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Search Results: 1 - 10 of 402074 matches for " Tina M. Oakes "
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Safety and Tolerability of Edivoxetine for Long-Term Treatment of Major Depressive Disorder in Adult Patients  [PDF]
Tina M. Oakes, James M. Martinez, Mary Anne Dellva, Celine Goldberger, Beth A. Pangallo, Mark E. Bangs, Jonna Ahl, William B. White
Open Journal of Psychiatry (OJPsych) , 2014, DOI: 10.4236/ojpsych.2014.42017
Abstract:

This 12-month open-label, but dose-blinded extension phase, evaluated the safety and tolerability of flexibly-dosed edivoxetine (6, 9, 12 or 18 mg once daily) in patients (N = 397) with major depressive disorder, who completed the 10-week randomized, double-blind, placebo-controlled acute phase of the study.All patients were treated with edivoxetine during the extension phase. The mean age of the patients was 45 years, and most were white females. Safety evaluations included assessment of treatment-emergent adverse events (TEAEs), laboratory and vital sign measures, and suicidality. Within-group t-tests based on a 2-sided significance level of 0.05 and 95% confidence levels were used to assess whether changes from baseline were statistically significant from zero. The overall completion rate was 54%. Adverse event was the most common (14.4%) reason for discontinuation, which included blood pressure increased (1.3%), heart rate increased (1.3%), anxiety (1.0%), and tachycardia (1.0%). At least 1 TEAE was reported by 72.3% of patients, of which headache (10.8%) and hyperhidrosis (10.1%) were the most common; 2.8% of patients had ≥1 serious adverse events, and there were no completed suicides. No

Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide
Tina M Sager, Vincent Castranova
Particle and Fibre Toxicology , 2009, DOI: 10.1186/1743-8977-6-15
Abstract: Ultrafine carbon black particles caused a dose dependent but transient inflammatory and cytotoxic response. On a mass basis, these responses were significantly (65 fold) greater than those for fine sized carbon black. However, when doses were equalized based on surface area of particles given, the ultrafine carbon black particles were only slightly (non-significantly) more inflammogenic and cytotoxic compared to the fine sized carbon black. At one day post-exposure, inflammatory potencies of the ultrafine carbon black and ultrafine titanium dioxide particles were similar. However, while the pulmonary reaction to ultrafine carbon black resolved with time, the inflammatory effects of ultrafine titanium dioxide were more persistent over a 42 day post-exposure period.These results indicate that for low toxicity low solubility materials, surface area of particles administered rather than mass burden of particles may be a more appropriate dose metric for pulmonary toxicity studies. In addition, ultrafine titanium dioxide appears to be more bioactive than ultrafine carbon black on an equivalent surface area of particles delivered basis.Nanotechnology is considered to be one of the world's most promising new technologies, able to impact all phases of life, just as the industrial revolution did in the past two centuries. Utilizing the quantum properties of atoms and molecules, nanotechnology proposes the construction of novel molecular devices possessing extraordinary properties. However, both epidemiological and toxicological studies have contributed to a body of evidence suggesting that nano or ultrafine particles may induce or exaggerate a number of adverse biological effects. It has been suggested that nanoparticles may interfere with a number of molecular processes that should be considered before such particles are brought into wide commercial use [1].Recent reports indicate that there can be considerable potential for exposure to nanoparticles in the workplace, especi
Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
Tina M. Thornton, Mercedes Rincon
International Journal of Biological Sciences , 2009,
Abstract: The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the process of differentiation and cell death has grown considerably in the recent years and is now relatively established. Here we discuss the role of p38 MAPK in the mediation of cell cycle checkpoints and cell survival, processes that have received less attention. We describe how p38 MAPK regulates both the G2/M as well as a G1/S cell cycle checkpoint in response to cellular stress such as DNA damage. While p38 MAPK has classically been associated with the induction of apoptosis, we discuss that p38 MAPK can also mediate cell survival in specific situations, such as in response to DNA damage. It is important to recognize these less appreciated functions of p38 MAPK when considering the potential use of pharmacological inhibitors of p38 MAPK in therapeutic treatments for disease.
Capitalizing Asian Studies: Critical Scholarship and the Production of Knowledge in a Globalizing World
Tim Oakes
PORTAL : Journal of Multidisciplinary International Studies , 2004,
Abstract: This paper explores the implications of the related trends of economic globalization and the corporatization of higher education in the United States for Asian area studies scholarship. It argues that the scales at which geographical knowledge is produced are increasingly in flux due to the shift in global political economy. Area studies scholarship is subsequently left scrambling to both understand this shift and make its knowledge production somehow relevant and valuable in an arena in which knowledge about Asia is being produced and diffused from an increasingly diverse array of sources. In response, the paper suggests that more attention to the production of scale is needed if area studies scholars are to comprehend the changing relationship between our categories of geographic knowledge and global political economy.
Virtual Pilgrimages in the Convent. Kathryn M. Rudy, Virtual Pilgrimages in the Convent. Imagining Jerusalem in the Late Middle Ages (Disciplina Monastica. Studies on Medieval Monastic Life 8), Brepols, 2011
Catherine Oakes
Journal of Art Historiography , 2012,
Abstract: This essay reviews Virtual Pilgrimages in the Convent. Imagining Jerusalem in the Late Middle Ages by Kathryn M. Rudy. This book explores the mental and physical interaction between female religious in late medieval Dutch convents and a group of manuscripts and artefacts created to assist their devotions as they travelled on imaginary pilgrimages.
Measurement of beta_s at CDF
Louise Oakes
Physics , 2011,
Abstract: The latest results for the measurement of the CP violating phase beta_s in B0s -> J/psi phi decays, from 5.2 fb-1 integrated luminosity of CDF data are presented. For the first time, this measurement includes the contribution of B0s -> J/psi K+K- or B0s -> J/psi f0 events to the signal sample, where the f0 and non-resonant K+K- are S-wave states. Additional improvements to the analysis include more than doubling the signal sample, improved selection and particle ID, and fully calibrated flavour tagging for the full dataset. Additionally, the world's most precise single measurements of the B0s lifetime, tau_s, and width difference, DeltaGamma_s are given.
Critical Period of Nonpromoter DNA Methylation Acquisition during Prenatal Male Germ Cell Development
Kirsten M. Niles, Donovan Chan, Sophie La Salle, Christopher C. Oakes, Jacquetta M. Trasler
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024156
Abstract: The prenatal period of germ cell development is a key time of epigenetic programming in the male, a window of development that has been shown to be influenced by maternal factors such as dietary methyl donor supply. DNA methylation occurring outside of promoter regions differs significantly between sperm and somatic tissues and has recently been linked with the regulation of gene expression during development as well as successful germline development. We examined DNA methylation at nonpromoter, intergenic sequences in purified prenatal and postnatal germ cells isolated from wildtype mice and mice deficient in the DNA methyltransferase cofactor DNMT3L. Erasure of the parental DNA methylation pattern occurred by 13.5 days post coitum (dpc) with the exception of approximately 8% of loci demonstrating incomplete erasure. For most loci, DNA methylation acquisition occurred between embryonic day 13.5 to 16.5 indicating that the key phase of epigenetic pattern establishment for intergenic sequences in male germ cells occurs prior to birth. In DNMT3L-deficient germ cells at 16.5 dpc, average DNA methylation levels were low, about 30% of wildtype levels; however, by postnatal day 6, about half of the DNMT3L deficiency-specific hypomethylated loci had acquired normal methylation levels. Those loci normally methylated earliest in the prenatal period were the least affected in the DNMT3L-deficient mice, suggesting that some loci may be more susceptible than others to perturbations occurring prenatally. These results indicate that the critical period of DNA methylation programming of nonpromoter, intergenic sequences occurs in male germline progenitor cells in the prenatal period, a time when external perturbations of epigenetic patterns could result in diminished fertility.
Maternal obesity is the new challenge; a qualitative study of health professionals’ views towards suitable care for pregnant women with a Body Mass Index (BMI) ≥30 kg/m2
Debbie M Smith, Alison Cooke, Tina Lavender
BMC Pregnancy and Childbirth , 2012, DOI: 10.1186/1471-2393-12-157
Abstract: Semi-structured interviews with 30 health professionals (including midwives, sonographers, anaesthetists and obstetricians) were conducted and analysed using thematic analysis. Recruitment occurred in two areas in the North West of England in early 2011.Three themes were evident. Firstly, obesity was seen as a conversation stopper; obesity can be a challenge to discuss. Secondly, obesity was seen as a maternity issue; obesity has a direct impact on maternity care and therefore intervention is needed. Finally, the long-term impact of maternal obesity intervention; lifestyle advice in pregnancy has the potential to break the cyclic obesity relationship. The health professionals believed that antenatal lifestyle advice can play a key role in addressing the public health issue of obesity as pregnancy is a time of increased motivation for women with a BMI ≥30 kg/m2.Maternal obesity is a challenge and details of the training content required for health professionals to feel confident to approach the issue of maternal obesity with women are presented. Support for the antenatal lifestyle programme for women with a BMI ≥30 kg/m2 highlights the need for further exploration of the impact of interventions on health promotion.Increasing rates of maternal obesity (Body Mass Index (BMI) ≥30 kg/m2) are a cause for concern for health professionals in clinical practice due to the increased risk for maternal complications [1,2], fetal complications [3] and the negative impact on their clinical time and resources [4,5]. Data suggests that maternal obesity is increasing in the USA [6] and the UK [7].Clinical guidelines in the UK recommend that advice and support should be provided in early pregnancy to encourage a healthy pregnancy for mother and baby [8-11]. The role of healthy eating and physical activity in the prevention of gestational diabetes and excessive weight gain must be explained to women [9]. However, there is currently little evidence to inform the content and structure of
Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area
Tina M Sager, C Kommineni, Vincent Castranova
Particle and Fibre Toxicology , 2008, DOI: 10.1186/1743-8977-5-17
Abstract: The findings of the study show that on a mass basis the ultrafine particles caused significantly more inflammation and were significantly more cytotoxic than the fine sized particles. However, when doses were equalized based on surface area of particles delivered, the ultrafine particles were only slightly more inflammogenic and cytotoxic when compared to the fine sized particles. Lung burden data indicate that ultrafine TiO2 appears to migrate to the interstitium to a much greater extent than fine TiO2.This study suggests that surface area of particles may be a more appropriate dose metric for pulmonary toxicity studies than mass of particles.Nanoscience and nanotechnology offer new opportunities for making superior materials for use in industrial and health applications [1,2]. As the field of nanotechnology vastly expands, many questions involving the effects of nanomaterials on the environment as well as human health have been raised which warrant investigation. The primary problem plaguing the field of nanotechnology is the possibility that nanoparticles can become suspended in air during production, incorporation into consumer products, and use or disposal of such products. Therefore, manufactured nanoparticles can become a component of the indoor and outdoor environments and, thus, the air we breathe [2].A number of toxicology studies have suggested that for some classes of materials, biological response following deposition in the lungs is dependent on particle surface area [3,4]. Materials of interest typically possess characteristics such as low solubility, which leads to extended persistence in the lungs. These materials can be produced as ultrafine particles, which have high specific surface areas [5]. Titanium dioxide (TiO2) is an example of a fine, low solubility particle which was considered to exhibit relatively low toxicity [6]. However, in a key study, Ferin et al. [7] demonstrated that ultrafine TiO2 (UFTiO2) caused more inflammation in rat lungs t
Differential Transcriptional Changes in Mice Exposed to Chemically Distinct Diesel Samples
Tina Stevens, Susan Hester and M. Ian Gilmour
Biomedical Informatics Insights , 2012, DOI: 10.4137/BII.S5363
Abstract: Epidemiological studies have linked exposure to ambient particulate matter (PM) with increased asthmatic symptoms. Diesel exhaust particles (DEP) are a predominant source of vehicle derived ambient PM, and experimental studies have demonstrated that they may have adjuvant potential when given with an antigen. We previously compared 3 DEP samples: N-DEP, A-DEP, and C-DEP in a murine ovalbumin (OVA) mucosal sensitization model and reported the adjuvant activity to be: C-DEP ≈ A-DEP > N-DEP. The present study analyzed gene expression changes from the lungs of these mice. Transcription profiling demonstrated that all the DEP samples altered cytokine and toll-like receptor pathways regardless of type, with or without antigen sensitization. Further analysis of DEP exposure with OVA showed that all DEP treatments altered networks involved in immune and inflammatory responses. The A- and C-DEP/OVA treatments induced differential expression of apoptosis pathways in association with stronger adjuvant responses, while expression of cell cycle control and DNA damage pathways were also altered in the C-DEP/OVA treatment. This comprehensive approach using gene expression analysis to examine changes at a pathway level provides detailed information on events occurring in the lung after DEP exposure, and confirms that the most bioactive sample induced many more individual genes and changes in immune-regulatory and homeostatic pathways.
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