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Search Results: 1 - 10 of 112706 matches for " Thomas W. Prior "
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Engineering more engineers - bridging the mathematics and careers advice gap
Eleri Bowen,Julie Prior,Stephen Lloyd,Stephen Thomas
Engineering Education , 2007,
Abstract: The popularity of engineering degrees among undergraduates is in decline. There are many barriers affecting the supply of engineering undergraduates and the School of Technology at the University of Glamorgan has identified lack of awareness of what engineering entails and lack of mathematical preparedness as two principal barriers to potential students studying engineering in higher education. To show how the School of Technology overcame these barriers, the role of the Network75 Recruitment and Support Officer will be explained along with the subsequent development of a remedial summer mathematics programme entitled ‘Bridging Technology with Mathematics’. These two initiatives are outlined and their success evaluated in terms of increasing engineering undergraduate enrolments for the academic year 2005/06. This paper would be of interest to anyone working in the field of engineering recruitment and admissions, as this programme can be replicated by other further education or higher education providers.
SMA CARNI-VAL TRIAL PART II: A Prospective, Single-Armed Trial of L-Carnitine and Valproic Acid in Ambulatory Children with Spinal Muscular Atrophy
John T. Kissel,Charles B. Scott,Sandra P. Reyna,Thomas O. Crawford,Louise R. Simard,Kristin J. Krosschell,Gyula Acsadi,Bakri Elsheik,Mary K. Schroth,Guy D'Anjou,Bernard LaSalle,Thomas W. Prior,Susan Sorenson,Jo Anne Maczulski,Mark B. Bromberg,Gary M. Chan,Kathryn J. Swoboda
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0021296
Abstract: Multiple lines of evidence have suggested that valproic acid (VPA) might benefit patients with spinal muscular atrophy (SMA). The SMA CARNIVAL TRIAL was a two part prospective trial to evaluate oral VPA and l-carnitine in SMA children. Part 1 targeted non-ambulatory children ages 2–8 in a 12 month cross over design. We report here Part 2, a twelve month prospective, open-label trial of VPA and L-carnitine in ambulatory SMA children.
Phase II Open Label Study of Valproic Acid in Spinal Muscular Atrophy
Kathryn J. Swoboda, Charles B. Scott, Sandra P. Reyna, Thomas W. Prior, Bernard LaSalle, Susan L. Sorenson, Janine Wood, Gyula Acsadi, Thomas O. Crawford, John T. Kissel, Kristin J. Krosschell, Guy D'Anjou, Mark B. Bromberg, Mary K. Schroth, Gary M. Chan, Bakri Elsheikh, Louise R. Simard
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005268
Abstract: Preliminary in vitro and in vivo studies with valproic acid (VPA) in cell lines and patients with spinal muscular atrophy (SMA) demonstrate increased expression of SMN, supporting the possibility of therapeutic benefit. We performed an open label trial of VPA in 42 subjects with SMA to assess safety and explore potential outcome measures to help guide design of future controlled clinical trials. Subjects included 2 SMA type I ages 2–3 years, 29 SMA type II ages 2–14 years and 11 type III ages 2–31 years, recruited from a natural history study. VPA was well-tolerated and without evident hepatotoxicity. Carnitine depletion was frequent and temporally associated with increased weakness in two subjects. Exploratory outcome measures included assessment of gross motor function via the modified Hammersmith Functional Motor Scale (MHFMS), electrophysiologic measures of innervation including maximum ulnar compound muscle action potential (CMAP) amplitudes and motor unit number estimation (MUNE), body composition and bone density via dual-energy X-ray absorptiometry (DEXA), and quantitative blood SMN mRNA levels. Clear decline in motor function occurred in several subjects in association with weight gain; mean fat mass increased without a corresponding increase in lean mass. We observed an increased mean score on the MHFMS scale in 27 subjects with SMA type II (p≤0.001); however, significant improvement was almost entirely restricted to participants <5 years of age. Full length SMN levels were unchanged and Δ7SMN levels were significantly reduced for 2 of 3 treatment visits. In contrast, bone mineral density (p≤0.0036) and maximum ulnar CMAP scores (p≤0.0001) increased significantly. Conclusions While VPA appears safe and well-tolerated in this initial pilot trial, these data suggest that weight gain and carnitine depletion are likely to be significant confounding factors in clinical trials. This study highlights potential strengths and limitations of various candidate outcome measures and underscores the need for additional controlled clinical trials with VPA targeting more restricted cohorts of subjects. Trial Registration ClinicalTrials.gov
SMA CARNI-VAL Trial Part I: Double-Blind, Randomized, Placebo-Controlled Trial of L-Carnitine and Valproic Acid in Spinal Muscular Atrophy
Kathryn J. Swoboda,Charles B. Scott,Thomas O. Crawford,Louise R. Simard,Sandra P. Reyna,Kristin J. Krosschell,Gyula Acsadi,Bakri Elsheik,Mary K. Schroth,Guy D'Anjou,Bernard LaSalle,Thomas W. Prior,Susan L. Sorenson,Jo Anne Maczulski,Mark B. Bromberg,Gary M. Chan,John T. Kissel
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012140
Abstract: Valproic acid (VPA) has demonstrated potential as a therapeutic candidate for spinal muscular atrophy (SMA) in vitro and in vivo.
Electrostriction Effects During Defibrillation
Michelle M. Fritz,Phil W. Prior,Bradley J. Roth
Physics , 2011,
Abstract: Background-The electric field applied to the heart during defibrillation causes mechanical forces (electrostriction), and as a result the heart deforms. This paper analyses the physical origin of the deformation, and how significant it is. Methods-We represent the heart as an anisotropic cylinder. This simple geometry allows us to obtain analytical solutions for the potential, current density, charge, stress, and strain. Results-Charge induced on the heart surface in the presence of the electric field results in forces that deform the heart. In addition, the anisotropy of cardiac tissue creates a charge density throughout the tissue volume, leading to body forces. These two forces cause the tissue to deform in a complicated manner, with the anisotropy suppressing radial displacements in favor of tangential ones. Quantitatively, the deformation of the tissue is small, although it may be significant when using some imaging techniques that require the measurement of small displacements. Conclusions-The anisotropy of cardiac tissue produces qualitatively new mechanical behavior during a strong, defibrillation-strength electric shock.
A Critique of Recent Criticisms of Freud on Religious Belief  [PDF]
Thomas W Smythe
Open Journal of Philosophy (OJPP) , 2011, DOI: 10.4236/ojpp.2011.11002
Abstract: The paper is a critique of recent criticisms of Sigmund Freud’s theory that religion is based on wishful thinking. The criticisms made by authors such as Alvin Plantinga, John Hick, William P. Alston, William Rowe, and Merol Westphal are critically examined. I defend Freud’s critique of religion as a satisfaction of our deepest desires for a heavenly father showing inductively that those desires render religious belief as unlikely to be true.
My Body: Is It Me?  [PDF]
Thomas W. Smythe
Open Journal of Philosophy (OJPP) , 2012, DOI: 10.4236/ojpp.2012.23027
Abstract: In this paper I will take the term “my” in the phrase “my body” to be typically used to refer to the self or person whose body it is. This raises a problem for materialism over how a body can own or have itself. I will articulate some ways in which we are and are not related to our bodies, and try to undo the linquistic knot of a body owning itself.
Kant on Self-Awareness  [PDF]
Thomas W. Smythe
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.34077
Abstract: This paper has three main parts. First, I discuss Kant on self-awareness in terms of inner sense, why he failed to make this account coherent, and why he failed to give such an account. Second, I give two reasons why such an account is bound to be inadequate. In the last section, I discuss another attempt Kant was tempted to give in terms of transcendental self-awareness involving a nonsensory intuitive perception that helps solve some of his problems.
An Investigation of the Effect of the Swamping Phenomenon on Several Block Procedures for Multiple Outliers in Univariate Samples  [PDF]
Thomas W. Woolley
Open Journal of Statistics (OJS) , 2013, DOI: 10.4236/ojs.2013.35035

In its broadest sense, this paper reviews the general outlier problem, the means available for addressing the discordancy (or lack thereof) of an outlier (or outliers), and possible strategies for dealing with them. Two alternate approaches to the multiple outlier problem, consecutive and block testing, and their respective inherent weaknesses, masking and swamping, are discussed. In addition, the relative susceptibility of several tests for outliers in normal samples to the swamping phenomena is reported.

Voluntary Control of Desire  [PDF]
Thomas W. Smythe
Open Journal of Philosophy (OJPP) , 2016, DOI: 10.4236/ojpp.2016.61010
Abstract: In this paper, I will investigate whether there is any way in which our desires or wants are under our voluntary control. I shall argue that even if our desires are not under our voluntary control, there are still significantly many cases in which we can properly be blamed, praised, or upbraided for having certain desires.
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