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Search Results: 1 - 10 of 4794 matches for " Tim Neumann "
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NEFI: Network Extraction From Images
Michael Dirnberger,Adrian Neumann,Tim Kehl
Computer Science , 2015,
Abstract: Networks and network-like structures are amongst the central building blocks of many technological and biological systems. Given a mathematical graph representation of a network, methods from graph theory enable a precise investigation of its properties. Software for the analysis of graphs is widely available and has been applied to graphs describing large scale networks such as social networks, protein-interaction networks, etc. In these applications, graph acquisition, i.e., the extraction of a mathematical graph from a network, is relatively simple. However, for many network-like structures, e.g. leaf venations, slime molds and mud cracks, data collection relies on images where graph extraction requires domain-specific solutions or even manual. Here we introduce Network Extraction From Images, NEFI, a software tool that automatically extracts accurate graphs from images of a wide range of networks originating in various domains. While there is previous work on graph extraction from images, theoretical results are fully accessible only to an expert audience and ready-to-use implementations for non-experts are rarely available or insufficiently documented. NEFI provides a novel platform allowing practitioners from many disciplines to easily extract graph representations from images by supplying flexible tools from image processing, computer vision and graph theory bundled in a convenient package. Thus, NEFI constitutes a scalable alternative to tedious and error-prone manual graph extraction and special purpose tools. We anticipate NEFI to enable the collection of larger datasets by reducing the time spent on graph extraction. The analysis of these new datasets may open up the possibility to gain new insights into the structure and function of various types of networks. NEFI is open source and available http://nefi.mpi-inf.mpg.de.
Gold Standard Program for Heavy Smokers in a Real-Life Setting
Tim Neumann,Mette Rasmussen,Berit L. Heitmann,Hanne T?nnesen
International Journal of Environmental Research and Public Health , 2013, DOI: 10.3390/ijerph10094186
Abstract: Background: High-intensity smoking cessation programs generally lead to more continuous abstinence, however, lower rates of success have been reported among heavy smokers. The aim was to evaluate continuous abstinence among heavy smokers during the intensive 6-week Gold Standard Program (GSP) and to identify modifiable factors associated with continuous abstinence. Methods: In this nationwide clinical study based on 36,550 smokers attending an intensive cessation program in Denmark. Heavy smoking was defined as ≥7 points in the Fagerstr?m Nicotine Dependency Test, smoking ≥20 cigarettes daily or ≥20 pack-years. Results: Overall, 28% had a Fagerstr?m score ≥7 points, 58% smoked ≥20 cigarettes daily and 68% smoked ≥20 pack-years. Continuous abstinence was 33% in responders (6-months response rate: 78%); however, abstinence was approximately 1–6% lower in the heavy smokers than the overall population. Attending GSP with an individual format ( vs. group/other, OR 1.23–1.44); in a hospital setting ( vs. pharmacy/municipality services, OR 1.05–1.11); and being compliant (attending the planned meetings OR 4.36–4.89) were associated with abstinence. Abstinence decreased in a dose-dependent manner with increasing smoking severity. Conclusions: Abstinence after GSP was 1–6% lower in the heavy smokers than in the overall study population. Modifiable factors may be used for small improvements in continued abstinence. However attempts to improve compliance seemed especially promising.
Health-related quality of life in urban surgical emergency department patients: Comparison with a representative German population sample
Bruno Neuner, Peter M Miller, Bodo Felsmann, Edith Weiss-Gerlach, Tim Neumann, Klaus Wernecke, Claudia Spies
Health and Quality of Life Outcomes , 2005, DOI: 10.1186/1477-7525-3-77
Abstract: An investigation in an Emergency Department in an inner city university hospital was conducted during 8 months. Overall, 1,596 patients completed the SF-36 and an established SES-questionnaire and were screened for substance use (harmful alcohol consumption (≥ 8 points in men and ≥ 5 points in women on the Alcohol Use Disorders Identification Test (AUDIT), smoking and illicit drug use). Results were compared with a representative German population sample (German Federal Health Survey 1998).Median age of participants was 32 years and 61.8% were male. Mean physical component summary score (PCS) of the Short Form-36 Health Survey (SF-36) was 53.4 ± 8.3 points and significantly higher than the age and gender-stratified German Federal Health Survey-data. Mean mental component summary score (MCS) was 47.9 ± 10.0 points and significantly lower than the age and gender-stratified German Federal Health Survey-data. In Emergency Department patients, prevalence of substance use was high and harmful alcohol consumption and illicit drug use were strongly associated with impaired mental health. Education and occupational status were strongly positively associated with physical health.We conclude that there is a high prevalence of substance use in young patients with minor trauma and mental quality of life is impaired. Screening and brief intervention strategies to reduce substance-use associated disorders should consider these findings.Recent investigators have shown in different settings that substance use is associated with impaired Health related Quality of Life (HRQoL). In alcohol dependent patients, Daeppen et al. [1] (1998; 147 patients in Switzerland), Mc Kenna et al. [2] (1996; 586 inpatients in Great Britain) and Volk et al. [3] (1997; 1333 primary care patients in USA) found impaired HRQoL in comparison to patients with lower severity of alcohol dependence, a normal population, and patients without alcohol disorders, respectively. In addition, HRQoL can be improved by th
Deficiency in Serine Protease Inhibitor Neuroserpin Exacerbates Ischemic Brain Injury by Increased Postischemic Inflammation
Mathias Gelderblom, Melanie Neumann, Peter Ludewig, Christian Bernreuther, Susanne Krasemann, Priyadharshini Arunachalam, Christian Gerloff, Markus Glatzel, Tim Magnus
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063118
Abstract: The only approved pharmacological treatment for ischemic stroke is intravenous administration of plasminogen activator (tPA) to re-canalize the occluded cerebral vessel. Not only reperfusion but also tPA itself can induce an inflammatory response. Microglia are the innate immune cells of the central nervous system and the first immune cells to become activated in stroke. Neuroserpin, an endogenous inhibitor of tPA, is up-regulated following cerebral ischemia. To examine neuroserpin-dependent mechanisms of neuroprotection in stroke, we studied neuroserpin deficient (Ns?/?) mice in an animal model of temporal focal ischemic stroke. Infarct size and neurological outcome were worse in neuroserpin deficient mice even though the fibrinolytic activity in the ischemic brain was increased. The increased infarct size was paralleled by a selective increase in proinflammatory microglia activation in Ns?/? mice. Our results show excessive microglial activation in Ns?/? mice mediated by an increased activity of tPA. This activation results in a worse outcome further underscoring the potential detrimental proinflammatory effects of tPA.
Personality of Students of Economics, Medicine, and Verbal Communication: Preliminary Results  [PDF]
J. Richter, R. Neumann
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.23039
Abstract: Differences on personality between students of economics, medicine and verbal communication should be explored by means of the Temperament and Character Inventory. Students of economics are mainly characterized by lower harm avoidance and lower reward dependence and higher self directedness than medical students and students of verbal communication. Students of all groups seem to overestimate their self-directedness with economical students showing the most pronounced tendency of overrating, whereas medical students tend to overrate their cooperativeness more than the students from the other groups. The obvious disturbed self-evaluation corresponds to the students’ professional orientation. The students can be characterized by specific and varying types and impact of social desirability depending on their professional career.
Lattice Boltzmann Simulations in the Slip and Transition Flow Regime with the Peano Framework  [PDF]
Philipp Neumann, Till Rohrmann
Open Journal of Fluid Dynamics (OJFD) , 2012, DOI: 10.4236/ojfd.2012.23010
Abstract: We present simulation results of flows in the finite Knudsen range, that is in the slip and transition flow regime. Our implementations are based on the Lattice Boltzmann method and are accomplished within the Peano framework. We validate our code by solving two- and three-dimensional channel flow problems and compare our results with respective experiments from other research groups. We further apply our Lattice Boltzmann solver to the geometrical setup of a microreactor consisting of differently sized channels and a reactor chamber. Here, we apply static adaptive grids to further reduce computational costs. We further investigate the influence of using a simple BGK collision kernel in coarse grid regions which are further away from the slip boundaries. Our results are in good agreement with theory and non-adaptive simulations, demonstrating the validity and the capabilities of our adaptive simulation software for flow problems at finite Knudsen numbers.
A Study on Configuration and Integration of Sub-Systems to System-of-Systems with Rule Verification  [PDF]
Tim Warnecke
Engineering (ENG) , 2015, DOI: 10.4236/eng.2015.710056
Abstract: Increasing complexity of today’s software systems is one of the major challenges software engineers have to face. This is aggravated by the fact that formerly isolated systems have to be interconnected to more complex systems, called System-of-Systems (SoS). Those systems are in charge to provide more functionality to the user than all of their independent sub-systems could do. Reducing the complexity of such systems is one goal of the software engineering paradigm called component-based software engineering (CBSE). CBSE enables the developers to treat individual sub-systems as components which interact via interfaces with a simulated environment. Thus those components can be developed and implemented independently from other components. After the implementation a system integrator is able to interconnect the components to a SoS. Despite this much-used approach it is possible to show that constraints, which are valid in an isolated sub-system, are broken after this system is integrated into a SoS. To emphasize this issue we developed a technique based on interconnected timed automata for modelling sub-systems and System-of-Systems in the model checking tool UPPAAL. The presented modelling technique allows it to verify the correctness of single sub-systems as well as the resulting SoS. Additionally we developed a tool which abstracts the complicated timed automata to an easy to read component based language with the goal to help system integrators building and verifying complex SoS.
Molecular Neuropathology of TDP-43 Proteinopathies
Manuela Neumann
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10010232
Abstract: The identification of TDP-43 as the major component of the pathologic inclusions in most forms of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS) resolved a long-standing enigma concerning the nature of the ubiquitinated disease protein under these conditions. Anti-TDP-43 immunohistochemistry and the recent development of novel tools, such as phosphorylation-specific TDP-43 antibodies, have increased our knowledge about the spectrum of pathological changes associated with FTLD-U and ALS and moreover, facilitated the neuropathological routine diagnosis of these conditions. This review summarizes the recent advances in our understanding on the molecular neuropathology and pathobiology of TDP-43 in FTLD and ALS.
"Mientras volaban correos por los pueblos": autogoverno e práticas letradas nas miss?es Guarani - século XVII
Neumann, Eduardo;
Horizontes Antropológicos , 2004, DOI: 10.1590/S0104-71832004000200005
Abstract: in the middle xviiith century, the "tratado de madrid" (1750) took place between portugal and spain. both countries were looking forward to define the new southern latin america frontier. the tratado de madrid had a strongly impact over the indians communities under jesuits influence, starting colonial rebellion named guaranitc war (1754-1756). during this period an intense communication by mail between the spanish authorities, priests and the guarani was noticed. the "indios principais" - the missions writing elite - expressed their opinion writing letters in the way to cancel the tratado de madrid. the different kinds of documents produced by the insurgent guaranis letters, notes and messages- let us to rethink the relation between the indians and the writing culture. it also indicates the lack of attention in the historical debate to the native point of view expressed by writing.
Vom Nachthunger“ und n chtlichen Zyn “. Die Darstellung ehelicher Sexualit t in Valentin Schumanns Nachtbüchlein I/II.
Franziska Neumann
AEON : Forum für Junge Geschichtswissenschaft , 2009,
Abstract: Die Schwanksammlungen des 16. Jahrhunderts sind gemeinhin für ihre obsz nen und unfl tigen Darstellungen des Sexuellen bekannt. Jedoch, so die These des Aufsatzes, l sst sich daraus keine generelle Unbefangenheit gegenüber K rperlichkeit und Sexualit t schlussfolgern. Vielmehr folgen die frivolen Geschichten einer spezifischen Vorstellung von Sexualit t, die auf der Interdependenz partnerschaftlichen Handelns ausgerichtet ist. Die k rperliche Beziehung der Ehepartner wird als grundlegender Teil des ehelichen Miteinanders verstanden. Diese Wahrnehmung wird exemplarisch in Valentin Schumanns Nachtbüchlein I und II (1559) herausgearbeitet.
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