oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 3 )

2019 ( 220 )

2018 ( 275 )

2017 ( 292 )

Custom range...

Search Results: 1 - 10 of 224891 matches for " Todorovi?-?ilas Ljiljana R. "
All listed articles are free for downloading (OA Articles)
Page 1 /224891
Display every page Item
Effects of hyperthyroidism on bone mass in women of reproductive age
Ili? Jana,Kova?ev Branka,Todorovi?-?ilas Ljiljana R.
Medicinski Pregled , 2004, DOI: 10.2298/mpns0404111i
Abstract: Introduction Hyperthyroidism is one of the most frequent endocrinopathies in women of reproductive age. Consequently, increased risk of osteoporosis may be expected. Material and methods The research has included a group of 30 hyperthyroid women and a control group of 30 healthy women of reproductive age. Age and some clinical characteristics were analyzed, as well as some anthropometric parameters. Bone mass parameters were determined by measuring bone mineral density using ultrasound devices (SAHARA-Hologic). Results Bone mass parameters in hyperthyroid women are significantly lower than in controls (BUA: 63.25±12.17; 69.73±10.02 dB/MHz respectively; SOS:1523.90± 24.47; 1540.19±26.59 m/s respec. QUI/STIFF 79.78±13.95; 89.09±13.99 % respec.) Duration of hyperthyroidism affects bone density and reduces it. Discussion Obtained results were expected, having in mind that hyper- thyroidism is a condition characterized by increased bone catabolic rate. Also, negative correlation between the duration of hyperthyroidism and bone mass parameters (BUA, SOS) was expected, because it is logical that consolidation of bone mass in adult life cannot be maintained in circumstances in which metabolic rate is increased. During hyperthyroidism, bone loss is expected. In order to confirm this, future studies of bone markers are necessary. Conclusion Based on results obtained in the study, the following conclusions were made: hyperthyroidism is accompanied by decreased values of bone mass parameters; this effect depends on duration of hyperthyroidism. We confirmed that hyperthyroidism may be the cause of decrease in bone mass, particularly if it lasts more than a year. To prevent osteoporosis in women of reproductive age with hyperthyroidism and involution osteoporosis later in life, early diagnosis and effective therapy of hyperthyroidism is imperative.
Autoimmune thyroid disease and other non-endocrine autoimmune diseases
Todorovi?-?ilas Ljiljana,I?in Tijana,Novakovi?-Paro Jovanka,Bajkin Ivana
Medicinski Pregled , 2011, DOI: 10.2298/mpns1104183t
Abstract: Introduction, Autoimmune diseases are chronic conditions initiated by the loss of immunological tolerance to self-antigens. They constitute heterogeneous group of disorders, in which multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Recent epidemiological studies have shown a possible shift of one autoimmune disease to another or the fact that more than one autoimmune disease may coexist in a single patient or in the same family. Numerous autoimmune diseases have been shown to coexist frequently with thyroid autoimmune diseases. Autoimmune thyroid disease and other organ specific non-endocrine autoimmune diseases. This part of the study reviews the prevalence of autoimmune thyroid disease coexisting with: pernicious anaemia, vitiligo, celiac disease, autoimmune liver disease, miastenia gravis, alopecia areata and sclerosis multiplex, and several recommendations for screening have been given. Autoimmune thyroid disease and other organ non-specific non-endocrine autoimmune diseases. Special attention is given to the correlation between autoimmune thyroid disease and rheumatoid arthritis, systemic lupus erythematosus, syndrome Sj gren, systemic sclerosis and mixed connective tissue disease. Conclusions. Screening for autoimmune thyroid diseases should be recommended in everyday clinical practice, in patients with primary organ-specific or organ non-specific autoimmune disease. Other-wise, in patients with primary thyroid autoimmune disease, there is no good reason of seeking for all other autoimmune diseases, although these patients have a greater risk of developing other autoimmune disease. Economic aspects of medicine require further analyzing of these data, from cost/benefit point of view to justified either mandatory screening or medical practitioner judgment.
Iodine and thyroid gland with or without nuclear catastrophe
Todorovi?-?ilas Ljiljana,Bajkin Ivana,I?in Tijana,Novakovi?-Paro Jovanka
Medicinski Pregled , 2012, DOI: 10.2298/mpns1212489t
Abstract: Introduction. Iodine, as a trace element, is a necessary and limiting substrate for thyroid gland hormone synthesis. It is an essential element that enables the thyroid gland to produce thyroid hormones thyroxine (T4) and triiodothyronine (T3). Synthesis of Thyroid Hormones and Iodine Metabolism. Three iodine molecules are added to make triiodothyronine, and four for thyroxine - the two key hormones produced by the thyroid gland. Iodine deficiency. The proper daily amount of iodine is required for optimal thyroid function. Iodine deficiency can cause hypothyroidism, developmental brain disorders and goiter. Iodine deficiency is the single most common cause of preventable mental retardation and brain damage in the world. It also decreases child survival, causes goiters, and impairs growth and development. Iodine deficiency disorders in pregnant women cause miscarriages, stillbirths, and other complications. Children with iodine deficiency disorders can grow up stunted, apathetic, mentally retarded, and incapable of normal movements, speech or hearing. Excessive Iodine Intake. Excessive iodine intake, which can trigger autoimmune thyroid disease and dysfunction, is on the other side. Iodine use in Case of Nuclear Catastrophe. In addition to other severe consequences of radioactivity, high amount of radioactive iodine causes significant increase in incidence of thyroid gland carcinoma after some of the nuclear catastrophes (Hiroshima, Nagasaki, Chernobyl, Fukushima). The incidence of thyroid carcinoma was increased mostly in children. This paper was aimed at clarifying some of the possibilities of prevention according to the recommendations given by the World Health Organization.
The role of autonomic cardiovascular neuropathy in pathogenesis of ischemic heart disease in patients with diabetes mellitus
Popovi?-Peji?i? Snje?ana,Todorovi?-?ilas Ljiljana,Pantelinac Pavle
Medicinski Pregled , 2006, DOI: 10.2298/mpns0604118p
Abstract: Introduction. Diabetes is strongly associated with macrovascular complications, among which ischemic heart disease is the major cause of mortality. Autonomic neuropathy increases the risk of complications, which calls for an early diagnosis. The aim of this study was to determine both presence and extent of cardiac autonomic neuropathy, in regard to the type of diabetes mellitus, as well as its correlation with coronary disease and major cardiovascular risk factors. Material and methods. We have examined 90 subjects, classified into three groups, with 30 patients each: those with type 1 diabetes, type 2 diabetes and control group of healthy subjects. All patients underwent cardiovascular tests (Valsalva maneuver, deep breathing test, response to standing, blood pressure response to standing sustained, handgrip test), electrocardiogram, treadmill exercise test and filled out a questionnaire referring to major cardiovascular risk factors: smoking, obesity, hypertension, and dyslipidemia. Results. Our results showed that cardiovascular autonomic neuropathy was more frequent in type 2 diabetes, manifesting as autonomic neuropathy. In patients with autonomic neuropathy, regardless of the type of diabetes, the treadmill test was positive, i.e. strongly correlating with coronary disease. In regard to coronary disease risk factors, the most frequent correlation was found for obesity and hypertension. Discussion Cardiovascular autonomic neuropathy is considered to be the principal cause of arteriosclerosis and coronary disease. Our results showed that the occurrence of cardiovascular autonomic neuropathy increases the risk of coronary disease due to dysfunction of autonomic nervous system. Conclusions. Cardiovascular autonomic neuropathy is a common complication of diabetes that significantly correlates with coronary disease. Early diagnosis of cardiovascular autonomic neuropathy points to increased cardiovascular risk, providing a basis for preventive and therapeutic measures. .
Bone metabolism during substitution therapy of primary hypothyroidism
Pejin Radoslav,?uri? Nikola,Kova?ev-Zavi?i? Branka,Todorovi?-?ilas Ljiljana
Medicinski Pregled , 2009, DOI: 10.2298/mpns0910407p
Abstract: Introduction. The relation between thyroid hormones and bone metabolism markers in hyperthyroidism is well known. Earlier studies indicate the possibility of bone metabolism acceleration during the excessive replacement therapy with l-thyroxin in hypothyroid patients especially in one with other risk factors for bone metabolism impairment. This study evaluated the effect of physiological l-thyroxine treatment on bone metabolism in patient with primary hypothyroidism. Material and methods. In the study group of 30 hypothyroid patients individual thyroxine replacement was performed targeting euthyroid status. Bone and calcium metabolism parameters (osteocalcin-OC, alkaline phosphates-ALP, C-terminal cross-linking telopeptide type I-CL, parathormone-PTH, Ca, ionized Ca, P), thyroid hormone levels (T3, T4, TSH) were measured before treatment and when euthyroid status was achieved. Results and discussion. A significant treatment effect was observed for bone formation and resorption parameters before and during the therapy; OC (p=0.000024), CL (p=0.002648). Ionized calcium levels also showed significantly higher values in euthyroid status confirming bone metabolism acceleration during the l-thyroxine therapy (p= 0.020). Thus, calcium metabolism hormone regulators were not significantly different before and after the therapy; PTH (p=0.27). Thyroid hormone levels showed significant correlation with bone metabolism parameters before the therapy whereas this correlation was not found during therapy because of different individual l-thyroxine doses. Conclusion. It can be concluded that physiological doses of l-thyroxine therapy accelerate bone metabolism in hypothyroid patients. Thus, the argument against bone loss during physiological substitution is highly specific mutual correlation between bone formation and resorption parameters. These assumptions require further investigations in long term prospective studies in patients on replacement l-thyroxine therapy.
Identifying enamel diffusion properties in feline teeth affected with resorptive lesions
?ivkovi? R.,Todorovi? A.,Tiha?ek-?oji? Ljiljana,Mili?-Lemi? Aleksandra
Acta Veterinaria , 2011, DOI: 10.2298/avb1106653z
Abstract: Various factors have been suggested in the pathogenesis of feline resorptive lesions, such as periodontal disease, dietary factors, mechanical stress, developmental tooth defects, breed and viral disease, although none of these factors have been definitively proven to be the direct cause. It was recently published that normally enamel in cats is significantly thinner at the cemento-enamel junction, and both enamel and dentine are significantly less mineralized than elsewhere on the tooth. However, it is still unclear what anatomical features of the tooth surface are associated with a predisposition for resorptive lesions, and what is the initiating cause for the clastic activity afterwards. The present study was undertaken with the aim to describe enamel properties of transport and distribution of organic molecules in intact feline teeth and teeth affected with resorptive lesions. The results indicate that damaged enamel is prone to a greater bilateral diffusion process, leading to continuous disruption of the enamel structure. Also, teeth that are subjected to occlusal stress are at greater risk of destruction because micro fractures produce disarrangements in feline dental tissue diffusion homeostasis. The relationship between these features with feline dental resorptive lesions requires further studies.
POTASSIUM CHANNELS AS DRUGS TARGETS IN THERAPY OF CARDIOVASCULAR DESEASES: 25 YEARS LATER
Proti? Dragana,Todorovi? Zoran,Gojkovi? Bukarica Ljiljana
SANAMED , 2013,
Abstract: Potassium channels are the most variable ion channel group. They participate in numerous cardiovascular functions, for example regulation of vascular tone, maintenance of resting cardiac membrane potential and excitability of cardiac conduction tissue. Both drugs and endogenous ligands could modulate potassium channel function, belonging to the potassium channel blockers or openers. Modulation of potassium channels could be a therapeutic or adverse drug action. Class III antiarrhythmic agents block the potassium channels, thereby prolonging repolarization phase of action potential with resulting prolongation of effective refractory period. Their effectiveness against supraventricular and ventricular arrhythmias should be weighted against their proarrhythmogenic potential. In addition, numerous other antiarrhythmic agents could modulate potassium channels as well. Diazoxide, minoxidil and nicorandil (well known arterial vasodilators), as well as numerous newly synthesized substances with still unknown therapeutic potential, belong to the potassium channel activators/ openers. Therapeutic use of such vasodilators may involve treatment of hypertension (diazoxide, minoxidil) and stable angina (nicorandil). Their use might be accompanied with side effects, such as vasodilation, edema, hypotension and reflex tachycardia. Potassium channel openers have also an important role in the treatment of peripheral vascular disease and pulmonary hypertension. In the future, drugs with selective effects on the vascular or cardiac potassium channels could be useful therapeutic agents.
Red blood cell counts in sows during lactation
Joksimovi?-Todorovi? Mirjana,Davidovi? Vesna,Bokan Ljiljana
Veterinarski Glasnik , 2010, DOI: 10.2298/vetgl1006359j
Abstract: In the course of parturition and lactation, sows are susceptible to stress and make an effort to adapt to the newly-formed situation through different endocrine and metabolic mechanisms. In addition to endocrine, biochemical changes, hematological changes also occur in the sow organism. Having these facts in mind, the objective of this work was to examine the changes in the number of erythrocytes, hemoglobin concentration, hematocrit value, hematological indexes: mean corpuscular erythrocyte volume (MCV), mean corpuscular hemoglobin (MCH) in erythrocyte and mean corpuscular hemoglobin concentration (MCHC) in erythrocytes, as well as sedimentation values during the period of lactation in sows. The experiment was performed on ten sows of the Swedish Landrace breed, from which blood was taken on the first day postpartum (1-6 h), and during the third and fourth weeks of lactation. The obtained results of hematological analyses indicated a reduced number of erythrocytes, haemoglobin concentration and hematocrit value during the lactation period. The number of erythrocytes was significantly lower at the end of lactation in comparison with the number established on the first day postpartum. The hemoglobin concentration and hematocrit value were very significantly lower at the end of lactation against the first day postpartum. The values of the hematological indexes MCV, MCH and MCHC did not differ significantly in any of the examined periods. The rate of erythrocyte sedimentation was determined 1 h and 2 h postpartum.
A contribution to the investigation of folk medicine in the Tamnava Region
Todorovi? Ivica R.
Glasnik Etnografskog Instituta SANU , 2002, DOI: 10.2298/gei0351135t
Abstract: Folk medicine in the Tamnava region means different forms of healing - from approaches based on rational conclusions and experience, right down to numerous magic interventions - which are the basic focus of this work. The ethnographic material presented, in combination with suitable research aims, should serve as a starting point for complex observation which concerns the structure of magic thought, that is in an even wider sense the basis laws of human thought. The basis of the majority of observed activities and beliefs are magic thoughts, based on the idea that one can influence reality simply, by ritually codified activity on the primary substance that is - the energy which exists in the basis of total reality .
Mythical creatures of the Tamnava region: a basic mythological code in the serbian folk religion
Todorovi? Ivica R.
Glasnik Etnografskog Instituta SANU , 2004, DOI: 10.2298/gei0452205t
Abstract: Based on the fieldwork data and literature on Serbian ethnicity, the author argues that a unique mythical pattern exists among Serbs. This pattern represents the basic global set of mythical entities in Serbian folk religion. After serious structural-semantic analysis of a number of various mythical entities and motives, the author discovers a unique mythological base, established in firm semantic categories and relations. In this sense there are four basic mythical relations found at the base of the corresponding semantic systems: a four-member base of the first and foremost mythological code. The cited mythical sets are found also in other areas occupied by Serbs; therefore, they should represent the base of the whole Serbian folk mythology. Some other specific mythical entities also exist, neither so universal nor a part of this set, and therefore are excluded from the discussion.
Page 1 /224891
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.