilation losses, which are of major importance in our buildings, special attention is paid to transmission losses, which are consequence of the quality and energy efficiency of the facade. All of the above statements are proved by measurements obtained on a representative building of the Block 34 in New Belgrade, built in the eighties of the last century. In addition to measurements performed the calculation of energy consumption for heating during winter has been made. The results of two different methods of calculation of energy consumption for heating are compared with the values obtained by measuring.
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