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Search Results: 1 - 10 of 65137 matches for " Tiffany Y. Tang "
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A Study of Interaction Patterns and Awareness Design Elements in a Massively Multiplayer Online Game
Tiffany Y. Tang,Cheung Yiu Man,Chu Pok Hang,Lam Shiu Cheuk,Chan Wai Kwong,Yiu Chung Chi,Ho Ka Fai,Sit Kam
International Journal of Computer Games Technology , 2008, DOI: 10.1155/2008/619108
Abstract: Massively multiplayer online games (MMOGs) have been known to create rich and versatile social worlds for thousands of millions of players to participate. As such, various game elements and advance technologies such as artificial intelligence have been applied to encourage and facilitate social interactions in these online communities, the key to the success of MMOGs. However, there is a lack of studies addressing the usability of these elements in games. In this paper, we look into interaction patterns and awareness design elements that support the awareness in LastWorld and FairyLand. Experimental results obtained through both in-game experiences and player interviews reveal that not all awareness tools (e.g., an in-game map) have been fully exploited by players. In addition, those players who are aware of these tools are not satisfied with them. Our findings suggest that awareness-oriented tools/channels should be easy to interpret and rich in conveying “knowledge” so as to reduce players-cognitive overload. These findings of this research recommend considerations of early stage MMOG design.
Romantic Breakups, Heartbreak and Bereavement—Romantic Breakups  [PDF]
Tiffany Field
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24060
Abstract: This literature review suggests that romantic breakups may lead to bereavement symptoms including intrusive thoughts and attempts to suppress them and insomnia as well as morbidity factors including broken heart syndrome and immune dysfunction. Although the broken heart syndrome has mimicked real heart attacks, angiograms revealed no clogged arteries or permanent heart damage. Compromised immune function may result from reduced vagal activity and increased cortisol and catecholamines leading to increased inflammatory cytokines and decreased natural killer cell activity. The model proposed here is that romantic breakups result in the loss of a person as a regulator of stimulation and arousal modulation that can then lead to these physiological and biochemical effects. These data highlight the complexity of romantic breakups, heartbreak and bereavement and the need for multi-variable research on these systems both before and after the breakups occur.
Relationships as Regulators  [PDF]
Tiffany Field
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.36066
Abstract: This paper reviews the Hofer (1984, 1996) and Field (1985, 1994) models on relationships as regulators, suggesting that relationships regulate optimal stimulation and thereby modulate arousal levels and attenuate stress. In these models, the behavioral, physiological and biochemical rhythms of individuals become synchronized within close relationships like mother-infant and peer relationships both in human and animal species, and they become more coordinated over time, with some potentially remaining stable, much like zeitgebers. Hofer supports his model by data on infant rat separation stress and Field describes “psychobiological attunement” between human infants and their mothers and between young peers. This review revisits the “relationships as regulators” model, summarizing studies on relationships between non-depressed versus depressed mothers and their infants, between infant, preschool and preadolescent friends versus acquaintances and between happily versus unhappily married couples. Although some behavioral and physiological data support Hofer’s and Field’s “relationships as regulators” model, many studies on relationships have focused instead on the effects of separation or loss. Both Hofer and Field suggest that the real question is “what was there about the relationship that was then missing after the loss?” Future research could address the question of potential mediators and underlying mechanisms for relationships becoming regulators. Potential mediators are explored here including mirror neurons, affective priming, imitation and empathy. The individuals’ rhythms and the attraction to others’ rhythms as regulators may be an epigenetic programming phenomenon, suggesting both genetic and early experience effects that endure across development.
Opportunities for nurses in the era of electronic health records  [PDF]
Tiffany Kelley
Open Journal of Nursing (OJN) , 2014, DOI: 10.4236/ojn.2014.41003

Nursing leaders are currently faced with opportunities to advance nursing’s role in the use of electronic health records (EHRs). Nurse leaders can advance the design of EHRs with nurse informaticists to improve health outcomes of individual and populations of patients.

Correction: Discovery and Analysis of Evolutionarily Conserved Intronic Splicing Regulatory Elements
Gene W Yeo,Eric L. Van Nostrand,Tiffany Y Liang
PLOS Genetics , 2007, DOI: 10.1371/journal.pgen.0030122
Discovery and Analysis of Evolutionarily Conserved Intronic Splicing Regulatory Elements
Gene W Yeo ,Eric L. Van Nostrand,Tiffany Y Liang
PLOS Genetics , 2007, DOI: 10.1371/journal.pgen.0030085
Abstract: Knowledge of the functional cis-regulatory elements that regulate constitutive and alternative pre-mRNA splicing is fundamental for biology and medicine. Here we undertook a genome-wide comparative genomics approach using available mammalian genomes to identify conserved intronic splicing regulatory elements (ISREs). Our approach yielded 314 ISREs, and insertions of ~70 ISREs between competing splice sites demonstrated that 84% of ISREs altered 5′ and 94% altered 3′ splice site choice in human cells. Consistent with our experiments, comparisons of ISREs to known splicing regulatory elements revealed that 40%–45% of ISREs might have dual roles as exonic splicing silencers. Supporting a role for ISREs in alternative splicing, we found that 30%–50% of ISREs were enriched near alternatively spliced (AS) exons, and included almost all known binding sites of tissue-specific alternative splicing factors. Further, we observed that genes harboring ISRE-proximal exons have biases for tissue expression and molecular functions that are ISRE-specific. Finally, we discovered that for Nova1, neuronal PTB, hnRNP C, and FOX1, the most frequently occurring ISRE proximal to an alternative conserved exon in the splicing factor strongly resembled its own known RNA binding site, suggesting a novel application of ISRE density and the propensity for splicing factors to auto-regulate to associate RNA binding sites to splicing factors. Our results demonstrate that ISREs are crucial building blocks in understanding general and tissue-specific AS regulation and the biological pathways and functions regulated by these AS events.
Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies
Tiffany Tang,Kevin Tay,Richard Quek,Miriam Tao,Soo Yong Tan,Leonard Tan,Soon Thye Lim
Advances in Hematology , 2010, DOI: 10.1155/2010/624040
Abstract: The classification of T-cell and natural-killer- (NK-) cell lymphomas has been updated in the 4th edition of the World Health Organization (WHO) classification of tumors of the haematopoietic and lymphoid tissue published in 2008. Based on recent epidemiological studies, NK-cell lymphomas occur almost exclusively in Asia and South America, although T-cell lymphomas appear to occur in the East as commonly as in the West. Due to the low prevalence of this disease, diagnosis and optimal treatment of patients have not been studied prospectively in large randomized trials. Nevertheless, there has been development in the understanding of T-cell lymphomas and how they should be managed; FDG-PET emerges as an increasingly important tool in diagnosis, gene-expression signatures may aid with prognostication in the future, and novel therapies are currently being studied to improve outcomes in T-cell lymphomas. More work, however, needs to be done, and international collaboration will be pertinent to deriving meaningful results from future clinical studies. 1. Introduction T-cell lymphoma and natural-killer- (NK-) cell lymphoma represent the smaller subsets of non-Hodgkin’s lymphoma (NHL) that appear to have a geographical predilection to Asia. In Europe and North America, T-cell and NK-cell lymphoma account for 5–10% of all cases of NHL whilst in Asia, this percentage is as high as 24% [1]. T-cell lymphomas, as a group, carry a poorer prognosis compared to their B cell counterpart [2]. In the subgroup of patients with a low international prognostic index (IPI) score of 1-2, 5-year overall survival (OS) was 55% in those with T-cell lymphomas and 71% in those with B-cell lymphomas, and this difference in survival was also reflected in patients with higher IPI scores [3]. T-cell lymphomas, however, represent a heterogeneous group of diseases with variations in clinical characteristics, prognosis and response to treatment. This paper reviews the developments in the understanding of mature peripheral T-cell lymphoma (PTCL) and its management. 1.1. WHO Classification of T-Cell Lymphoma The 4th edition of the World Health Organization (WHO) classification of tumours of the haematopoietic and lymphoid tissue published in 2008 builds upon the previous edition published in 2001, and reclassifies clinicopathological entities based on better understanding from research in the last few years [4]. The WHO classification now contains 22 different T-cell lymphomas, 7 more than the previous classification. These can be subclassified according to whether they are predominantly
Wireless Meter Reading Based Energy-Balanced Steady Clustering Routing Algorithm for Sensor Networks
Advances in Electrical and Computer Engineering , 2011, DOI: 10.4316/aece.2011.02002
Abstract: According to the characteristics of wireless meter reading system, an energy-balanced and energy-efficient steady clustering routing algorithm (EBSC, Energy-Balanced Steady Clustering) is proposed. In the clustering mechanism, the current cluster head nodes determine cluster head nodes for next round according to the residual energy of the cluster members. In the next round, each non-cluster head node decides the cluster to which it will belong according to energy-distance function. The cluster head nodes send data to base station by the communication model of single hop and multi-hop that is decided according to the criterion of minimum energy consumption. In EBSC algorithm, the number of cluster head nodes generated in each round is very steady, and EBSC combines the advantage both distributed and centralized clustering algorithm. Experimental results show that the proposed routing algorithm not only efficiently uses limited energy of network nodes, but also well balances energy consumption of all nodes, and significantly prolongs network lifetime.
Knowledge and Anchoring: Verification of Three Circumstances in Which Knowledge Does Not Interfere with Anchoring  [PDF]
Fu-Yuan Tang, Tom M. Y. Lin
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.57010
Abstract: Many researchers have demonstrated that those people with higher knowledge are less subject to the impact of a given anchor. In real life, however, a situation might be quite complicated and not simply a question of an existing high (or low) anchor. We have designed four tests to demonstrate the relation between knowledge and anchoring. We hold that only in general situations can knowledge interfere with the anchoring effect. Study 1 was used to demonstrate this hypothesis. The research result in turn served as the foundation for our follow-up studies. Based on this foundation, we conducted three experiments to demonstrate that, when faced with a complicated and difficult estimation that must be completed within a short period of time (Study 2), when the source of information possesses a high degree of reliability (Study 3), and when practical experience is lacking (Study 4), the anchoring effect will still exert influences on people with higher knowledge.
Genetics and Regulatory Impact of Alternative Polyadenylation in Human B-Lymphoblastoid Cells
Oh Kyu Yoon,Tiffany Y. Hsu,Joo Hyun Im,Rachel B. Brem
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002882
Abstract: Gene expression varies widely between individuals of a population, and regulatory change can underlie phenotypes of evolutionary and biomedical relevance. A key question in the field is how DNA sequence variants impact gene expression, with most mechanistic studies to date focused on the effects of genetic change on regulatory regions upstream of protein-coding sequence. By contrast, the role of RNA 3′-end processing in regulatory variation remains largely unknown, owing in part to the challenge of identifying functional elements in 3′ untranslated regions. In this work, we conducted a genomic survey of transcript ends in lymphoblastoid cells from genetically distinct human individuals. Our analysis mapped the cis-regulatory architecture of 3′ gene ends, finding that transcript end positions did not fall randomly in untranslated regions, but rather preferentially flanked the locations of 3′ regulatory elements, including miRNA sites. The usage of these transcript length forms and motifs varied across human individuals, and polymorphisms in polyadenylation signals and other 3′ motifs were significant predictors of expression levels of the genes in which they lay. Independent single-gene experiments confirmed the effects of polyadenylation variants on steady-state expression of their respective genes, and validated the regulatory function of 3′ cis-regulatory sequence elements that mediated expression of these distinct RNA length forms. Focusing on the immune regulator IRF5, we established the effect of natural variation in RNA 3′-end processing on regulatory response to antigen stimulation. Our results underscore the importance of two mechanisms at play in the genetics of 3′-end variation: the usage of distinct 3′-end processing signals and the effects of 3′ sequence elements that determine transcript fate. Our findings suggest that the strategy of integrating observed 3′-end positions with inferred 3′ regulatory motifs will prove to be a critical tool in continued efforts to interpret human genome variation.
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