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Search Results: 1 - 10 of 10826 matches for " Ting Miao "
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Two-Dimensional Medical Image 3D Visualization System’s Realization  [PDF]
Ai Ting, Li Zhe, Miao Yu
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.31B007
Abstract: With the development of virtual reality application in the medical field, two-dimensional medical image of the three-dimensional visualization technology made possible. Surgery gets into minimally invasive operation microscopy Era, and gradually becomes a new research hotspot. This paper studies the realization of two-dimensional medical im-age 3D reconstruction visualization system method, and the overall process and management module. Using the main technology of VTK (The Visualization Toolkit) to achieve a two-dimensional medical image three-dimensional visua-lization system, which can help the physician to obtain help clinical diagnosis Information and play an important role in treatment, accurate positioning in diseased tissue and tumor early diagnosis.
Dose Perturbations of Gold Fiducial Markers in the Prostate Cancer Intensity Modulated Proton Radiation Therapy (IMPT)  [PDF]
Miao Zhang, Sung Kim, Ting Chen, Xiaohu Mo, Bruce G. Haffty, Ning J. Yue
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2012, DOI: 10.4236/ijmpcero.2012.11002
Abstract: The objective of this study is to investigate the dose perturbations introduced by the implanted gold fiducial markers in the prostate cancer intensity modulated proton therapy (IMPT) and the impacts of different plan designs on the pertur-bations. Five proton plans: a single lateral field 3D-modulation (3D-mod) plan, 2 fields laterally opposing 3D-mod plan, 6-, 9-, and 18-field distal edge tracking (DET) plans were designed on the CT images of a prostate patient. The dose distributions were first generated for the plans free of fiducial markers with 78 Gy prescribed to 95% of the PTV. To derive the dose perturbations of the gold fiducial markers, three cylindrical shaped gold fiducial markers (3 mm long and 1 mm in diameter) were artificially inserted into the prostate, and the dose distributions were re-computed. Monte Carlo method was used for dose computation. It was found that the gold fiducial markers perturbed the dose distribu-tions, especially along the beam paths. The markers caused a shadowing effect reducing the doses in the areas beyond the markers. Overall, due to the presence of the fiducial markers, D99% of prostate were reduced by 2.96 Gy, 4.21 Gy, 0.16 Gy, 0.34 Gy, 0.15 Gy for the plans of single field 3D-mod, 2-field parallel opposed 3D-mod, 6-, 9-, and 18-field DET respectively. Our study showed these dose perturbation effects decreased with the increase of number of beam angles. Up to 6 beam angles may be required to reduce the dose perturbations from the gold fiducial markers to a clini- cally acceptable level in IMPT.
Clinical, Pathological and Surgical Risk Factors Associated with Craniopharyngioma Recurrence: A Literature Review  [PDF]
James Lubuulwa, Zhuang Miao, Shengwen Liu, Juan Chen, Sheng Wang, Wei Jiang, Kai Shu, Ting Lei
Open Journal of Modern Neurosurgery (OJMN) , 2019, DOI: 10.4236/ojmn.2019.91008
Abstract: Objective: This review article attempts to examine and provide an overview of the risk factors associated with craniopharyngioma recurrence. Methods: A literature review of articles relating to the recurrences of craniopharyngioma and the clinical, molecular prognostic indicators of recurrence and treatment outcomes was performed retrospectively. Results: A total of 107 studies which described specific risk factors related to craniopharyngioma recurrence were identified which included but not limited to 54 retrospective case series, 7 systematic reviews, 21 laboratory reports, 13 case reports and 12 literature reviews. Conclusion: Based on the evidence identified in this review, the risk factors for recurrence in craniopharyngioma management are interrelated in a complex way, and surgery with or without adjuvant radiotherapy is reported to be of long-term benefit, but a disparity in findings suggests no definitive consensus on the risk factors of craniopharyngioma recurrence. More high-quality research is needed.
Characterization of the Estradiol-Binding Site Structure of Human Protein Disulfide Isomerase (PDI)
Xin-Miao Fu, Pan Wang, Bao Ting Zhu
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027185
Abstract: Background Earlier studies showed that 17β-estradiol (E2), an endogenous female sex hormone, can bind to human protein disulfide isomerase (PDI), a protein folding catalyst for disulfide bond formation and rearrangement. This binding interaction can modulate the intracellular levels of E2 and its biological actions. However, the structure of PDI's E2-binding site is still unclear at present, which is the focus of this study. Methodology/Principal Findings The E2-binding site structure of human PDI was studied by using various biochemical approaches coupled with radiometric receptor-binding assays, site-directed mutagenesis, and molecular computational modeling. Analysis of various PDI protein fragments showed that the [3H]E2-binding activity is not associated with the single b or b' domain but is associated with the b-b' domain combination. Computational docking analyses predicted that the E2-binding site is located in a hydrophobic pocket composed mainly of the b' domain and partially of the b domain. A hydrogen bond, formed between the 3-hydroxyl group of E2 and His256 of PDI is critical for the binding interaction. This binding model was jointly confirmed by a series of detailed experiments, including site-directed mutagenesis of the His256 residue coupled with selective modifications of the ligand structures to alter the binding interaction. Conclusions/Significance The results of this study elucidated the structural basis for the PDI–E2 binding interaction and the reservoir role of PDI in modulating the intracellular E2 levels. The identified PDI E2-binding site is quite different from its known peptide binding sites. Given that PDI is a potential therapeutic target for cancer chemotherapy and HIV prevention and that E2 can inhibit PDI activity in vitro, the E2-binding site structure of human PDI determined here offers structural insights which may aid in the rational design of novel PDI inhibitors.
Formononetin could increase soluble-APPα secretion by up-regulating ADAM10 level
Zhou Ting,Shun Miao,Zhou Liang,Yang Huan
Molecular Neurodegeneration , 2012, DOI: 10.1186/1750-1326-7-s1-o10
Antiallodynic Effect of Hyperbaric Oxygen on Paclitaxel-Induced Peripheral Neuropathy in a Model of Rat and Its Mechanism  [PDF]
Ting Miao, Xianze Meng, Hong He, Xiaojun Ji
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105339
Objective: To investigate the antiallodynic effect of Hyperbaric oxygen treat-ment (HBOT) on paclitaxel (PTX)-induced peripheral neuropathy in a model of rat and the influence on Astrocyte activation-Inflammatory pathway. Method: 45 male Sprague-Dawley rats were equally divided into 3 groups, the Control group (Control), the Model group (PTX), the Therapy group (PTX HBOT). Except for the Control group, all groups were intraperitoneally injected with paclitaxel 2 mg/kg on day 1, 3, 5, 7, respectively, and a stable peripheral neuralgia model was established on the 14th day. The Therapy group was treated with HBOT on 2.5 ATA for 7 days after modeling. We used the UP and Down method to test the mechanical withdraw threshold (MWT) of rats before and after modeling, during and after treatment. One week after the end of treatment, each group of rats was taken spinal cord L4-L6 for subsequent molecular biology experiments. The expression and location of astrocyte activation marker GFAP in spinal cord were assayed by Immunohistochemistry. The expression of GFAP, TNF-α, IL-1β was assayed by western blot analysis. The expression of mRNA of GFAP, TNF-α, IL-1β was assayed by realtime-RT PCR. Results: On the nineteenth day of the experiment (the fifth day of treatment), the MWT of Treatment group was significantly higher than that of Model group (p < 0.001). This effect persisted for one week after the end of treatment (day 21 - 28, p < 0.001). Immunohistochemistry showed that the expression of GFAP was significantly lower in Treatment group than in Model group (p < 0.01). Western Blot Analysis showed that the expression of GFAP, IL-1β, TNF-α was significantly lower in Treatment group than in Model group (p < 0.05, p < 0.01, p < 0.01). Realtime-RT PCR showed that the expression of mRNA levels of GFAP was slightly higher in Model group than in Control group (p = 0.0467), but there was no statistical difference between the two groups. The expression of mRNA of IL-1β, TNF-α was significantly lower in Treatment group than in Model group (p < 0.01, p < 0.01). Conclusion: Hyperbaric oxygen treatment alleviates paclitaxel-induced peripheral neuralgia which has a long-term therapeutic effect, and inhibits the activation of spinal astrocytes and the level of in-flammatory cytokines for neuroinflammation.
Theoretical calculations of thermophysical properties of single-wall carbon nanotube bundles

Miao Ting-Ting,Song Meng-Xuan,Ma Wei-Gang,Zhang Xing,

中国物理 B , 2011,
Abstract: Carbon nanotube bundles are promising thermal interfacial materials due to their excellent thermal and mechanical characteristics. In this study, the phonon dispersion relations and density of states of the single-wall carbon nanotube bundles are calculated by using the force constant model. The calculation results show that the inter-tube interaction leads to a significant frequency raise of the low frequency modes. To verify the applied calculation method, the specific heat of a single single-wall carbon nanotube is calculated first based on the obtained phonon dispersion relations and the results coincide well with the experimental data. Moreover, the specific heat of the bundles is calculated and exhibits a slight reduction at low temperatures in comparison with that of the single tube. The thermal conductivity of the bundles at low temperatures is calculated by using the ballistic transport model. The calculation results indicate that the inter-tube interaction, i.e. van der Waals interaction, hinders heat transfer and cannot be neglected at extremely low temperatures. For (5, 5) bundles, the relative difference of the thermal conductivity caused by ignoring inter-tube effect reaches the maximum value of 26% around 17 K, which indicates the significant inter-tube interaction effect on the thermal conductivity at low temperatures.
Correcting the systematic error of the density functional theory calculation: the alternate combination approach of genetic algorithm and neural network

Wang Ting-Ting,Li Wen-Long,Chen Zhang-Hui,Miao Ling,

中国物理 B , 2010,
Abstract: The alternate combinational approach of genetic algorithm and neural network (AGANN) has been presented to correct the systematic error of the density functional theory (DFT) calculation. It treats the DFT as a black box and models the error through external statistical information. As a demonstration, the AGANN method has been applied in the correction of the lattice energies from the DFT calculation for 72 metal halides and hydrides. Through the AGANN correction, the mean absolute value of the relative errors of the calculated lattice energies to the experimental values decreases from 4.93% to 1.20% in the testing set. For comparison, the neural network approach reduces the mean value to 2.56%. And for the common combinational approach of genetic algorithm and neural network, the value drops to 2.15%. The multiple linear regression method almost has no correction effect here.
Study on Regional Efficiency and Productivity of Guangdong Province
—Based on Hicks-Moorsteen TFP Index

Jia Miao
Modern Economy (ME) , 2018, DOI: 10.4236/me.2018.912134
Abstract: In this paper, Hicks-Moorsteen TFP index is employed to investigate regional efficiency and productivity of 21 cities in Guangdong province during 2000-2015. The findings demonstrate that the efficiency of the whole province first rises and then falls, and has rebounded in recent years. Technical efficiency and scope efficiency have increased, while regional scale efficiency has declined. The Pearl River Delta region has obvious competitive advantages, and scope efficiency alleviates the decline in the efficiency of the non PRD. Secondly, the results indicate that Shenzhen has strong regional development competitiveness, and the economic development efficiency which leads Guangdong province. Thirdly, although the total factor productivity of 21 cities in Guangdong province has increase 0.38 percent with an average level of 1.0165 during this period with a comparatively large fluctuation, the slow growth of technological progress hindered the progress of TFP to some extent. In addition, the TFP level in the PRD region has some advantages over the non PRD region. Finally, as the most efficient city, Shenzhen’s TFP level is in the middle and upper reaches and has great potential.
Factors Associated with Parents’ Perceptions of Parental Smoking in the Presence of Children and Its Consequences on Children
Yu-Ting Chen,Fei-Hsiu Hsiao,Nae-Fang Miao,Ping-Ling Chen
International Journal of Environmental Research and Public Health , 2013, DOI: 10.3390/ijerph10010192
Abstract: Parental smoking is the major source of children’s secondhand smoke exposure and is influenced by parents’ perception of children’s exposure. However, the factors associated with these perceptions remain unclear. The objective of this study was to examine factors associated with parents’ perceptions about parental smoking in the presence of children and its consequences. We conducted a cross-sectional study on parents’ perceptions of parental smoking and measured their evaluations of its consequences using a self-report questionnaire. Other variables include socio-demographic characteristics and smoking-related experience. Results show that parents’ gender, education level, occupational type, smoking status, and agreement on a home smoking ban independently predict parents’ evaluation of the consequences of parental smoking in the presence of children. Parents’ gender, education level, annual family income, smoking status, agreement on a home smoking ban, and evaluation of the consequences of parental smoking independently predicted parents’ perceptions. Findings indicated that a specific group expressed greater acceptance of parental smoking and was less aware of its risks. Motivating parents to create a smoke-free home and increasing awareness of the adverse consequences of parental smoking is beneficial in reinforcing attitudes opposed to parental smoking.
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